Behrooz Mahasseni

Jingping Nie, Ran Liu, Behrooz Mahasseni et al.

Acoustic signals are crucial for health monitoring, particularly heart sounds which provide essential data like heart rate and detect cardiac anomalies such as murmurs. This study utilizes a publicly available phonocardiogram (PCG) dataset to estimate heart rate using model-driven methods and extends the best-performing model to a multi-task learning (MTL) framework for simultaneous heart rate estimation and murmur detection. Heart rate estimates are derived using a sliding window technique on heart sound snippets, analyzed with a combination of acoustic features (Mel spectrogram, cepstral coefficients, power spectral density, root mean square energy). Our findings indicate that a 2D convolutional neural network (\textbf{\texttt{2dCNN}}) is most effective for heart rate estimation, achieving a mean absolute error (MAE) of 1.312 bpm. We systematically investigate the impact of different feature combinations and find that utilizing all four features yields the best results. The MTL model (\textbf{\texttt{2dCNN-MTL}}) achieves accuracy over 95% in murmur detection, surpassing existing models, while maintaining an MAE of 1.636 bpm in heart rate estimation, satisfying the requirements stated by Association for the Advancement of Medical Instrumentation (AAMI).

Christopher Sandino, Sayeri Lala, Geeling Chau et al.

Self-supervised learning (SSL) offers a promising approach for learning electroencephalography (EEG) representations from unlabeled data, reducing the need for expensive annotations for clinical applications like sleep staging and seizure detection. While current EEG SSL methods predominantly use masked reconstruction strategies like masked autoencoders (MAE) that capture local temporal patterns, position prediction pretraining remains underexplored despite its potential to learn long-range dependencies in neural signals. We introduce PAirwise Relative Shift or PARS pretraining, a novel pretext task that predicts relative temporal shifts between randomly sampled EEG window pairs. Unlike reconstruction-based methods that focus on local pattern recovery, PARS encourages encoders to capture relative temporal composition and long-range dependencies inherent in neural signals. Through comprehensive evaluation on various EEG decoding tasks, we demonstrate that PARS-pretrained transformers consistently outperform existing pretraining strategies in label-efficient and transfer learning settings, establishing a new paradigm for self-supervised EEG representation learning.

Ching Fang, Christopher Sandino, Behrooz Mahasseni et al.

Many healthcare applications are inherently multimodal, involving several physiological signals. As sensors for these signals become more common, improving machine learning methods for multimodal healthcare data is crucial. Pretraining foundation models is a promising avenue for success. However, methods for developing foundation models in healthcare are still in early exploration and it is unclear which pretraining strategies are most effective given the diversity of physiological signals. This is partly due to challenges in multimodal health data: obtaining data across many patients is difficult and costly, there is a lot of inter-subject variability, and modalities are often heterogeneously informative across downstream tasks. Here, we explore these challenges in the PhysioNet 2018 dataset. We use a masked autoencoding objective to pretrain a multimodal model. We show that the model learns representations that can be linearly probed for a diverse set of downstream tasks. We hypothesize that cross-modal reconstruction objectives are important for successful multimodal training, as they encourage the model to integrate information across modalities. We demonstrate that modality dropout in the input space improves performance across downstream tasks. We also find that late-fusion models pretrained with contrastive learning objectives are less effective across multiple tasks. Finally, we analyze the model's representations, showing that attention weights become more cross-modal and temporally aligned with our pretraining strategy. The learned embeddings also become more distributed in terms of the modalities encoded by each unit. Overall, our work demonstrates the utility of multimodal foundation models with health data, even across diverse physiological data sources. We further argue that explicit methods for inducing cross-modality may enhance multimodal pretraining strategies.