Thanh-Huy Nguyen

Thanh-Huy Nguyen, Quang Hien Kha, Thai Ngoc Toan Truong et al.

In recent years, many mammographic image analysis methods have been introduced for improving cancer classification tasks. Two major issues of mammogram classification tasks are leveraging multi-view mammographic information and class-imbalance handling. In the first problem, many multi-view methods have been released for concatenating features of two or more views for the training and inference stage. Having said that, most multi-view existing methods are not explainable in the meaning of feature fusion, and treat many views equally for diagnosing. Our work aims to propose a simple but novel method for enhancing examined view (main view) by leveraging low-level feature information from the auxiliary view (ipsilateral view) before learning the high-level feature that contains the cancerous features. For the second issue, we also propose a simple but novel malignant mammogram synthesis framework for upsampling minor class samples. Our easy-to-implement and no-training framework has eliminated the current limitation of the CutMix algorithm which is unreliable synthesized images with random pasted patches, hard-contour problems, and domain shift problems. Our results on VinDr-Mammo and CMMD datasets show the effectiveness of our two new frameworks for both multi-view training and synthesizing mammographic images, outperforming the previous conventional methods in our experimental settings.

Le Thien Phuc Nguyen, Zhuoran Yu, Samuel Low Yu Hang et al.

Multimodal large language models (MLLMs) are expected to jointly interpret vision, audio, and language, yet existing video benchmarks rarely assess fine-grained reasoning about human speech. Many tasks remain visually solvable or only coarsely evaluate speech, offering limited insight into whether models can align who speaks, what is said, and when it occurs. We introduce AV-SpeakerBench, a curated benchmark of 3,212 multiple-choice questions focused on speaker-centric audiovisual reasoning in real-world videos. It features: (1) a speaker-centered formulation that treats speakers-not scenes-as the core reasoning unit; (2) fusion-grounded question design embedding audiovisual dependencies into question semantics; and (3) expert-curated annotations ensuring temporal precision and cross-modal validity. Comprehensive evaluations show that the Gemini family consistently outperforms open-source systems, with Gemini 2.5 Pro achieving the best results. Among open models, Qwen3-Omni-30B approaches Gemini 2.0 Flash but remains far behind Gemini 2.5 Pro, primarily due to weaker audiovisual fusion rather than visual perception. We believe AV-SpeakerBench establishes a rigorous foundation for advancing fine-grained audiovisual reasoning in future multimodal systems.

Huy T. Nguyen, Thinh B. Lam, Quan D. D. Tran et al.

This paper investigates the impact of breast density distribution on the generalization performance of deep-learning models on mammography images using the VinDr-Mammo dataset. We explore the use of domain adaptation techniques, specifically Domain Adaptive Object Detection (DAOD) with the Noise Latent Transferability Exploration (NLTE) framework, to improve model performance across breast densities under noisy labeling circumstances. We propose a robust augmentation framework to bridge the domain gap between the source and target inside a dataset. Our results show that DAOD-based methods, along with the proposed augmentation framework, can improve the generalization performance of deep-learning models (+5% overall mAP improvement approximately in our experimental results compared to commonly used detection models). This paper highlights the importance of domain adaptation techniques in medical imaging, particularly in the context of breast density distribution, which is critical in mammography.

Thai Ngoc Toan Truong, Thanh-Huy Nguyen, Ba Thinh Lam et al.

In many recent years, multi-view mammogram analysis has been focused widely on AI-based cancer assessment. In this work, we aim to explore diverse fusion strategies (average and concatenate) and examine the model's learning behavior with varying individuals and fusion pathways, involving Coarse Layer and Fine Layer. The Ipsilateral Multi-View Network, comprising five fusion types (Pre, Early, Middle, Last, and Post Fusion) in ResNet-18, is employed. Notably, the Middle Fusion emerges as the most balanced and effective approach, enhancing deep-learning models' generalization performance by +2.06% (concatenate) and +5.29% (average) in VinDr-Mammo dataset and +2.03% (concatenate) and +3% (average) in CMMD dataset on macro F1-Score. The paper emphasizes the crucial role of layer assignment in multi-view network extraction with various strategies.

