Yubiao Yue

Yubiao Yue, Minghua Jiang, Xinyue Zhang et al.

Swift and accurate diagnosis for earlier-stage monkeypox (mpox) patients is crucial to avoiding its spread. However, the similarities between common skin disorders and mpox and the need for professional diagnosis unavoidably impaired the diagnosis of earlier-stage mpox patients and contributed to mpox outbreak. To address the challenge, we proposed "Super Monitoring", a real-time visualization technique employing artificial intelligence (AI) and Internet technology to diagnose earlier-stage mpox cheaply, conveniently, and quickly. Concretely, AI-mediated "Super Monitoring" (mpox-AISM) integrates deep learning models, data augmentation, self-supervised learning, and cloud services. According to publicly accessible datasets, mpox-AISM's Precision, Recall, Specificity, and F1-score in diagnosing mpox reach 99.3%, 94.1%, 99.9%, and 96.6%, respectively, and it achieves 94.51% accuracy in diagnosing mpox, six like-mpox skin disorders, and normal skin. With the Internet and communication terminal, mpox-AISM has the potential to perform real-time and accurate diagnosis for earlier-stage mpox in real-world scenarios, thereby preventing mpox outbreak.

Yubiao Yue, Xiaoqiang Shi, Li Qin et al.

Due to the absence of more efficient diagnostic tools, the spread of mpox continues to be unchecked. Although related studies have demonstrated the high efficiency of deep learning models in diagnosing mpox, key aspects such as model inference speed and parameter size have always been overlooked. Herein, an ultrafast and ultralight network named Fast-MpoxNet is proposed. Fast-MpoxNet, with only 0.27M parameters, can process input images at 68 frames per second (FPS) on the CPU. To detect subtle image differences and optimize model parameters better, Fast-MpoxNet incorporates an attention-based feature fusion module and a multiple auxiliary losses enhancement strategy. Experimental results indicate that Fast-MpoxNet, utilizing transfer learning and data augmentation, produces 98.40% classification accuracy for four classes on the mpox dataset. Furthermore, its Recall for early-stage mpox is 93.65%. Most importantly, an application system named Mpox-AISM V2 is developed, suitable for both personal computers and smartphones. Mpox-AISM V2 can rapidly and accurately diagnose mpox and can be easily deployed in various scenarios to offer the public real-time mpox diagnosis services. This work has the potential to mitigate future mpox outbreaks and pave the way for developing real-time diagnostic tools in the healthcare field.

Yubiao Yue, Zhenzhang Li

Since the era of deep learning, convolutional neural networks (CNNs) and vision transformers (ViTs) have been extensively studied and widely used in medical image classification tasks. Unfortunately, CNN's limitations in modeling long-range dependencies result in poor classification performances. In contrast, ViTs are hampered by the quadratic computational complexity of their self-attention mechanism, making them difficult to deploy in real-world settings with limited computational resources. Recent studies have shown that state space models (SSMs) represented by Mamba can effectively model long-range dependencies while maintaining linear computational complexity. Inspired by it, we proposed MedMamba, the first Vision Mamba for generalized medical image classification. Concretely, we introduced a novel hybrid basic block named SS-Conv-SSM, which purely integrates the convolutional layers for extracting local features with the abilities of SSM to capture long-range dependencies, aiming to model medical images from different image modalities efficiently. By employing the grouped convolution strategy and channel-shuffle operation, MedMamba successfully provides fewer model parameters and a lower computational burden for efficient applications without sacrificing accuracy. We thoroughly evaluated MedMamba using 16 datasets containing ten imaging modalities and 411,007 images. Experimental results show that MedMamba demonstrates competitive performance on most tasks compared with the state-of-the-art methods. This work aims to explore the potential of Vision Mamba and establish a new baseline for medical image classification, thereby providing valuable insights for developing more powerful Mamba-based artificial intelligence algorithms and applications in medicine. The source codes and all pre-trained weights of MedMamba are available at https://github.com/YubiaoYue/MedMamba.

