Somesh Jha

Jihye Choi, Nils Palumbo, Prasad Chalasani et al.

In the era of Large Language Models (LLMs), given their remarkable text understanding and generation abilities, there is an unprecedented opportunity to develop new, LLM-based methods for trustworthy medical knowledge synthesis, extraction and summarization. This paper focuses on the problem of Pharmacovigilance (PhV), where the significance and challenges lie in identifying Adverse Drug Events (ADEs) from diverse text sources, such as medical literature, clinical notes, and drug labels. Unfortunately, this task is hindered by factors including variations in the terminologies of drugs and outcomes, and ADE descriptions often being buried in large amounts of narrative text. We present MALADE, the first effective collaborative multi-agent system powered by LLM with Retrieval Augmented Generation for ADE extraction from drug label data. This technique involves augmenting a query to an LLM with relevant information extracted from text resources, and instructing the LLM to compose a response consistent with the augmented data. MALADE is a general LLM-agnostic architecture, and its unique capabilities are: (1) leveraging a variety of external sources, such as medical literature, drug labels, and FDA tools (e.g., OpenFDA drug information API), (2) extracting drug-outcome association in a structured format along with the strength of the association, and (3) providing explanations for established associations. Instantiated with GPT-4 Turbo or GPT-4o, and FDA drug label data, MALADE demonstrates its efficacy with an Area Under ROC Curve of 0.90 against the OMOP Ground Truth table of ADEs. Our implementation leverages the Langroid multi-agent LLM framework and can be found at https://github.com/jihyechoi77/malade.

Fangzhou Wu, Ning Zhang, Somesh Jha et al.

Large Language Model (LLM) systems are inherently compositional, with individual LLM serving as the core foundation with additional layers of objects such as plugins, sandbox, and so on. Along with the great potential, there are also increasing concerns over the security of such probabilistic intelligent systems. However, existing studies on LLM security often focus on individual LLM, but without examining the ecosystem through the lens of LLM systems with other objects (e.g., Frontend, Webtool, Sandbox, and so on). In this paper, we systematically analyze the security of LLM systems, instead of focusing on the individual LLMs. To do so, we build on top of the information flow and formulate the security of LLM systems as constraints on the alignment of the information flow within LLM and between LLM and other objects. Based on this construction and the unique probabilistic nature of LLM, the attack surface of the LLM system can be decomposed into three key components: (1) multi-layer security analysis, (2) analysis of the existence of constraints, and (3) analysis of the robustness of these constraints. To ground this new attack surface, we propose a multi-layer and multi-step approach and apply it to the state-of-art LLM system, OpenAI GPT4. Our investigation exposes several security issues, not just within the LLM model itself but also in its integration with other components. We found that although the OpenAI GPT4 has designed numerous safety constraints to improve its safety features, these safety constraints are still vulnerable to attackers. To further demonstrate the real-world threats of our discovered vulnerabilities, we construct an end-to-end attack where an adversary can illicitly acquire the user's chat history, all without the need to manipulate the user's input or gain direct access to OpenAI GPT4. Our demo is in the link: https://fzwark.github.io/LLM-System-Attack-Demo/

Mihai Christodorescu, Ryan Craven, Soheil Feizi et al.

The rise of Generative AI (GenAI) brings about transformative potential across sectors, but its dual-use nature also amplifies risks. Governments globally are grappling with the challenge of regulating GenAI, balancing innovation against safety. China, the United States (US), and the European Union (EU) are at the forefront with initiatives like the Management of Algorithmic Recommendations, the Executive Order, and the AI Act, respectively. However, the rapid evolution of GenAI capabilities often outpaces the development of comprehensive safety measures, creating a gap between regulatory needs and technical advancements. A workshop co-organized by Google, University of Wisconsin, Madison (UW-Madison), and Stanford University aimed to bridge this gap between GenAI policy and technology. The diverse stakeholders of the GenAI space -- from the public and governments to academia and industry -- make any safety measures under consideration more complex, as both technical feasibility and regulatory guidance must be realized. This paper summarizes the discussions during the workshop which addressed questions, such as: How regulation can be designed without hindering technological progress? How technology can evolve to meet regulatory standards? The interplay between legislation and technology is a very vast topic, and we don't claim that this paper is a comprehensive treatment on this topic. This paper is meant to capture findings based on the workshop, and hopefully, can guide discussion on this topic.