Yu Han

Jinze Bai, Shuai Bai, Yunfei Chu et al. · pku, tsinghua

Large language models (LLMs) have revolutionized the field of artificial intelligence, enabling natural language processing tasks that were previously thought to be exclusive to humans. In this work, we introduce Qwen, the first installment of our large language model series. Qwen is a comprehensive language model series that encompasses distinct models with varying parameter counts. It includes Qwen, the base pretrained language models, and Qwen-Chat, the chat models finetuned with human alignment techniques. The base language models consistently demonstrate superior performance across a multitude of downstream tasks, and the chat models, particularly those trained using Reinforcement Learning from Human Feedback (RLHF), are highly competitive. The chat models possess advanced tool-use and planning capabilities for creating agent applications, showcasing impressive performance even when compared to bigger models on complex tasks like utilizing a code interpreter. Furthermore, we have developed coding-specialized models, Code-Qwen and Code-Qwen-Chat, as well as mathematics-focused models, Math-Qwen-Chat, which are built upon base language models. These models demonstrate significantly improved performance in comparison with open-source models, and slightly fall behind the proprietary models.

Jinze Bai, Rui Men, Hao Yang et al. · pku

Generalist models, which are capable of performing diverse multi-modal tasks in a task-agnostic way within a single model, have been explored recently. Being, hopefully, an alternative to approaching general-purpose AI, existing generalist models are still at an early stage, where modality and task coverage is limited. To empower multi-modal task-scaling and speed up this line of research, we release a generalist model learning system, OFASys, built on top of a declarative task interface named multi-modal instruction. At the core of OFASys is the idea of decoupling multi-modal task representations from the underlying model implementations. In OFASys, a task involving multiple modalities can be defined declaratively even with just a single line of code. The system automatically generates task plans from such instructions for training and inference. It also facilitates multi-task training for diverse multi-modal workloads. As a starting point, we provide presets of 7 different modalities and 23 highly-diverse example tasks in OFASys, with which we also develop a first-in-kind, single model, OFA+, that can handle text, image, speech, video, and motion data. The single OFA+ model achieves 95% performance in average with only 16% parameters of 15 task-finetuned models, showcasing the performance reliability of multi-modal task-scaling provided by OFASys. Available at https://github.com/OFA-Sys/OFASys

Quanjun Zhang, Chengyu Gao, Yu Han et al.

Large Language Models (LLMs) have enabled intelligent agents that autonomously interact with environments and invoke external tools. Recently, agent-based software repair has drawn wide attention, as repair agents can localize bugs, generate patches, and achieve state-of-the-art performance on repository-level benchmarks (e.g., SWE-Bench). However, existing approaches usually adopt a localize-then-fix paradigm, jumping directly from "where the bug is" to "how to fix it", leaving a fundamental reasoning gap. To this end, we propose SGAgent, a Suggestion-Guided multi-Agent framework for repository-level software repair, which follows a localize-suggest-fix paradigm. SGAgent introduces a suggestion phase to strengthen the transition from localization to repair: the suggester starts from the buggy locations, incrementally retrieves relevant context until it fully understands the bug, and provides actionable repair suggestions. We further construct a Knowledge Graph (KG) from the target repository and develop a KG-based toolkit to strengthen SGAgent's global contextual awareness and repository-level reasoning. Three specialized sub-agents (i.e., localizer, suggester, and fixer) collaborate to achieve automated end-to-end software repair. We evaluate SGAgent on SWE-Bench-Lite. SGAgent with Claude-3.5 achieves 51.3% repair accuracy, 81.2% file-level, and 52.4% function-level localization accuracy at an average cost of $1.48 per instance, outperforming all baselines using the same base model. SGAgent also generalizes well across base LLMs, reaching a 60.7% resolution rate with Claude-4. When extended to vulnerability repair, it achieves 48.0% on VUL4J and VJBench, demonstrating strong generalization across tasks and programming languages.

Yihe Wang, Yu Han, Haishuai Wang et al.

Contrastive representation learning is crucial in medical time series analysis as it alleviates dependency on labor-intensive, domain-specific, and scarce expert annotations. However, existing contrastive learning methods primarily focus on one single data level, which fails to fully exploit the intricate nature of medical time series. To address this issue, we present COMET, an innovative hierarchical framework that leverages data consistencies at all inherent levels in medical time series. Our meticulously designed model systematically captures data consistency from four potential levels: observation, sample, trial, and patient levels. By developing contrastive loss at multiple levels, we can learn effective representations that preserve comprehensive data consistency, maximizing information utilization in a self-supervised manner. We conduct experiments in the challenging patient-independent setting. We compare COMET against six baselines using three diverse datasets, which include ECG signals for myocardial infarction and EEG signals for Alzheimer's and Parkinson's diseases. The results demonstrate that COMET consistently outperforms all baselines, particularly in setup with 10% and 1% labeled data fractions across all datasets. These results underscore the significant impact of our framework in advancing contrastive representation learning techniques for medical time series. The source code is available at https://github.com/DL4mHealth/COMET.

Jiajie Yu, Pierre-Antoine Laharotte, Yu Han et al.

