Peilin Zhou

Hongjian Zhou, Fenglin Liu, Boyang Gu et al.

Large language models (LLMs), such as ChatGPT, have received substantial attention due to their capabilities for understanding and generating human language. While there has been a burgeoning trend in research focusing on the employment of LLMs in supporting different medical tasks (e.g., enhancing clinical diagnostics and providing medical education), a review of these efforts, particularly their development, practical applications, and outcomes in medicine, remains scarce. Therefore, this review aims to provide a detailed overview of the development and deployment of LLMs in medicine, including the challenges and opportunities they face. In terms of development, we provide a detailed introduction to the principles of existing medical LLMs, including their basic model structures, number of parameters, and sources and scales of data used for model development. It serves as a guide for practitioners in developing medical LLMs tailored to their specific needs. In terms of deployment, we offer a comparison of the performance of different LLMs across various medical tasks, and further compare them with state-of-the-art lightweight models, aiming to provide an understanding of the advantages and limitations of LLMs in medicine. Overall, in this review, we address the following questions: 1) What are the practices for developing medical LLMs 2) How to measure the medical task performance of LLMs in a medical setting? 3) How have medical LLMs been employed in real-world practice? 4) What challenges arise from the use of medical LLMs? and 5) How to more effectively develop and deploy medical LLMs? By answering these questions, this review aims to provide insights into the opportunities for LLMs in medicine and serve as a practical resource. We also maintain a regularly updated list of practical guides on medical LLMs at https://github.com/AI-in-Health/MedLLMsPracticalGuide

Yueqi Xie, Peilin Zhou, Sunghun Kim

Side information fusion for sequential recommendation (SR) aims to effectively leverage various side information to enhance the performance of next-item prediction. Most state-of-the-art methods build on self-attention networks and focus on exploring various solutions to integrate the item embedding and side information embeddings before the attention layer. However, our analysis shows that the early integration of various types of embeddings limits the expressiveness of attention matrices due to a rank bottleneck and constrains the flexibility of gradients. Also, it involves mixed correlations among the different heterogeneous information resources, which brings extra disturbance to attention calculation. Motivated by this, we propose Decoupled Side Information Fusion for Sequential Recommendation (DIF-SR), which moves the side information from the input to the attention layer and decouples the attention calculation of various side information and item representation. We theoretically and empirically show that the proposed solution allows higher-rank attention matrices and flexible gradients to enhance the modeling capacity of side information fusion. Also, auxiliary attribute predictors are proposed to further activate the beneficial interaction between side information and item representation learning. Extensive experiments on four real-world datasets demonstrate that our proposed solution stably outperforms state-of-the-art SR models. Further studies show that our proposed solution can be readily incorporated into current attention-based SR models and significantly boost performance. Our source code is available at https://github.com/AIM-SE/DIF-SR.

Peilin Zhou, Meng Cao, You-Liang Huang et al.

Large Multimodal Models (LMMs) have demonstrated impressive performance across various vision and language tasks, yet their potential applications in recommendation tasks with visual assistance remain unexplored. To bridge this gap, we present a preliminary case study investigating the recommendation capabilities of GPT-4V(ison), a recently released LMM by OpenAI. We construct a series of qualitative test samples spanning multiple domains and employ these samples to assess the quality of GPT-4V's responses within recommendation scenarios. Evaluation results on these test samples prove that GPT-4V has remarkable zero-shot recommendation abilities across diverse domains, thanks to its robust visual-text comprehension capabilities and extensive general knowledge. However, we have also identified some limitations in using GPT-4V for recommendations, including a tendency to provide similar responses when given similar inputs. This report concludes with an in-depth discussion of the challenges and research opportunities associated with utilizing GPT-4V in recommendation scenarios. Our objective is to explore the potential of extending LMMs from vision and language tasks to recommendation tasks. We hope to inspire further research into next-generation multimodal generative recommendation models, which can enhance user experiences by offering greater diversity and interactivity. All images and prompts used in this report will be accessible at https://github.com/PALIN2018/Evaluate_GPT-4V_Rec.

