Ziyan Huang

Haoyu Wang, Sizheng Guo, Jin Ye et al.

Existing volumetric medical image segmentation models are typically task-specific, excelling at specific target but struggling to generalize across anatomical structures or modalities. This limitation restricts their broader clinical use. In this paper, we introduce SAM-Med3D for general-purpose segmentation on volumetric medical images. Given only a few 3D prompt points, SAM-Med3D can accurately segment diverse anatomical structures and lesions across various modalities. To achieve this, we gather and process a large-scale 3D medical image dataset, SA-Med3D-140K, from a blend of public sources and licensed private datasets. This dataset includes 22K 3D images and 143K corresponding 3D masks. Then SAM-Med3D, a promptable segmentation model characterized by the fully learnable 3D structure, is trained on this dataset using a two-stage procedure and exhibits impressive performance on both seen and unseen segmentation targets. We comprehensively evaluate SAM-Med3D on 16 datasets covering diverse medical scenarios, including different anatomical structures, modalities, targets, and zero-shot transferability to new/unseen tasks. The evaluation shows the efficiency and efficacy of SAM-Med3D, as well as its promising application to diverse downstream tasks as a pre-trained model. Our approach demonstrates that substantial medical resources can be utilized to develop a general-purpose medical AI for various potential applications. Our dataset, code, and models are available at https://github.com/uni-medical/SAM-Med3D.

Jin Ye, Ying Chen, Yanjun Li et al.

Computed Tomography (CT) is one of the most popular modalities for medical imaging. By far, CT images have contributed to the largest publicly available datasets for volumetric medical segmentation tasks, covering full-body anatomical structures. Large amounts of full-body CT images provide the opportunity to pre-train powerful models, e.g., STU-Net pre-trained in a supervised fashion, to segment numerous anatomical structures. However, it remains unclear in which conditions these pre-trained models can be transferred to various downstream medical segmentation tasks, particularly segmenting the other modalities and diverse targets. To address this problem, a large-scale benchmark for comprehensive evaluation is crucial for finding these conditions. Thus, we collected 87 public datasets varying in modality, target, and sample size to evaluate the transfer ability of full-body CT pre-trained models. We then employed a representative model, STU-Net with multiple model scales, to conduct transfer learning across modalities and targets. Our experimental results show that (1) there may be a bottleneck effect concerning the dataset size in fine-tuning, with more improvement on both small- and large-scale datasets than medium-size ones. (2) Models pre-trained on full-body CT demonstrate effective modality transfer, adapting well to other modalities such as MRI. (3) Pre-training on the full-body CT not only supports strong performance in structure detection but also shows efficacy in lesion detection, showcasing adaptability across target tasks. We hope that this large-scale open evaluation of transfer learning can direct future research in volumetric medical image segmentation.

Jianjiang Yang, Ziyan Huang, Yanshu li et al.

Despite remarkable progress in image quality and prompt fidelity, text-to-image (T2I) diffusion models continue to exhibit persistent "hallucinations", where generated content subtly or significantly diverges from the intended prompt semantics. While often regarded as unpredictable artifacts, we argue that these failures reflect deeper, structured misalignments within the generative process. In this work, we propose a cognitively inspired perspective that reinterprets hallucinations as trajectory drift within a latent alignment space. Empirical observations reveal that generation unfolds within a multiaxial cognitive tension field, where the model must continuously negotiate competing demands across three key critical axes: semantic coherence, structural alignment, and knowledge grounding. We then formalize this three-axis space as the Hallucination Tri-Space and introduce the Alignment Risk Code (ARC): a dynamic vector representation that quantifies real-time alignment tension during generation. The magnitude of ARC captures overall misalignment, its direction identifies the dominant failure axis, and its imbalance reflects tension asymmetry. Based on this formulation, we develop the TensionModulator (TM-ARC): a lightweight controller that operates entirely in latent space. TM-ARC monitors ARC signals and applies targeted, axis-specific interventions during the sampling process. Extensive experiments on standard T2I benchmarks demonstrate that our approach significantly reduces hallucination without compromising image quality or diversity. This framework offers a unified and interpretable approach for understanding and mitigating generative failures in diffusion-based T2I systems.