Perimeter Control (PC) strategies have been proposed to address urban road network control in oversaturated situations by regulating the transfer flow of the Protected Network (PN) based on the Macroscopic Fundamental Diagram (MFD). The uniform metering rate for cordon signals in most existing studies overlooks the variance of local traffic states at the intersection level, which may cause severe local traffic congestion and degradation of the network stability. PC strategies with heterogeneous metering rates for cordon signals allow precise control for the perimeter but the complexity of the problem increases exponentially with the scale of the PN. This paper leverages a Multi-Agent Reinforcement Learning (MARL)-based traffic signal control framework to decompose this PC problem, which considers heterogeneous metering rates for cordon signals, into multi-agent cooperation tasks. Each agent controls an individual signal located in the cordon, decreasing the dimension of action space for the controller compared to centralized methods. A physics regularization approach for the MARL framework is proposed to ensure the distributed cordon signal controllers are aware of the global network state by encoding MFD-based knowledge into the action-value functions of the local agents. The proposed PC strategy is operated as a two-stage system, with a feedback PC strategy detecting the overall traffic state within the PN and then distributing local instructions to cordon signals controllers in the MARL framework via the physics regularization. Through numerical tests with different demand patterns in a microscopic traffic environment, the proposed PC strategy shows promising robustness and transferability. It outperforms state-of-the-art feedback PC strategies in increasing network throughput, decreasing distributed delay for gate links, and reducing carbon emissions.

Xinkai Ji, Pan Liu, Ying Yang et al.

In Part I of this companion paper series, we introduced SWIFTraj, a new open-source vehicle trajectory dataset collected using a unmanned aerial vehicle (UAV) swarm. The dataset has two distinctive features. First, by connecting trajectories across consecutive UAV videos, it provides long-distance continuous trajectories, with the longest exceeding 4.5 km. Second, it covers an integrated traffic network consisting of both freeways and their connected urban roads. Obtaining such long-distance continuous trajectories from a UAV swarm is challenging, due to the need for accurate time alignment across multiple videos and the irregular spatial distribution of UAVs. To address these challenges, this paper proposes a novel graph-based approach for connecting vehicle trajectories captured by a UAV swarm. An undirected graph is constructed to represent flexible UAV layouts, and an automatic time alignment method based on trajectory matching cost minimization is developed to estimate optimal time offsets across videos. To associate trajectories of the same vehicle observed in different videos, a vehicle matching table is established using the Hungarian algorithm. The proposed approach is evaluated using both simulated and real-world data. Results from real-world experiments show that the time alignment error is within three video frames, corresponding to approximately 0.1 s, and that the vehicle matching achieves an F1-score of about 0.99. These results demonstrate the effectiveness of the proposed method in addressing key challenges in UAV-based trajectory connection and highlight its potential for large-scale vehicle trajectory collection.

Yu Han, Lehan Pan, Jie Peng et al.

Sparse Mixture of Experts (SMoE) enables scalable parameter growth in large language models (LLMs) by selectively activating a subset of experts, and its large parameter count necessitates distributed deployment for inference. However, distributed inference faces a critical dilemma: although communication overhead constitutes the primary bottleneck, reducing it often exacerbates computational load imbalance, leading to resource waste. In this paper, we present GRACE-MoE, which stands for Grouping and Replication with Locality-Aware Routing for SMoE inference. GRACE-MoE is a lossless co-optimization framework that integrates expert grouping to reduce communication and dynamic replication to correct load skew, together with locality-aware routing to resolve replica selection. To underpin this coordinated optimization in multi-node settings, GRACE-MoE adopts a hierarchical sparse communication design that reduces cross-node traffic while implicitly aligning execution across nodes, thereby mitigating synchronization overhead. Experiments on diverse models and multi-node, multi-GPU environments demonstrate that GRACE-MoE efficiently reduces end-to-end inference latency, achieving up to 4.66x speedup over existing systems, and the code will be released upon acceptance.

Yaran Chen, Xueyu Chen, Yu Han et al.

Non alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease, which can be predicted accurately to prevent advanced fibrosis and cirrhosis. While, a liver biopsy, the gold standard for NAFLD diagnosis, is invasive, expensive, and prone to sampling errors. Therefore, non-invasive studies are extremely promising, yet they are still in their infancy due to the lack of comprehensive research data and intelligent methods for multi-modal data. This paper proposes a NAFLD diagnosis system (DeepFLDDiag) combining a comprehensive clinical dataset (FLDData) and a multi-modal learning based NAFLD prediction method (DeepFLD). The dataset includes over 6000 participants physical examinations, laboratory and imaging studies, extensive questionnaires, and facial images of partial participants, which is comprehensive and valuable for clinical studies. From the dataset, we quantitatively analyze and select clinical metadata that most contribute to NAFLD prediction. Furthermore, the proposed DeepFLD, a deep neural network model designed to predict NAFLD using multi-modal input, including metadata and facial images, outperforms the approach that only uses metadata. Satisfactory performance is also verified on other unseen datasets. Inspiringly, DeepFLD can achieve competitive results using only facial images as input rather than metadata, paving the way for a more robust and simpler non-invasive NAFLD diagnosis.

