Qiwei Meng

QiWei Meng

Large Protein Language Models have shown strong potential for generative protein design, yet they frequently produce structural hallucinations, generating sequences with high linguistic likelihood that fold into thermodynamically unstable conformations. Existing alignment approaches such as Direct Preference Optimization are limited in this setting, as they model preferences as binary labels and ignore the continuous structure of the physical energy landscape. We propose Physio-DPO, a physics informed alignment framework that grounds protein language models in thermodynamic stability. Physio-DPO introduces a magnitude aware objective that scales optimization updates according to the energy gap between native structures and physics perturbed hard negatives. Experiments show that Physio-DPO consistently outperforms strong baselines including SFT, PPO, and standard DPO, reducing self consistency RMSD to 1.28 Å and increasing foldability to 92.8%. Qualitative analysis further demonstrates that Physio-DPO effectively mitigates structural hallucinations by recovering biophysical interactions such as hydrophobic core packing and hydrogen bond networks.

Nuo Xu, Jianfeng Liao, Qiwei Meng et al.

Efficient waste management and recycling heavily rely on garbage exploration and identification. In this study, we propose GSA2Seg (Garbage Segmentation and Attribute Analysis), a novel visual approach that utilizes quadruped robotic dogs as autonomous agents to address waste management and recycling challenges in diverse indoor and outdoor environments. Equipped with advanced visual perception system, including visual sensors and instance segmentators, the robotic dogs adeptly navigate their surroundings, diligently searching for common garbage items. Inspired by open-vocabulary algorithms, we introduce an innovative method for object attribute analysis. By combining garbage segmentation and attribute analysis techniques, the robotic dogs accurately determine the state of the trash, including its position and placement properties. This information enhances the robotic arm's grasping capabilities, facilitating successful garbage retrieval. Additionally, we contribute an image dataset, named GSA2D, to support evaluation. Through extensive experiments on GSA2D, this paper provides a comprehensive analysis of GSA2Seg's effectiveness. Dataset available: \href{https://www.kaggle.com/datasets/hellob/gsa2d-2024}{https://www.kaggle.com/datasets/hellob/gsa2d-2024}.