Jijun Cheng

Simon Graham, Quoc Dang Vu, Mostafa Jahanifar et al.

Nuclear detection, segmentation and morphometric profiling are essential in helping us further understand the relationship between histology and patient outcome. To drive innovation in this area, we setup a community-wide challenge using the largest available dataset of its kind to assess nuclear segmentation and cellular composition. Our challenge, named CoNIC, stimulated the development of reproducible algorithms for cellular recognition with real-time result inspection on public leaderboards. We conducted an extensive post-challenge analysis based on the top-performing models using 1,658 whole-slide images of colon tissue. With around 700 million detected nuclei per model, associated features were used for dysplasia grading and survival analysis, where we demonstrated that the challenge's improvement over the previous state-of-the-art led to significant boosts in downstream performance. Our findings also suggest that eosinophils and neutrophils play an important role in the tumour microevironment. We release challenge models and WSI-level results to foster the development of further methods for biomarker discovery.

Jijun Cheng, Xipeng Pan, Feihu Hou et al.

Nuclear segmentation and classification is an essential step for computational pathology. TIA lab from Warwick University organized a nuclear segmentation and classification challenge (CoNIC) for H&E stained histopathology images in colorectal cancer with two highly correlated tasks, nuclei segmentation and classification task and cellular composition task. There are a few obstacles we have to address in this challenge, 1) limited training samples, 2) color variation, 3) imbalanced annotations, 4) similar morphological appearance among classes. To deal with these challenges, we proposed a standardized pipeline for nuclear segmentation and classification by integrating several pluggable components. First, we built a GAN-based model to automatically generate pseudo images for data augmentation. Then we trained a self-supervised stain normalization model to solve the color variation problem. Next we constructed a baseline model HoVer-Net with cost-sensitive loss to encourage the model pay more attention on the minority classes. According to the results of the leaderboard, our proposed pipeline achieves 0.40665 mPQ+ (Rank 49th) and 0.62199 r2 (Rank 10th) in the preliminary test phase.

Pengyu Wang, Chenkun Tan, Shaojun Zhou et al.

Video understanding is shifting from the offline paradigm -- taking a fully recorded video as input and producing a single answer after it ends -- toward real-time interaction, in which the model perceives new frames while still replying, revises its answer as new evidence appears, and remains silent when there is nothing to say. We present MOSS-Video-Preview to validate this paradigm. Our central claim is that perception must not be blocked by generation; its natural realization is a two-channel architecture. We argue that a cross-attention backbone is better suited to real-time vision-language fusion than the prevailing decoder-only design: visual features enter through a side channel rather than joining the autoregressive sequence, so perception and generation run on separate, non-blocking pathways -- reducing the frequency of visual processing and exposing a clean channel-wise interface for independent compression. We complement this with a data synthesis pipeline that converts dense captions into real-time understanding QA whose answers are revised to match what the model has perceived so far, and we specialize an offline model on these data to elicit real-time behavior. Our model trails the strong Qwen2.5-VL-7B baseline overall -- a gap we attribute primarily to data and scale rather than the architecture -- yet attains competitive offline video and multimodal understanding, remains robust on the spatial and fine-grained temporal reasoning central to real-time use, and acquires behaviors that offline models lack: continuous perception, answer revision, and timely silence. On a single H200 with 256 frames per video, it achieves about a 5x speedup in time to first token and 2.7x higher decoding throughput, with negligible degradation in offline ability. Our study of paradigm, architecture, and data outlines a viable path toward real-time video understanding.