Yi Feng, Yu Han, Xijing Zhang et al.

Inferring the 3D structure of a scene from a single image is an ill-posed and challenging problem in the field of vision-centric autonomous driving. Existing methods usually employ neural radiance fields to produce voxelized 3D occupancy, lacking instance-level semantic reasoning and temporal photometric consistency. In this paper, we propose ViPOcc, which leverages the visual priors from vision foundation models (VFMs) for fine-grained 3D occupancy prediction. Unlike previous works that solely employ volume rendering for RGB and depth image reconstruction, we introduce a metric depth estimation branch, in which an inverse depth alignment module is proposed to bridge the domain gap in depth distribution between VFM predictions and the ground truth. The recovered metric depth is then utilized in temporal photometric alignment and spatial geometric alignment to ensure accurate and consistent 3D occupancy prediction. Additionally, we also propose a semantic-guided non-overlapping Gaussian mixture sampler for efficient, instance-aware ray sampling, which addresses the redundant and imbalanced sampling issue that still exists in previous state-of-the-art methods. Extensive experiments demonstrate the superior performance of ViPOcc in both 3D occupancy prediction and depth estimation tasks on the KITTI-360 and KITTI Raw datasets. Our code is available at: \url{https://mias.group/ViPOcc}.

Kequan Chen, Yuxuan Wang, Pan Liu et al.

When a traffic crash occurs, following vehicles need to change lanes to bypass the obstruction. We define these maneuvers as post crash lane changes. In such scenarios, vehicles in the target lane may refuse to yield even after the lane change has already begun, increasing the complexity and crash risk of post crash LCs. However, the behavioral characteristics and motion patterns of post crash LCs remain unknown. To address this gap, we construct a post crash LC dataset by extracting vehicle trajectories from drone videos captured after crashes. Our empirical analysis reveals that, compared to mandatory LCs (MLCs) and discretionary LCs (DLCs), post crash LCs exhibit longer durations, lower insertion speeds, and higher crash risks. Notably, 79.4% of post crash LCs involve at least one instance of non yielding behavior from the new follower, compared to 21.7% for DLCs and 28.6% for MLCs. Building on these findings, we develop a novel trajectory prediction framework for post crash LCs. At its core is a graph based attention module that explicitly models yielding behavior as an auxiliary interaction aware task. This module is designed to guide both a conditional variational autoencoder and a Transformer based decoder to predict the lane changer's trajectory. By incorporating the interaction aware module, our model outperforms existing baselines in trajectory prediction performance by more than 10% in both average displacement error and final displacement error across different prediction horizons. Moreover, our model provides more reliable crash risk analysis by reducing false crash rates and improving conflict prediction accuracy. Finally, we validate the model's transferability using additional post crash LC datasets collected from different sites.

Yu Han, Aaron Ceross

Medical device regulators in the United States(FDA), China (NMPA), and Europe (EU MDR) all use the language of risk, but classify devices through structurally different mechanisms. Whether these apparently shared concepts carry transferable classificatory signal across jurisdictions remains unclear. We test this by reframing explainable AI as an empirical probe of cross-jurisdictional regulatory overlap. Using 141,942 device records, we derive seven EU MDR risk factors, including implantability, invasiveness, and duration of use, and evaluate their contribution across a three-by-three transfer matrix. Under a symmetric extraction pipeline designed to remove jurisdiction-specific advantages, factor contribution is negligible in all jurisdictions, indicating that clean cross-jurisdictional signal is at most marginal. Under jurisdiction specific pipelines, a modest gain appears only in the EU MDR-to-NMPA direction, but sensitivity analyses show that this effect is weak, context-dependent, and partly confounded by extraction and representation choices. Reverse direction probes show strong asymmetry: FDA-derived factors do not transfer meaningfully in any direction, and NMPA-derived factors do not carry signal back to EU MDR. Zero-shot transfer further fails on EU MDR Class I, consistent with a mismatch between residual and positional class definitions. Overall, cross-jurisdictional transfer is sparse, asymmetric, and weak. Shared regulatory vocabulary does not, under this operationalisation, translate into strong portable classification logic. The findings challenge a common assumption in cross-jurisdictional regulatory AI and show how explainable AI can be used to measure, rather than assume, regulatory overlap.

Mengyuan Li, Qianfan Lu, Jiachen Tian et al.

In near-field extremely large-scale multiple-input multiple-output (XL-MIMO) systems, spherical wavefront propagation expands the traditional beam codebook into the joint angular-distance domain, rendering conventional beam training prohibitively inefficient, especially in complex 3-dimensional (3D) low-altitude environments. Furthermore, since near-field beam variations are deeply coupled not only with user positions but also with the physical surroundings, precise beam alignment demands profound environmental understanding capabilities. To address this, we propose a large language model (LLM)-driven multimodal framework that fuses historical GPS data, RGB image, LiDAR data, and strategically designed task-specific textual prompts. By utilizing the powerful emergent reasoning and generalization capabilities of the LLM, our approach learns complex spatial dynamics to achieve superior environmental comprehension...

