Giusy Spacone

Run Wang, Victor J. B. Jung, Philip Wiese et al.

Biosignals exhibit substantial cross-subject and cross-session variability, inducing severe domain shifts that degrade post-deployment performance for small, edge-oriented AI models. On-device adaptation is therefore essential to both preserve user privacy and ensure system reliability. However, existing sub-100 mW MCU-based wearable platforms can only support shallow or sparse adaptation schemes due to the prohibitive memory footprint and computational cost of full backpropagation (BP). In this paper, we propose BioTrain, a framework enabling full-network fine-tuning of state-of-the-art biosignal models under milliwatt-scale power and sub-megabyte memory constraints. We validate BioTrain using both offline and on-device benchmarks on EEG and EOG datasets, covering Day-1 new-subject calibration and longitudinal adaptation to signal drift. Experimental results show that full-network fine-tuning achieves accuracy improvements of up to 35% over non-adapted baselines and outperforms last-layer updates by approximately 7% during new-subject calibration. On the GAP9 MCU platform, BioTrain enables efficient on-device training throughput of 17 samples/s for EEG and 85 samples/s for EOG models within a power envelope below 50 mW. In addition, BioTrain's efficient memory allocator and network topology optimization enable the use of a large batch size, reducing peak memory usage. For fully on-chip BP on GAP9, BioTrain reduces the memory footprint by 8.1x, from 5.4 MB to 0.67 MB, compared to conventional full-network fine-tuning using batch normalization with batch size 8.

Giusy Spacone, Luca Benini, Andrea Cossettini

A-mode ultrasound (US) has emerged as a promising modality for hand and wrist motion tracking. Prior works have mainly addressed static gesture classification or regression of a few degrees of freedom (DoFs), typically relying on non-wearable systems and external computing devices, and highlight the need for strategies to ensure robustness to sensor repositioning. In this work, we propose a framework for robust whole-hand and wrist kinematic tracking via wearable A-mode US using the WULPUS platform, tackling the regression of 23 DoFs directly on the probe. First, we introduce a compact (11285 parameters) multi-output convolutional neural network combined with an incremental training strategy, which improves inter-session generalization and reduces mean absolute error by more than 17% compared to a non-incremental approach. Second, we demonstrate, for the first time, the feasibility of end-to-end hand and wrist kinematic tracking entirely on-device. We deploy the model on the WULPUS nRF52832 microcontroller, achieving 0.73 mJ per inference, 29.1 ms latency, and showing the feasibility of full operation (data acquisition, online inference, and BLE streaming of results) within 33 mW, enabling up to 36 hours of continuous use and an 88% reduction in wireless bandwidth compared to raw data transmission.

Giusy Spacone, Sebastian Frey, Enzo Baraldi et al.

A-mode ultrasound (US) is a promising sensing modality for Virtual Reality (VR) interaction, as it enables the mapping of muscular activity into control commands while retaining the benefits of wearable sensing. However, existing approaches still face limitations in terms of wearability and interaction complexity, often relying on external hardware such as cameras. In this work, we propose a fully wearable multimodal interface for real-time VR-interaction, based on concurrent US and inertial (accelerometry) sensing from the forearm and upper arm. The system is built on the WULPUS platform and integrates an end-to-end software framework for real-time acquisition, visualization, and communication with a Unity-based VR environment. A multimodal learning pipeline is introduced for concurrent hand pose and forearm position estimation in 2D space. The interface is evaluated through offline and online experiments with five subjects, during the execution of three functional tasks: cylinder grasping (gross motor) and relocation, marble pinching (fine motor) and relocation, and liquid pouring. For offline experiments, we collect 5 acquisition sessions across multiple days, achieving an average inter-session accuracy across subjects of 80$\pm$6\% for hand pose estimation and 77$\pm$7\% for forearm position estimation. Online validation with minimal fine-tuning (5 min) demonstrates success rates of 92.0$\pm$16.0\%, 88.0$\pm$9.8\%, and 96.0$\pm$8.0\% for the three tasks, respectively. With a power consumption of only 19.9~mW, our system enables more than 2.5 days of continuous use on a small 350 mAh LiPo battery without the need for recharge, enabling truly wearable, multimodal, and functionally meaningful VR interaction.

Matteo Fasulo, Giusy Spacone, Thorir Mar Ingolfsson et al.

Objective: Surface electromyography (EMG) is a non-invasive sensing modality widely used in biomechanics, rehabilitation, prosthetic control, and human-machine interfaces. Despite decades of use, achieving robust generalization across subjects, recording systems, and acquisition protocols remains challenging. While foundation models (FMs) are gaining traction for EMG, existing approaches remain limited to single downstream tasks and lack deployability on embedded platforms. This work addresses these limitations. Methods: We present TinyMyo, a lightweight FM based on a Transformer encoder architecture. The model is pre-trained in a self-supervised manner using masked reconstruction on publicly available datasets. With only 3.6M parameters, TinyMyo is designed to support multiple downstream tasks through minimal task-specific head adaptations. Results: We demonstrate generalization across hand gesture classification, hand kinematic regression, speech production and speech recognition, with performance comparable to or surpassing the state of the art (SoA), and model size below 5M parameters. We achieve SoA results compared to previous FM-based works on the NinaPro DB5 (89.4%), UCI-EMG (97.56%), and EPN-612 (96.74%) datasets. We demonstrate the first-time deployment of an EMG FM on an ultra-low power microcontroller (GAP9), with an inference time of 0.785 s, energy of 44.91 mJ and power envelope of 57.18 mW. Conclusion: TinyMyo demonstrates that compact, self-supervised EMG FM can guarantee strong generalization across multiple downstream tasks while remaining compatible with low-power edge devices. Significance: TinyMyo is the first EMG FM for ultra-low power edge devices, enabling scalable and energy-efficient sensing for motor intent decoding, neuromuscular assessment, and biosignal driven human-machine interaction.