Junyi Xie

Guifeng Deng, Pan Wang, Jiquan Wang et al.

While automated sleep staging has achieved expert-level accuracy, its clinical adoption is hindered by a lack of auditable reasoning. We introduce SleepVLM, a rule-grounded vision-language model (VLM) designed to stage sleep from multi-channel polysomnography (PSG) waveform images while generating clinician-readable rationales based on American Academy of Sleep Medicine (AASM) scoring criteria. Utilizing waveform-perceptual pre-training and rule-grounded supervised fine-tuning, SleepVLM achieved Cohen's kappa scores of 0.767 on an held out test set (MASS-SS1) and 0.743 on an external cohort (ZUAMHCS), matching state-of-the-art performance. Expert evaluations further validated the quality of the model's reasoning, with mean scores exceeding 4.0/5.0 for factual accuracy, evidence comprehensiveness, and logical coherence. By coupling competitive performance with transparent, rule-based explanations, SleepVLM may improve the trustworthiness and auditability of automated sleep staging in clinical workflows. To facilitate further research in interpretable sleep medicine, we release MASS-EX, a novel expert-annotated dataset.

Xinnan Zhang, Jialin Wu, Junyi Xie et al.

The prediction modeling of drug-target interactions is crucial to drug discovery and design, which has seen rapid advancements owing to deep learning technologies. Recently developed methods, such as those based on graph neural networks (GNNs) and Transformers, demonstrate exceptional performance across various datasets by effectively extracting structural information. However, the benchmarking of these novel methods often varies significantly in terms of hyperparameter settings and datasets, which limits algorithmic progress. In view of these, we conducted a comprehensive survey and benchmark for drug-target interaction modeling from a structural perspective via integrating tens of explicit (i.e., GNN-based) and implicit (i.e., Transformer-based) structure learning algorithms. We conducted a macroscopical comparison between these two classes of encoding strategies as well as the different featurization techniques that inform molecules' chemical and physical properties. We then carry out the microscopical comparison between all the integrated models across the six datasets via comprehensively benchmarking their effectiveness and efficiency. To ensure fairness, we investigate model performance under individually optimized configuration. Remarkably, the summarized insights from the benchmark studies lead to the design of model combos. We demonstrate that our combos can achieve new state-of-the-art performance on various datasets associated with cost-effective memory and computation.

Jiyoon Pyo, Yuankun Jiao, Dongwon Jung et al.

Cartographic reasoning is the skill of interpreting geographic relationships by aligning legends, map scales, compass directions, map texts, and geometries across one or more map images. Although essential as a concrete cognitive capability and for critical tasks such as disaster response and urban planning, it remains largely unevaluated. Building on progress in chart and infographic understanding, recent large vision language model studies on map visual question-answering often treat maps as a special case of charts. In contrast, map VQA demands comprehension of layered symbology (e.g., symbols, geometries, and text labels) as well as spatial relations tied to orientation and distance that often span multiple maps and are not captured by chart-style evaluations. To address this gap, we introduce FRIEDA, a benchmark for testing complex open-ended cartographic reasoning in LVLMs. FRIEDA sources real map images from documents and reports in various domains and geographical areas. Following classifications in Geographic Information System (GIS) literature, FRIEDA targets all three categories of spatial relations: topological (border, equal, intersect, within), metric (distance), and directional (orientation). All questions require multi-step inference, and many require cross-map grounding and reasoning. We evaluate eleven state-of-the-art LVLMs under two settings: (1) the direct setting, where we provide the maps relevant to the question, and (2) the contextual setting, where the model may have to identify the maps relevant to the question before reasoning. Even the strongest models, Gemini-2.5-Pro and GPT-5-Think, achieve only 38.20% and 37.20% accuracy, respectively, far below human performance of 84.87%. These results reveal a persistent gap in multi-step cartographic reasoning, positioning FRIEDA as a rigorous benchmark to drive progress on spatial intelligence in LVLMs.

Guifeng Deng, Shuyin Rao, Tianyu Lin et al.

