Y. S. Lai

Yunghwei Lai, Weizhi Ma, Yang Liu

Synthetic data generation using large language models (LLMs) has emerged as a promising solution across various domains, particularly in medical field, to mitigate data collection challenges. However, existing studies mainly utilize LLMs to rewrite and complete existing medical records, where the limitations in data privacy, accuracy, and diversity sill exist, and additionally lack the ability to interact like real patients. To address these issues, we propose a realistic patient generation framework, Patient-Zero, which requires no real medical records. Patient-Zero first introduces a medically-aligned multi-step generation architecture, which builds comprehensive patient records through hierarchical medical knowledge injection without real medical records. Then, to optimize the virtual patient's interaction abilities with humans, Patient-Zero designs a dynamic updating mechanism to improve the consistency and conversational performance. Our framework enables the generation of contextually diverse patient records while maintaining strict medical coherence, supported by adaptive dialogue strategies and real-time clinical plausibility verification. Experimental results demonstrate that our model achieves good performance in accuracy, diversity, and consistency. After training with our generated virtual patients, existing models show significant improvements on the MedQA dataset.

Chunxia Ren, Ning Zhu, Yue Lai et al.

Dentocraniofacial hard tissue defects profoundly affect patients' physiological functions, facial aesthetics, and psychological well-being, posing significant challenges for precise reconstruction. Current deep learning models are limited to single-tissue scenarios and modality-specific imaging inputs, resulting in poor generalizability and trade-offs between anatomical fidelity, computational efficiency, and cross-tissue adaptability. Here we introduce UniDCF, a unified framework capable of reconstructing multiple dentocraniofacial hard tissues through multimodal fusion encoding of point clouds and multi-view images. By leveraging the complementary strengths of each modality and incorporating a score-based denoising module to refine surface smoothness, UniDCF overcomes the limitations of prior single-modality approaches. We curated the largest multimodal dataset, comprising intraoral scans, CBCT, and CT from 6,609 patients, resulting in 54,555 annotated instances. Evaluations demonstrate that UniDCF outperforms existing state-of-the-art methods in terms of geometric precision, structural completeness, and spatial accuracy. Clinical simulations indicate UniDCF reduces reconstruction design time by 99% and achieves clinician-rated acceptability exceeding 94%. Overall, UniDCF enables rapid, automated, and high-fidelity reconstruction, supporting personalized and precise restorative treatments, streamlining clinical workflows, and enhancing patient outcomes.

Chandler Jones, Mark Bandstra, Stefan Faaland et al.

Spectroscopic anomaly detection and isotope identification algorithms are integral components in nuclear nonproliferation applications such as search operations. The task is especially challenging in the case of mobile detector systems due to the fact that the observed gamma-ray background changes more than for a static detector system, and a pretrained background model can easily find itself out of domain. The result is that algorithms may exceed their intended false alarm rate, or sacrifice detection sensitivity in order to maintain the desired false alarm rate. Non-negative matrix factorization (NMF) has been shown to be a powerful tool for spectral anomaly detection and identification, but, like many similar algorithms that rely on data-driven background models, in its conventional implementation it is unable to update in real time to account for environmental changes that affect the background spectroscopic signature. We have developed a novel NMF-based algorithm that periodically updates its background model to accommodate changing environmental conditions. The Adaptive NMF algorithm involves fewer assumptions about its environment, making it more generalizable than existing NMF-based methods while maintaining or exceeding detection performance on simulated and real-world datasets.