Jiawei Du

Shengzhu Yang, Jiawei Du, Jia Guo et al.

Subtle semantic differences in retinal image and text data present great challenges for pre-training visual-language models. Moreover, false negative samples, i.e., image-text pairs having the same semantics but incorrectly regarded as negatives, disrupt the visual-language pre-training process and affect the model's learning ability. This work aims to develop a retinal foundation model, called ViLReF, by pre-training on a paired dataset comprising 451,956 retinal images and corresponding diagnostic text reports. In our vision-language pre-training strategy, we leverage expert knowledge to facilitate the extraction of labels and propose a novel constraint, the Weighted Similarity Coupling Loss, to adjust the speed of pushing sample pairs further apart dynamically within the feature space. Furthermore, we employ a batch expansion module with dynamic memory queues, maintained by momentum encoders, to supply extra samples and compensate for the vacancies caused by eliminating false negatives. Extensive experiments are conducted on multiple datasets for downstream classification and segmentation tasks. The experimental results demonstrate the powerful zero-shot and transfer learning capabilities of ViLReF, verifying the effectiveness of our pre-training strategy. Our ViLReF model is available at: https://github.com/T6Yang/ViLReF.

Jia Guo, Jiawei Du, Shengzhu Yang et al.

Current retinal foundation models remain constrained by curated research datasets that lack authentic clinical context, and require extensive task-specific optimization for each application, limiting their deployment efficiency in low-resource settings. Here, we show that these barriers can be overcome by building clinical native intelligence directly from real-world medical practice. Our key insight is that large-scale telemedicine programs, where expert centers provide remote consultations across distributed facilities, represent a natural reservoir for learning clinical image interpretation. We present ReVision, a retinal foundation model that learns from the natural alignment between 485,980 color fundus photographs and their corresponding diagnostic reports, accumulated through a decade-long telemedicine program spanning 162 medical institutions across China. Through extensive evaluation across 27 ophthalmic benchmarks, we demonstrate that ReVison enables deployment efficiency with minimal local resources. Without any task-specific training, ReVision achieves zero-shot disease detection with an average AUROC of 0.946 across 12 public benchmarks and 0.952 on 3 independent clinical cohorts. When minimal adaptation is feasible, ReVision matches extensively fine-tuned alternatives while requiring orders of magnitude fewer trainable parameters and labeled examples. The learned representations also transfer effectively to new clinical sites, imaging domains, imaging modalities, and systemic health prediction tasks. In a prospective reader study with 33 ophthalmologists, ReVision's zero-shot assistance improved diagnostic accuracy by 14.8% across all experience levels. These results demonstrate that clinical native intelligence can be directly extracted from clinical archives without any further annotation to build medical AI systems suited to various low-resource settings.

Jiawei Du, Jia Guo, Weihang Zhang et al.

The Vision-Language Foundation model is increasingly investigated in the fields of computer vision and natural language processing, yet its exploration in ophthalmology and broader medical applications remains limited. The challenge is the lack of labeled data for the training of foundation model. To handle this issue, a CLIP-style retinal image foundation model is developed in this paper. Our foundation model, RET-CLIP, is specifically trained on a dataset of 193,865 patients to extract general features of color fundus photographs (CFPs), employing a tripartite optimization strategy to focus on left eye, right eye, and patient level to reflect real-world clinical scenarios. Extensive experiments demonstrate that RET-CLIP outperforms existing benchmarks across eight diverse datasets spanning four critical diagnostic categories: diabetic retinopathy, glaucoma, multiple disease diagnosis, and multi-label classification of multiple diseases, which demonstrate the performance and generality of our foundation model. The sourse code and pre-trained model are available at https://github.com/sStonemason/RET-CLIP.

Tianmi Ma, Jiawei Du, Wenxin Huang et al.

