Davide Bianchi

Davide Bianchi, Sonia Colombo Serra, Davide Evangelista et al.

The adoption of contrast agents in medical imaging protocols is crucial for accurate and timely diagnosis. While highly effective and characterized by an excellent safety profile, the use of contrast agents has its limitation, including rare risk of allergic reactions, potential environmental impact and economic burdens on patients and healthcare systems. In this work, we address the contrast agent reduction (CAR) problem, which involves reducing the administered dosage of contrast agent while preserving the visual enhancement. The current literature on the CAR task is based on deep learning techniques within a fully image processing framework. These techniques digitally simulate high-dose images from images acquired with a low dose of contrast agent. We investigate the feasibility of a ``learned inverse problem'' (LIP) approach, as opposed to the end-to-end paradigm in the state-of-the-art literature. Specifically, we learn the image-to-image operator that maps high-dose images to their corresponding low-dose counterparts, and we frame the CAR task as an inverse problem. We then solve this problem through a regularized optimization reformulation. Regularization methods are well-established mathematical techniques that offer robustness and explainability. Our approach combines these rigorous techniques with cutting-edge deep learning tools. Numerical experiments performed on pre-clinical medical images confirm the effectiveness of this strategy, showing improved stability and accuracy in the simulated high-dose images.

Davide Bianchi, Florian Bossmann, Wenlong Wang et al.

We introduce a data-adaptive inversion method that integrates classical or deep learning-based approaches with iterative graph Laplacian regularization, specifically targeting acoustic impedance inversion - a critical task in seismic exploration. Our method initiates from an impedance estimate derived using either traditional inversion techniques or neural network-based methods. This initial estimate guides the construction of a graph Laplacian operator, effectively capturing structural characteristics of the impedance profile. Utilizing a Tikhonov-inspired variational framework with this graph-informed prior, our approach iteratively updates and refines the impedance estimate while continuously recalibrating the graph Laplacian. This iterative refinement shows rapid convergence, increased accuracy, and enhanced robustness to noise compared to initial reconstructions alone. Extensive validation performed on synthetic and real seismic datasets across varying noise levels confirms the effectiveness of our method. Performance evaluations include four initial inversion methods: two classical techniques and two neural networks - previously established in the literature.

Yuantao Cai, Marco Donatelli, Davide Bianchi et al.

Thresholding iterative methods are recently successfully applied to image deblurring problems. In this paper, we investigate the modified linearized Bregman algorithm (MLBA) used in image deblurring problems, with a proper treatment of the boundary artifacts. We consider two standard approaches: the imposition of boundary conditions and the use of the rectangular blurring matrix. The fast convergence of the MLBA depends on a regularizing preconditioner that could be computationally expensive and hence it is usually chosen as a block circulant circulant block (BCCB) matrix, diagonalized by discrete Fourier transform. We show that the standard approach based on the BCCB preconditioner may provide low quality restored images and we propose different preconditioning strategies, that improve the quality of the restoration and save some computational cost at the same time. Motivated by a recent nonstationary preconditioned iteration, we propose a new algorithm that combines such method with the MLBA.We prove that it is a regularizing and convergent method. A variant with a stationary preconditioner is also considered. Finally, a large number of numerical experiments shows that our methods provide accurate and fast restorations, when compared with the state of the art.

Davide Bianchi, Alessandro Buccini, Marco Donatelli et al.

Fractional Tikhonov regularization methods have been recently proposed to reduce the oversmoothing property of the Tikhonov regularization in standard form, in order to preserve the details of the approximated solution. Their regularization and convergence properties have been previously investigated showing that they are of optimal order. This paper provides saturation and converse results on their convergence rates. Using the same iterative refinement strategy of iterated Tikhonov regularization, new iterated fractional Tikhonov regularization methods are introduced. We show that these iterated methods are of optimal order and overcome the previous saturation results. Furthermore, nonstationary iterated fractional Tikhonov regularization methods are investigated, establishing their convergence rate under general conditions on the iteration parameters. Numerical results confirm the effectiveness of the proposed regularization iterations.