Weisong Liu

Avijit Mitra, Richeek Pradhan, Rachel D Melamed et al.

Importance: Social determinants of health (SDOH) are known to be associated with increased risk of suicidal behaviors, but few studies utilized SDOH from unstructured electronic health record (EHR) notes. Objective: To investigate associations between suicide and recent SDOH, identified using structured and unstructured data. Design: Nested case-control study. Setting: EHR data from the US Veterans Health Administration (VHA). Participants: 6,122,785 Veterans who received care in the US VHA between October 1, 2010, and September 30, 2015. Exposures: Occurrence of SDOH over a maximum span of two years compared with no occurrence of SDOH. Main Outcomes and Measures: Cases of suicide deaths were matched with 4 controls on birth year, cohort entry date, sex, and duration of follow-up. We developed an NLP system to extract SDOH from unstructured notes. Structured data, NLP on unstructured data, and combining them yielded six, eight and nine SDOH respectively. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression. Results: In our cohort, 8,821 Veterans committed suicide during 23,725,382 person-years of follow-up (incidence rate 37.18/100,000 person-years). Our cohort was mostly male (92.23%) and white (76.99%). Across the five common SDOH as covariates, NLP-extracted SDOH, on average, covered 80.03% of all SDOH occurrences. All SDOH, measured by structured data and NLP, were significantly associated with increased risk of suicide. The SDOH with the largest effects was legal problems (aOR=2.66, 95% CI=.46-2.89), followed by violence (aOR=2.12, 95% CI=1.98-2.27). NLP-extracted and structured SDOH were also associated with suicide. Conclusions and Relevance: NLP-extracted SDOH were always significantly associated with increased risk of suicide among Veterans, suggesting the potential of NLP in public health studies.

Zonghai Yao, Jack Tsai, Weisong Liu et al.

Objective: Evictions are important social and behavioral determinants of health. Evictions are associated with a cascade of negative events that can lead to unemployment, housing insecurity/homelessness, long-term poverty, and mental health problems. In this study, we developed a natural language processing system to automatically detect eviction status from electronic health record (EHR) notes. Materials and Methods: We first defined eviction status (eviction presence and eviction period) and then annotated eviction status in 5000 EHR notes from the Veterans Health Administration (VHA). We developed a novel model, KIRESH, that has shown to substantially outperform other state-of-the-art models such as fine-tuning pre-trained language models like BioBERT and BioClinicalBERT. Moreover, we designed a novel prompt to further improve the model performance by using the intrinsic connection between the two sub-tasks of eviction presence and period prediction. Finally, we used the Temperature Scaling-based Calibration on our KIRESH-Prompt method to avoid over-confidence issues arising from the imbalance dataset. Results: KIRESH-Prompt substantially outperformed strong baseline models including fine-tuning the BioClinicalBERT model to achieve 0.74672 MCC, 0.71153 Macro-F1, and 0.83396 Micro-F1 in predicting eviction period and 0.66827 MCC, 0.62734 Macro-F1, and 0.7863 Micro-F1 in predicting eviction presence. We also conducted additional experiments on a benchmark social determinants of health (SBDH) dataset to demonstrate the generalizability of our methods. Conclusion and Future Work: KIRESH-Prompt has substantially improved eviction status classification. We plan to deploy KIRESH-Prompt to the VHA EHRs as an eviction surveillance system to help address the US Veterans' housing insecurity.

Sunjae Kwon, Xun Wang, Weisong Liu et al.

Opioid related aberrant behaviors (ORABs) present novel risk factors for opioid overdose. This paper introduces a novel biomedical natural language processing benchmark dataset named ODD, for ORAB Detection Dataset. ODD is an expert-annotated dataset designed to identify ORABs from patients' EHR notes and classify them into nine categories; 1) Confirmed Aberrant Behavior, 2) Suggested Aberrant Behavior, 3) Opioids, 4) Indication, 5) Diagnosed opioid dependency, 6) Benzodiazepines, 7) Medication Changes, 8) Central Nervous System-related, and 9) Social Determinants of Health. We explored two state-of-the-art natural language processing models (fine-tuning and prompt-tuning approaches) to identify ORAB. Experimental results show that the prompt-tuning models outperformed the fine-tuning models in most categories and the gains were especially higher among uncommon categories (Suggested Aberrant Behavior, Confirmed Aberrant Behaviors, Diagnosed Opioid Dependence, and Medication Change). Although the best model achieved the highest 88.17% on macro average area under precision recall curve, uncommon classes still have a large room for performance improvement. ODD is publicly available.

Rumeng Li, Xun Wang, Dan Berlowitz et al.

Early prediction of Alzheimer's disease (AD) is crucial for timely intervention and treatment. This study aims to use machine learning approaches to analyze longitudinal electronic health records (EHRs) of patients with AD and identify signs and symptoms that can predict AD onset earlier. We used a case-control design with longitudinal EHRs from the U.S. Department of Veterans Affairs Veterans Health Administration (VHA) from 2004 to 2021. Cases were VHA patients with AD diagnosed after 1/1/2016 based on ICD-10-CM codes, matched 1:9 with controls by age, sex and clinical utilization with replacement. We used a panel of AD-related keywords and their occurrences over time in a patient's longitudinal EHRs as predictors for AD prediction with four machine learning models. We performed subgroup analyses by age, sex, and race/ethnicity, and validated the model in a hold-out and "unseen" VHA stations group. Model discrimination, calibration, and other relevant metrics were reported for predictions up to ten years before ICD-based diagnosis. The study population included 16,701 cases and 39,097 matched controls. The average number of AD-related keywords (e.g., "concentration", "speaking") per year increased rapidly for cases as diagnosis approached, from around 10 to over 40, while remaining flat at 10 for controls. The best model achieved high discriminative accuracy (ROCAUC 0.997) for predictions using data from at least ten years before ICD-based diagnoses. The model was well-calibrated (Hosmer-Lemeshow goodness-of-fit p-value = 0.99) and consistent across subgroups of age, sex and race/ethnicity, except for patients younger than 65 (ROCAUC 0.746). Machine learning models using AD-related keywords identified from EHR notes can predict future AD diagnoses, suggesting its potential use for identifying AD risk using EHR notes, offering an affordable way for early screening on large population.