Nguyen Lan Vi Vu, Thanh-Huy Nguyen, Thien Nguyen et al.

Semi-supervised learning has been employed to alleviate the need for extensive labeled data for histopathology image segmentation, but existing methods struggle with noisy pseudo-labels due to ambiguous gland boundaries and morphological misclassification. This paper introduces Semi-MOE, to the best of our knowledge, the first multi-task Mixture-of-Experts framework for semi-supervised histopathology image segmentation. Our approach leverages three specialized expert networks: A main segmentation expert, a signed distance field regression expert, and a boundary prediction expert, each dedicated to capturing distinct morphological features. Subsequently, the Multi-Gating Pseudo-labeling module dynamically aggregates expert features, enabling a robust fuse-and-refine pseudo-labeling mechanism. Furthermore, to eliminate manual tuning while dynamically balancing multiple learning objectives, we propose an Adaptive Multi-Objective Loss. Extensive experiments on GlaS and CRAG benchmarks show that our method outperforms state-of-the-art approaches in low-label settings, highlighting the potential of MoE-based architectures in advancing semi-supervised segmentation. Our code is available at https://github.com/vnlvi2k3/Semi-MoE.

Yen-Linh Vu, Dinh-Thang Duong, Truong-Binh Duong et al.

Recent progress has been made in region-aware vision-language modeling, particularly with the emergence of the Describe Anything Model (DAM). DAM is capable of generating detailed descriptions of any specific image areas or objects without the need for additional localized image-text alignment supervision. We hypothesize that such region-level descriptive capability is beneficial for the task of Visual Question Answering (VQA), especially in challenging scenarios involving images with dense text. In such settings, the fine-grained extraction of textual information is crucial to producing correct answers. Motivated by this, we introduce DAM-QA, a framework with a tailored evaluation protocol, developed to investigate and harness the region-aware capabilities from DAM for the text-rich VQA problem that requires reasoning over text-based information within images. DAM-QA incorporates a mechanism that aggregates answers from multiple regional views of image content, enabling more effective identification of evidence that may be tied to text-related elements. Experiments on six VQA benchmarks show that our approach consistently outperforms the baseline DAM, with a notable 7+ point gain on DocVQA. DAM-QA also achieves the best overall performance among region-aware models with fewer parameters, significantly narrowing the gap with strong generalist VLMs. These results highlight the potential of DAM-like models for text-rich and broader VQA tasks when paired with efficient usage and integration strategies. Our code is publicly available at https://github.com/Linvyl/DAM-QA.git.

Ha-Hieu Pham, Nguyen Lan Vi Vu, Thanh-Huy Nguyen et al.

Accurate gland segmentation in histopathology images is essential for cancer diagnosis and prognosis. However, significant variability in Hematoxylin and Eosin (H&E) staining and tissue morphology, combined with limited annotated data, poses major challenges for automated segmentation. To address this, we propose Color-Structure Dual-Student (CSDS), a novel semi-supervised segmentation framework designed to learn disentangled representations of stain appearance and tissue structure. CSDS comprises two specialized student networks: one trained on stain-augmented inputs to model chromatic variation, and the other on structure-augmented inputs to capture morphological cues. A shared teacher network, updated via Exponential Moving Average (EMA), supervises both students through pseudo-labels. To further improve label reliability, we introduce stain-aware and structure-aware uncertainty estimation modules that adaptively modulate the contribution of each student during training. Experiments on the GlaS and CRAG datasets show that CSDS achieves state-of-the-art performance in low-label settings, with Dice score improvements of up to 1.2% on GlaS and 0.7% on CRAG at 5% labeled data, and 0.7% and 1.4% at 10%. Our code and pre-trained models are available at https://github.com/hieuphamha19/CSDS.