Large language models (LLMs) have demonstrated remarkable capabilities in natural language tasks, yet their performance in dynamic, real-world financial environments remains underexplored. Existing approaches are limited to historical backtesting, where trading actions cannot influence market prices and agents train only on static data. To address this limitation, we present the Agent Trading Arena, a virtual zero-sum stock market in which LLM-based agents engage in competitive multi-agent trading and directly impact price dynamics. By simulating realistic bid-ask interactions, our platform enables training in scenarios that closely mirror live markets, thereby narrowing the gap between training and evaluation. Experiments reveal that LLMs struggle with numerical reasoning when given plain-text data, often overfitting to local patterns and recent values. In contrast, chart-based visualizations significantly enhance both numerical reasoning and trading performance. Furthermore, incorporating a reflection module yields additional improvements, especially with visual inputs. Evaluations on NASDAQ and CSI datasets demonstrate the superiority of our method, particularly under high volatility. All code and data are available at https://github.com/wekjsdvnm/Agent-Trading-Arena.

Shengzhu Yang, Jiawei Du, Shuai Lu et al.

Large-scale natural image-text datasets, especially those automatically collected from the web, often suffer from loose semantic alignment due to weak supervision, while medical datasets tend to have high cross-modal correlation but low content diversity. These properties pose a common challenge for contrastive language-image pretraining (CLIP): they hinder the model's ability to learn robust and generalizable representations. In this work, we propose CLIPin, a unified non-contrastive plug-in that can be seamlessly integrated into CLIP-style architectures to improve multimodal semantic alignment, providing stronger supervision and enhancing alignment robustness. Furthermore, two shared pre-projectors are designed for image and text modalities respectively to facilitate the integration of contrastive and non-contrastive learning in a parameter-compromise manner. Extensive experiments on diverse downstream tasks demonstrate the effectiveness and generality of CLIPin as a plug-and-play component compatible with various contrastive frameworks. Code is available at https://github.com/T6Yang/CLIPin.

Yujing Xue, Jiaxiang Liu, Jiawei Du et al.

Recently, polar coordinate-based representations have shown promise for 3D perceptual tasks. Compared to Cartesian methods, polar grids provide a viable alternative, offering better detail preservation in nearby spaces while covering larger areas. However, they face feature distortion due to non-uniform division. To address these issues, we introduce the Polar Voxel Occupancy Predictor (PVP), a novel 3D multi-modal predictor that operates in polar coordinates. PVP features two key design elements to overcome distortion: a Global Represent Propagation (GRP) module that integrates global spatial data into 3D volumes, and a Plane Decomposed Convolution (PD-Conv) that simplifies 3D distortions into 2D convolutions. These innovations enable PVP to outperform existing methods, achieving significant improvements in mIoU and IoU metrics on the OpenOccupancy dataset.

Jiaxiang Liu, Yuan Wang, Jiawei Du et al.

Cross-modal alignment aims to map heterogeneous modalities into a shared latent space, as exemplified by models like CLIP, which benefit from large-scale image-text pretraining for strong recognition capabilities. However, when operating in resource-constrained settings with limited or low-quality data, these models often suffer from overconfidence and degraded performance due to the prevalence of ambiguous or weakly correlated image-text pairs. Current contrastive learning approaches, which rely on single positive pairs, further exacerbate this issue by reinforcing overconfidence on uncertain samples. To address these challenges, we propose Modest-Align, a lightweight alignment framework designed for robustness and efficiency. Our approach leverages two complementary strategies -- Random Perturbation, which introduces controlled noise to simulate uncertainty, and Embedding Smoothing, which calibrates similarity distributions in the embedding space. These mechanisms collectively reduce overconfidence and improve performance on noisy or weakly aligned samples. Extensive experiments across multiple benchmark datasets demonstrate that Modest-Align outperforms state-of-the-art methods in retrieval tasks, achieving competitive results with over 100x less training data and 600x less GPU time than CLIP. Our method offers a practical and scalable solution for cross-modal alignment in real-world, low-resource scenarios.