Yubiao Yue, Jun Xue, Haihuang Liang et al.

Due to the lack of effective mpox detection tools, the mpox virus continues to spread worldwide and has once again been declared a public health emergency of international concern by the World Health Organization. Lightweight deep learning model-based detection systems are crucial to alleviate mpox outbreaks since they are suitable for widespread deployment, especially in resource-limited scenarios. However, the key to its successful application depends on ensuring that the model can effectively model local features and long-range dependencies in mpox lesions while maintaining lightweight. Inspired by the success of Mamba in modeling long-range dependencies and its linear complexity, we proposed a lightweight hybrid architecture called MpoxMamba for efficient mpox detection. MpoxMamba utilizes depth-wise separable convolutions to extract local feature representations in mpox skin lesions and greatly enhances the model's ability to model the global contextual information by grouped Mamba modules. Notably, MpoxMamba's parameter size and FLOPs are 0.77M and 0.53G, respectively. Experimental results on two widely recognized benchmark datasets demonstrate that MpoxMamba outperforms state-of-the-art lightweight models and existing mpox detection methods. Importantly, we developed a web-based online application to provide free mpox detection (http://5227i971s5.goho.co:30290). The source codes of MpoxMamba are available at https://github.com/YubiaoYue/MpoxMamba.

Yubiao Yue, Zhenzhang Li

Due to the lack of efficient mpox diagnostic technology, mpox cases continue to increase. Recently, the great potential of deep learning models in detecting mpox and non-mpox has been proven. However, existing models learn image representations via image classification, which results in they may be easily susceptible to interference from real-world noise, require diverse non-mpox images, and fail to detect abnormal input. These drawbacks make classification models inapplicable in real-world settings. To address these challenges, we propose "Mask, Inpainting, and Measure" (MIM). In MIM's pipeline, a generative adversarial network only learns mpox image representations by inpainting the masked mpox images. Then, MIM determines whether the input belongs to mpox by measuring the similarity between the inpainted image and the original image. The underlying intuition is that since MIM solely models mpox images, it struggles to accurately inpaint non-mpox images in real-world settings. Without utilizing any non-mpox images, MIM cleverly detects mpox and non-mpox and can handle abnormal inputs. We used the recognized mpox dataset (MSLD) and images of eighteen non-mpox skin diseases to verify the effectiveness and robustness of MIM. Experimental results show that the average AUROC of MIM achieves 0.8237. In addition, we demonstrated the drawbacks of classification models and buttressed the potential of MIM through clinical validation. Finally, we developed an online smartphone app to provide free testing to the public in affected areas. This work first employs generative models to improve mpox detection and provides new insights into binary decision-making tasks in medical images.

Yubiao Yue, Jun Xue, Haihua Liang et al.

Booming deep learning has substantially improved the diagnosis for diverse lesions in ultrasound images, but a conspicuous research gap concerning cervical lymph node lesions still remains. The objective of this work is to diagnose cervical lymph node lesions in ultrasound images by leveraging a deep learning model. To this end, we first collected 3392 cervical ultrasound images containing normal lymph nodes, benign lymph node lesions, malignant primary lymph node lesions, and malignant metastatic lymph node lesions. Given that ultrasound images are generated by the reflection and scattering of sound waves across varied bodily tissues, we proposed the Conv-FFT Block. It integrates convolutional operations with the fast Fourier transform to more astutely model the images. Building upon this foundation, we designed a novel architecture, named SFUSNet. SFUSNet not only discerns variances in ultrasound images from the spatial domain but also adeptly captures micro-structural alterations across various lesions in the frequency domain. To ascertain the potential of SFUSNet, we benchmarked it against 12 popular architectures through five-fold cross-validation. The results show that SFUSNet is the state-of-the-art model and can achieve 92.89% accuracy. Moreover, its average precision, average sensitivity and average specificity for four types of lesions achieve 90.46%, 89.95% and 97.49%, respectively.