Wenzheng Feng, Jie Zhang, Yuxiao Dong et al.

We study the problem of semi-supervised learning on graphs, for which graph neural networks (GNNs) have been extensively explored. However, most existing GNNs inherently suffer from the limitations of over-smoothing, non-robustness, and weak-generalization when labeled nodes are scarce. In this paper, we propose a simple yet effective framework -- GRAPH RANDOM NEURAL NETWORKS (GRAND) -- to address these issues. In GRAND, we first design a random propagation strategy to perform graph data augmentation. Then we leverage consistency regularization to optimize the prediction consistency of unlabeled nodes across different data augmentations. Extensive experiments on graph benchmark datasets suggest that GRAND significantly outperforms state-of-the-art GNN baselines on semi-supervised node classification. Finally, we show that GRAND mitigates the issues of over-smoothing and non-robustness, exhibiting better generalization behavior than existing GNNs. The source code of GRAND is publicly available at https://github.com/Grand20/grand.

Wenfeng Feng, Chuzhan Hao, Yuewei Zhang et al.

Instruction Tuning has the potential to stimulate or enhance specific capabilities of large language models (LLMs). However, achieving the right balance of data is crucial to prevent catastrophic forgetting and interference between tasks. To address these limitations and enhance training flexibility, we propose the Mixture-of-LoRAs (MoA) architecture which is a novel and parameter-efficient tuning method designed for multi-task learning with LLMs. In this paper, we start by individually training multiple domain-specific LoRA modules using corresponding supervised corpus data. These LoRA modules can be aligned with the expert design principles observed in Mixture-of-Experts (MoE). Subsequently, we combine the multiple LoRAs using an explicit routing strategy and introduce domain labels to facilitate multi-task learning, which help prevent interference between tasks and ultimately enhances the performance of each individual task. Furthermore, each LoRA model can be iteratively adapted to a new domain, allowing for quick domain-specific adaptation. Experiments on diverse tasks demonstrate superior and robust performance, which can further promote the wide application of domain-specific LLMs.

Teng Yan, Zhendong Ruan, Yaobang Cai et al.

As a data-driven paradigm, offline reinforcement learning (Offline RL) has been formulated as sequence modeling, where the Decision Transformer (DT) has demonstrated exceptional capabilities. Unlike previous reinforcement learning methods that fit value functions or compute policy gradients, DT adjusts the autoregressive model based on the expected returns, past states, and actions, using a causally masked Transformer to output the optimal action. However, due to the inconsistency between the sampled returns within a single trajectory and the optimal returns across multiple trajectories, it is challenging to set an expected return to output the optimal action and stitch together suboptimal trajectories. Decision ConvFormer (DC) is easier to understand in the context of modeling RL trajectories within a Markov Decision Process compared to DT. We propose the Q-value Regularized Decision ConvFormer (QDC), which combines the understanding of RL trajectories by DC and incorporates a term that maximizes action values using dynamic programming methods during training. This ensures that the expected returns of the sampled actions are consistent with the optimal returns. QDC achieves excellent performance on the D4RL benchmark, outperforming or approaching the optimal level in all tested environments. It particularly demonstrates outstanding competitiveness in trajectory stitching capability.

Yu Han, Jingwen Tao

This document offers a critical overview of the emerging trends and significant advancements in artificial intelligence (AI) within the pharmaceutical industry. Detailing its application across key operational areas, including research and development, animal testing, clinical trials, hospital clinical stages, production, regulatory affairs, quality control and other supporting areas, the paper categorically examines AI's role in each sector. Special emphasis is placed on cutting-edge AI technologies like machine learning algorithms and their contributions to various aspects of pharmaceutical operations. Through this comprehensive analysis, the paper highlights the transformative potential of AI in reshaping the pharmaceutical industry's future.

Xuangeng Chu, Yu Han, Wei Mao et al.

Audio-driven facial animation is essential for immersive digital interaction, yet existing frameworks fail to reconcile real-time streaming with high-fidelity personalization. Current methods often rely on latency-inducing audio look-ahead, or require high user compliance to pre-encode static embeddings that fails to capture dynamic idiosyncrasies. We present an end-to-end causal framework for personalizing causal facial motion generation via dynamic multi-modal style retrieval, enabling ultra-low latency while uniquely leveraging unstructured style references. We introduce two key innovations: (1) a temporal hierarchical motion representation that captures global temporal context and high-frequency details while maintaining decoding causality, and (2) a multi-modal style retriever that jointly queries audio and motion to dynamically extract stylistic priors without breaking causality. This mechanism allows for scalable personalization with total flexibility regarding the number and contents of templates. By integrating these components into a causal autoregressive architecture, our method significantly outperforms state-of-the-art approaches in lip-sync accuracy, identity consistency, and perceived realism, supported by extensive quantitative evaluations and user studies.

