Le Song

Zixiao Wang, Duzhen Zhang, Ishita Agrawal et al.

Previous approaches to persona simulation large language models (LLMs) have typically relied on learning basic biographical information, or using limited role-play dialogue datasets to capture a character's responses. However, a holistic representation of an individual goes beyond surface-level facts or conversations to deeper thoughts and thinking. In this work, we introduce CharacterBot, a model designed to replicate both the linguistic patterns and distinctive thought patterns as manifested in the textual works of a character. Using Lu Xun, a renowned Chinese writer as a case study, we propose four training tasks derived from his 17 essay collections. These include a pre-training task focused on mastering external linguistic structures and knowledge, as well as three fine-tuning tasks: multiple-choice question answering, generative question answering, and style transfer, each aligning the LLM with Lu Xun's internal ideation and writing style. To optimize learning across these tasks, we introduce a CharLoRA parameter updating mechanism, where a general linguistic style expert collaborates with other task-specific experts to better study both the language style and the understanding of deeper thoughts. We evaluate CharacterBot on three tasks for linguistic accuracy and opinion comprehension, demonstrating that it significantly outperforms the baselines on our adapted metrics. We hope this work inspires future research on deep character persona simulation LLMs while considering the importance of ethical standards.

Jiayang Wu, Xingyi Zhang, Xiangyu Dong et al.

Antibody co-design represents a critical frontier in drug development, where accurate prediction of both 1D sequence and 3D structure of complementarity-determining regions (CDRs) is essential for targeting specific epitopes. Despite recent advances in equivariant graph neural networks for antibody design, current approaches often fall short in capturing the intricate interactions that govern antibody-antigen recognition and binding specificity. In this work, we present Igformer, a novel end-to-end framework that addresses these limitations through innovative modeling of antibody-antigen binding interfaces. Our approach refines the inter-graph representation by integrating personalized propagation with global attention mechanisms, enabling comprehensive capture of the intricate interplay between local chemical interactions and global conformational dependencies that characterize effective antibody-antigen binding. Through extensive validation on epitope-binding CDR design and structure prediction tasks, Igformer demonstrates significant improvements over existing methods, suggesting that explicit modeling of multi-scale residue interactions can substantially advance computational antibody design for therapeutic applications.