Tien-Dat Chung, Ba-Thinh Lam, Thanh-Huy Nguyen et al.

Semi-supervised learning (SSL) has become a promising direction for medical image segmentation, enabling models to learn from limited labeled data alongside abundant unlabeled samples. However, existing SSL approaches for multi-modal medical imaging often struggle to exploit the complementary information between modalities due to semantic discrepancies and misalignment across MRI sequences. To address this, we propose a novel semi-supervised multi-modal framework that explicitly enhances modality-specific representations and facilitates adaptive cross-modal information fusion. Specifically, we introduce a Modality-specific Enhancing Module (MEM) to strengthen semantic cues unique to each modality via channel-wise attention, and a learnable Complementary Information Fusion (CIF) module to adaptively exchange complementary knowledge between modalities. The overall framework is optimized using a hybrid objective combining supervised segmentation loss and cross-modal consistency regularization on unlabeled data. Extensive experiments on the BraTS 2019 (HGG subset) demonstrate that our method consistently outperforms strong semi-supervised and multi-modal baselines under 1\%, 5\%, and 10\% labeled data settings, achieving significant improvements in both Dice and Sensitivity scores. Ablation studies further confirm the complementary effects of our proposed MEM and CIF in bridging cross-modality discrepancies and improving segmentation robustness under scarce supervision.

Anh Mai Vu, Tuan L. Vo, Ngoc Lam Quang Bui et al.

Interpretability is essential in Whole Slide Image (WSI) analysis for computational pathology, where understanding model predictions helps build trust in AI-assisted diagnostics. While Integrated Gradients (IG) and related attribution methods have shown promise, applying them directly to WSIs introduces challenges due to their high-resolution nature. These methods capture model decision patterns but may overlook class-discriminative signals that are crucial for distinguishing between tumor subtypes. In this work, we introduce Contrastive Integrated Gradients (CIG), a novel attribution method that enhances interpretability by computing contrastive gradients in logit space. First, CIG highlights class-discriminative regions by comparing feature importance relative to a reference class, offering sharper differentiation between tumor and non-tumor areas. Second, CIG satisfies the axioms of integrated attribution, ensuring consistency and theoretical soundness. Third, we propose two attribution quality metrics, MIL-AIC and MIL-SIC, which measure how predictive information and model confidence evolve with access to salient regions, particularly under weak supervision. We validate CIG across three datasets spanning distinct cancer types: CAMELYON16 (breast cancer metastasis in lymph nodes), TCGA-RCC (renal cell carcinoma), and TCGA-Lung (lung cancer). Experimental results demonstrate that CIG yields more informative attributions both quantitatively, using MIL-AIC and MIL-SIC, and qualitatively, through visualizations that align closely with ground truth tumor regions, underscoring its potential for interpretable and trustworthy WSI-based diagnostics

Khang Le, Ha Thach, Anh M. Vu et al.

Weakly supervised semantic segmentation (WSSS) in histopathology relies heavily on classification backbones, yet these models often localize only the most discriminative regions and struggle to capture the full spatial extent of tissue structures. Vision-language models such as CONCH offer rich semantic alignment and morphology-aware representations, while modern segmentation backbones like SegFormer preserve fine-grained spatial cues. However, combining these complementary strengths remains challenging, especially under weak supervision and without dense annotations. We propose a prototype learning framework for WSSS in histopathological images that integrates morphology-aware representations from CONCH, multi-scale structural cues from SegFormer, and text-guided semantic alignment to produce prototypes that are simultaneously semantically discriminative and spatially coherent. To effectively leverage these heterogeneous sources, we introduce text-guided prototype initialization that incorporates pathology descriptions to generate more complete and semantically accurate pseudo-masks. A structural distillation mechanism transfers spatial knowledge from SegFormer to preserve fine-grained morphological patterns and local tissue boundaries during prototype learning. Our approach produces high-quality pseudo masks without pixel-level annotations, improves localization completeness, and enhances semantic consistency across tissue types. Experiments on BCSS-WSSS datasets demonstrate that our prototype learning framework outperforms existing WSSS methods while remaining computationally efficient through frozen foundation model backbones and lightweight trainable adapters.

