Giulio Franzese

Giulio Franzese, Simone Rossi, Lixuan Yang et al.

Score-based diffusion models are a class of generative models whose dynamics is described by stochastic differential equations that map noise into data. While recent works have started to lay down a theoretical foundation for these models, an analytical understanding of the role of the diffusion time T is still lacking. Current best practice advocates for a large T to ensure that the forward dynamics brings the diffusion sufficiently close to a known and simple noise distribution; however, a smaller value of T should be preferred for a better approximation of the score-matching objective and higher computational efficiency. Starting from a variational interpretation of diffusion models, in this work we quantify this trade-off, and suggest a new method to improve quality and efficiency of both training and sampling, by adopting smaller diffusion times. Indeed, we show how an auxiliary model can be used to bridge the gap between the ideal and the simulated forward dynamics, followed by a standard reverse diffusion process. Empirical results support our analysis; for image data, our method is competitive w.r.t. the state-of-the-art, according to standard sample quality metrics and log-likelihood.

Giulio Franzese, Giulio Corallo, Simone Rossi et al.

We introduce Functional Diffusion Processes (FDPs), which generalize score-based diffusion models to infinite-dimensional function spaces. FDPs require a new mathematical framework to describe the forward and backward dynamics, and several extensions to derive practical training objectives. These include infinite-dimensional versions of Girsanov theorem, in order to be able to compute an ELBO, and of the sampling theorem, in order to guarantee that functional evaluations in a countable set of points are equivalent to infinite-dimensional functions. We use FDPs to build a new breed of generative models in function spaces, which do not require specialized network architectures, and that can work with any kind of continuous data. Our results on real data show that FDPs achieve high-quality image generation, using a simple MLP architecture with orders of magnitude fewer parameters than existing diffusion models.

Giulio Franzese, Mustapha Bounoua, Pietro Michiardi

In this work we present a new method for the estimation of Mutual Information (MI) between random variables. Our approach is based on an original interpretation of the Girsanov theorem, which allows us to use score-based diffusion models to estimate the Kullback Leibler divergence between two densities as a difference between their score functions. As a by-product, our method also enables the estimation of the entropy of random variables. Armed with such building blocks, we present a general recipe to measure MI, which unfolds in two directions: one uses conditional diffusion process, whereas the other uses joint diffusion processes that allow simultaneous modelling of two random variables. Our results, which derive from a thorough experimental protocol over all the variants of our approach, indicate that our method is more accurate than the main alternatives from the literature, especially for challenging distributions. Furthermore, our methods pass MI self-consistency tests, including data processing and additivity under independence, which instead are a pain-point of existing methods.

Mustapha Bounoua, Giulio Franzese, Pietro Michiardi

Multi-modal data-sets are ubiquitous in modern applications, and multi-modal Variational Autoencoders are a popular family of models that aim to learn a joint representation of the different modalities. However, existing approaches suffer from a coherence-quality tradeoff, where models with good generation quality lack generative coherence across modalities, and vice versa. We discuss the limitations underlying the unsatisfactory performance of existing methods, to motivate the need for a different approach. We propose a novel method that uses a set of independently trained, uni-modal, deterministic autoencoders. Individual latent variables are concatenated into a common latent space, which is fed to a masked diffusion model to enable generative modeling. We also introduce a new multi-time training method to learn the conditional score network for multi-modal diffusion. Our methodology substantially outperforms competitors in both generation quality and coherence, as shown through an extensive experimental campaign.

Alberto Foresti, Mustapha Bounoua, Giulio Franzese et al.

Discrete diffusion models have emerged as a powerful paradigm for generative modeling on sequence data; however, the information-theoretic principles governing their reverse processes remain significantly less understood than those of their continuous counterparts. In this work, we bridge this gap by analyzing the reverse process dynamics through the lens of thermodynamic entropy production. We propose the entropy production rate as a rigorous proxy for quantifying information generation, deriving as a byproduct a bound on the Wasserstein distance between intermediate states and the data distribution. Leveraging these insights, we introduce two novel sampling schedules that are uniformly spaced with respect to their corresponding physics-inspired metrics: the Entropic Discrete Schedule (EDS), which is defined by maintaining a constant rate of information gain, and the Wasserstein Discrete Schedule (WDS), which is defined by taking equal steps in terms of the Wasserstein distance. We empirically demonstrate that our proposed schedules significantly outperform state-of-the-art strategies across diverse application domains, including synthetic data, music notation, vision and language modeling, consistently achieving superior performance at a lower computational budget.