Yu Han, Aaron Ceross, Jeroen H. M. Bergmann

Understanding the text in legal documents can be challenging due to their complex structure and the inclusion of domain-specific jargon. Laws and regulations are often crafted in such a manner that engagement with them requires formal training, potentially leading to vastly different interpretations of the same texts. Linguistic complexity is an important contributor to the difficulties experienced by readers. Simplifying texts could enhance comprehension across a broader audience, not just among trained professionals. Various metrics have been developed to measure document readability. Therefore, we adopted a systematic review approach to examine the linguistic and readability metrics currently employed for legal and regulatory texts. A total of 3566 initial papers were screened, with 34 relevant studies found and further assessed. Our primary objective was to identify which current metrics were applied for evaluating readability within the legal field. Sixteen different metrics were identified, with the Flesch-Kincaid Grade Level being the most frequently used method. The majority of studies (73.5%) were found in the domain of "informed consent forms". From the analysis, it is clear that not all legal domains are well represented in terms of readability metrics and that there is a further need to develop more consensus on which metrics should be applied for legal documents.

Yu Han, Zekun Guo

The increasing complexity of regulatory updates from global authorities presents significant challenges for medical device manufacturers, necessitating agile strategies to sustain compliance and maintain market access. Concurrently, regulatory bodies must effectively monitor manufacturers' responses and develop strategic surveillance plans. This study employs a multi-agent modeling approach, enhanced with Large Language Models (LLMs), to simulate regulatory dynamics and examine the adaptive behaviors of key actors, including regulatory bodies, manufacturers, and competitors. These agents operate within a simulated environment governed by regulatory flow theory, capturing the impacts of regulatory changes on compliance decisions, market adaptation, and innovation strategies. Our findings illuminate the influence of regulatory shifts on industry behaviour and identify strategic opportunities for improving regulatory practices, optimizing compliance, and fostering innovation. By leveraging the integration of multi-agent systems and LLMs, this research provides a novel perspective and offers actionable insights for stakeholders navigating the evolving regulatory landscape of the medical device industry.

Nachuan Ma, Zhengfei Song, Qiang Hu et al.

In the emerging field of urban digital twins (UDTs), advancing intelligent road inspection (IRI) vehicles with automatic road crack detection systems is essential for maintaining civil infrastructure. Over the past decade, deep learning-based road crack detection methods have been developed to detect cracks more efficiently, accurately, and objectively, with the goal of replacing manual visual inspection. Nonetheless, there is a lack of systematic reviews on state-of-the-art (SoTA) deep learning techniques, especially data-fusion and label-efficient algorithms for this task. This paper thoroughly reviews the SoTA deep learning-based algorithms, including (1) supervised, (2) unsupervised, (3) semi-supervised, and (4) weakly-supervised methods developed for road crack detection. Also, we create a dataset called UDTIRI-Crack, comprising $2,500$ high-quality images from seven public annotated sources, as the first extensive online benchmark in this field. Comprehensive experiments are conducted to compare the detection performance, computational efficiency, and generalizability of public SoTA deep learning-based algorithms for road crack detection. In addition, the feasibility of foundation models and large language models (LLMs) for road crack detection is explored. Afterwards, the existing challenges and future development trends of deep learning-based road crack detection algorithms are discussed. We believe this review can serve as practical guidance for developing intelligent road detection vehicles with the next-generation road condition assessment systems. The released benchmark UDTIRI-Crack is available at https://udtiri.com/submission/.

Wenhao Li, Xiu Su, Yu Han et al.

Diffusion models have demonstrated remarkable efficacy in various generative tasks with the predictive prowess of denoising model. Currently, diffusion models employ a uniform denoising model across all timesteps. However, the inherent variations in data distributions at different timesteps lead to conflicts during training, constraining the potential of diffusion models. To address this challenge, we propose a novel two-stage divide-and-conquer training strategy termed TDC Training. It groups timesteps based on task similarity and difficulty, assigning highly customized denoising models to each group, thereby enhancing the performance of diffusion models. While two-stage training avoids the need to train each model separately, the total training cost is even lower than training a single unified denoising model. Additionally, we introduce Proxy-based Pruning to further customize the denoising models. This method transforms the pruning problem of diffusion models into a multi-round decision-making problem, enabling precise pruning of diffusion models. Our experiments validate the effectiveness of TDC Training, demonstrating improvements in FID of 1.5 on ImageNet64 compared to original IDDPM, while saving about 20\% of computational resources.

Yu Han, Aaron Ceross, Jeroen H. M. Bergmann

This study investigates the complexity of regulatory affairs in the medical device industry, a critical factor influencing market access and patient care. Through qualitative research, we sought expert insights to understand the factors contributing to this complexity. The study involved semi-structured interviews with 28 professionals from medical device companies, specializing in various aspects of regulatory affairs. These interviews were analyzed using open coding and Natural Language Processing (NLP) techniques. The findings reveal key sources of complexity within the regulatory landscape, divided into five domains: (A) Regulatory language complexity, (B) Intricacies within the regulatory process, (C) Global-level complexities, (D) Database-related considerations, and (E) Product-level issues. The participants highlighted the need for strategies to streamline regulatory compliance, enhance interactions between regulatory bodies and industry players, and develop adaptable frameworks for rapid technological advancements. Emphasizing interdisciplinary collaboration and increased transparency, the study concludes that these elements are vital for establishing coherent and effective regulatory procedures in the medical device sector.

