Haojian Ning

Haojian Ning, Chengliang Wang, Xinrun Chen et al.

Optical coherence tomography angiography (OCTA) is a noninvasive imaging technique that can reveal high-resolution retinal vessels. In this work, we propose an accurate and efficient neural network for retinal vessel segmentation in OCTA images. The proposed network achieves accuracy comparable to other SOTA methods, while having fewer parameters and faster inference speed (e.g. 110x lighter and 1.3x faster than U-Net), which is very friendly for industrial applications. This is achieved by applying the modified Recurrent ConvNeXt Block to a full resolution convolutional network. In addition, we create a new dataset containing 918 OCTA images and their corresponding vessel annotations. The data set is semi-automatically annotated with the help of Segment Anything Model (SAM), which greatly improves the annotation speed. For the benefit of the community, our code and dataset can be obtained from https://github.com/nhjydywd/OCTA-FRNet.

Chengliang Wang, Xinrun Chen, Haojian Ning et al.

In the analysis of optical coherence tomography angiography (OCTA) images, the operation of segmenting specific targets is necessary. Existing methods typically train on supervised datasets with limited samples (approximately a few hundred), which can lead to overfitting. To address this, the low-rank adaptation technique is adopted for foundation model fine-tuning and proposed corresponding prompt point generation strategies to process various segmentation tasks on OCTA datasets. This method is named SAM-OCTA and has been experimented on the publicly available OCTA-500 dataset. While achieving state-of-the-art performance metrics, this method accomplishes local vessel segmentation as well as effective artery-vein segmentation, which was not well-solved in previous works. The code is available at: https://github.com/ShellRedia/SAM-OCTA.

Xinrun Chen, Chengliang Wang, Haojian Ning et al.

Segmenting specific targets or biomarkers is necessary to analyze optical coherence tomography angiography (OCTA) images. Previous methods typically segment all the targets in an OCTA sample, such as retinal vessels (RVs). Although these methods perform well in accuracy and precision, OCTA analyses often focusing local information within the images which has not been fulfilled. In this paper, we propose a method called SAM-OCTA for local segmentation in OCTA images. The method fine-tunes a pre-trained segment anything model (SAM) using low-rank adaptation (LoRA) and utilizes prompt points for local RVs, arteries, and veins segmentation in OCTA. To explore the effect and mechanism of prompt points, we set up global and local segmentation modes with two prompt point generation strategies, namely random selection and special annotation. Considering practical usage, we conducted extended experiments with different model scales and analyzed the model performance before and after fine-tuning besides the general segmentation task. From comprehensive experimental results with the OCTA-500 dataset, our SAM-OCTA method has achieved state-of-the-art performance in common OCTA segmentation tasks related to RV and FAZ, and it also performs accurate segmentation of artery-vein and local vessels. The code is available at https://github.com/ShellRedia/SAM-OCTA-extend.

Xinrun Chen, Chengliang Wang, Haojian Ning et al.

Segmentation of indicated targets aids in the precise analysis of optical coherence tomography angiography (OCTA) samples. Existing segmentation methods typically perform on 2D projection targets, making it challenging to capture the variance of segmented objects through the 3D volume. To address this limitation, the low-rank adaptation technique is adopted to fine-tune the Segment Anything Model (SAM) version 2, enabling the tracking and segmentation of specified objects across the OCTA scanning layer sequence. To further this work, a prompt point generation strategy in frame sequence and a sparse annotation method to acquire retinal vessel (RV) layer masks are proposed. This method is named SAM-OCTA2 and has been experimented on the OCTA-500 dataset. It achieves state-of-the-art performance in segmenting the foveal avascular zone (FAZ) on regular 2D en-face and effectively tracks local vessels across scanning layer sequences. The code is available at: https://github.com/ShellRedia/SAM-OCTA2.

Xinrun Chen, Mei Shen, Haojian Ning et al.

Segmenting specific targets or structures in optical coherence tomography angiography (OCTA) images is fundamental for conducting further pathological studies. The retinal vascular layers are rich and intricate, and such vascular with complex shapes can be captured by the widely-studied OCTA images. In this paper, we thus study how to use OCTA images with projection vascular layers to segment retinal structures. To this end, we propose the SSW-OCTA model, which integrates the advantages of deformable convolutions suited for tubular structures and the swin-transformer for global feature extraction, adapting to the characteristics of OCTA modality images. Our model underwent testing and comparison on the OCTA-500 dataset, achieving state-of-the-art performance. The code is available at: https://github.com/ShellRedia/Snake-SWin-OCTA.