Chao Wang, Luca Nepote, Giulio Franzese et al.

Trajectory Inference (TI) seeks to recover latent dynamical processes from snapshot data, where only independent samples from time-indexed marginals are observed. In applications such as single-cell genomics, destructive measurements make path-space laws non-identifiable from finitely many marginals, leaving held-out marginal prediction as the dominant but limited evaluation protocol. We introduce a general framework for estimating the Kullback-Leibler divergence (KL) divergence between probability measures on function space, yielding a tractable, data-driven estimator that is scalable to realistic snapshot datasets. We validate the accuracy of our estimator on a benchmark suite, where the estimated functional KL closely matches the analytic KL. Applying this framework to synthetic and real scRNA-seq datasets, we show that current evaluation metrics often give inconsistent assessments, whereas path-space KL enables a coherent comparison of trajectory inference methods and exposes discrepancies in inferred dynamics, especially in regions with sparse or missing data. These results support functional KL as a principled criterion for evaluating trajectory inference under partial observability.

Mustapha Bounoua, Giulio Franzese, Pietro Michiardi

Multimodal data is a precious asset enabling a variety of downstream tasks in machine learning. However, real-world data collected across different modalities is often not paired, which is a significant challenge to learn a joint distribution. A prominent approach to address the modality coupling problem is Minimum Entropy Coupling (MEC), which seeks to minimize the joint Entropy, while satisfying constraints on the marginals. Existing approaches to the MEC problem focus on finite, discrete distributions, limiting their application for cases involving continuous data. In this work, we propose a novel method to solve the continuous MEC problem, using well-known generative diffusion models that learn to approximate and minimize the joint Entropy through a cooperative scheme, while satisfying a relaxed version of the marginal constraints. We empirically demonstrate that our method, DDMEC, is general and can be easily used to address challenging tasks, including unsupervised single-cell multi-omics data alignment and unpaired image translation, outperforming specialized methods.

Mustapha Bounoua, Giulio Franzese, Pietro Michiardi

The analysis of scientific data and complex multivariate systems requires information quantities that capture relationships among multiple random variables. Recently, new information-theoretic measures have been developed to overcome the shortcomings of classical ones, such as mutual information, that are restricted to considering pairwise interactions. Among them, the concept of information synergy and redundancy is crucial for understanding the high-order dependencies between variables. One of the most prominent and versatile measures based on this concept is O-information, which provides a clear and scalable way to quantify the synergy-redundancy balance in multivariate systems. However, its practical application is limited to simplified cases. In this work, we introduce S$Ω$I, which allows for the first time to compute O-information without restrictive assumptions about the system. Our experiments validate our approach on synthetic data, and demonstrate the effectiveness of S$Ω$I in the context of a real-world use case.

Chao Wang, Giulio Franzese, Alessandro Finamore et al.

Rectified Flow (RF) models trained with a Flow matching framework have achieved state-of-the-art performance on Text-to-Image (T2I) conditional generation. Yet, multiple benchmarks show that synthetic images can still suffer from poor alignment with the prompt, i.e., images show wrong attribute binding, subject positioning, numeracy, etc. While the literature offers many methods to improve T2I alignment, they all consider only Diffusion Models, and require auxiliary datasets, scoring models, and linguistic analysis of the prompt. In this paper we aim to address these gaps. First, we introduce RFMI, a novel Mutual Information (MI) estimator for RF models that uses the pre-trained model itself for the MI estimation. Then, we investigate a self-supervised fine-tuning approach for T2I alignment based on RFMI that does not require auxiliary information other than the pre-trained model itself. Specifically, a fine-tuning set is constructed by selecting synthetic images generated from the pre-trained RF model and having high point-wise MI between images and prompts. Our experiments on MI estimation benchmarks demonstrate the validity of RFMI, and empirical fine-tuning on SD3.5-Medium confirms the effectiveness of RFMI for improving T2I alignment while maintaining image quality.

Simone Clemente, Zied Ben Houidi, Alexis Huet et al.