Yu Han, Aaron Ceross, Jeroen H. M. Bergmann

Identifying the appropriate regulatory standard applicability remains a critical yet understudied challenge in medical device compliance, frequently necessitating expert interpretation of fragmented and heterogeneous documentation across different jurisdictions. To address this challenge, we introduce a modular AI system that leverages a retrieval-augmented generation (RAG) pipeline to automate standard applicability determination. Given a free-text device description, our system retrieves candidate standards from a curated corpus and uses large language models to infer jurisdiction-specific applicability, classified as Mandatory, Recommended, or Not Applicable, with traceable justifications. We construct an international benchmark dataset of medical device descriptions with expert-annotated standard mappings, and evaluate our system against retrieval-only, zero-shot, and rule-based baselines. The proposed approach attains a classification accuracy of 73% and a Top-5 retrieval recall of 87%, demonstrating its effectiveness in identifying relevant regulatory standards. We introduce the first end-to-end system for standard applicability reasoning, enabling scalable and interpretable AI-supported regulatory science. Notably, our region-aware RAG agent performs cross-jurisdictional reasoning between Chinese and U.S. standards, supporting conflict resolution and applicability justification across regulatory frameworks.

Yu Han, Ziwei Long, Yanting Zhang et al.

Correspondence matching plays a crucial role in numerous robotics applications. In comparison to conventional hand-crafted methods and recent data-driven approaches, there is significant interest in plug-and-play algorithms that make full use of pre-trained backbone networks for multi-scale feature extraction and leverage hierarchical refinement strategies to generate matched correspondences. The primary focus of this paper is to address the limitations of deep feature matching (DFM), a state-of-the-art (SoTA) plug-and-play correspondence matching approach. First, we eliminate the pre-defined threshold employed in the hierarchical refinement process of DFM by leveraging a more flexible nearest neighbor search strategy, thereby preventing the exclusion of repetitive yet valid matches during the early stages. Our second technical contribution is the integration of a patch descriptor, which extends the applicability of DFM to accommodate a wide range of backbone networks pre-trained across diverse computer vision tasks, including image classification, semantic segmentation, and stereo matching. Taking into account the practical applicability of our method in real-world robotics applications, we also propose a novel patch descriptor distillation strategy to further reduce the computational complexity of correspondence matching. Extensive experiments conducted on three public datasets demonstrate the superior performance of our proposed method. Specifically, it achieves an overall performance in terms of mean matching accuracy of 0.68, 0.92, and 0.95 with respect to the tolerances of 1, 3, and 5 pixels, respectively, on the HPatches dataset, outperforming all other SoTA algorithms. Our source code, demo video, and supplement are publicly available at mias.group/GCM.

Xiaojie Li, Yu Han, Zhizheng Lu et al.

The upper 6 GHz (U6G) band with XL-MIMO is a key enabler for sixth-generation wireless systems, yet intelligent radiomap prediction for such systems remains challenging. Existing datasets support only small-scale arrays (up to 8x8) with predominantly isotropic antennas, far from the 1024-element directional arrays envisioned for 6G. Moreover, current methods encode array configurations as scalar parameters, forcing neural networks to extrapolate array-specific radiation patterns, which fails when predicting radiomaps for configurations absent from training data. To jointly address data scarcity and generalization limitations, this paper advances XL-MIMO radiomap prediction from three aspects. To overcome data limitations, we construct the first XL-MIMO radiomap dataset containing 78400 radiomaps across 800 urban scenes, five frequency bands (1.8-6.7 GHz), and nine array configurations up to 32x32 uniform planar arrays with directional elements. To enable systematic evaluation, we establish a comprehensive benchmark framework covering practical scenarios from coverage estimation without field measurements to generalization across unseen configurations and environments. To enable generalization to arbitrary beam configurations without retraining, we propose the beam map, a physics-informed spatial feature that analytically computes array-specific coverage patterns. By decoupling deterministic array radiation from data learned multipath propagation, beam maps shift generalization from neural network extrapolation to physics-based computation. Integrating beam maps into existing architectures reduces mean absolute error by up to 60.0% when generalizing to unseen configurations and up to 50.5% when transferring to unseen environments. The complete dataset and code are publicly available at https://lxj321.github.io/MulticonfigRadiomapDataset/.

Weiying Shen, Hao Yu, Yu Dong et al.

Real-time crash detection is essential for developing proactive safety management strategy and enhancing overall traffic efficiency. To address the limitations associated with trajectory acquisition and vehicle tracking, road segment maps recording the individual-level traffic dynamic data were directly served in crash detection. A novel two-stage trajectory-free crash detection framework, was present to generate the rational future road segment map and identify crashes. The first-stage diffusion-based segment map generation model, Mapfusion, conducts a noisy-to-normal process that progressively adds noise to the road segment map until the map is corrupted to pure Gaussian noise. The denoising process is guided by sequential embedding components capturing the temporal dynamics of segment map sequences. Furthermore, the generation model is designed to incorporate background context through ControlNet to enhance generation control. Crash detection is achieved by comparing the monitored segment map with the generations from diffusion model in second stage. Trained on non-crash vehicle motion data, Mapfusion successfully generates realistic road segment evolution maps based on learned motion patterns and remains robust across different sampling intervals. Experiments on real-world crashes indicate the effectiveness of the proposed two-stage method in accurately detecting crashes.

