Yonghua Du

Xi Yu, Yang Yang, Qun Liu et al.

Cellular image segmentation is essential for quantitative biology yet remains difficult due to heterogeneous modalities, morphological variability, and limited annotations. We present GenCellAgent, a training-free multi-agent framework that orchestrates specialist segmenters and generalist vision-language models via a planner-executor-evaluator loop (choose tool $\rightarrow$ run $\rightarrow$ quality-check) with long-term memory. The system (i) automatically routes images to the best tool, (ii) adapts on the fly using a few reference images when imaging conditions differ from what a tool expects, (iii) supports text-guided segmentation of organelles not covered by existing models, and (iv) commits expert edits to memory, enabling self-evolution and personalized workflows. Across four cell-segmentation benchmarks, this routing yields a 15.7\% mean accuracy gain over state-of-the-art baselines. On endoplasmic reticulum and mitochondria from new datasets, GenCellAgent improves average IoU by 37.6\% over specialist models. It also segments novel objects such as the Golgi apparatus via iterative text-guided refinement, with light human correction further boosting performance. Together, these capabilities provide a practical path to robust, adaptable cellular image segmentation without retraining, while reducing annotation burden and matching user preferences.

Baolu Li, Hongkai Yu, Huiming Sun et al.

The synchrotron light source, a cutting-edge large-scale user facility, requires autonomous synchrotron beamline operations, a crucial technique that should enable experiments to be conducted automatically, reliably, and safely with minimum human intervention. However, current state-of-the-art synchrotron beamlines still heavily rely on human safety oversight. To bridge the gap between automated and autonomous operation, a computer vision-based system is proposed, integrating deep learning and multiview cameras for real-time collision detection. The system utilizes equipment segmentation, tracking, and geometric analysis to assess potential collisions with transfer learning that enhances robustness. In addition, an interactive annotation module has been developed to improve the adaptability to new object classes. Experiments on a real beamline dataset demonstrate high accuracy, real-time performance, and strong potential for autonomous synchrotron beamline operations.