Ye Chen

Jinxian Liu, Ye Chen, Bingbing Ni et al.

Humans have a strong intuitive understanding of physical processes such as fluid falling by just a glimpse of such a scene picture, i.e., quickly derived from our immersive visual experiences in memory. This work achieves such a photo-to-fluid-dynamics reconstruction functionality learned from unannotated videos, without any supervision of ground-truth fluid dynamics. In a nutshell, a differentiable Euler simulator modeled with a ConvNet-based pressure projection solver, is integrated with a volumetric renderer, supporting end-to-end/coherent differentiable dynamic simulation and rendering. By endowing each sampled point with a fluid volume value, we derive a NeRF-like differentiable renderer dedicated from fluid data; and thanks to this volume-augmented representation, fluid dynamics could be inversely inferred from the error signal between the rendered result and ground-truth video frame (i.e., inverse rendering). Experiments on our generated Fluid Fall datasets and DPI Dam Break dataset are conducted to demonstrate both effectiveness and generalization ability of our method.

Junzhuo Liu, Xuemei Du, Daniel Reisenbuchler et al.

Automatic integration of whole slide images (WSIs) and gene expression profiles has demonstrated substantial potential in precision clinical diagnosis and cancer progression studies. However, most existing studies focus on individual gene sequences and slide level classification tasks, with limited attention to spatial transcriptomics and patch level applications. To address this limitation, we propose a multimodal network, BioMorphNet, which automatically integrates tissue morphological features and spatial gene expression to support tissue classification and differential gene analysis. For considering morphological features, BioMorphNet constructs a graph to model the relationships between target patches and their neighbors, and adjusts the response strength based on morphological and molecular level similarity, to better characterize the tumor microenvironment. In terms of multimodal interactions, BioMorphNet derives clinical pathway features from spatial transcriptomic data based on a predefined pathway database, serving as a bridge between tissue morphology and gene expression. In addition, a novel learnable pathway module is designed to automatically simulate the biological pathway formation process, providing a complementary representation to existing clinical pathways. Compared with the latest morphology gene multimodal methods, BioMorphNet's average classification metrics improve by 2.67%, 5.48%, and 6.29% for prostate cancer, colorectal cancer, and breast cancer datasets, respectively. BioMorphNet not only classifies tissue categories within WSIs accurately to support tumor localization, but also analyzes differential gene expression between tissue categories based on prediction confidence, contributing to the discovery of potential tumor biomarkers.

Ye Chen, Wei Cai, Liangmin Wu et al.

We release and introduce the TigerBot family of large language models (LLMs), consisting of base and chat models, sized from 7, 13, 70 and 180 billion parameters. We develop our models embarking from Llama-2 and BLOOM, and push the boundary further in data, training algorithm, infrastructure, and application tools. Our models yield meaningful performance gain over SOTA open-source models, e.g., Llama-2, specifically 6% gain in English and 20% gain in Chinese. TigerBot model family also achieves leading performance in major academic and industrial benchmarks and leaderboards. We believe that TigerBot represents just a snapshot of lightning-fast progression in LLM open-source community. Therefore, we are thrilled to give back by publicly releasing our models and reporting our approach behind, with additional emphases on building SOTA LLMs in a democratized way and making LLMs of use in real-world applications.

Xiaoyu Ma, Yiwen Li, Haoyue Liu et al.

Automatic prompt optimization (APO) hinges on the quality of its evaluation signal, yet scoring every prompt candidate on the full training set is prohibitively expensive. Existing methods either fix a single evaluation subset before optimization begins (principled but prompt-agnostic) or adapt it heuristically during optimization (flexible but unstable and lacking formal guarantees). We observe that APO naturally maps to an online adaptive testing problem: prompts are examinees, training examples are test items, and the scheduler should select items that best discriminate among the strongest candidates. This insight motivates Prompt-Aware Online Evaluation Scheduling (POES), which integrates an IRT-based discrimination utility, a facility-location coverage term, and switching-cost-aware warm-start swaps into a unified objective that is provably monotone submodular, yielding a (1-1/e) greedy guarantee for cold starts and bounded drift for warm-start updates. An adaptive controller modulates the exploration-exploitation balance based on optimization progress. Across 36 tasks spanning three benchmark families, POES achieves the highest overall average accuracy (6.2 percent improvement over the best baseline) with negligible token overhead (approximately 4 percent) at the same evaluation budget. Moreover, principled selection at k = 20 examples matches or exceeds the performance of naive evaluation at k = 30-50, reducing token consumption by 35-60 percent, showing that selecting smarter is more effective than selecting more. Our results demonstrate that evaluation scheduling is a first-class component of APO, not an implementation detail.

