Hongyuan Dong

Yutai Hou, Hongyuan Dong, Xinghao Wang et al. · cmu

Prompting method is regarded as one of the crucial progress for few-shot nature language processing. Recent research on prompting moves from discrete tokens based ``hard prompts'' to continuous ``soft prompts'', which employ learnable vectors as pseudo prompt tokens and achieve better performance. Though showing promising prospects, these soft-prompting methods are observed to rely heavily on good initialization to take effect. Unfortunately, obtaining a perfect initialization for soft prompts requires understanding of inner language models working and elaborate design, which is no easy task and has to restart from scratch for each new task. To remedy this, we propose a generalized soft prompting method called MetaPrompting, which adopts the well-recognized model-agnostic meta-learning algorithm to automatically find better prompt initialization that facilitates fast adaptation to new prompting tasks.Extensive experiments show MetaPrompting tackles soft prompt initialization problem and brings significant improvement on four different datasets (over 6 points improvement in accuracy for 1-shot setting), achieving new state-of-the-art performance.

Hongyuan Dong, Weinan Zhang, Wanxiang Che

Prompting methods have shown impressive performance in a variety of text mining tasks and applications, especially few-shot ones. Despite the promising prospects, the performance of prompting model largely depends on the design of prompt template and verbalizer. In this work, we propose MetricPrompt, which eases verbalizer design difficulty by reformulating few-shot text classification task into text pair relevance estimation task. MetricPrompt adopts prompting model as the relevance metric, further bridging the gap between Pre-trained Language Model's (PLM) pre-training objective and text classification task, making possible PLM's smooth adaption. Taking a training sample and a query one simultaneously, MetricPrompt captures cross-sample relevance information for accurate relevance estimation. We conduct experiments on three widely used text classification datasets across four few-shot settings. Results show that MetricPrompt outperforms manual verbalizer and other automatic verbalizer design methods across all few-shot settings, achieving new state-of-the-art (SOTA) performance.

Hongyuan Dong, Jiaqing Xie, Zhi Jing et al.

Cancer is a primary cause of human death, but discovering drugs and tailoring cancer therapies are expensive and time-consuming. We seek to facilitate the discovery of new drugs and treatment strategies for cancer using variational autoencoders (VAEs) and multi-layer perceptrons (MLPs) to predict anti-cancer drug responses. Our model takes as input gene expression data of cancer cell lines and anti-cancer drug molecular data and encodes these data with our {\sc {GeneVae}} model, which is an ordinary VAE model, and a rectified junction tree variational autoencoder ({\sc JTVae}) model, respectively. A multi-layer perceptron processes these encoded features to produce a final prediction. Our tests show our system attains a high average coefficient of determination ($R^{2} = 0.83$) in predicting drug responses for breast cancer cell lines and an average $R^{2} = 0.845$ for pan-cancer cell lines. Additionally, we show that our model can generates effective drug compounds not previously used for specific cancer cell lines.