Li Wu

Chen Zhao, Joyce H Keyak, Xuewei Cao et al.

The aim of this paper is to design a deep learning-based model to predict proximal femoral strength using multi-view information fusion. Method: We developed new models using multi-view variational autoencoder (MVAE) for feature representation learning and a product of expert (PoE) model for multi-view information fusion. We applied the proposed models to an in-house Louisiana Osteoporosis Study (LOS) cohort with 931 male subjects, including 345 African Americans and 586 Caucasians. With an analytical solution of the product of Gaussian distribution, we adopted variational inference to train the designed MVAE-PoE model to perform common latent feature extraction. We performed genome-wide association studies (GWAS) to select 256 genetic variants with the lowest p-values for each proximal femoral strength and integrated whole genome sequence (WGS) features and DXA-derived imaging features to predict proximal femoral strength. Results: The best prediction model for fall fracture load was acquired by integrating WGS features and DXA-derived imaging features. The designed models achieved the mean absolute percentage error of 18.04%, 6.84% and 7.95% for predicting proximal femoral fracture loads using linear models of fall loading, nonlinear models of fall loading, and nonlinear models of stance loading, respectively. Compared to existing multi-view information fusion methods, the proposed MVAE-PoE achieved the best performance. Conclusion: The proposed models are capable of predicting proximal femoral strength using WGS features and DXA-derived imaging features. Though this tool is not a substitute for FEA using QCT images, it would make improved assessment of hip fracture risk more widely available while avoiding the increased radiation dosage and clinical costs from QCT.

Jasmin Bogatinovski, Sasho Nedelkoski, Li Wu et al.

The reliability of cloud platforms is of significant relevance because society increasingly relies on complex software systems running on the cloud. To improve it, cloud providers are automating various maintenance tasks, with failure identification frequently being considered. The precondition for automation is the availability of observability tools, with system logs commonly being used. The focus of this paper is log-based failure identification. This problem is challenging because of the instability of the log data and the incompleteness of the explicit logging failure coverage within the code. To address the two challenges, we present CLog as a method for failure identification. The key idea presented herein based is on our observation that by representing the log data as sequences of subprocesses instead of sequences of log events, the effect of the unstable log data is reduced. CLog introduces a novel subprocess extraction method that uses context-aware neural network and clustering methods to extract meaningful subprocesses. The direct modeling of log event contexts allows the identification of failures with respect to the abrupt context changes, addressing the challenge of insufficient logging failure coverage. Our experimental results demonstrate that the learned subprocesses representations reduce the instability in the input, allowing CLog to outperform the baselines on the failure identification subproblems - 1) failure detection by 9-24% on F1 score and 2) failure type identification by 7% on the macro averaged F1 score. Further analysis shows the existent negative correlation between the instability in the input event sequences and the detection performance in a model-agnostic manner.

Zhongzhen Huang, Yan Ling, Hong Chen et al.

We present PULSE, a medical reasoning agent that combines a domain-tuned large language model with scientific literature retrieval to support diagnostic decision-making in complex real-world cases. To evaluate its capabilities, we curated a benchmark of 82 authentic endocrinology case reports encompassing a broad spectrum of disease types and incidence levels. In controlled experiments, we compared PULSE's performance against physicians with varying levels of expertise-from residents to senior specialists-and examined how AI assistance influenced human diagnostic reasoning. PULSE attained expert-competitive accuracy, outperforming residents and junior specialists while matching senior specialist performance at both Top@1 and Top@4 thresholds. Unlike physicians, whose accuracy declined with disease rarity, PULSE maintained stable performance across incidence tiers. The agent also exhibited adaptive reasoning, increasing output length with case difficulty in a manner analogous to the longer deliberation observed among expert clinicians. When used collaboratively, PULSE enabled physicians to correct initial errors and broaden diagnostic hypotheses, but also introduced risks of automation bias. The study explores both serial and concurrent collaboration workflows, revealing that PULSE offers robust support across common and rare presentations. These findings underscore both the promise and the limitations of language model-based agents in clinical diagnosis, and offer a framework for evaluating their role in real-world decision-making.

Luoying Hao, Yan Hu, Yang Yue et al.

A comprehensive and explicit understanding of surgical scenes plays a vital role in developing context-aware computer-assisted systems in the operating theatre. However, few works provide systematical analysis to enable hierarchical surgical scene understanding. In this work, we propose to represent the tasks set [phase recognition --> step recognition --> action and instrument detection] as multi-level semantic scene understanding (MSSU). For this target, we propose a novel hierarchical context transformer (HCT) network and thoroughly explore the relations across the different level tasks. Specifically, a hierarchical relation aggregation module (HRAM) is designed to concurrently relate entries inside multi-level interaction information and then augment task-specific features. To further boost the representation learning of the different tasks, inter-task contrastive learning (ICL) is presented to guide the model to learn task-wise features via absorbing complementary information from other tasks. Furthermore, considering the computational costs of the transformer, we propose HCT+ to integrate the spatial and temporal adapter to access competitive performance on substantially fewer tunable parameters. Extensive experiments on our cataract dataset and a publicly available endoscopic PSI-AVA dataset demonstrate the outstanding performance of our method, consistently exceeding the state-of-the-art methods by a large margin. The code is available at https://github.com/Aurora-hao/HCT.