Ye Chen, Igor Couto, Wei Cai et al.

We introduce SoftTiger, a clinical large language model (CLaM) designed as a foundation model for healthcare workflows. The narrative and unstructured nature of clinical notes is a major obstacle for healthcare intelligentization. We address a critical problem of structuring clinical notes into clinical data, according to international interoperability standards. We collect and annotate data for three subtasks, namely, international patient summary, clinical impression and medical encounter. We then supervised fine-tuned a state-of-the-art LLM using public and credentialed clinical data. The training is orchestrated in a way that the target model can first support basic clinical tasks such as abbreviation expansion and temporal information extraction, and then learn to perform more complex downstream clinical tasks. Moreover, we address several modeling challenges in the healthcare context, e.g., extra long context window. Our blind pairwise evaluation shows that SoftTiger outperforms other popular open-source models and GPT-3.5, comparable to Gemini-pro, with a mild gap from GPT-4. We believe that LLMs may become a step-stone towards healthcare digitalization and democratization. Therefore, we publicly release SoftTiger models at scales of 13 billion and 70 billion parameters, as well as datasets and code for our innovative scalable evaluation, hopefully, making a significant contribution to the healthcare industry.

Shulian Zhang, Yong Guo, Long Peng et al.

Video Face Enhancement (VFE) aims to restore high-quality facial regions from degraded video sequences, enabling a wide range of practical applications. Despite substantial progress in the field, current methods that primarily rely on video super-resolution and generative frameworks continue to face three fundamental challenges: (1) computational inefficiency caused by iterative multi-step denoising in diffusion models; (2) faithfully modeling intricate facial textures while preserving temporal consistency; and (3) limited model generalization due to the lack of high-quality face video training data. To address these challenges, we propose VividFace, a novel and efficient one-step diffusion framework for VFE. Built upon the pretrained WANX video generation model, VividFace reformulates the traditional multi-step diffusion process as a single-step flow matching paradigm that directly maps degraded inputs to high-quality outputs with significantly reduced inference time. To enhance facial detail recovery, we introduce a Joint Latent-Pixel Face-Focused Training strategy that constructs spatiotemporally aligned facial masks to guide optimization toward critical facial regions in both latent and pixel spaces. Furthermore, we develop an MLLM-driven automated filtering pipeline that produces MLLM-Face90, a meticulously curated high-quality face video dataset, ensuring models learn from photorealistic facial textures. Extensive experiments demonstrate that VividFace achieves superior performance in perceptual quality, identity preservation, and temporal consistency across both synthetic and real-world benchmarks. We will publicly release our code, models, and dataset to support future research.

Wenhao fan, Liang Zhao, Jiayang Wang et al.

Android is currently the most extensively used smartphone platform in the world. Due to its popularity and open source nature, Android malware has been rapidly growing in recent years, and bringing great risks to users' privacy. The malware applications in a malware family may have common features and similar behaviors, which are beneficial for malware detection and inspection. Thus, classifying Android malware into their corresponding families is an important task in malware analysis. At present, the main problem of existing research works on Android malware family classification lies in that the extracted features are inadequate to represent the common behavior characteristics of the malware in malicious families, and leveraging a single classifier or a static ensemble classifier is restricted to further improve the accuracy of classification. In this paper, we propose FamDroid, a learning-based Android malware family classification scheme using static analysis technology. In FamDroid, the explicit features including permissions, hardware components, app components, intent filters are extracted from the apk files of a malware application. Besides, a hidden feature generated from the extracted APIs is used to represents the API call relationship in the application. Then, we design an adaptive weighted ensemble classifier, which considers the adaptability of the sample to each base classifier, to carry out accurate malware family classification. We conducted experiments on the Drebin dataset which contains 5560 Android malicious applications. The superiority of FamDroid is demonstrated through comparing it with 5 traditional machine learning models and 4 state-of-the-art reference schemes. FamDroid can correctly classify 98.92% of malware samples into their families and achieve 99.12% F1-Score.