Through systematic empirical investigation, we uncover a fundamental and concerning property of Large Language Models: while they can safely learn facts that don't contradict their knowledge, attempting to update facts with contradictory information triggers catastrophic corruption of unrelated knowledge. Unlike humans, who naturally resist contradictory information, these models indiscriminately accept contradictions, leading to devastating interference, destroying up to 80% of unrelated knowledge even when learning as few as 10-100 contradicting facts. To understand whether this interference could be mitigated through selective plasticity, we experiment with targeted network updates, distinguishing between previously used (stubborn) and rarely used (plastic) neurons. We uncover another asymmetry: while sparing frequently-used neurons significantly improves retention of existing knowledge for non-contradictory updates (98% vs 93% with standard updates), contradictory updates trigger catastrophic interference regardless of targeting strategy. This effect which persists across tested model scales (GPT-2 to GPT-J-6B), suggests a fundamental limitation in how neural networks handle contradictions. Finally, we demonstrate that contradictory information can be reliably detected (95%+ accuracy) using simple model features, offering a potential protective mechanism. These findings motivate new architectures that can, like humans, naturally resist contradictions rather than allowing destructive overwrites.

Simon Pedro Galeano Munoz, Mustapha Bounoua, Giulio Franzese et al.

Transfer entropy measures directed information flow in time series, and it has become a fundamental quantity in applications spanning neuroscience, finance, and complex systems analysis. However, existing estimation methods suffer from the curse of dimensionality, require restrictive distributional assumptions, or need exponentially large datasets for reliable convergence. We address these limitations in the literature by proposing TENDE (Transfer Entropy Neural Diffusion Estimation), a novel approach that leverages score-based diffusion models to estimate transfer entropy through conditional mutual information. By learning score functions of the relevant conditional distributions, TENDE provides flexible, scalable estimation while making minimal assumptions about the underlying data-generating process. We demonstrate superior accuracy and robustness compared to existing neural estimators and other state-of-the-art approaches across synthetic benchmarks and real data.

Mattia Rosso, Simone Rossi, Giulio Franzese et al.

Deep learning has recently revealed the existence of scaling laws, demonstrating that model performance follows predictable trends based on dataset and model sizes. Inspired by these findings and fascinating phenomena emerging in the over-parameterized regime, we examine a parallel direction: do similar scaling laws govern predictive uncertainties in deep learning? In identifiable parametric models, such scaling laws can be derived in a straightforward manner by treating model parameters in a Bayesian way. In this case, for example, we obtain $O(1/N)$ contraction rates for epistemic uncertainty with respect to the number of data $N$. However, in over-parameterized models, these guarantees do not hold, leading to largely unexplored behaviors. In this work, we empirically show the existence of scaling laws associated with various measures of predictive uncertainty with respect to dataset and model sizes. Through experiments on vision and language tasks, we observe such scaling laws for in- and out-of-distribution predictive uncertainty estimated through popular approximate Bayesian inference and ensemble methods. Besides the elegance of scaling laws and the practical utility of extrapolating uncertainties to larger data or models, this work provides strong evidence to dispel recurring skepticism against Bayesian approaches: "In many applications of deep learning we have so much data available: what do we need Bayes for?". Our findings show that "so much data" is typically not enough to make epistemic uncertainty negligible.

Alberto Foresti, Giulio Franzese, Pietro Michiardi

Information-theoretic quantities play a crucial role in understanding non-linear relationships between random variables and are widely used across scientific disciplines. However, estimating these quantities remains an open problem, particularly in the case of high-dimensional discrete distributions. Current approaches typically rely on embedding discrete data into a continuous space and applying neural estimators originally designed for continuous distributions, a process that may not fully capture the discrete nature of the underlying data. We consider Continuous-Time Markov Chains (CTMCs), stochastic processes on discrete state-spaces which have gained popularity due to their generative modeling applications. In this work, we introduce INFO-SEDD, a novel method for estimating information-theoretic quantities of discrete data, including mutual information and entropy. Our approach requires the training of a single parametric model, offering significant computational and memory advantages. Additionally, it seamlessly integrates with pretrained networks, allowing for efficient reuse of pretrained generative models. To evaluate our approach, we construct a challenging synthetic benchmark. Our experiments demonstrate that INFO-SEDD is robust and outperforms neural competitors that rely on embedding techniques. Moreover, we validate our method on a real-world task: estimating the entropy of an Ising model. Overall, INFO-SEDD outperforms competing methods and shows scalability to high-dimensional scenarios, paving the way for new applications where estimating MI between discrete distribution is the focus. The promising results in this complex, high-dimensional scenario highlight INFO-SEDD as a powerful new estimator in the toolkit for information-theoretical analysis.