Zhikai Wei, Wenhui Dong, Peilin Zhou et al.

Deep learning based methods often suffer from performance degradation caused by domain shift. In recent years, many sophisticated network structures have been designed to tackle this problem. However, the advent of large model trained on massive data, with its exceptional segmentation capability, introduces a new perspective for solving medical segmentation problems. In this paper, we propose a novel Domain-Adaptive Prompt framework for fine-tuning the Segment Anything Model (termed as DAPSAM) to address single-source domain generalization (SDG) in segmenting medical images. DAPSAM not only utilizes a more generalization-friendly adapter to fine-tune the large model, but also introduces a self-learning prototype-based prompt generator to enhance model's generalization ability. Specifically, we first merge the important low-level features into intermediate features before feeding to each adapter, followed by an attention filter to remove redundant information. This yields more robust image embeddings. Then, we propose using a learnable memory bank to construct domain-adaptive prototypes for prompt generation, helping to achieve generalizable medical image segmentation. Extensive experimental results demonstrate that our DAPSAM achieves state-of-the-art performance on two SDG medical image segmentation tasks with different modalities. The code is available at https://github.com/wkklavis/DAPSAM.

Junling Liu, Ziming Wang, Qichen Ye et al.

Large Language Models (LLMs) have introduced a new era of proficiency in comprehending complex healthcare and biomedical topics. However, there is a noticeable lack of models in languages other than English and models that can interpret multi-modal input, which is crucial for global healthcare accessibility. In response, this study introduces Qilin-Med-VL, the first Chinese large vision-language model designed to integrate the analysis of textual and visual data. Qilin-Med-VL combines a pre-trained Vision Transformer (ViT) with a foundational LLM. It undergoes a thorough two-stage curriculum training process that includes feature alignment and instruction tuning. This method enhances the model's ability to generate medical captions and answer complex medical queries. We also release ChiMed-VL, a dataset consisting of more than 1M image-text pairs. This dataset has been carefully curated to enable detailed and comprehensive interpretation of medical data using various types of images.

Peilin Zhou, Dading Chong, Helin Wang et al.

The past ten years have witnessed the rapid development of text-based intent detection, whose benchmark performances have already been taken to a remarkable level by deep learning techniques. However, automatic speech recognition (ASR) errors are inevitable in real-world applications due to the environment noise, unique speech patterns and etc, leading to sharp performance drop in state-of-the-art text-based intent detection models. Essentially, this phenomenon is caused by the semantic drift brought by ASR errors and most existing works tend to focus on designing new model structures to reduce its impact, which is at the expense of versatility and flexibility. Different from previous one-piece model, in this paper, we propose a novel and agile framework called CR-ID for ASR error robust intent detection with two plug-and-play modules, namely semantic drift calibration module (SDCM) and phonemic refinement module (PRM), which are both model-agnostic and thus could be easily integrated to any existing intent detection models without modifying their structures. Experimental results on SNIPS dataset show that, our proposed CR-ID framework achieves competitive performance and outperform all the baseline methods on ASR outputs, which verifies that CR-ID can effectively alleviate the semantic drift caused by ASR errors.

Jian Chen, Peilin Zhou, Yining Hua et al.

