Yuanyuan Xu

Jiaqi Cui, Pinxian Zeng, Yuanyuan Xu et al.

To acquire high-quality positron emission tomography (PET) images while reducing the radiation tracer dose, numerous efforts have been devoted to reconstructing standard-dose PET (SPET) images from low-dose PET (LPET). However, the success of current fully-supervised approaches relies on abundant paired LPET and SPET images, which are often unavailable in clinic. Moreover, these methods often mix the dose-invariant content with dose level-related dose-specific details during reconstruction, resulting in distorted images. To alleviate these problems, in this paper, we propose a two-stage Semi-Supervised SPET reconstruction framework, namely S3PET, to accommodate the training of abundant unpaired and limited paired SPET and LPET images. Our S3PET involves an un-supervised pre-training stage (Stage I) to extract representations from unpaired images, and a supervised dose-aware reconstruction stage (Stage II) to achieve LPET-to-SPET reconstruction by transferring the dose-specific knowledge between paired images. Specifically, in stage I, two independent dose-specific masked autoencoders (DsMAEs) are adopted to comprehensively understand the unpaired SPET and LPET images. Then, in Stage II, the pre-trained DsMAEs are further finetuned using paired images. To prevent distortions in both content and details, we introduce two elaborate modules, i.e., a dose knowledge decouple module to disentangle the respective dose-specific and dose-invariant knowledge of LPET and SPET, and a dose-specific knowledge learning module to transfer the dose-specific information from SPET to LPET, thereby achieving high-quality SPET reconstruction from LPET images. Experiments on two datasets demonstrate that our S3PET achieves state-of-the-art performance quantitatively and qualitatively.

Yuxiang Yang, Lu Wen, Yuanyuan Xu et al.

Universal Multi-source Domain Adaptation (UniMDA) transfers knowledge from multiple labeled source domains to an unlabeled target domain under domain shifts (different data distribution) and class shifts (unknown target classes). Existing solutions focus on excavating image features to detect unknown samples, ignoring abundant information contained in textual semantics. In this paper, we propose an Adaptive Prompt learning with Negative textual semantics and uncErtainty modeling method based on Contrastive Language-Image Pre-training (APNE-CLIP) for UniMDA classification tasks. Concretely, we utilize the CLIP with adaptive prompts to leverage textual information of class semantics and domain representations, helping the model identify unknown samples and address domain shifts. Additionally, we design a novel global instance-level alignment objective by utilizing negative textual semantics to achieve more precise image-text pair alignment. Furthermore, we propose an energy-based uncertainty modeling strategy to enlarge the margin distance between known and unknown samples. Extensive experiments demonstrate the superiority of our proposed method.

Zhenghao Feng, Lu Wen, Yuanyuan Xu et al.

Semi-supervised learning (SSL) has shown notable potential in relieving the heavy demand of dense prediction tasks on large-scale well-annotated datasets, especially for the challenging multi-organ segmentation (MoS). However, the prevailing class-imbalance problem in MoS caused by the substantial variations in organ size exacerbates the learning difficulty of the SSL network. To address this issue, in this paper, we propose an innovative semi-supervised network with BAlanced Subclass regularIzation and semantic-Conflict penalty mechanism (BASIC) to effectively learn the unbiased knowledge for semi-supervised MoS. Concretely, we construct a novel auxiliary subclass segmentation (SCS) task based on priorly generated balanced subclasses, thus deeply excavating the unbiased information for the main MoS task with the fashion of multi-task learning. Additionally, based on a mean teacher framework, we elaborately design a balanced subclass regularization to utilize the teacher predictions of SCS task to supervise the student predictions of MoS task, thus effectively transferring unbiased knowledge to the MoS subnetwork and alleviating the influence of the class-imbalance problem. Considering the similar semantic information inside the subclasses and their corresponding original classes (i.e., parent classes), we devise a semantic-conflict penalty mechanism to give heavier punishments to the conflicting SCS predictions with wrong parent classes and provide a more accurate constraint to the MoS predictions. Extensive experiments conducted on two publicly available datasets, i.e., the WORD dataset and the MICCAI FLARE 2022 dataset, have verified the superior performance of our proposed BASIC compared to other state-of-the-art methods.