Zheng Wei

Yiyang Jia, Zheng Wei, Zheng Yang et al.

Understanding the complex and stochastic nature of Gene Regulatory Networks (GRNs) remains a central challenge in systems biology. Existing modeling paradigms often struggle to effectively capture the intricate, multi-factor regulatory logic and to rigorously manage the dual uncertainties of network structure and kinetic parameters. In response, this work introduces the Probabilistic Categorical GRN(PC-GRN) framework. It is a novel theoretical approach founded on the synergistic integration of three core methodologies. Firstly, category theory provides a formal language for the modularity and composition of regulatory pathways. Secondly, Bayesian Typed Petri Nets (BTPNs) serve as an interpretable,mechanistic substrate for modeling stochastic cellular processes, with kinetic parameters themselves represented as probability distributions. The central innovation of PC-GRN is its end-to-end generative Bayesian inference engine, which learns a full posterior distribution over BTPN models (P (G, Θ|D)) directly from data. This is achieved by the novel interplay of a GFlowNet, which learns a policy to sample network topologies, and a HyperNetwork, which performs amortized inference to predict their corresponding parameter distributions. The resulting framework provides a mathematically rigorous, biologically interpretable, and uncertainty-aware representation of GRNs, advancing predictive modeling and systems-level analysis.

Jiabin Liu, Zheng Wei, Zhengpin Li et al.

Recently, textual information has been proved to play a positive role in recommendation systems. However, most of the existing methods only focus on representation learning of textual information in ratings, while potential selection bias induced by the textual information is ignored. In this work, we propose a novel and general self-adaptive module, the Self-adaptive Attention Module (SAM), which adjusts the selection bias by capturing contextual information based on its representation. This module can be embedded into recommendation systems that contain learning components of contextual information. Experimental results on three real-world datasets demonstrate the effectiveness of our proposal, and the state-of-the-art models with SAM significantly outperform the original ones.