Accurate evaluation of financial question answering (QA) systems necessitates a comprehensive dataset encompassing diverse question types and contexts. However, current financial QA datasets lack scope diversity and question complexity. This work introduces FinTextQA, a novel dataset for long-form question answering (LFQA) in finance. FinTextQA comprises 1,262 high-quality, source-attributed QA pairs extracted and selected from finance textbooks and government agency websites.Moreover, we developed a Retrieval-Augmented Generation (RAG)-based LFQA system, comprising an embedder, retriever, reranker, and generator. A multi-faceted evaluation approach, including human ranking, automatic metrics, and GPT-4 scoring, was employed to benchmark the performance of different LFQA system configurations under heightened noisy conditions. The results indicate that: (1) Among all compared generators, Baichuan2-7B competes closely with GPT-3.5-turbo in accuracy score; (2) The most effective system configuration on our dataset involved setting the embedder, retriever, reranker, and generator as Ada2, Automated Merged Retrieval, Bge-Reranker-Base, and Baichuan2-7B, respectively; (3) models are less susceptible to noise after the length of contexts reaching a specific threshold.

Peilin Zhou, Bo Du, Yongchao Xu

Recent trends in cell segmentation have shifted towards universal models to handle diverse cell morphologies and imaging modalities. However, for continuously emerging cell types and imaging techniques, these models still require hundreds or thousands of annotated cells for fine-tuning. We introduce CellSeg1, a practical solution for segmenting cells of arbitrary morphology and modality with a few dozen cell annotations in 1 image. By adopting Low-Rank Adaptation of the Segment Anything Model (SAM), we achieve robust cell segmentation. Tested on 19 diverse cell datasets, CellSeg1 trained on 1 image achieved 0.81 average mAP at 0.5 IoU, performing comparably to existing models trained on over 500 images. It also demonstrated superior generalization in cross-dataset tests on TissueNet. We found that high-quality annotation of a few dozen densely packed cells of varied sizes is key to effective segmentation. CellSeg1 provides an efficient solution for cell segmentation with minimal annotation effort.

Yuda Zou, Xin Xiao, Peilin Zhou et al.

Object counting typically uses 2D point annotations. The complexity of object shapes and the subjectivity of annotators may lead to annotation inconsistency, potentially confusing counting model training. Some sophisticated noise-resistance counting methods have been proposed to alleviate this issue. Differently, we aim to directly refine the initial point annotations before training counting models. For that, we propose the Shifted Autoencoders (SAE), which enhances annotation consistency. Specifically, SAE applies random shifts to initial point annotations and employs a UNet to restore them to their original positions. Similar to MAE reconstruction, the trained SAE captures general position knowledge and ignores specific manual offset noise. This allows to restore the initial point annotations to more general and thus consistent positions. Extensive experiments show that using such refined consistent annotations to train some advanced (including noise-resistance) object counting models steadily/significantly boosts their performances. Remarkably, the proposed SAE helps to set new records on nine datasets. We will make codes and refined point annotations available.

Ziyue Xu, Peilin Zhou, Xinyu Shi et al.

Accurate and transparent financial information disclosure is essential in accounting and finance, fostering trust and enabling informed investment decisions that drive economic development. Among many information disclosure platforms, the Chinese stock exchanges' investor interactive platform provides a novel and interactive way for listed firms to disclose information of interest to investors through an online question-and-answer (Q&A) format. However, it is common for listed firms to respond to questions with limited or no substantive information, and automatically evaluating the quality of financial information disclosure on large amounts of Q&A pairs is challenging. In this study, our interdisciplinary team of AI and finance professionals proposed FinTruthQA, a benchmark designed to evaluate advanced natural language processing (NLP) techniques for the automatic quality assessment of information disclosure in financial Q&A data. It comprises 6,000 real-world financial Q&A entries and each Q&A was manually annotated based on four key evaluation criteria. We benchmarked various NLP techniques on FinTruthQA, including large language models(LLMs). Experiments showed that existing NLP models have strong predictive ability for question identification and question relevance tasks, but are suboptimal for answer readability and answer relevance tasks. By establishing this benchmark, we provide a robust foundation for the automatic evaluation of information disclosure, demonstrating how AI can be leveraged for social good by promoting transparency, fairness, and investor protection in financial disclosure practices. FinTruthQA can be used by auditors, regulators, and financial analysts for real-time monitoring and data-driven decision-making, as well as by researchers for advanced studies in accounting and finance, ultimately fostering greater trust and efficiency in the financial markets.