Li Wu, Wenbin Pei, Jiulong Jiao et al.

Multivariate Time series forecasting is crucial in domains such as transportation, meteorology, and finance, especially for predicting extreme weather events. State-of-the-art methods predominantly rely on Transformer architectures, which utilize attention mechanisms to capture temporal dependencies. However, these methods are hindered by quadratic time complexity, limiting the model's scalability with respect to input sequence length. This significantly restricts their practicality in the real world. Mamba, based on state space models (SSM), provides a solution with linear time complexity, increasing the potential for efficient forecasting of sequential data. In this study, we propose UmambaTSF, a novel long-term time series forecasting framework that integrates multi-scale feature extraction capabilities of U-shaped encoder-decoder multilayer perceptrons (MLP) with Mamba's long sequence representation. To improve performance and efficiency, the Mamba blocks introduced in the framework adopt a refined residual structure and adaptable design, enabling the capture of unique temporal signals and flexible channel processing. In the experiments, UmambaTSF achieves state-of-the-art performance and excellent generality on widely used benchmark datasets while maintaining linear time complexity and low memory consumption.

Yuan Tian, Min Zhou, Yitong Chen et al.

Patient face images provide a convenient mean for evaluating eye diseases, while also raising privacy concerns. Here, we introduce ROFI, a deep learning-based privacy protection framework for ophthalmology. Using weakly supervised learning and neural identity translation, ROFI anonymizes facial features while retaining disease features (over 98\% accuracy, $κ> 0.90$). It achieves 100\% diagnostic sensitivity and high agreement ($κ> 0.90$) across eleven eye diseases in three cohorts, anonymizing over 95\% of images. ROFI works with AI systems, maintaining original diagnoses ($κ> 0.80$), and supports secure image reversal (over 98\% similarity), enabling audits and long-term care. These results show ROFI's effectiveness of protecting patient privacy in the digital medicine era.

Hetvi Shastri, Walid A. Hanafy, Li Wu et al.

Today's Internet of Things (IoT) has evolved from simple sensing and actuation devices to those with embedded processing and intelligent services, enabling rich collaborations between users and their devices. However, enabling such collaboration becomes challenging when transient devices need to interact with host devices in temporarily visited environments. In such cases, fine-grained access control policies are necessary to ensure secure interactions; however, manually implementing them is often impractical for non-expert users. Moreover, at run-time, the system must automatically configure the devices and enforce such fine-grained access control rules. Additionally, the system must address the heterogeneity of devices. In this paper, we present CollabIoT, a system that enables secure and seamless device collaboration in transient IoT environments. CollabIoT employs a Large language Model (LLM)-driven approach to convert users' high-level intents to fine-grained access control policies. To support secure and seamless device collaboration, CollabIoT adopts capability-based access control for authorization and uses lightweight proxies for policy enforcement, providing hardware-independent abstractions. We implement a prototype of CollabIoT's policy generation and auto configuration pipelines and evaluate its efficacy on an IoT testbed and in large-scale emulated environments. We show that our LLM-based policy generation pipeline is able to generate functional and correct policies with 100% accuracy. At runtime, our evaluation shows that our system configures new devices in ~150 ms, and our proxy-based data plane incurs network overheads of up to 2 ms and access control overheads up to 0.3 ms.

Wenxuan Zhang, Xuechao Zou, Li Wu et al.

Spatiotemporal prediction aims to generate future sequences by paradigms learned from historical contexts. It is essential in numerous domains, such as traffic flow prediction and weather forecasting. Recently, research in this field has been predominantly driven by deep neural networks based on autoencoder architectures. However, existing methods commonly adopt autoencoder architectures with identical receptive field sizes. To address this issue, we propose an Asymmetric Receptive Field Autoencoder (ARFA) model, which introduces corresponding sizes of receptive field modules tailored to the distinct functionalities of the encoder and decoder. In the encoder, we present a large kernel module for global spatiotemporal feature extraction. In the decoder, we develop a small kernel module for local spatiotemporal information reconstruction. Experimental results demonstrate that ARFA consistently achieves state-of-the-art performance on popular datasets. Additionally, we construct the RainBench, a large-scale radar echo dataset for precipitation prediction, to address the scarcity of meteorological data in the domain.