Ba-Hien Tran, Giulio Franzese, Pietro Michiardi et al.

Generative Models (GMs) have attracted considerable attention due to their tremendous success in various domains, such as computer vision where they are capable to generate impressive realistic-looking images. Likelihood-based GMs are attractive due to the possibility to generate new data by a single model evaluation. However, they typically achieve lower sample quality compared to state-of-the-art score-based diffusion models (DMs). This paper provides a significant step in the direction of addressing this limitation. The idea is to borrow one of the strengths of score-based DMs, which is the ability to perform accurate density estimation in low-density regions and to address manifold overfitting by means of data mollification. We connect data mollification through the addition of Gaussian noise to Gaussian homotopy, which is a well-known technique to improve optimization. Data mollification can be implemented by adding one line of code in the optimization loop, and we demonstrate that this provides a boost in generation quality of likelihood-based GMs, without computational overheads. We report results on image data sets with popular likelihood-based GMs, including variants of variational autoencoders and normalizing flows, showing large improvements in FID score.

Giulio Franzese, Dimitrios Milios, Maurizio Filippone et al.

We revisit the theoretical properties of Hamiltonian stochastic differential equations (SDES) for Bayesian posterior sampling, and we study the two types of errors that arise from numerical SDE simulation: the discretization error and the error due to noisy gradient estimates in the context of data subsampling. Our main result is a novel analysis for the effect of mini-batches through the lens of differential operator splitting, revising previous literature results. The stochastic component of a Hamiltonian SDE is decoupled from the gradient noise, for which we make no normality assumptions. This leads to the identification of a convergence bottleneck: when considering mini-batches, the best achievable error rate is $\mathcal{O}(η^2)$, with $η$ being the integrator step size. Our theoretical results are supported by an empirical study on a variety of regression and classification tasks for Bayesian neural networks.

Giulio Franzese, Rosa Candela, Dimitrios Milios et al.

In this work we define a unified mathematical framework to deepen our understanding of the role of stochastic gradient (SG) noise on the behavior of Markov chain Monte Carlo sampling (SGMCMC) algorithms. Our formulation unlocks the design of a novel, practical approach to posterior sampling, which makes the SG noise isotropic using a fixed learning rate that we determine analytically, and that requires weaker assumptions than existing algorithms. In contrast, the common traits of existing \sgmcmc algorithms is to approximate the isotropy condition either by drowning the gradients in additive noise (annealing the learning rate) or by making restrictive assumptions on the \sg noise covariance and the geometry of the loss landscape. Extensive experimental validations indicate that our proposal is competitive with the state-of-the-art on \sgmcmc, while being much more practical to use.

Rosa Candela, Giulio Franzese, Maurizio Filippone et al.

Large scale machine learning is increasingly relying on distributed optimization, whereby several machines contribute to the training process of a statistical model. In this work we study the performance of asynchronous, distributed settings, when applying sparsification, a technique used to reduce communication overheads. In particular, for the first time in an asynchronous, non-convex setting, we theoretically prove that, in presence of staleness, sparsification does not harm SGD performance: the ergodic convergence rate matches the known result of standard SGD, that is $\mathcal{O} \left( 1/\sqrt{T} \right)$. We also carry out an empirical study to complement our theory, and confirm that the effects of sparsification on the convergence rate are negligible, when compared to 'vanilla' SGD, even in the challenging scenario of an asynchronous, distributed system.

Giulio Franzese, Monica Visintin

We describe a novel classifier with a tree structure, designed using information theory concepts. This Information Network is made of information nodes, that compress the input data, and multiplexers, that connect two or more input nodes to an output node. Each information node is trained, independently of the others, to minimize a local cost function that minimizes the mutual information between its input and output with the constraint of keeping a given mutual information between its output and the target (information bottleneck). We show that the system is able to provide good results in terms of accuracy, while it shows many advantages in terms of modularity and reduced complexity.