Dongyi He

Dongyi He, Bin Jiang, Kecheng Feng et al.

Although obtaining deep brain activity from non-invasive scalp electroencephalography (sEEG) is crucial for neuroscience and clinical diagnosis, directly generating high-fidelity intracranial electroencephalography (iEEG) signals remains a largely unexplored field, limiting our understanding of deep brain dynamics. Current research primarily focuses on traditional signal processing or source localization methods, which struggle to capture the complex waveforms and random characteristics of iEEG. To address this critical challenge, this paper introduces NeuroFlowNet, a novel cross-modal generative framework whose core contribution lies in the first-ever reconstruction of iEEG signals from the entire deep temporal lobe region using sEEG signals. NeuroFlowNet is built on Conditional Normalizing Flow (CNF), which directly models complex conditional probability distributions through reversible transformations, thereby explicitly capturing the randomness of brain signals and fundamentally avoiding the pattern collapse issues common in existing generative models. Additionally, the model integrates a multi-scale architecture and self-attention mechanisms to robustly capture fine-grained temporal details and long-range dependencies. Validation results on a publicly available synchronized sEEG-iEEG dataset demonstrate NeuroFlowNet's effectiveness in terms of temporal waveform fidelity, spectral feature reproduction, and functional connectivity restoration. This study establishes a more reliable and scalable new paradigm for non-invasive analysis of deep brain dynamics. The code of this study is available in https://github.com/hdy6438/NeuroFlowNet

Dongyi He, Xiangkai Wang, Binbing Xu et al.

Few-shot brain tumor segmentation remains challenging due to noisy support masks, inter-patient variations between support and query images, and the lack of pixel-wise confidence estimation. This study proposes RUFNet, a Hybrid Mamba-based few-shot framework that combines support mask refinement with uncertainty-aware posterior fusion. To preserve support-query dependencies with manageable cost, RUFNet adopts a Hybrid Mamba interaction backbone with linear complexity. To reduce support-mask noise, an Attention-Guided Mask Refinement module (AGMR) uses query features to recalibrate support masks and improve prototype consistency. To handle ambiguous predictions, an Uncertainty-Aware Posterior Fusion module (UAPF) estimates pixel-wise variance and adaptively balances few-shot predictions with query-aligned priors. On the Brain Tumor Segmentation Challenge (BraTS) 2020 dataset, RUFNet achieves Dice coefficients of 84.3% and 86.1% in the 1-way 1-shot and 1-way 5-shot settings, respectively, outperforming the compared state-of-the-art methods. These results suggest that Hybrid Mamba interaction, mask refinement and uncertainty modelling can improve the robustness of few-shot medical image segmentation. The official implementation code is available at https://github.com/hdy6438/RUFNet.

Dongyi He, Shiyang Li, Bin Jiang et al.

High-resolution functional magnetic resonance imaging (fMRI) is essential for mapping human brain activity; however, it remains costly and logistically challenging. If comparable volumes could be generated directly from widely available scalp electroencephalography (EEG), advanced neuroimaging would become significantly more accessible. Existing EEG-to-fMRI generators rely on plain Convolutional Neural Networks (CNNs) that fail to capture cross-channel time-frequency cues or on heavy transformer/Generative Adversarial Network (GAN) decoders that strain memory and stability. To address these limitations, we propose Spec2VolCAMU-Net, a lightweight architecture featuring a Multi-directional Time-Frequency Convolutional Attention Encoder for rich feature extraction and a Vision-Mamba U-Net decoder that uses linear-time state-space blocks for efficient long-range spatial modelling. We frame the goal of this work as establishing a new state of the art in the spatial fidelity of single-volume reconstruction, a foundational prerequisite for the ultimate aim of generating temporally coherent fMRI time series. Trained end-to-end with a hybrid SSI-MSE loss, Spec2VolCAMU-Net achieves state-of-the-art fidelity on three public benchmarks, recording Structural Similarity Index (SSIM) of 0.693 on NODDI, 0.725 on Oddball and 0.788 on CN-EPFL, representing improvements of 14.5%, 14.9%, and 16.9% respectively over previous best SSIM scores. Furthermore, it achieves competitive Signal-to-Noise Ratio (PSNR) scores, particularly excelling on the CN-EPFL dataset with a 4.6% improvement over the previous best PSNR, thus striking a better balance in reconstruction quality. The proposed model is lightweight and efficient, making it suitable for real-time applications in clinical and research settings. The code is available at https://github.com/hdy6438/Spec2VolCAMU-Net.