Zhonghua Wang

Zunlei Feng, Zhonghua Wang, Xinchao Wang et al.

The microvascular invasion (MVI) is a major prognostic factor in hepatocellular carcinoma, which is one of the malignant tumors with the highest mortality rate. The diagnosis of MVI needs discovering the vessels that contain hepatocellular carcinoma cells and counting their number in each vessel, which depends heavily on experiences of the doctor, is largely subjective and time-consuming. However, there is no algorithm as yet tailored for the MVI detection from pathological images. This paper collects the first pathological liver image dataset containing 522 whole slide images with labels of vessels, MVI, and hepatocellular carcinoma grades. The first and essential step for the automatic diagnosis of MVI is the accurate segmentation of vessels. The unique characteristics of pathological liver images, such as super-large size, multi-scale vessel, and blurred vessel edges, make the accurate vessel segmentation challenging. Based on the collected dataset, we propose an Edge-competing Vessel Segmentation Network (EVS-Net), which contains a segmentation network and two edge segmentation discriminators. The segmentation network, combined with an edge-aware self-supervision mechanism, is devised to conduct vessel segmentation with limited labeled patches. Meanwhile, two discriminators are introduced to distinguish whether the segmented vessel and background contain residual features in an adversarial manner. In the training stage, two discriminators are devised tocompete for the predicted position of edges. Exhaustive experiments demonstrate that, with only limited labeled patches, EVS-Net achieves a close performance of fully supervised methods, which provides a convenient tool for the pathological liver vessel segmentation. Code is publicly available at https://github.com/zju-vipa/EVS-Net.

Ming Hu, Chenglong Ma, Wei Li et al. · pku

Scientific Large Language Models (Sci-LLMs) are transforming how knowledge is represented, integrated, and applied in scientific research, yet their progress is shaped by the complex nature of scientific data. This survey presents a comprehensive, data-centric synthesis that reframes the development of Sci-LLMs as a co-evolution between models and their underlying data substrate. We formulate a unified taxonomy of scientific data and a hierarchical model of scientific knowledge, emphasizing the multimodal, cross-scale, and domain-specific challenges that differentiate scientific corpora from general natural language processing datasets. We systematically review recent Sci-LLMs, from general-purpose foundations to specialized models across diverse scientific disciplines, alongside an extensive analysis of over 270 pre-/post-training datasets, showing why Sci-LLMs pose distinct demands -- heterogeneous, multi-scale, uncertainty-laden corpora that require representations preserving domain invariance and enabling cross-modal reasoning. On evaluation, we examine over 190 benchmark datasets and trace a shift from static exams toward process- and discovery-oriented assessments with advanced evaluation protocols. These data-centric analyses highlight persistent issues in scientific data development and discuss emerging solutions involving semi-automated annotation pipelines and expert validation. Finally, we outline a paradigm shift toward closed-loop systems where autonomous agents based on Sci-LLMs actively experiment, validate, and contribute to a living, evolving knowledge base. Collectively, this work provides a roadmap for building trustworthy, continually evolving artificial intelligence (AI) systems that function as a true partner in accelerating scientific discovery.