Anh M. Vu, Khang P. Le, Trang T. K. Vo et al.

Weakly supervised semantic segmentation (WSSS) in histopathology seeks to reduce annotation cost by learning from image-level labels, yet it remains limited by inter-class homogeneity, intra-class heterogeneity, and the region-shrinkage effect of CAM-based supervision. We propose a simple and effective prototype-driven framework that leverages vision-language alignment to improve region discovery under weak supervision. Our method integrates CoOp-style learnable prompt tuning to generate text-based prototypes and combines them with learnable image prototypes, forming a dual-modal prototype bank that captures both semantic and appearance cues. To address oversmoothing in ViT representations, we incorporate a multi-scale pyramid module that enhances spatial precision and improves localization quality. Experiments on the BCSS-WSSS benchmark show that our approach surpasses existing state-of-the-art methods, and detailed analyses demonstrate the benefits of text description diversity, context length, and the complementary behavior of text and image prototypes. These results highlight the effectiveness of jointly leveraging textual semantics and visual prototype learning for WSSS in digital pathology.

Xi Xiao, Yunbei Zhang, Thanh-Huy Nguyen et al.

Localized image captioning has made significant progress with models like the Describe Anything Model (DAM), which can generate detailed region-specific descriptions without explicit region-text supervision. However, such capabilities have yet to be widely applied to specialized domains like medical imaging, where diagnostic interpretation relies on subtle regional findings rather than global understanding. To mitigate this gap, we propose MedDAM, the first comprehensive framework leveraging large vision-language models for region-specific captioning in medical images. MedDAM employs medical expert-designed prompts tailored to specific imaging modalities and establishes a robust evaluation benchmark comprising a customized assessment protocol, data pre-processing pipeline, and specialized QA template library. This benchmark evaluates both MedDAM and other adaptable large vision-language models, focusing on clinical factuality through attribute-level verification tasks, thereby circumventing the absence of ground-truth region-caption pairs in medical datasets. Extensive experiments on the VinDr-CXR, LIDC-IDRI, and SkinCon datasets demonstrate MedDAM's superiority over leading peers (including GPT-4o, Claude 3.7 Sonnet, LLaMA-3.2 Vision, Qwen2.5-VL, GPT-4Rol, and OMG-LLaVA) in the task, revealing the importance of region-level semantic alignment in medical image understanding and establishing MedDAM as a promising foundation for clinical vision-language integration.

Dinh Dai Quan Tran, Hoang-Thien Nguyen, Thanh-Huy Nguyen et al.

Semi-Supervised Semantic Segmentation (SSSS) aims to improve segmentation accuracy by leveraging a small set of labeled images alongside a larger pool of unlabeled data. Recent advances primarily focus on pseudo-labeling, consistency regularization, and co-training strategies. However, existing methods struggle to balance global semantic representation with fine-grained local feature extraction. To address this challenge, we propose a novel tri-branch semi-supervised segmentation framework incorporating a dual-teacher strategy, named IGL-DT. Our approach employs SwinUnet for high-level semantic guidance through Global Context Learning and ResUnet for detailed feature refinement via Local Regional Learning. Additionally, a Discrepancy Learning mechanism mitigates over-reliance on a single teacher, promoting adaptive feature learning. Extensive experiments on benchmark datasets demonstrate that our method outperforms state-of-the-art approaches, achieving superior segmentation performance across various data regimes.

Ngoc Bui Lam Quang, Nam Le Nguyen Binh, Thanh-Huy Nguyen et al.