Zhangli Hu, Ye Chen, Jiajun Yao et al.

Oil painting, as a high-level medium that blends human abstract thinking with artistic expression, poses substantial challenges for digital generation and editing due to its intricate brushstroke dynamics and stylized characteristics. Existing generation and editing techniques are often constrained by the distribution of training data and primarily focus on modifying real photographs. In this work, we introduce a unified multimodal framework for oil painting generation and editing. The proposed system allows users to incorporate reference images for precise semantic control, hand-drawn sketches for spatial structure alignment, and natural language prompts for high-level semantic guidance, while consistently maintaining a unified painting style across all outputs. Our method achieves interactive oil painting creation through three crucial technical advancements. First, we enhance the training stage with spatial alignment and semantic enhancement conditioning strategy, which map masks and sketches into spatial constraints, and encode contextual embedding from reference images and text into feature constraints, enabling object-level semantic alignment. Second, to overcome data scarcity, we propose a self-supervised style transfer pipeline based on Stroke-Based Rendering (SBR), which simulates the inpainting dynamics of oil painting restoration, converting real images into stylized oil paintings with preserved brushstroke textures to construct a large-scale paired training dataset. Finally, during inference, we integrate features using the AdaIN operator to ensure stylistic consistency. Extensive experiments demonstrate that our interactive system enables fine-grained editing while preserving the artistic qualities of oil paintings, achieving an unprecedented level of imagination realization in stylized oil paintings generation and editing.

Ye Chen, Yupeng Zhu, Xiongzhen Zhang et al.

Prevailing image representation methods, including explicit representations such as raster images and Gaussian primitives, as well as implicit representations such as latent images, either suffer from representation redundancy that leads to heavy manual editing effort, or lack a direct mapping from latent variables to semantic instances or parts, making fine-grained manipulation difficult. These limitations hinder efficient and controllable image and video editing. To address these issues, we propose a hierarchical proxy-based parametric image representation that disentangles semantic, geometric, and textural attributes into independent and manipulable parameter spaces. Based on a semantic-aware decomposition of the input image, our representation constructs hierarchical proxy geometries through adaptive Bezier fitting and iterative internal region subdivision and meshing. Multi-scale implicit texture parameters are embedded into the resulting geometry-aware distributed proxy nodes, enabling continuous high-fidelity reconstruction in the pixel domain and instance- or part-independent semantic editing. In addition, we introduce a locality-adaptive feature indexing mechanism to ensure spatial texture coherence, which further supports high-quality background completion without relying on generative models. Extensive experiments on image reconstruction and editing benchmarks, including ImageNet, OIR-Bench, and HumanEdit, demonstrate that our method achieves state-of-the-art rendering fidelity with significantly fewer parameters, while enabling intuitive, interactive, and physically plausible manipulation. Moreover, by integrating proxy nodes with Position-Based Dynamics, our framework supports real-time physics-driven animation using lightweight implicit rendering, achieving superior temporal consistency and visual realism compared with generative approaches.

Lorenzo Nava, Ye Chen, Maximillian Van Wyk de Vries

Predicting geohazard runout is critical for protecting lives, infrastructure and ecosystems. Rapid mass flows, including landslides and avalanches, cause several thousand deaths across a wide range of environments, often travelling many kilometres from their source. The wide range of source conditions and material properties governing these flows makes their runout difficult to anticipate, particularly for downstream communities that may be suddenly exposed to severe impacts. Accurately predicting runout at scale requires models that are both physically realistic and computationally efficient, yet existing approaches face a fundamental speed-realism trade-off. Here we train a machine learning model to predict geohazard runout across representative real world terrains. The model predicts both flow extent and deposit thickness with high accuracy and 100 to 10,000 times faster computation than numerical solvers. It is trained on over 100,000 numerical simulations across over 10,000 real world digital elevation model chips and reproduces key physical behaviours, including avulsion and deposition patterns, while generalizing across different flow types, sizes and landscapes. Our results demonstrate that neural emulation enables rapid, spatially resolved runout prediction across diverse real world terrains, opening new opportunities for disaster risk reduction and impact-based forecasting. These results highlight neural emulation as a promising pathway for extending physically realistic geohazard modelling to spatial and temporal scales relevant for large scale early warning systems.

Jinfan Liu, Wuze Zhang, Zhangli Hu et al.

