Zhao Ren

Zhao Ren, Yongjian Kang, Yingying Fan et al.

Heterogeneity is often natural in many contemporary applications involving massive data. While posing new challenges to effective learning, it can play a crucial role in powering meaningful scientific discoveries through the understanding of important differences among subpopulations of interest. In this paper, we exploit multiple networks with Gaussian graphs to encode the connectivity patterns of a large number of features on the subpopulations. To uncover the heterogeneity of these structures across subpopulations, we suggest a new framework of tuning-free heterogeneity pursuit (THP) via large-scale inference, where the number of networks is allowed to diverge. In particular, two new tests, the chi-based test and the linear functional-based test, are introduced and their asymptotic null distributions are established. Under mild regularity conditions, we establish that both tests are optimal in achieving the testable region boundary and the sample size requirement for the latter test is minimal. Both theoretical guarantees and the tuning-free feature stem from efficient multiple-network estimation by our newly suggested approach of heterogeneous group square-root Lasso (HGSL) for high-dimensional multi-response regression with heterogeneous noises. To solve this convex program, we further introduce a tuning-free algorithm that is scalable and enjoys provable convergence to the global optimum. Both computational and theoretical advantages of our procedure are elucidated through simulation and real data examples.

Mengjie Chen, Chao Gao, Zhao Ren et al.

Sparse Canonical Correlation Analysis (CCA) has received considerable attention in high-dimensional data analysis to study the relationship between two sets of random variables. However, there has been remarkably little theoretical statistical foundation on sparse CCA in high-dimensional settings despite active methodological and applied research activities. In this paper, we introduce an elementary sufficient and necessary characterization such that the solution of CCA is indeed sparse, propose a computationally efficient procedure, called CAPIT, to estimate the canonical directions, and show that the procedure is rate-optimal under various assumptions on nuisance parameters. The procedure is applied to a breast cancer dataset from The Cancer Genome Atlas project. We identify methylation probes that are associated with genes, which have been previously characterized as prognosis signatures of the metastasis of breast cancer.

Zhao Ren, Tingni Sun, Cun-Hui Zhang et al.

The Gaussian graphical model, a popular paradigm for studying relationship among variables in a wide range of applications, has attracted great attention in recent years. This paper considers a fundamental question: When is it possible to estimate low-dimensional parameters at parametric square-root rate in a large Gaussian graphical model? A novel regression approach is proposed to obtain asymptotically efficient estimation of each entry of a precision matrix under a sparseness condition relative to the sample size. When the precision matrix is not sufficiently sparse, or equivalently the sample size is not sufficiently large, a lower bound is established to show that it is no longer possible to achieve the parametric rate in the estimation of each entry. This lower bound result, which provides an answer to the delicate sample size question, is established with a novel construction of a subset of sparse precision matrices in an application of Le Cam's lemma. Moreover, the proposed estimator is proven to have optimal convergence rate when the parametric rate cannot be achieved, under a minimal sample requirement. The proposed estimator is applied to test the presence of an edge in the Gaussian graphical model or to recover the support of the entire model, to obtain adaptive rate-optimal estimation of the entire precision matrix as measured by the matrix $\ell_q$ operator norm and to make inference in latent variables in the graphical model. All of this is achieved under a sparsity condition on the precision matrix and a side condition on the range of its spectrum. This significantly relaxes the commonly imposed uniform signal strength condition on the precision matrix, irrepresentability condition on the Hessian tensor operator of the covariance matrix or the $\ell_1$ constraint on the precision matrix. Numerical results confirm our theoretical findings. The ROC curve of the proposed algorithm, Asymptotic Normal Thresholding (ANT), for support recovery significantly outperforms that of the popular GLasso algorithm.