Yu Han, Zhiwei Huang, Yanting Zhang et al.

Point-pixel registration between LiDAR point clouds and camera images is a fundamental yet challenging task in autonomous driving and robotic perception. A key difficulty lies in the modality gap between unstructured point clouds and structured images, especially under sparse single-frame LiDAR settings. Existing methods typically extract features separately from point clouds and images, then rely on hand-crafted or learned matching strategies. This separate encoding fails to bridge the modality gap effectively, and more critically, these methods struggle with the sparsity and noise of single-frame LiDAR, often requiring point cloud accumulation or additional priors to improve reliability. Inspired by recent progress in detector-free matching paradigms (e.g. MatchAnything), we revisit the projection-based approach and introduce the detector-free framework for direct point-pixel matching between LiDAR and camera views. Specifically, we project the LiDAR intensity map into a 2D view from the LiDAR perspective and feed it into an attention-based detector-free matching network, enabling cross-modal correspondence estimation without relying on multi-frame accumulation. To further enhance matching reliability, we introduce a repeatability scoring mechanism that acts as a soft visibility prior. This guides the network to suppress unreliable matches in regions with low intensity variation, improving robustness under sparse input. Extensive experiments on KITTI, nuScenes, and MIAS-LCEC-TF70 benchmarks demonstrate that our method achieves state-of-the-art performance, outperforming prior approaches on nuScenes (even those relying on accumulated point clouds), despite using only single-frame LiDAR.

Yu Han, Aaron Ceross, Jeroen H. M. Bergmann

Regulatory affairs, which sits at the intersection of medicine and law, can benefit significantly from AI-enabled automation. Classification task is the initial step in which manufacturers position their products to regulatory authorities, and it plays a critical role in determining market access, regulatory scrutiny, and ultimately, patient safety. In this study, we investigate a broad range of AI models -- including traditional machine learning (ML) algorithms, deep learning architectures, and large language models -- using a regulatory dataset of medical device descriptions. We evaluate each model along three key dimensions: accuracy, interpretability, and computational cost.

Yu Han, Aaron Ceross, Jeroen H. M. Bergmann

Accurate classification of medical device risk levels is essential for regulatory oversight and clinical safety. We present a Transformer-based multimodal framework that integrates textual descriptions and visual information to predict device regulatory classification. The model incorporates a cross-attention mechanism to capture intermodal dependencies and employs a self-training strategy for improved generalization under limited supervision. Experiments on a real-world regulatory dataset demonstrate that our approach achieves up to 90.4% accuracy and 97.9% AUROC, significantly outperforming text-only (77.2%) and image-only (54.8%) baselines. Compared to standard multimodal fusion, the self-training mechanism improved SVM performance by 3.3 percentage points in accuracy (from 87.1% to 90.4%) and 1.4 points in macro-F1, suggesting that pseudo-labeling can effectively enhance generalization under limited supervision. Ablation studies further confirm the complementary benefits of both cross-modal attention and self-training.

Yu Han, Aaron Ceross, Sarim Ather et al.

Artificial intelligence (AI) in medical device software (MDSW) represents a transformative clinical technology, attracting increasing attention within both the medical community and the regulators. In this study, we leverage a data-driven approach to automatically extract and analyze AI-enabled medical devices (AIMD) from the National Medical Products Administration (NMPA) regulatory database. The continued increase in publicly available regulatory data requires scalable methods for analysis. Automation of regulatory information screening is essential to create reproducible insights that can be quickly updated in an ever changing medical device landscape. More than 4 million entries were assessed, identifying 2,174 MDSW registrations, including 531 standalone applications and 1,643 integrated within medical devices, of which 43 were AI-enabled. It was shown that the leading medical specialties utilizing AIMD include respiratory (20.5%), ophthalmology/endocrinology (12.8%), and orthopedics (10.3%). This approach greatly improves the speed of data extracting providing a greater ability to compare and contrast. This study provides the first extensive, data-driven exploration of AIMD in China, showcasing the potential of automated regulatory data analysis in understanding and advancing the landscape of AI in medical technology.

Siyuan Jiang, Jia Li, He Zong et al. · pku

Large Language Models (LLMs) have been widely used in code completion, and researchers are focusing on scaling up LLMs to improve their accuracy. However, larger LLMs have lower inference efficiency, affecting developers' experience and productivity. In this paper, we propose a lightweight and effective LLM for code completion named aiXcoder-7B. Compared to existing LLMs, aiXcoder-7B achieves higher code completion accuracy while having smaller scales (i.e., 7 billion parameters). We attribute the superiority of aiXcoder-7B to three key factors: (1) Multi-objective training. We employ three training objectives, one of which is our proposed Structured Fill-In-the-Middle (SFIM). SFIM considers the syntax structures in code and effectively improves the performance of LLMs for code. (2) Diverse data sampling strategies. They consider inter-file relationships and enhance the capability of LLMs in understanding cross-file contexts. (3) Extensive high-quality data. We establish a rigorous data collection pipeline and consume a total of 1.2 trillion unique tokens for training aiXcoder-7B. This vast volume of data enables aiXcoder-7B to learn a broad distribution of code. We evaluate aiXcoder-7B in five popular code completion benchmarks and a new benchmark collected by this paper. The results show that aiXcoder-7B outperforms the latest six LLMs with similar sizes and even surpasses four larger LLMs (e.g., StarCoder2-15B and CodeLlama-34B), positioning aiXcoder-7B as a lightweight and effective LLM for academia and industry. Finally, we summarize three valuable insights for helping practitioners train the next generations of LLMs for code. aiXcoder-7B has been open-souced and gained significant attention. Until January 2025, aiXcoder-7B has received 2,226 GitHub Stars.