In stroke-based rendering, search methods often get trapped in local minima due to discrete stroke placement, while differentiable optimizers lack structural awareness and produce unstructured layouts. To bridge this gap, we propose a dual representation that couples discrete polylines with continuous Bézier control points via a bidirectional mapping mechanism. This enables collaborative optimization: local gradients refine global stroke structures, while content-aware stroke proposals help escape poor local optima. Our representation further supports Gaussian-splatting-inspired initialization, enabling highly parallel stroke optimization across the image. Experiments show that our approach reduces the number of strokes by 30-50%, achieves more structurally coherent layouts, and improves reconstruction quality, while cutting optimization time by 30-40% compared to existing differentiable vectorization methods.

Alexander Klemps, Denis Ilia, Pradeep Kr. Banerjee et al.

Controlling the longitudinal laser pulse shape in photoinjectors of Free-Electron Lasers is a powerful lever for optimizing electron beam quality, but systematic exploration of the vast design space is limited by the cost of brute-force pulse propagation simulations. We present a generative modeling framework based on Wasserstein Autoencoders to learn a differentiable latent interface between pulse shaping and downstream beam dynamics. Our empirical findings show that the learned latent space is continuous and interpretable while maintaining high-fidelity reconstructions. Pulse families such as higher-order Gaussians trace coherent trajectories, while standardizing the temporal pulse lengths shows a latent organization correlated with pulse energy. Analysis via principal components and Gaussian Mixture Models reveals a well behaved latent geometry, enabling smooth transitions between distinct pulse types via linear interpolation. The model generalizes from simulated data to real experimental pulse measurements, accurately reconstructing pulses and embedding them consistently into the learned manifold. Overall, the approach reduces reliance on expensive pulse-propagation simulations and facilitates downstream beam dynamics simulation and analysis.

Zhuoran Zhuang, Ye Chen, Jianghao Su et al.

Large Language Models (LLMs) empowered with Tool-Integrated Reasoning (TIR) can iteratively plan, call external tools, and integrate returned information to solve complex, long-horizon reasoning tasks. Agentic Reinforcement Learning (Agentic RL) optimizes such models over full tool-interaction trajectories, but two key challenges hinder effectiveness: (1) Sparse, non-instructive rewards, such as binary 0-1 verifiable signals, provide limited guidance for intermediate steps and slow convergence; (2) Gradient degradation in Group Relative Policy Optimization (GRPO), where identical rewards within a rollout group yield zero advantage, reducing sample efficiency and destabilizing training. To address these challenges, we propose two complementary techniques: Progressive Reward Shaping (PRS) and Value-based Sampling Policy Optimization (VSPO). PRS is a curriculum-inspired reward design that introduces dense, stage-wise feedback - encouraging models to first master parseable and properly formatted tool calls, then optimize for factual correctness and answer quality. We instantiate PRS for short-form QA (with a length-aware BLEU to fairly score concise answers) and long-form QA (with LLM-as-a-Judge scoring to prevent reward hacking). VSPO is an enhanced GRPO variant that replaces low-value samples with prompts selected by a task-value metric balancing difficulty and uncertainty, and applies value-smoothing clipping to stabilize gradient updates. Experiments on multiple short-form and long-form QA benchmarks show that PRS consistently outperforms traditional binary rewards, and VSPO achieves superior stability, faster convergence, and higher final performance compared to PPO, GRPO, CISPO, and SFT-only baselines. Together, PRS and VSPO yield LLM-based TIR agents that generalize better across domains.

Zeyi Xu, Jinfan Liu, Kuangxu Chen et al.

Accurately and efficiently simulating complex fluid dynamics is a challenging task that has traditionally relied on computationally intensive methods. Neural network-based approaches, such as convolutional and graph neural networks, have partially alleviated this burden by enabling efficient local feature extraction. However, they struggle to capture long-range dependencies due to limited receptive fields, and Transformer-based models, while providing global context, incur prohibitive computational costs. To tackle these challenges, we propose AMR-Transformer, an efficient and accurate neural CFD-solving pipeline that integrates a novel adaptive mesh refinement scheme with a Navier-Stokes constraint-aware fast pruning module. This design encourages long-range interactions between simulation cells and facilitates the modeling of global fluid wave patterns, such as turbulence and shockwaves. Experiments show that our approach achieves significant gains in efficiency while preserving critical details, making it suitable for high-resolution physical simulations with long-range dependencies. On CFDBench, PDEBench and a new shockwave dataset, our pipeline demonstrates up to an order-of-magnitude improvement in accuracy over baseline models. Additionally, compared to ViT, our approach achieves a reduction in FLOPs of up to 60 times.

