Xianpeng Wang

Yining Qian, Lijie Su, Meiling Xu et al.

Predicting protein secondary structure is essential for understanding protein function and advancing drug discovery. However, the intricate sequence-structure relationship poses significant challenges for accurate modeling. To address these, we propose MOGP-MMF, a multi-objective genetic programming framework that reformulates PSSP as an automated optimization task focused on feature selection and fusion. Specifically, MOGP-MMF introduces a multi-view multi-level representation strategy that integrates evolutionary, semantic, and newly introduced structural views to capture the comprehensive protein folding logic. Leveraging an enriched operator set, the framework evolves both linear and nonlinear fusion functions, effectively capturing high-order feature interactions while reducing fusion complexity. To resolve the accuracy-complexity trade-off, an improved multi-objective GP algorithm is developed, incorporating a knowledge transfer mechanism that utilizes prior evolutionary experience to guide the population toward global optima. Extensive experiments across seven benchmark datasets demonstrate that MOGP-MMF surpasses state-of-the-art methods, particularly in Q8 accuracy and structural integrity. Furthermore, MOGP-MMF generates a diverse set of non-dominated solutions, offering flexible model selection schemes for various practical application scenarios. The source code is available on GitHub: https://github.com/qian-ann/MOGP-MMF/tree/main.

Wendi Xu, Xianpeng Wang

Evolutionary transfer optimization(ETO) serves as "a new frontier in evolutionary computation research", which will avoid zero reuse of experience and knowledge from solved problems in traditional evolutionary computation. In scheduling applications via ETO, a highly competitive "meeting" framework between them could be constituted towards both intelligent scheduling and green scheduling, especially for carbon neutrality within the context of China. To the best of our knowledge, our study on scheduling here, is the 1st work of ETO for complex optimization when multiobjective problem "meets" single-objective problems in combinatorial case (not multitasking optimization). More specifically, key knowledge like positional building blocks clustered, could be learned and transferred for permutation flow shop scheduling problem (PFSP). Empirical studies on well-studied benchmarks validate relatively firm effectiveness and great potential of our proposed ETO-PFSP framework.

Yiming Gao, Liuyi Xu, Pengshan Cui et al.

Accurate identification of protein-nucleotide binding sites is fundamental to deciphering molecular mechanisms and accelerating drug discovery. However, current computational methods often struggle with suboptimal performance due to inadequate feature representation and rigid fusion mechanisms, which hinder the effective exploitation of cross-task information synergy. To bridge this gap, we propose MTGA-MGE, a framework that integrates a Multi-Task Genetic Algorithm with Multi-Granularity Encoding to enhance binding site prediction. Specifically, we develop a Multi-Granularity Encoding (MGE) network that synergizes multi-scale convolutions and self-attention mechanisms to distill discriminative signals from high-dimensional, redundant biological data. To overcome the constraints of static fusion, a genetic algorithm is employed to adaptively evolve task-specific fusion strategies, thereby effectively improving model generalization. Furthermore, to catalyze collaborative learning, we introduce an External-Neighborhood Mechanism (ENM) that leverages biological similarities to facilitate targeted information exchange across tasks. Extensive evaluations on fifteen nucleotide datasets demonstrate that MTGA-MGE not only establishes a new state-of-the-art in data-abundant, high-resource scenarios but also maintains a robust competitive edge in rare, low-resource regimes, presenting a highly adaptive scheme for decoding complex protein-ligand interactions in the post-genomic era.

Yumeng Zha, Shengxiang Yang, Xianpeng Wang

Industrial forecasting often involves multi-source asynchronous signals and multi-output targets, while deployment requires explicit trade-offs between prediction error and model complexity. Current practices typically fix alignment strategies or network designs, making it difficult to systematically co-design preprocessing, architecture, and hyperparameters in budget-limited training-based evaluations. To address this issue, we propose an auto-configuration framework that outputs a deployable Pareto set of forecasting models balancing error and complexity. At the model level, a Multi-Scale Bi-Branch Convolutional Neural Network (MS--BCNN) is developed, where short- and long-kernel branches capture local fluctuations and long-term trends, respectively, for multi-output regression. At the search level, we unify alignment operators, architectural choices, and training hyperparameters into a hierarchical-conditional mixed configuration space, and apply Player-based Hybrid Multi-Objective Evolutionary Algorithm (PHMOEA) to approximate the error--complexity Pareto frontier within a limited computational budget. Experiments on hierarchical synthetic benchmarks and a real-world sintering dataset demonstrate that our framework outperforms competitive baselines under the same budget and offers flexible deployment choices.