Multiple Instance Learning (MIL) is the leading approach for whole slide image (WSI) classification, enabling efficient analysis of gigapixel pathology slides. Recent work has introduced vision-language models (VLMs) into MIL pipelines to incorporate medical knowledge through text-based class descriptions rather than simple class names. However, when these methods rely on large language models (LLMs) to generate clinical descriptions or use fixed-length prompts to represent complex pathology concepts, the limited token capacity of VLMs often constrains the expressiveness and richness of the encoded class information. Additionally, descriptions generated solely by LLMs may lack domain grounding and fine-grained medical specificity, leading to suboptimal alignment with visual features. To address these challenges, we propose a vision-language MIL framework with two key contributions: (1) A grounded multi-agent description generation system that leverages curated pathology textbooks and agent specialization (e.g., morphology, spatial context) to produce accurate and diverse clinical descriptions; (2) A text encoding strategy using a list of descriptions rather than a single prompt, capturing fine-grained and complementary clinical signals for better alignment with visual features. Integrated into a VLM-MIL pipeline, our approach shows improved performance over single-prompt class baselines and achieves results comparable to state-of-the-art models, as demonstrated on renal and lung cancer datasets.

Ngoc C. Lê, Hai-Chung Nguyen-Phung, Thu-Huong Pham Thi et al.

The COVID-19 pandemic caused great losses worldwide, efforts are taken place to prevent but many countries have failed. In Vietnam, the traceability, localization, and quarantine of people who contact with patients contribute to effective disease prevention. However, this is done by hand, and take a lot of work. In this research, we describe a named-entity recognition (NER) study that assists in the prevention of COVID-19 pandemic in Vietnam. We also present our manually annotated COVID-19 dataset with nested named entity recognition task for Vietnamese which be defined new entity types using for our system.

Dat T. Chung, Minh-Anh Dang, Mai-Anh Vu et al.

Breast Ultrasound plays a vital role in cancer diagnosis as a non-invasive approach with cost-effective. In recent years, with the development of deep learning, many CNN-based approaches have been widely researched in both tumor localization and cancer classification tasks. Even though previous single models achieved great performance in both tasks, these methods have some limitations in inference time, GPU requirement, and separate fine-tuning for each model. In this study, we aim to redesign and build end-to-end multi-task architecture to conduct both segmentation and classification. With our proposed approach, we achieved outstanding performance and time efficiency, with 79.8% and 86.4% in DeepLabV3+ architecture in the segmentation task.

Khang Le, Anh Mai Vu, Thi Kim Trang Vo et al.

Weakly supervised semantic segmentation (WSSS) in histopathology reduces pixel-level labeling by learning from image-level labels, but it is hindered by inter-class homogeneity, intra-class heterogeneity, and CAM-induced region shrinkage (global pooling-based class activation maps whose activations highlight only the most distinctive areas and miss nearby class regions). Recent works address these challenges by constructing a clustering prototype bank and then refining masks in a separate stage; however, such two-stage pipelines are costly, sensitive to hyperparameters, and decouple prototype discovery from segmentation learning, limiting their effectiveness and efficiency. We propose a cluster-free, one-stage learnable-prototype framework with diversity regularization to enhance morphological intra-class heterogeneity coverage. Our approach achieves state-of-the-art (SOTA) performance on BCSS-WSSS, outperforming prior methods in mIoU and mDice. Qualitative segmentation maps show sharper boundaries and fewer mislabels, and activation heatmaps further reveal that, compared with clustering-based prototypes, our learnable prototypes cover more diverse and complementary regions within each class, providing consistent qualitative evidence for their effectiveness.

Thanh-Huy Nguyen, Hoang-Thien Nguyen, Vi Vu et al.