Psychological support hotlines are critical for crisis intervention but face significant challenges due to rising demand. Large language models (LLMs) could support crisis assessments, yet their capabilities in emotionally sensitive contexts remain unclear. We introduce PsyCrisisBench, a benchmark of 540 annotated transcripts from the Hangzhou Psychological Assistance Hotline, assessing four tasks: mood status recognition, suicidal ideation detection, suicide plan identification, and risk assessment. We evaluated 64 LLMs across 15 families (e.g., GPT, Claude, Gemini, Llama, Qwen, DeepSeek) using zero-shot, few-shot, and fine-tuning paradigms. Performance was measured by F1-score, with statistical comparisons via Welch's t-tests. LLMs performed strongly on suicidal ideation detection (F1=0.880), suicide plan identification (F1=0.779), and risk assessment (F1=0.907), improved with few-shot and fine-tuning. Mood status recognition was more challenging (max F1=0.709), likely due to lost vocal cues and ambiguity. A fine-tuned 1.5B-parameter model (Qwen2.5-1.5B) surpassed larger models on mood and suicidal ideation. Open-source models like QwQ-32B performed comparably to closed-source on most tasks (p>0.3), though closed models retained an edge in mood detection (p=0.007). Performance scaled with size up to a point; quantization (AWQ) reduced GPU memory by 70% with minimal F1 degradation. LLMs show substantial promise in structured psychological crisis assessments, especially with fine-tuning. Mood recognition remains limited due to contextual complexity. The narrowing gap between open- and closed-source models, combined with efficient quantization, suggests feasible integration. PsyCrisisBench offers a robust evaluation framework to guide model development and ethical deployment in mental health.

Junyi Xie, Jina Kim, Yao-Yi Chiang et al.

Traditional anomaly detection in human mobility has primarily focused on trajectory-level analysis, identifying statistical outliers or spatiotemporal inconsistencies across aggregated movement traces. However, detecting individual-level anomalies, i.e., unusual deviations in a person's mobility behavior relative to their own historical patterns, within datasets encompassing large populations remains a significant challenge. In this paper, we present BeSTAD (Behavior-aware Spatio-Temporal Anomaly Detection for Human Mobility Data), an unsupervised framework that captures individualized behavioral signatures across large populations and uncovers fine-grained anomalies by jointly modeling spatial context and temporal dynamics. BeSTAD learns semantically enriched mobility representations that integrate location meaning and temporal patterns, enabling the detection of subtle deviations in individual movement behavior. BeSTAD further employs a behavior-cluster-aware modeling mechanism that builds personalized behavioral profiles from normal activity and identifies anomalies through cross-period behavioral comparison with consistent semantic alignment. Building on prior work in mobility behavior clustering, this approach enables not only the detection of behavioral shifts and deviations from established routines but also the identification of individuals exhibiting such changes within large-scale mobility datasets. By learning individual behaviors directly from unlabeled data, BeSTAD advances anomaly detection toward personalized and interpretable mobility analysis.

Junyi Xie, Yuankun Jiao, Jina Kim et al.

Inferring demographic attributes such as age, sex, or income level from human mobility patterns enables critical applications such as targeted public health interventions, equitable urban planning, and personalized transportation services. Existing mobility-based demographic inference studies heavily rely on large-scale trajectory data with demographic labels, leading to limited interpretability and poor generalizability across different datasets and user groups. We propose HiCoTraj (Zero-Shot Demographic Reasoning via Hierarchical Chain-of-Thought Prompting from Trajectory), a framework that leverages LLMs' zero-shot learning and semantic understanding capabilities to perform demographic inference without labeled training data. HiCoTraj transforms trajectories into semantically rich, natural language representations by creating detailed activity chronicles and multi-scale visiting summaries. Then HiCoTraj uses a novel hierarchical chain of thought reasoning to systematically guide LLMs through three cognitive stages: factual feature extraction, behavioral pattern analysis, and demographic inference with structured output. This approach addresses the scarcity challenge of labeled demographic data while providing transparent reasoning chains. Experimental evaluation on real-world trajectory data demonstrates that HiCoTraj achieves competitive performance across multiple demographic attributes in zero-shot scenarios.