Mikhail Bessmeltsev

Cedric Martens, Philip Trettner, Mikhail Bessmeltsev

Generalized winding numbers provide a robust measure of point insidedness for 3D surfaces - whether open, self-intersecting, or non-manifold - and are central to numerous geometry processing tasks. However, existing methods trade off between accuracy and computational efficiency, limiting their use in interactive and large-scale applications. We introduce a new formulation and algorithm for computing generalized winding numbers that is both fast and accurate to arbitrary precision, applicable to meshes and parametric surfaces. Our approach expresses the winding number as the sum of two intuitive geometric quantities: the signed number of ray-surface intersections and a boundary integral over the surface's projection onto the unit sphere. This insight leads to an efficient discretization that avoids expensive surface integrals and spherical arrangements. For meshes, our method achieves average speedups of $22\times$ on a CPU compared to the fastest precise methods and $3\times$ compared to the fastest approximation method, while maintaining full precision. On a GPU, for moderately complex meshes we reach a throughput of $10^9$ queries per second, or $4K$ generalized winding number slices at 120 FPS ($13\times$ faster than a naive GPU method). For parametric surfaces, our method is on average $5.6\times$ faster than the state-of-the-art method, with the same precision. Our method naturally handles complex topologies and non-manifold inputs. We extensively validate its accuracy, robustness, and time performance. Our code is available at https://github.com/MartensCedric/antipodal.

Ahmed Bourouis, Mikhail Bessmeltsev, Yulia Gryaditskaya

Recent years have witnessed remarkable progress in generative AI, with natural language emerging as the most common conditioning input. As underlying models grow more powerful, researchers are exploring increasingly diverse conditioning signals, such as depth maps, edge maps, camera parameters, and reference images, to give users finer control over generation. Among different modalities, sketches are a natural and long-standing form of human communication, enabling rapid expression of visual concepts. Previous literature has largely focused on edge maps, often misnamed 'sketches', yet algorithms that effectively handle true freehand sketches, with their inherent abstraction and distortions, remain underexplored. We pursue the challenging goal of balancing photorealism with sketch adherence when generating images from freehand input. A key obstacle is the absence of ground-truth, pixel-aligned images: by their nature, freehand sketches do not have a single correct alignment. To address this, we propose a modulation-based approach that prioritizes semantic interpretation of the sketch over strict adherence to individual edge positions. We further introduce a novel loss that enables training on freehand sketches without requiring ground-truth pixel-aligned images. We show that our method outperforms existing approaches in both semantic alignment with freehand sketch inputs and in the realism and overall quality of the generated images.

S. Mazdak Abulnaga, Esra Abaci Turk, Mikhail Bessmeltsev et al.

We present a volumetric mesh-based algorithm for parameterizing the placenta to a flattened template to enable effective visualization of local anatomy and function. MRI shows potential as a research tool as it provides signals directly related to placental function. However, due to the curved and highly variable in vivo shape of the placenta, interpreting and visualizing these images is difficult. We address interpretation challenges by mapping the placenta so that it resembles the familiar ex vivo shape. We formulate the parameterization as an optimization problem for mapping the placental shape represented by a volumetric mesh to a flattened template. We employ the symmetric Dirichlet energy to control local distortion throughout the volume. Local injectivity in the mapping is enforced by a constrained line search during the gradient descent optimization. We validate our method using a research study of 111 placental shapes extracted from BOLD MRI images. Our mapping achieves sub-voxel accuracy in matching the template while maintaining low distortion throughout the volume. We demonstrate how the resulting flattening of the placenta improves visualization of anatomy and function. Our code is freely available at https://github.com/mabulnaga/placenta-flattening .

S. Mazdak Abulnaga, Esra Abaci Turk, Mikhail Bessmeltsev et al.

We present a volumetric mesh-based algorithm for flattening the placenta to a canonical template to enable effective visualization of local anatomy and function. Monitoring placental function in vivo promises to support pregnancy assessment and to improve care outcomes. We aim to alleviate visualization and interpretation challenges presented by the shape of the placenta when it is attached to the curved uterine wall. To do so, we flatten the volumetric mesh that captures placental shape to resemble the well-studied ex vivo shape. We formulate our method as a map from the in vivo shape to a flattened template that minimizes the symmetric Dirichlet energy to control distortion throughout the volume. Local injectivity is enforced via constrained line search during gradient descent. We evaluate the proposed method on 28 placenta shapes extracted from MRI images in a clinical study of placental function. We achieve sub-voxel accuracy in mapping the boundary of the placenta to the template while successfully controlling distortion throughout the volume. We illustrate how the resulting mapping of the placenta enhances visualization of placental anatomy and function. Our code is freely available at https://github.com/mabulnaga/placenta-flattening .

Leslie Gu, Jason Ken Adhinarta, Mikhail Bessmeltsev et al. · harvard

Accurately segmenting 3D curvilinear structures in medical imaging remains challenging due to their complex geometry and the scarcity of diverse, large-scale datasets for algorithm development and evaluation. In this paper, we use dendritic spine segmentation as a case study and address these challenges by introducing a novel Frenet--Serret Frame-based Decomposition, which decomposes 3D curvilinear structures into a globally \( C^2 \) continuous curve that captures the overall shape, and a cylindrical primitive that encodes local geometric properties. This approach leverages Frenet--Serret Frames and arc length parameterization to preserve essential geometric features while reducing representational complexity, facilitating data-efficient learning, improved segmentation accuracy, and generalization on 3D curvilinear structures. To rigorously evaluate our method, we introduce two datasets: CurviSeg, a synthetic dataset for 3D curvilinear structure segmentation that validates our method's key properties, and DenSpineEM, a benchmark for dendritic spine segmentation, which comprises 4,476 manually annotated spines from 70 dendrites across three public electron microscopy datasets, covering multiple brain regions and species. Our experiments on DenSpineEM demonstrate exceptional cross-region and cross-species generalization: models trained on the mouse somatosensory cortex subset achieve 91.9\% Dice, maintaining strong performance in zero-shot segmentation on both mouse visual cortex (94.1\% Dice) and human frontal lobe (81.8\% Dice) subsets. Moreover, we test the generalizability of our method on the IntrA dataset, where it achieves 77.08\% Dice (5.29\% higher than prior arts) on intracranial aneurysm segmentation. These findings demonstrate the potential of our approach for accurately analyzing complex curvilinear structures across diverse medical imaging fields.