Arokia Nathan

Shengbo Wang, Shuo Gao, Chenyu Tang et al.

Efficient operation of intelligent machines in the real world requires methods that allow them to understand and predict the uncertainties presented by the unstructured environments with good accuracy, scalability and generalization, similar to humans. Current methods rely on pretrained networks instead of continuously learning from the dynamic signal properties of working environments and suffer inherent limitations, such as data-hungry procedures, and limited generalization capabilities. Herein, we present a memristor-based differential neuromorphic computing, perceptual signal processing and learning method for intelligent machines. The main features of environmental information such as amplification (>720%) and adaptation (<50%) of mechanical stimuli encoded in memristors, are extracted to obtain human-like processing in unstructured environments. The developed method takes advantage of the intrinsic multi-state property of memristors and exhibits good scalability and generalization, as confirmed by validation in two different application scenarios: object grasping and autonomous driving. In the former, a robot hand experimentally realizes safe and stable grasping through fast learning (in ~1 ms) the unknown object features (e.g., sharp corner and smooth surface) with a single memristor. In the latter, the decision-making information of 10 unstructured environments in autonomous driving (e.g., overtaking cars, pedestrians) is accurately (94%) extracted with a 40*25 memristor array. By mimicking the intrinsic nature of human low-level perception mechanisms, the electronic memristive neuromorphic circuit-based method, presented here shows the potential for adapting to diverse sensing technologies and helping intelligent machines generate smart high-level decisions in the real world.

Mengtian Kang, Yansong Hu, Shuo Gao et al.

Childhood myopia constitutes a significant global health concern. It exhibits an escalating prevalence and has the potential to evolve into severe, irreversible conditions that detrimentally impact familial well-being and create substantial economic costs. Contemporary research underscores the importance of precisely predicting myopia progression to enable timely and effective interventions, thereby averting severe visual impairment in children. Such predictions predominantly rely on subjective clinical assessments, which are inherently biased and resource-intensive, thus hindering their widespread application. In this study, we introduce a novel, high-accuracy method for quantitatively predicting the myopic trajectory and myopia risk in children using only fundus images and baseline refraction data. This approach was validated through a six-year longitudinal study of 3,408 children in Henan, utilizing 16,211 fundus images and corresponding refractive data. Our method based on deep learning demonstrated predictive accuracy with an error margin of 0.311D per year and AUC scores of 0.944 and 0.995 for forecasting the risks of developing myopia and high myopia, respectively. These findings confirm the utility of our model in supporting early intervention strategies and in significantly reducing healthcare costs, particularly by obviating the need for additional metadata and repeated consultations. Furthermore, our method was designed to rely only on fundus images and refractive error data, without the need for meta data or multiple inquiries from doctors, strongly reducing the associated medical costs and facilitating large-scale screening. Our model can even provide good predictions based on only a single time measurement. Consequently, the proposed method is an important means to reduce medical inequities caused by economic disparities.

Shengbo Wang, Jingwen Zhao, Tongming Pu et al.

Optical flow, inspired by the mechanisms of biological visual systems, calculates spatial motion vectors within visual scenes that are necessary for enabling robotics to excel in complex and dynamic working environments. However, current optical flow algorithms, despite human-competitive task performance on benchmark datasets, remain constrained by unacceptable time delays (~0.6 seconds per inference, 4X human processing speed) in practical deployment. Here, we introduce a neuromorphic optical flow approach that addresses delay bottlenecks by encoding temporal information directly in a synaptic transistor array to assist spatial motion analysis. Compared to conventional spatial-only optical flow methods, our spatiotemporal neuromorphic optical flow offers the spatial-temporal consistency of motion information, rapidly identifying regions of interest in as little as 1-2 ms using the temporal motion cues derived from the embedded temporal information in the two-dimensional floating gate synaptic transistors. Thus, the visual input can be selectively filtered to achieve faster velocity calculations and various task execution. At the hardware level, due to the atomically sharp interfaces between distinct functional layers in two-dimensional van der Waals heterostructures, the synaptic transistor offers high-frequency response (~100 μs), robust non-volatility (>10000 s), and excellent endurance (>8000 cycles), enabling robust visual processing. In software benchmarks, our system outperforms state-of-the-art algorithms with a 400% speedup, frequently surpassing human-level performance while maintaining or enhancing accuracy by utilizing the temporal priors provided by the embedded temporal information.

Yong Liu, Mengtian Kang, Shuo Gao et al.

Fundus diseases are major causes of visual impairment and blindness worldwide, especially in underdeveloped regions, where the shortage of ophthalmologists hinders timely diagnosis. AI-assisted fundus image analysis has several advantages, such as high accuracy, reduced workload, and improved accessibility, but it requires a large amount of expert-annotated data to build reliable models. To address this dilemma, we propose a general self-supervised machine learning framework that can handle diverse fundus diseases from unlabeled fundus images. Our method's AUC surpasses existing supervised approaches by 15.7%, and even exceeds performance of a single human expert. Furthermore, our model adapts well to various datasets from different regions, races, and heterogeneous image sources or qualities from multiple cameras or devices. Our method offers a label-free general framework to diagnose fundus diseases, which could potentially benefit telehealth programs for early screening of people at risk of vision loss.

Yanning Dai, Chenyu Tang, Ruizhi Zhang et al.

Dynamic prediction of locomotor capacity after stroke could enable more individualized rehabilitation, yet current assessments largely provide static impairment scores and do not indicate whether patients can perform specific tasks such as slope walking or stair climbing. Here, we present a wearable-informed data-physics hybrid generative framework that reconstructs a stroke survivor's locomotor control from wearable inertial sensing and predicts task-conditioned post-stroke locomotion in new environments. From a single 20 m level-ground walking trial recorded by five IMUs, the framework personalizes a physics-based digital avatar using a healthy-motion prior and hybrid imitation learning, generating dynamically feasible, patient-specific movements for inclined walking and stair negotiation. Across 11 stroke inpatients, predicted postures reached 82.2% similarity for slopes and 69.9% for stairs, substantially exceeding a physics-only baseline. In a multicentre pilot randomized study (n = 21; 28 days), access to scenario-specific locomotion predictions to support task selection and difficulty titration was associated with larger gains in Fugl-Meyer lower-extremity scores than standard care (mean change 6.0 vs 3.7 points; $p < 0.05$). These results suggest that wearable-informed generative digital avatars may augment individualized gait rehabilitation planning and provide a pathway toward dynamically personalized post-stroke motor recovery strategies.