Ye Chen, Dongdong Huang, Haoyun Xu et al.

We introduce the world's first clinical terminology for the Chinese healthcare community, namely MedCT, accompanied by a clinical foundation model MedBERT and an entity linking model MedLink. The MedCT system enables standardized and programmable representation of Chinese clinical data, successively stimulating the development of new medicines, treatment pathways, and better patient outcomes for the populous Chinese community. Moreover, the MedCT knowledge graph provides a principled mechanism to minimize the hallucination problem of large language models (LLMs), therefore achieving significant levels of accuracy and safety in LLM-based clinical applications. By leveraging the LLMs' emergent capabilities of generativeness and expressiveness, we were able to rapidly built a production-quality terminology system and deployed to real-world clinical field within three months, while classical terminologies like SNOMED CT have gone through more than twenty years development. Our experiments show that the MedCT system achieves state-of-the-art (SOTA) performance in semantic matching and entity linking tasks, not only for Chinese but also for English. We also conducted a longitudinal field experiment by applying MedCT and LLMs in a representative spectrum of clinical tasks, including electronic health record (EHR) auto-generation and medical document search for diagnostic decision making. Our study shows a multitude of values of MedCT for clinical workflows and patient outcomes, especially in the new genre of clinical LLM applications. We present our approach in sufficient engineering detail, such that implementing a clinical terminology for other non-English societies should be readily reproducible. We openly release our terminology, models and algorithms, along with real-world clinical datasets for the development.

Yupeng Zhu, Xiongzhen Zhang, Ye Chen et al.

3D animation is central to modern visual media, yet traditional production pipelines remain labor-intensive, expertise-demanding, and computationally expensive. Recent AIGC-based approaches partially automate asset creation and rigging, but they either inherit the heavy costs of full 3D pipelines or rely on video-synthesis paradigms that sacrifice 3D controllability and interactivity. We focus on single-image 3D animation generation and argue that progress is fundamentally constrained by a trade-off between rendering quality and 3D control. To address this limitation, we propose a lightweight 3D animation framework that decouples geometric control from appearance synthesis. The core idea is a 2D-3D aligned proxy representation that uses a coarse 3D estimate as a structural carrier, while delegating high-fidelity appearance and view synthesis to learned image-space generative priors. This proxy formulation enables 3D-aware motion control and interaction comparable to classical pipelines, without requiring accurate geometry or expensive optimization, and naturally extends to coherent background animation. Extensive experiments demonstrate that our method achieves efficient animation generation on low-power platforms and outperforms video-based 3D animation generation in identity preservation, geometric and textural consistency, and the level of precise, interactive control it offers to users.

Xuanzhang Liu, Jianglun Feng, Zhuoran Zhuang et al.

Large Language Model (LLM) agents trained with reinforcement learning (RL) show great promise for solving complex, multi-step tasks. However, their performance is often crippled by "Context Explosion", where the accumulation of long text outputs overwhelms the model's context window and leads to reasoning failures. To address this, we introduce CoDA, a Context-Decoupled hierarchical Agent, a simple but effective reinforcement learning framework that decouples high-level planning from low-level execution. It employs a single, shared LLM backbone that learns to operate in two distinct, contextually isolated roles: a high-level Planner that decomposes tasks within a concise strategic context, and a low-level Executor that handles tool interactions in an ephemeral, isolated workspace. We train this unified agent end-to-end using PECO (Planner-Executor Co-Optimization), a reinforcement learning methodology that applies a trajectory-level reward to jointly optimize both roles, fostering seamless collaboration through context-dependent policy updates. Extensive experiments demonstrate that CoDA achieves significant performance improvements over state-of-the-art baselines on complex multi-hop question-answering benchmarks, and it exhibits strong robustness in long-context scenarios, maintaining stable performance while all other baselines suffer severe degradation, thus further validating the effectiveness of our hierarchical design in mitigating context overload.

Ye Chen, Liming Tan, Yupeng Zhu et al.