Jiatong Bai, Feng Shu, Qinghe Zheng et al.

Due to its excellent performance in rate and resolution, fully-digital (FD) massive multiple-input multiple-output (MIMO) antenna arrays has been widely applied in data transmission and direction of arrival (DOA) measurements, etc. But it confronts with two main challenges: high computational complexity and circuit cost. The two problems may be addressed well by hybrid analog-digital (HAD) structure. But there exists the problem of phase ambiguity for HAD, which leads to its low-efficiency or high-latency. Does exist there such a MIMO structure of owning low-cost, low-complexity and high time efficiency at the same time. To satisfy the three properties, a novel heterogeneous hybrid MIMO receiver structure of integrating FD and heterogeneous HAD ($\rm{H}^2$AD-FD) is proposed and corresponding multi-modal (MD)-learning framework is developed. The framework includes three major stages: 1) generate the candidate sets via root multiple signal classification (Root-MUSIC) or deep learning (DL); 2) infer the class of true solutions from candidate sets using machine learning (ML) methods; 3) fuse the two-part true solutions to achieve a better DOA estimation. The above process form two methods named MD-Root-MUSIC and MDDL. To improve DOA estimation accuracy and reduce the clustering complexity, a co-learning-aided MD framework is proposed to form two enhanced methods named CoMDDL and CoMD-RootMUSIC. Moreover, the Cramer-Rao lower bound (CRLB) for the proposed $\rm{H}^2$AD-FD structure is also derived. Experimental results demonstrate that our proposed four methods could approach the CRLB for signal-to-noise ratio (SNR) > 0 dB and the proposed CoMDDL and MDDL perform better than CoMD-RootMUSIC and MD-RootMUSIC, particularly in the extremely low SNR region.

Yumeng Zhao, Shengxiang Yang, Xianpeng Wang

Accurate prediction of nonstationary multivariate time series remains a critical challenge in complex industrial systems such as iron ore sintering. In practice, pronounced concept drift compounded by significant label verification latency rapidly degrades the performance of offline-trained models. Existing methods based on static architectures or passive update strategies struggle to simultaneously extract multi-scale spatiotemporal features and overcome the stability-plasticity dilemma without immediate supervision. To address these limitations, a Drift-Aware Multi-Scale Dynamic Learning (DA-MSDL) framework is proposed to maintain robust multi-output predictive performance via online adaptive mechanisms on nonstationary data streams. The framework employs a multi-scale bi-branch convolutional network as its backbone to disentangle local fluctuations from long-term trends, thereby enhancing representational capacity for complex dynamic patterns. To circumvent the label latency bottleneck, DA-MSDL leverages Maximum Mean Discrepancy (MMD) for unsupervised drift detection. By quantifying online statistical deviations in feature distributions, DA-MSDL proactively triggers model adaptation prior to inference. Furthermore, a drift-severity-guided hierarchical fine-tuning strategy is developed. Supported by prioritized experience replay from a dynamic memory queue, this approach achieves rapid distribution alignment while effectively mitigating catastrophic forgetting. Long-horizon experiments on real-world industrial sintering data and a public benchmark dataset demonstrate that DA-MSDL consistently outperforms representative baselines under severe concept drift. Exhibiting strong cross-domain generalization and predictive stability, the proposed framework provides an effective online dynamic learning paradigm for quality monitoring in nonstationary environments.

Shaokuan Wang, Pengshan Cui, Yining Qian et al.

Intrinsically disordered regions of proteins play a crucial role in cell signaling and drug discovery. However, their high structural flexibility makes accurate residue-level prediction challenging. Existing methods often rely on single-view representations or rigid manual fusion strategies, which fail to effectively balance the complex interplay between local amino acid preferences and long-range sequence patterns. To address these limitations, we propose D2MOE, a Dual-View Multiscale Features and Multi-objective Evolutionary Algorithm, which consists of two stages. First, a dual-view multiscale feature extraction method is introduced. This method integrates evolutionary views with deep semantic views and employs multiscale extractors to capture structural information across diverse receptive fields. Second, a multi-objective evolutionary algorithm is designed to adaptively discover optimal fusion architectures. By co-evolving discrete feature selection and continuous fusion weights, the algorithm adaptively explores optimal cross-feature architectures to enhance predictive accuracy while maintaining model compactness. Experimental results across three benchmark datasets demonstrate that D2MOE consistently outperforms state-of-the-art methods. D2MOE combines the feature extraction capabilities of deep learning with the global search advantages of evolutionary algorithms, enabling efficient feature integration without manual design, and providing a robust computational tool for protein disorder prediction.