Yixin Wu

Keyue Qiu, Yixin Wu, Lihao Wang et al.

We present AMix-2, a protein-text foundation model that establishes protein as a native modality in large language models (LLMs), unifying protein understanding and sequence design within a single foundation model. AMix-2 is built upon two key ideas: (1) a unified protein-text formulation that embeds natural language and protein sequence in a shared token space, enabling one model to perform biological reasoning and conditional design instead of separate downstream task-specialized models; and (2) a block-wise diffusion language modeling backbone that combines causal generation across blocks with bidirectional context and iterative refinement within blocks. This scheme better matches the intrinsic nature of proteins than a strict left-to-right factorization. To evaluate protein foundation models under realistic generalization settings, we further introduce ProteinArena, a comprehensive benchmark with time-aware and homology-aware protocols across various understanding and design tasks, and with baselines covering classical bioinformatics tools, protein-specialized models and LLMs. On ProteinArena, AMix-2 outperforms frontier LLMs and demonstrates competitive performance to task-specific protein models. Controlled experiments further show that the diffusion-based paradigm generally surpasses its autoregressive counterpart, highlighting the advantage of flexible generation order for protein sequences. We release both AMix-2 and ProteinArena to facilitate open research in protein foundation models.

Yixin Wu, Yun Shen, Michael Backes et al.

Text-to-image models, such as Stable Diffusion (SD), undergo iterative updates to improve image quality and address concerns such as safety. Improvements in image quality are straightforward to assess. However, how model updates resolve existing concerns and whether they raise new questions remain unexplored. This study takes an initial step in investigating the evolution of text-to-image models from the perspectives of safety, bias, and authenticity. Our findings, centered on Stable Diffusion, indicate that model updates paint a mixed picture. While updates progressively reduce the generation of unsafe images, the bias issue, particularly in gender, intensifies. We also find that negative stereotypes either persist within the same Non-White race group or shift towards other Non-White race groups through SD updates, yet with minimal association of these traits with the White race group. Additionally, our evaluation reveals a new concern stemming from SD updates: State-of-the-art fake image detectors, initially trained for earlier SD versions, struggle to identify fake images generated by updated versions. We show that fine-tuning these detectors on fake images generated by updated versions achieves at least 96.6\% accuracy across various SD versions, addressing this issue. Our insights highlight the importance of continued efforts to mitigate biases and vulnerabilities in evolving text-to-image models.

Feiran Zhang, Yixin Wu, Zhenghua Wang et al.

Vision-Language Models (VLMs) have demonstrated remarkable progress in multimodal tasks, but remain susceptible to hallucinations, where generated text deviates from the underlying visual content. Existing hallucination detection methods primarily rely on output logits or external verification tools, often overlooking their internal mechanisms. In this work, we investigate the outputs of internal attention heads, postulating that specific heads carry the primary signals for truthful generation.However, directly probing these high-dimensional states is challenging due to the entanglement of visual-linguistic syntax and noise. To address this, we propose VIB-Probe, a novel hallucination detection and mitigation framework leveraging the Variational Information Bottleneck (VIB) theory. Our method extracts discriminative patterns across layers and heads while filtering out semantic nuisances through the information bottleneck principle. Furthermore, by leveraging the gradients of our VIB probe, we identify attention heads with strong causal influence on hallucinations and introduce an inference-time intervention strategy for hallucination mitigation. Extensive experiments across diverse benchmarks demonstrate that VIB-Probe significantly outperforms existing baselines in both settings. Our code will be made publicly available.

Ziqing Yang, Yixin Wu, Yun Shen et al.

The tremendous commercial potential of large language models (LLMs) has heightened concerns about their unauthorized use. Third parties can customize LLMs through fine-tuning and offer only black-box API access, effectively concealing unauthorized usage and complicating external auditing processes. This practice not only exacerbates unfair competition, but also violates licensing agreements. In response, identifying the origin of black-box LLMs is an intrinsic solution to this issue. In this paper, we first reveal the limitations of state-of-the-art passive and proactive identification methods with experiments on 30 LLMs and two real-world black-box APIs. Then, we propose the proactive technique, PlugAE, which optimizes adversarial token embeddings in a continuous space and proactively plugs them into the LLM for tracing and identification. The experiments show that PlugAE can achieve substantial improvement in identifying fine-tuned derivatives. We further advocate for legal frameworks and regulations to better address the challenges posed by the unauthorized use of LLMs.

Xinyu Zhang, Yixin Wu, Boyang Zhang et al.

Images shared on social media often expose geographic cues. While early geolocation methods required expert effort and lacked generalization, the rise of Large Vision Language Models (LVLMs) now enables accurate geolocation even for ordinary users. However, existing approaches are not optimized for this task. To explore the full potential and associated privacy risks, we present Geo-Detective, an agent that mimics human reasoning and tool use for image geolocation inference. It follows a procedure with four steps that adaptively selects strategies based on image difficulty and is equipped with specialized tools such as visual reverse search, which emulates how humans gather external geographic clues. Experimental results show that GEO-Detective outperforms baseline large vision language models (LVLMs) overall, particularly on images lacking visible geographic features. In country level geolocation tasks, it achieves an improvement of over 11.1% compared to baseline LLMs, and even at finer grained levels, it still provides around a 5.2% performance gain. Meanwhile, when equipped with external clues, GEO-Detective becomes more likely to produce accurate predictions, reducing the "unknown" prediction rate by more than 50.6%. We further explore multiple defense strategies and find that Geo-Detective exhibits stronger robustness, highlighting the need for more effective privacy safeguards.

Yixin Wu, Rui Wen, Chi Cui et al.

Inference attacks have been widely studied and offer a systematic risk assessment of ML services; however, their implementation and the attack parameters for optimal estimation are challenging for non-experts. The emergence of advanced large language models presents a promising yet largely unexplored opportunity to develop autonomous agents as inference attack experts, helping address this challenge. In this paper, we propose AttackPilot, an autonomous agent capable of independently conducting inference attacks without human intervention. We evaluate it on 20 target services. The evaluation shows that our agent, using GPT-4o, achieves a 100.0% task completion rate and near-expert attack performance, with an average token cost of only $0.627 per run. The agent can also be powered by many other representative LLMs and can adaptively optimize its strategy under service constraints. We further perform trace analysis, demonstrating that design choices, such as a multi-agent framework and task-specific action spaces, effectively mitigate errors such as bad plans, inability to follow instructions, task context loss, and hallucinations. We anticipate that such agents could empower non-expert ML service providers, auditors, or regulators to systematically assess the risks of ML services without requiring deep domain expertise.