Current video representations heavily rely on unstable and over-grained priors for motion and appearance modelling, \emph{i.e.}, pixel-level matching and tracking. A tracking error of just a few pixels would lead to the collapse of the visual object representation, not to mention occlusions and large motion frequently occurring in videos. To overcome the above mentioned vulnerability, this work proposes spatio-temporally consistent proxy nodes to represent dynamically changing objects/scenes in the video. On the one hand, the hierarchical proxy nodes have the ability to stably express the multi-scale structure of visual objects, so they are not affected by accumulated tracking error, long-term motion, occlusion, and viewpoint variation. On the other hand, the dynamic representation update mechanism of the proxy nodes adequately leverages spatio-temporal priors of the video to mitigate the impact of inaccurate trackers, thereby effectively handling drastic changes in scenes and objects. Additionally, the decoupled encoding manner of the shape and texture representations across different visual objects in the video facilitates controllable and fine-grained appearance editing capability. Extensive experiments demonstrate that the proposed representation achieves high video reconstruction accuracy with fewer parameters and supports complex video processing tasks, including video in-painting and keyframe-based temporally consistent video editing.

Zhuoran Zhuang, Ye Chen, Xia Zeng et al.

We study deploying large language models (LLMs) as business development (BD) agents for persuasive price negotiation in online travel agencies (OTAs), where aligning traveler affordability and hotel profitability directly affects bookings, partner relationships, and access to travel. The agent must follow a Standard Operating Procedure (SOP) while conducting multi-turn persuasion, interpreting colloquial inputs, and adhering to guardrails (no over-promising, no hallucinations). Conventional post-training -- supervised fine-tuning (SFT) or single-source reward optimization -- overfits scripts, misses nuanced persuasive style, and fails to enforce verifiable business constraints. We propose Reward-Enhanced Policy Optimization (REPO), a reinforcement learning post-training framework that aligns an LLM with heterogeneous rewards: a preference-trained reward model (RM) for dense human alignment, a reward judge (RJ) for high-level persuasive behavior and SOP compliance, and programmatic reward functions (RF) for deterministic checks on numerics, formatting, and guardrails. A straightforward enhancement mechanism is proposed to combine the RM with RJ and RF signals to curb reward hacking and improve negotiation quality. In production-style evaluations -- approximately 150 turns from real dialogues and 225 turns from curated bad-case dialogues -- REPO lifts average dialogue rating to 4.63: +1.20 over base, +0.83 over Direct Preference Optimization (DPO); +0.33 over Group Relative Policy Optimization (GRPO), increases the share of conversations with at least one excellent response to 66.67% (+23.34 percentage points over GRPO), and achieves a 93.33% bad-case fix rate with 75.56% clean fixes, outperforming SFT, DPO, PPO, and GRPO. We also observe emergent capabilities -- proactive empathy, localized reasoning, calibrated tactics -- that surpass gold annotations.

Hanqi Chen, Zhongyin Zhao, Ye Chen et al.

Scalable Vector Graphics (SVG) is a code-based representation for 2D visuals. Leveraging recent advances in large language models (LLMs), we study text-to-SVG generation and address two persistent gaps: weak generalization and poor adherence to input instructions. We present SVGThinker, a reasoning-driven framework that aligns the production of SVG code with the visualization process and supports the full set of SVG primitives. Our pipeline first renders each primitive in sequence and uses a multimodal model to annotate the image and code; we then build stepwise updates that mirror the incremental addition of primitives. On this data, we train an LLM with supervised fine-tuning that exposes its chain-of-thought as intermediate reasoning, improving robustness and reducing errors and hallucinations. Experiments against state-of-the-art baselines show that SVGThinker produces more stable, editable, and higher-quality SVGs while preserving the structural advantages of vector graphics. Unlike image-based methods, our outputs enable precise and hierarchical editing, opening new directions for design, content creation, and automated graphics generation.

Yikun Ma, Bo Li, Ying Chen et al.

