Sheng Bi

Wenlong Hou, Sheng Bi, Guangqian Yang et al.

Alzheimer's disease (AD) is a growing global health challenge as populations age, and timely, accurate diagnosis is essential to reduce individual and societal burden. However, real-world AD assessment is hampered by incomplete, heterogeneous multimodal data and variability across sites and patient demographics. Although large language models (LLMs) have shown promise in biomedicine, their use in AD has largely been confined to answering narrow, disease-specific questions rather than generating comprehensive diagnostic reports that support clinical decision-making. Here we expand LLM capabilities for clinical decision support by introducing AD-CARE, a modality-agnostic agent that performs guideline-grounded diagnostic assessment from incomplete, heterogeneous inputs without imputing missing modalities. By dynamically orchestrating specialized diagnostic tools and embedding clinical guidelines into LLM-driven reasoning, AD-CARE generates transparent, report-style outputs aligned with real-world clinical workflows. Across six cohorts comprising 10,303 cases, AD-CARE achieved 84.9% diagnostic accuracy, delivering 4.2%-13.7% relative improvements over baseline methods. Despite cohort-level differences, dataset-specific accuracies remain robust (80.4%-98.8%), and the agent consistently outperforms all baselines. AD-CARE reduced performance disparities across racial and age subgroups, decreasing the average dispersion of four metrics by 21%-68% and 28%-51%, respectively. In a controlled reader study, the agent improved neurologist and radiologist accuracy by 6%-11% and more than halved decision time. The framework yielded 2.29%-10.66% absolute gains over eight backbone LLMs and converges their performance. These results show that AD-CARE is a scalable, practically deployable framework that can be integrated into routine clinical workflows for multimodal decision support in AD.

Jiaqi Li, Qianshan Wei, Chuanyi Zhang et al.

Machine unlearning empowers individuals with the `right to be forgotten' by removing their private or sensitive information encoded in machine learning models. However, it remains uncertain whether MU can be effectively applied to Multimodal Large Language Models (MLLMs), particularly in scenarios of forgetting the leaked visual data of concepts. To overcome the challenge, we propose an efficient method, Single Image Unlearning (SIU), to unlearn the visual recognition of a concept by fine-tuning a single associated image for few steps. SIU consists of two key aspects: (i) Constructing Multifaceted fine-tuning data. We introduce four targets, based on which we construct fine-tuning data for the concepts to be forgotten; (ii) Jointly training loss. To synchronously forget the visual recognition of concepts and preserve the utility of MLLMs, we fine-tune MLLMs through a novel Dual Masked KL-divergence Loss combined with Cross Entropy loss. Alongside our method, we establish MMUBench, a new benchmark for MU in MLLMs and introduce a collection of metrics for its evaluation. Experimental results on MMUBench show that SIU completely surpasses the performance of existing methods. Furthermore, we surprisingly find that SIU can avoid invasive membership inference attacks and jailbreak attacks. To the best of our knowledge, we are the first to explore MU in MLLMs. We will release the code and benchmark in the near future.

Jianyu Liu, Yi Huang, Sheng Bi et al.

In a conversational system, dynamically generating follow-up questions based on context can help users explore information and provide a better user experience. Humans are usually able to ask questions that involve some general life knowledge and demonstrate higher order cognitive skills. However, the questions generated by existing methods are often limited to shallow contextual questions that are uninspiring and have a large gap to the human level. In this paper, we propose a three-stage external knowledge-enhanced follow-up question generation method, which generates questions by identifying contextual topics, constructing a knowledge graph (KG) online, and finally combining these with a large language model to generate the final question. The model generates information-rich and exploratory follow-up questions by introducing external common sense knowledge and performing a knowledge fusion operation. Experiments show that compared to baseline models, our method generates questions that are more informative and closer to human questioning levels while maintaining contextual relevance.

Sheng Bi, Xiya Cheng, Yuan-Fang Li et al.

The ability to generate natural-language questions with controlled complexity levels is highly desirable as it further expands the applicability of question generation. In this paper, we propose an end-to-end neural complexity-controllable question generation model, which incorporates a mixture of experts (MoE) as the selector of soft templates to improve the accuracy of complexity control and the quality of generated questions. The soft templates capture question similarity while avoiding the expensive construction of actual templates. Our method introduces a novel, cross-domain complexity estimator to assess the complexity of a question, taking into account the passage, the question, the answer and their interactions. The experimental results on two benchmark QA datasets demonstrate that our QG model is superior to state-of-the-art methods in both automatic and manual evaluation. Moreover, our complexity estimator is significantly more accurate than the baselines in both in-domain and out-domain settings.

Shirong Shen, Tongtong Wu, Guilin Qi et al.

Event detection (ED) aims at detecting event trigger words in sentences and classifying them into specific event types. In real-world applications, ED typically does not have sufficient labelled data, thus can be formulated as a few-shot learning problem. To tackle the issue of low sample diversity in few-shot ED, we propose a novel knowledge-based few-shot event detection method which uses a definition-based encoder to introduce external event knowledge as the knowledge prior of event types. Furthermore, as external knowledge typically provides limited and imperfect coverage of event types, we introduce an adaptive knowledge-enhanced Bayesian meta-learning method to dynamically adjust the knowledge prior of event types. Experiments show our method consistently and substantially outperforms a number of baselines by at least 15 absolute F1 points under the same few-shot settings.

Sheng Bi, Xiya Cheng, Yuan-Fang Li et al.

Question generation over knowledge bases (KBQG) aims at generating natural-language questions about a subgraph, i.e. a set of (connected) triples. Two main challenges still face the current crop of encoder-decoder-based methods, especially on small subgraphs: (1) low diversity and poor fluency due to the limited information contained in the subgraphs, and (2) semantic drift due to the decoder's oblivion of the semantics of the answer entity. We propose an innovative knowledge-enriched, type-constrained and grammar-guided KBQG model, named KTG, to addresses the above challenges. In our model, the encoder is equipped with auxiliary information from the KB, and the decoder is constrained with word types during QG. Specifically, entity domain and description, as well as relation hierarchy information are considered to construct question contexts, while a conditional copy mechanism is incorporated to modulate question semantics according to current word types. Besides, a novel reward function featuring grammatical similarity is designed to improve both generative richness and syntactic correctness via reinforcement learning. Extensive experiments show that our proposed model outperforms existing methods by a significant margin on two widely-used benchmark datasets SimpleQuestion and PathQuestion.