Lisong Chen, Peilin Zhou, Yuexian Zou

Intent detection and slot filling are two main tasks in natural language understanding (NLU) for identifying users' needs from their utterances. These two tasks are highly related and often trained jointly. However, most previous works assume that each utterance only corresponds to one intent, ignoring the fact that a user utterance in many cases could include multiple intents. In this paper, we propose a novel Self-Distillation Joint NLU model (SDJN) for multi-intent NLU. First, we formulate multiple intent detection as a weakly supervised problem and approach with multiple instance learning (MIL). Then, we design an auxiliary loop via self-distillation with three orderly arranged decoders: Initial Slot Decoder, MIL Intent Decoder, and Final Slot Decoder. The output of each decoder will serve as auxiliary information for the next decoder. With the auxiliary knowledge provided by the MIL Intent Decoder, we set Final Slot Decoder as the teacher model that imparts knowledge back to Initial Slot Decoder to complete the loop. The auxiliary loop enables intents and slots to guide mutually in-depth and further boost the overall NLU performance. Experimental results on two public multi-intent datasets indicate that our model achieves strong performance compared to others.

Nuo Chen, Fenglin Liu, Chenyu You et al.

Recently, the attention-enhanced multi-layer encoder, such as Transformer, has been extensively studied in Machine Reading Comprehension (MRC). To predict the answer, it is common practice to employ a predictor to draw information only from the final encoder layer which generates the \textit{coarse-grained} representations of the source sequences, i.e., passage and question. Previous studies have shown that the representation of source sequence becomes more \textit{coarse-grained} from \textit{fine-grained} as the encoding layer increases. It is generally believed that with the growing number of layers in deep neural networks, the encoding process will gather relevant information for each location increasingly, resulting in more \textit{coarse-grained} representations, which adds the likelihood of similarity to other locations (referring to homogeneity). Such a phenomenon will mislead the model to make wrong judgments so as to degrade the performance. To this end, we propose a novel approach called Adaptive Bidirectional Attention, which adaptively exploits the source representations of different levels to the predictor. Experimental results on the benchmark dataset, SQuAD 2.0 demonstrate the effectiveness of our approach, and the results are better than the previous state-of-the-art model by 2.5$\%$ EM and 2.3$\%$ F1 scores.

Peilin Zhou, Zhiqi Huang, Fenglin Liu et al.

Spoken Language Understanding (SLU) is an essential part of the spoken dialogue system, which typically consists of intent detection (ID) and slot filling (SF) tasks. Recently, recurrent neural networks (RNNs) based methods achieved the state-of-the-art for SLU. It is noted that, in the existing RNN-based approaches, ID and SF tasks are often jointly modeled to utilize the correlation information between them. However, we noted that, so far, the efforts to obtain better performance by supporting bidirectional and explicit information exchange between ID and SF are not well studied.In addition, few studies attempt to capture the local context information to enhance the performance of SF. Motivated by these findings, in this paper, Parallel Interactive Network (PIN) is proposed to model the mutual guidance between ID and SF. Specifically, given an utterance, a Gaussian self-attentive encoder is introduced to generate the context-aware feature embedding of the utterance which is able to capture local context information. Taking the feature embedding of the utterance, Slot2Intent module and Intent2Slot module are developed to capture the bidirectional information flow for ID and SF tasks. Finally, a cooperation mechanism is constructed to fuse the information obtained from Slot2Intent and Intent2Slot modules to further reduce the prediction bias.The experiments on two benchmark datasets, i.e., SNIPS and ATIS, demonstrate the effectiveness of our approach, which achieves a competitive result with state-of-the-art models. More encouragingly, by using the feature embedding of the utterance generated by the pre-trained language model BERT, our method achieves the state-of-the-art among all comparison approaches.