The early detection of esophagogastric junction adenocarcinoma (EGJA) is crucial for improving patient prognosis, yet its current diagnosis is highly operator-dependent. This paper aims to make the first attempt to develop an artificial intelligence (AI) foundation model-based method for both screening and staging diagnosis of EGJA using endoscopic images. In this cohort and learning study, we conducted a multicentre study across seven Chinese hospitals between December 28, 2016 and December 30, 2024. It comprises 12,302 images from 1,546 patients; 8,249 of them were employed for model training, while the remaining were divided into the held-out (112 patients, 914 images), external (230 patients, 1,539 images), and prospective (198 patients, 1,600 images) test sets for evaluation. The proposed model employs DINOv2 (a vision foundation model) and ResNet50 (a convolutional neural network) to extract features of global appearance and local details of endoscopic images for EGJA staging diagnosis. Our model demonstrates satisfactory performance for EGJA staging diagnosis across three test sets, achieving an accuracy of 0.9256, 0.8895, and 0.8956, respectively. In contrast, among representative AI models, the best one (ResNet50) achieves an accuracy of 0.9125, 0.8382, and 0.8519 on the three test sets, respectively; the expert endoscopists achieve an accuracy of 0.8147 on the held-out test set. Moreover, with the assistance of our model, the overall accuracy for the trainee, competent, and expert endoscopists improves from 0.7035, 0.7350, and 0.8147 to 0.8497, 0.8521, and 0.8696, respectively. To our knowledge, our model is the first application of foundation models for EGJA staging diagnosis and demonstrates great potential in both diagnostic accuracy and efficiency.

Tielong Wang, Yuxuan Xiong, Jinfan Liu et al.

Current 3D representations like meshes, voxels, point clouds, and NeRF-based neural implicit fields exhibit significant limitations: they are often task-specific, lacking universal applicability across reconstruction, generation, editing, and driving. While meshes offer high precision, their dense vertex data complicates editing; NeRFs deliver excellent rendering but suffer from structural ambiguity, hindering animation and manipulation; all representations inherently struggle with the trade-off between data complexity and fidelity. To overcome these issues, we introduce a novel 3D Hierarchical Proxy Node representation. Its core innovation lies in representing an object's shape and texture via a sparse set of hierarchically organized (tree-structured) proxy nodes distributed on its surface and interior. Each node stores local shape and texture information (implicitly encoded by a small MLP) within its neighborhood. Querying any 3D coordinate's properties involves efficient neural interpolation and lightweight decoding from relevant nearby and parent nodes. This framework yields a highly compact representation where nodes align with local semantics, enabling direct drag-and-edit manipulation, and offers scalable quality-complexity control. Extensive experiments across 3D reconstruction and editing demonstrate our method's expressive efficiency, high-fidelity rendering quality, and superior editability.

Junran Guo, Tonglin Mu, Keyuan Li et al.

Detecting small objects, such as drones, over long distances presents a significant challenge with broad implications for security, surveillance, environmental monitoring, and autonomous systems. Traditional imaging-based methods rely on high-resolution image acquisition, but are often constrained by range, power consumption, and cost. In contrast, data-driven single-photon-single-pixel light detection and ranging (\text{D\textsuperscript{2}SP\textsuperscript{2}-LiDAR}) provides an imaging-free alternative, directly enabling target identification while reducing system complexity and cost. However, its detection range has been limited to a few hundred meters. Here, we introduce a novel integration of residual neural networks (ResNet) with \text{D\textsuperscript{2}SP\textsuperscript{2}-LiDAR}, incorporating a refined observation model to extend the detection range to 5~\si{\kilo\meter} in an intracity environment while enabling high-accuracy identification of drone poses and types. Experimental results demonstrate that our approach not only outperforms conventional imaging-based recognition systems, but also achieves 94.93\% pose identification accuracy and 97.99\% type classification accuracy, even under weak signal conditions with long distances and low signal-to-noise ratios (SNRs). These findings highlight the potential of imaging-free methods for robust long-range detection of small targets in real-world scenarios.

Yi Zhang, Xiaoyang Huang, Yishun Dou et al.