The limited availability of annotated data in medical imaging makes semi-supervised learning increasingly appealing for its ability to learn from imperfect supervision. Recently, teacher-student frameworks have gained popularity for their training benefits and robust performance. However, jointly optimizing the entire network can hinder convergence and stability, especially in challenging scenarios. To address this for medical image segmentation, we propose DuetMatch, a novel dual-branch semi-supervised framework with asynchronous optimization, where each branch optimizes either the encoder or decoder while keeping the other frozen. To improve consistency under noisy conditions, we introduce Decoupled Dropout Perturbation, enforcing regularization across branches. We also design Pair-wise CutMix Cross-Guidance to enhance model diversity by exchanging pseudo-labels through augmented input pairs. To mitigate confirmation bias from noisy pseudo-labels, we propose Consistency Matching, refining labels using stable predictions from frozen teacher models. Extensive experiments on benchmark brain MRI segmentation datasets, including ISLES2022 and BraTS, show that DuetMatch consistently outperforms state-of-the-art methods, demonstrating its effectiveness and robustness across diverse semi-supervised segmentation scenarios.

Quang-Khai Bui-Tran, Minh-Toan Dinh, Thanh-Huy Nguyen et al.

Accurate liver segmentation in multi-phase MRI is vital for liver fibrosis assessment, yet labeled data is often scarce and unevenly distributed across imaging modalities and vendor systems. We propose a label-efficient segmentation approach that promotes cross-modality generalization under real-world conditions, where GED4 hepatobiliary-phase annotations are limited, non-contrast sequences (T1WI, T2WI, DWI) are unlabeled, and spatial misalignment and missing phases are common. Our method integrates a foundation-scale 3D segmentation backbone adapted via fine-tuning, co-training with cross pseudo supervision to leverage unlabeled volumes, and a standardized preprocessing pipeline. Without requiring spatial registration, the model learns to generalize across MRI phases and vendors, demonstrating robust segmentation performance in both labeled and unlabeled domains. Our results exhibit the effectiveness of our proposed label-efficient baseline for liver segmentation in multi-phase, multi-vendor MRI and highlight the potential of combining foundation model adaptation with co-training for real-world clinical imaging tasks.

Akwasi Asare, Ulas Bagci

Colorectal cancer (CRC) remains one of the leading causes of cancer-related morbidity and mortality worldwide, with gastrointestinal (GI) polyps serving as critical precursors according to the World Health Organization (WHO). Early and accurate segmentation of polyps during colonoscopy is essential for reducing CRC progression, yet manual delineation is labor-intensive and prone to observer variability. Deep learning methods have demonstrated strong potential for automated polyp analysis, but their limited interpretability remains a barrier to clinical adoption. In this study, we present PolypSeg-GradCAM, an explainable deep learning framework that integrates the U-Net architecture with Gradient-weighted Class Activation Mapping (Grad-CAM) for transparent polyp segmentation. The model was trained and evaluated on the Kvasir-SEG dataset of 1000 annotated endoscopic images. Experimental results demonstrate robust segmentation performance, achieving a mean Intersection over Union (IoU) of 0.9257 on the test set and consistently high Dice coefficients (F-score > 0.96) on training and validation sets. Grad-CAM visualizations further confirmed that predictions were guided by clinically relevant regions, enhancing transparency and trust in the model's decisions. By coupling high segmentation accuracy with interpretability, PolypSeg-GradCAM represents a step toward reliable, trustworthy AI-assisted colonoscopy and improved early colorectal cancer prevention.

Thanh-Huy Nguyen, Thi Kim Ngan Ngo, Mai Anh Vu et al.

The ability of three-dimensional (3D) spheroid modeling to study the invasive behavior of breast cancer cells has drawn increased attention. The deep learning-based image processing framework is very effective at speeding up the cell morphological analysis process. Out-of-focus photos taken while capturing 3D cells under several z-slices, however, could negatively impact the deep learning model. In this work, we created a new algorithm to handle blurry images while preserving the stacked image quality. Furthermore, we proposed a unique training architecture that leverages consistency training to help reduce the bias of the model when dense-slice stacking is applied. Additionally, the model's stability is increased under the sparse-slice stacking effect by utilizing the self-training approach. The new blurring stacking technique and training flow are combined with the suggested architecture and self-training mechanism to provide an innovative yet easy-to-use framework. Our methods produced noteworthy experimental outcomes in terms of both quantitative and qualitative aspects.