Gengyue Han, Xiaohan Liu, Xianyue Peng et al.

This study introduces CycLight, a novel cycle-level deep reinforcement learning (RL) approach for network-level adaptive traffic signal control (NATSC) systems. Unlike most traditional RL-based traffic controllers that focus on step-by-step decision making, CycLight adopts a cycle-level strategy, optimizing cycle length and splits simultaneously using Parameterized Deep Q-Networks (PDQN) algorithm. This cycle-level approach effectively reduces the computational burden associated with frequent data communication, meanwhile enhancing the practicality and safety of real-world applications. A decentralized framework is formulated for multi-agent cooperation, while attention mechanism is integrated to accurately assess the impact of the surroundings on the current intersection. CycLight is tested in a large synthetic traffic grid using the microscopic traffic simulation tool, SUMO. Experimental results not only demonstrate the superiority of CycLight over other state-of-the-art approaches but also showcase its robustness against information transmission delays.

Yu Han, Kazuyuki Nakamura

Particle filtering methods are widely applied in sequential state estimation within nonlinear non-Gaussian state space model. However, the traditional particle filtering methods suffer the weight degeneracy in the high-dimensional state space model. Currently, there are many methods to improve the performance of particle filtering in high-dimensional state space model. Among these, the more advanced method is to construct the Sequential Makov chian Monte Carlo (SMCMC) framework by implementing the Composite Metropolis-Hasting (MH) Kernel. In this paper, we proposed to discrete the Zig-Zag Sampler and apply the Zig-Zag Sampler in the refinement stage of the Composite MH Kernel within the SMCMC framework which is implemented the invertible particle flow in the joint draw stage. We evaluate the performance of proposed method through numerical experiments of the challenging complex high-dimensional filtering examples. Nemurical experiments show that in high-dimensional state estimation examples, the proposed method improves estimation accuracy and increases the acceptance ratio compared with state-of-the-art filtering methods.

Yu Han, Shizhan Lu, Haiyan Xu

Cluster analysis, which focuses on the grouping and categorization of similar elements, is widely used in various fields of research. A novel and fast clustering algorithm, fission clustering algorithm, is proposed in recent year. In this article, we propose a robust fission clustering (RFC) algorithm and a self-adaptive noise identification method. The RFC and the self-adaptive noise identification method are combine to propose a self-adaptive robust fission clustering (SARFC) algorithm. Several frequently-used datasets were applied to test the performance of the proposed clustering approach and to compare the results with those of other algorithms. The comprehensive comparisons indicate that the proposed method has advantages over other common methods.

Yu Han, Shuai Yang, Wenjing Wang et al.

Fashion manipulation has attracted growing interest due to its great application value, which inspires many researches towards fashion images. However, little attention has been paid to fashion design draft. In this paper, we study a new unaligned translation problem between design drafts and real fashion items, whose main challenge lies in the huge misalignment between the two modalities. We first collect paired design drafts and real fashion item images without pixel-wise alignment. To solve the misalignment problem, our main idea is to train a sampling network to adaptively adjust the input to an intermediate state with structure alignment to the output. Moreover, built upon the sampling network, we present design draft to real fashion item translation network (D2RNet), where two separate translation streams that focus on texture and shape, respectively, are combined tactfully to get both benefits. D2RNet is able to generate realistic garments with both texture and shape consistency to their design drafts. We show that this idea can be effectively applied to the reverse translation problem and present R2DNet accordingly. Extensive experiments on unaligned fashion design translation demonstrate the superiority of our method over state-of-the-art methods. Our project website is available at: https://victoriahy.github.io/MM2020/ .

Yu Han, Zhongru Wang, Qiang Ruan et al.

Recently, cybersecurity becomes more and more important due to the rapid development of Internet. However, existing methods are in reality highly sensitive to attacks and are far more vulnerable than expected, as they are lack of trustable measures. In this paper, to address the aforementioned problems, we propose a blockchain-based cybersecurity framework, termed as Sapiens Chain, which can protect the privacy of the anonymous users and ensure that the transactions are immutable by providing decentralized and trustable services. Integrating semantic analysis, symbolic execution, and routing learning methods into intelligent auditing, this framework can achieve good accuracy for detecting hidden vulnerabilities. In addition, a revenue incentive mechanism, which aims to donate participants, is built. The practical results demonstrate the effectiveness of the proposed framework.