We present InstantSticker, a disentangled reconstruction pipeline based on Image-Based Lighting (IBL), which focuses on highly realistic decal blending, simulates stickers attached to the reconstructed surface, and allows for instant editing and real-time rendering. To achieve stereoscopic impression of the decal, we introduce shadow factor into IBL, which can be adaptively optimized during training. This allows the shadow brightness of surfaces to be accurately decomposed rather than baked into the diffuse color, ensuring that the edited texture exhibits authentic shading. To address the issues of warping and blurriness in previous methods, we apply As-Rigid-As-Possible (ARAP) parameterization to pre-unfold a specified area of the mesh and use the local UV mapping combined with a neural texture map to enhance the ability to express high-frequency details in that area. For instant editing, we utilize the Disney BRDF model, explicitly defining material colors with 3-channel diffuse albedo. This enables instant replacement of albedo RGB values during the editing process, avoiding the prolonged optimization required in previous approaches. In our experiment, we introduce the Ratio Variance Warping (RVW) metric to evaluate the local geometric warping of the decal area. Extensive experimental results demonstrate that our method surpasses previous decal blending methods in terms of editing quality, editing speed and rendering speed, achieving the state-of-the-art.

Jun Zhu, Ye Chen, Frank Brinker et al.

Modeling of large-scale research facilities is extremely challenging due to complex physical processes and engineering problems. Here, we adopt a data-driven approach to model the longitudinal phase-space diagnostic beamline at the photoinector of the European XFEL with an encoder-decoder neural network model. A deep convolutional neural network (decoder) is used to build images measured on the screen from a small feature map generated by another neural network (encoder). We demonstrate that the model trained only with experimental data can make high-fidelity predictions of megapixel images for the longitudinal phase-space measurement without any prior knowledge of photoinjectors and electron beams. The prediction significantly outperforms existing methods. We also show the scalability and interpretability of the model by sharing the same decoder with more than one encoder used for different setups of the photoinjector, and propose a pragmatic way to model a facility with various diagnostics and working points. This opens the door to a new way of accurately modeling a photoinjector using neural networks and experimental data. The approach can possibly be extended to the whole accelerator and even other types of scientific facilities.

Ye Chen, Yuankai Huo

Multi-object tracking (MOT) in computer vision and cell tracking in biomedical image analysis are two similar research fields, whose common aim is to achieve instance level object detection/segmentation and associate such objects across different video frames. However, one major difference between these two tasks is that cell tracking also aim to detect mitosis (cell division), which is typically not considered in MOT tasks. Therefore, the acyclic oriented graphs matching (AOGM) has been used as de facto standard evaluation metrics for cell tracking, rather than directly using the evaluation metrics in computer vision, such as multiple object tracking accuracy (MOTA), ID Switches (IDS), ID F1 Score (IDF1) etc. However, based on our experiments, we realized that AOGM did not always function as expected for mitosis events. In this paper, we exhibit the limitations of evaluating mitosis with AOGM using both simulated and real cell tracking data.

Jinxian Liu, Minghui Yu, Bingbing Ni et al.

We develop a novel learning scheme named Self-Prediction for 3D instance and semantic segmentation of point clouds. Distinct from most existing methods that focus on designing convolutional operators, our method designs a new learning scheme to enhance point relation exploring for better segmentation. More specifically, we divide a point cloud sample into two subsets and construct a complete graph based on their representations. Then we use label propagation algorithm to predict labels of one subset when given labels of the other subset. By training with this Self-Prediction task, the backbone network is constrained to fully explore relational context/geometric/shape information and learn more discriminative features for segmentation. Moreover, a general associated framework equipped with our Self-Prediction scheme is designed for enhancing instance and semantic segmentation simultaneously, where instance and semantic representations are combined to perform Self-Prediction. Through this way, instance and semantic segmentation are collaborated and mutually reinforced. Significant performance improvements on instance and semantic segmentation compared with baseline are achieved on S3DIS and ShapeNet. Our method achieves state-of-the-art instance segmentation results on S3DIS and comparable semantic segmentation results compared with state-of-the-arts on S3DIS and ShapeNet when we only take PointNet++ as the backbone network.

Haichun Yang, Ruining Deng, Yuzhe Lu et al.

Object detection networks are powerful in computer vision, but not necessarily optimized for biomedical object detection. In this work, we propose CircleNet, a simple anchor-free detection method with circle representation for detection of the ball-shaped glomerulus. Different from the traditional bounding box based detection method, the bounding circle (1) reduces the degrees of freedom of detection representation, (2) is naturally rotation invariant, (3) and optimized for ball-shaped objects. The key innovation to enable this representation is the anchor-free framework with the circle detection head. We evaluate CircleNet in the context of detection of glomerulus. CircleNet increases average precision of the glomerulus detection from 0.598 to 0.647. Another key advantage is that CircleNet achieves better rotation consistency compared with bounding box representations.