Zhichao Yang, Weisong Liu, Dan Berlowitz et al.

Question: Can an encoder-decoder architecture pretrained on a large dataset of longitudinal electronic health records improves patient outcome predictions? Findings: In this prognostic study of 6.8 million patients, our denoising sequence-to-sequence prediction model of multiple outcomes outperformed state-of-the-art models scuh pretrained BERT on a broad range of patient outcomes, including intentional self-harm and pancreatic cancer. Meaning: Deep bidirectional and autoregressive representation improves patient outcome prediction.

Wei Suo, Mengyang Sun, Weisong Liu et al.

VQA Natural Language Explanation (VQA-NLE) task aims to explain the decision-making process of VQA models in natural language. Unlike traditional attention or gradient analysis, free-text rationales can be easier to understand and gain users' trust. Existing methods mostly use post-hoc or self-rationalization models to obtain a plausible explanation. However, these frameworks are bottlenecked by the following challenges: 1) the reasoning process cannot be faithfully responded to and suffer from the problem of logical inconsistency. 2) Human-annotated explanations are expensive and time-consuming to collect. In this paper, we propose a new Semi-Supervised VQA-NLE via Self-Critical Learning (S3C), which evaluates the candidate explanations by answering rewards to improve the logical consistency between answers and rationales. With a semi-supervised learning framework, the S3C can benefit from a tremendous amount of samples without human-annotated explanations. A large number of automatic measures and human evaluations all show the effectiveness of our method. Meanwhile, the framework achieves a new state-of-the-art performance on the two VQA-NLE datasets.

Yaoting Wang, Weisong Liu, Guangyao Li et al.

Never having seen an object and heard its sound simultaneously, can the model still accurately localize its visual position from the input audio? In this work, we concentrate on the Audio-Visual Localization and Segmentation tasks but under the demanding zero-shot and few-shot scenarios. To achieve this goal, different from existing approaches that mostly employ the encoder-fusion-decoder paradigm to decode localization information from the fused audio-visual feature, we introduce the encoder-prompt-decoder paradigm, aiming to better fit the data scarcity and varying data distribution dilemmas with the help of abundant knowledge from pre-trained models. Specifically, we first propose to construct Semantic-aware Audio Prompt (SAP) to help the visual foundation model focus on sounding objects, meanwhile, the semantic gap between the visual and audio modalities is also encouraged to shrink. Then, we develop a Correlation Adapter (ColA) to keep minimal training efforts as well as maintain adequate knowledge of the visual foundation model. By equipping with these means, extensive experiments demonstrate that this new paradigm outperforms other fusion-based methods in both the unseen class and cross-dataset settings. We hope that our work can further promote the generalization study of Audio-Visual Localization and Segmentation in practical application scenarios.

Jiahao Meng, Tan Yue, Qi Xu et al.

Recent video multimodal large language models achieve impressive results across various benchmarks. However, current evaluations suffer from two critical limitations: (1) inflated scores can mask deficiencies in fine-grained visual understanding and reasoning, and (2) answer correctness is often measured without verifying whether models identify the precise spatio-temporal evidence supporting their predictions. To address this, we present VideoZeroBench, a hierarchical benchmark designed for challenging long-video question answering that rigorously verifies spatio-temporal evidence. It comprises 500 manually annotated questions across 13 domains, paired with temporal intervals and spatial bounding boxes as evidence. To disentangle answering generation, temporal grounding, and spatial grounding, we introduce a five-level evaluation protocol that progressively tightens evidence requirements. Experiments show that even Gemini-3-Pro correctly answers fewer than 17% of questions under the standard end-to-end QA setting (Level-3). When grounding constraints are imposed, performance drops sharply: No model exceeds 1% accuracy when both correct answering and accurate spatio-temporal localization are required (Level-5), with most failing to achieve any correct grounded predictions. These results expose a significant gap between surface-level answer correctness and genuine evidence-based reasoning, revealing that grounded video understanding remains a bottleneck for long-video QA. We further analyze performance across minimal evidence spans, atomic abilities, and inference paradigms, providing insights for future research in grounded video reasoning. The benchmark and code will be made publicly available.

Yingyan Li, Shuyao Shang, Weisong Liu et al.

Scaling Vision-Language-Action (VLA) models on large-scale data offers a promising path to achieving a more generalized driving intelligence. However, VLA models are limited by a ``supervision deficit'': the vast model capacity is supervised by sparse, low-dimensional actions, leaving much of their representational power underutilized. To remedy this, we propose \textbf{DriveVLA-W0}, a training paradigm that employs world modeling to predict future images. This task generates a dense, self-supervised signal that compels the model to learn the underlying dynamics of the driving environment. We showcase the paradigm's versatility by instantiating it for two dominant VLA archetypes: an autoregressive world model for VLAs that use discrete visual tokens, and a diffusion world model for those operating on continuous visual features. Building on the rich representations learned from world modeling, we introduce a lightweight action expert to address the inference latency for real-time deployment. Extensive experiments on the NAVSIM v1/v2 benchmark and a 680x larger in-house dataset demonstrate that DriveVLA-W0 significantly outperforms BEV and VLA baselines. Crucially, it amplifies the data scaling law, showing that performance gains accelerate as the training dataset size increases.