Yubiao Yue, Jun Xue, Chao Wang et al.

Numerous studies have affirmed that deep learning models can facilitate early diagnosis of lesions in endoscopic images. However, the lack of available datasets stymies advancements in research on nasal endoscopy, and existing models fail to strike a good trade-off between model diagnosis performance, model complexity and parameters size, rendering them unsuitable for real-world application. To bridge these gaps, we created the first large-scale nasal endoscopy dataset, named 7-NasalEID, comprising 11,352 images that contain six common nasal diseases and normal samples. Subsequently, we proposed U-SEANNet, an innovative U-shaped architecture, underpinned by depth-wise separable convolution. Moreover, to enhance its capacity for detecting nuanced discrepancies in input images, U-SEANNet employs the Global-Local Channel Feature Fusion module, enabling it to utilize salient channel features from both global and local contexts. To demonstrate U-SEANNet's potential, we benchmarked U-SEANNet against seventeen modern architectures through five-fold cross-validation. The experimental results show that U-SEANNet achieves a commendable accuracy of 93.58%. Notably, U-SEANNet's parameters size and GFLOPs are only 0.78M and 0.21, respectively. Our findings suggest U-SEANNet is the state-of-the-art model for nasal diseases diagnosis in endoscopic images.

Feiyan Lu, Yubiao Yue, Zhenzhang Li et al.

Early and accurate detection systems for ear diseases, powered by deep learning, are essential for preventing hearing impairment and improving population health. However, the limited diversity of existing otoendoscopy datasets and the poor balance between diagnostic accuracy, computational efficiency, and model size have hindered the translation of artificial intelligence (AI) algorithms into healthcare applications. In this study, we constructed a large-scale, multi-center otoendoscopy dataset covering eight common ear diseases and healthy cases. Building upon this resource, we developed Best-EarNet, an ultrafast and lightweight deep learning architecture integrating a novel Local-Global Spatial Feature Fusion Module with a multi-scale supervision strategy, enabling real-time and accurate classification of ear conditions. Leveraging transfer learning, Best-EarNet, with a model size of only 2.94 MB, achieved diagnostic accuracies of 95.23% on an internal test set (22,581 images) and 92.14% on an external test set (1,652 images), while requiring only 0.0125 seconds (80 frames per second) to process a single image on a standard CPU. Further subgroup analysis by gender and age showed consistently excellent performance of Best-EarNet across all demographic groups. To enhance clinical interpretability and user trust, we incorporated Grad-CAM-based visualization, highlighting the specific abnormal ear regions contributing to AI predictions. Most importantly, we developed Ear-Keeper, a cross-platform intelligent diagnosis system built upon Best-EarNet, deployable on smartphones, tablets, and personal computers. Ear-Keeper enables public users and healthcare providers to perform comprehensive real-time video-based ear canal screening, supporting early detection and timely intervention of ear diseases.

Zesheng Hong, Yubiao Yue, Yubin Chen et al.

Computer-aided diagnostics has benefited from the development of deep learning-based computer vision techniques in these years. Traditional supervised deep learning methods assume that the test sample is drawn from the identical distribution as the training data. However, it is possible to encounter out-of-distribution samples in real-world clinical scenarios, which may cause silent failure in deep learning-based medical image analysis tasks. Recently, research has explored various out-of-distribution (OOD) detection situations and techniques to enable a trustworthy medical AI system. In this survey, we systematically review the recent advances in OOD detection in medical image analysis. We first explore several factors that may cause a distributional shift when using a deep-learning-based model in clinic scenarios, with three different types of distributional shift well defined on top of these factors. Then a framework is suggested to categorize and feature existing solutions, while the previous studies are reviewed based on the methodology taxonomy. Our discussion also includes evaluation protocols and metrics, as well as the challenge and a research direction lack of exploration.