John Morris

Sayantan Kumar, Tom Earnest, Braden Yang et al.

INTRODUCTION: Previous studies have applied normative modeling on a single neuroimaging modality to investigate Alzheimer Disease (AD) heterogeneity. We employed a deep learning-based multimodal normative framework to analyze individual-level variation across ATN (amyloid-tau-neurodegeneration) imaging biomarkers. METHODS: We selected cross-sectional discovery (n = 665) and replication cohorts (n = 430) with available T1-weighted MRI, amyloid and tau PET. Normative modeling estimated individual-level abnormal deviations in amyloid-positive individuals compared to amyloid-negative controls. Regional abnormality patterns were mapped at different clinical group levels to assess intra-group heterogeneity. An individual-level disease severity index (DSI) was calculated using both the spatial extent and magnitude of abnormal deviations across ATN. RESULTS: Greater intra-group heterogeneity in ATN abnormality patterns was observed in more severe clinical stages of AD. Higher DSI was associated with worse cognitive function and increased risk of disease progression. DISCUSSION: Subject-specific abnormality maps across ATN reveal the heterogeneous impact of AD on the brain.

Tejaswini Mallavarapu, Luke Cranfill, Junggab Son et al.

As online retail services proliferate and are pervasive in modern lives, applications for classifying fashion apparel features from image data are becoming more indispensable. Online retailers, from leading companies to start-ups, can leverage such applications in order to increase profit margin and enhance the consumer experience. Many notable schemes have been proposed to classify fashion items, however, the majority of which focused upon classifying basic-level categories, such as T-shirts, pants, skirts, shoes, bags, and so forth. In contrast to most prior efforts, this paper aims to enable an in-depth classification of fashion item attributes within the same category. Beginning with a single dress, we seek to classify the type of dress hem, the hem length, and the sleeve length. The proposed scheme is comprised of three major stages: (a) localization of a target item from an input image using semantic segmentation, (b) detection of human key points (e.g., point of shoulder) using a pre-trained CNN and a bounding box, and (c) three phases to classify the attributes using a combination of algorithmic approaches and deep neural networks. The experimental results demonstrate that the proposed scheme is highly effective, with all categories having average precision of above 93.02%, and outperforms existing Convolutional Neural Networks (CNNs)-based schemes.