Panayiota Poirazi

Michalis Pagkalos, Roman Makarov, Panayiota Poirazi

The brain is a remarkably capable and efficient system. It can process and store huge amounts of noisy and unstructured information using minimal energy. In contrast, current artificial intelligence (AI) systems require vast resources for training while still struggling to compete in tasks that are trivial for biological agents. Thus, brain-inspired engineering has emerged as a promising new avenue for designing sustainable, next-generation AI systems. Here, we describe how dendritic mechanisms of biological neurons have inspired innovative solutions for significant AI problems, including credit assignment in multilayer networks, catastrophic forgetting, and high energy consumption. These findings provide exciting alternatives to existing architectures, showing how dendritic research can pave the way for building more powerful and energy-efficient artificial learning systems.

Spyridon Chavlis, Panayiota Poirazi

Artificial neural networks (ANNs) are at the core of most Deep learning (DL) algorithms that successfully tackle complex problems like image recognition, autonomous driving, and natural language processing. However, unlike biological brains who tackle similar problems in a very efficient manner, DL algorithms require a large number of trainable parameters, making them energy-intensive and prone to overfitting. Here, we show that a new ANN architecture that incorporates the structured connectivity and restricted sampling properties of biological dendrites counteracts these limitations. We find that dendritic ANNs are more robust to overfitting and outperform traditional ANNs on several image classification tasks while using significantly fewer trainable parameters. These advantages are likely the result of a different learning strategy, whereby most of the nodes in dendritic ANNs respond to multiple classes, unlike classical ANNs that strive for class-specificity. Our findings suggest that the incorporation of dendritic properties can make learning in ANNs more precise, resilient, and parameter-efficient and shed new light on how biological features can impact the learning strategies of ANNs.

Anirvan Dutta, Simone Tasciotti, Claudia Cusseddu et al.

Estimating physical properties is critical for safe and efficient autonomous robotic manipulation, particularly during contact-rich interactions. In such settings, vision and tactile sensing provide complementary information about object geometry, pose, inertia, stiffness, and contact dynamics, such as stick-slip behavior. However, these properties are only indirectly observable and cannot always be modeled precisely (e.g., deformation in non-rigid objects coupled with nonlinear contact friction), making the estimation problem inherently complex and requiring sustained exploitation of visuo-tactile sensory information during action. Existing visuo-tactile perception frameworks have primarily emphasized forceful sensor fusion or static cross-modal alignment, with limited consideration of how uncertainty and beliefs about object properties evolve over time. Inspired by human multi-sensory perception and active inference, we propose the Cross-Modal Latent Filter (CMLF) to learn a structured, causal latent state-space of physical object properties. CMLF supports bidirectional transfer of cross-modal priors between vision and touch and integrates sensory evidence through a Bayesian inference process that evolves over time. Real-world robotic experiments demonstrate that CMLF improves the efficiency and robustness of latent physical properties estimation under uncertainty compared to baseline approaches. Beyond performance gains, the model exhibits perceptual coupling phenomena analogous to those observed in humans, including susceptibility to cross-modal illusions and similar trajectories in learning cross-sensory associations. Together, these results constitutes a significant step toward generalizable, robust and physically consistent cross-modal integration for robotic multi-sensory perception.

Kosmas Pinitas, Spyridon Chavlis, Panayiota Poirazi

Current deep learning architectures show remarkable performance when trained in large-scale, controlled datasets. However, the predictive ability of these architectures significantly decreases when learning new classes incrementally. This is due to their inclination to forget the knowledge acquired from previously seen data, a phenomenon termed catastrophic-forgetting. On the other hand, Self-Organizing Maps (SOMs) can model the input space utilizing constrained k-means and thus maintain past knowledge. Here, we propose a novel algorithm inspired by biological neurons, termed Dendritic-Self-Organizing Map (DendSOM). DendSOM consists of a single layer of SOMs, which extract patterns from specific regions of the input space accompanied by a set of hit matrices, one per SOM, which estimate the association between units and labels. The best-matching unit of an input pattern is selected using the maximum cosine similarity rule, while the point-wise mutual information is employed for class inference. DendSOM performs unsupervised feature extraction as it does not use labels for targeted updating of the weights. It outperforms classical SOMs and several state-of-the-art continual learning algorithms on benchmark datasets, such as the Split-MNIST and Split-CIFAR-10. We propose that the incorporation of neuronal properties in SOMs may help remedy catastrophic forgetting.

Eirini Troullinou, Grigorios Tsagkatakis, Spyridon Chavlis et al.

Identification of different neuronal cell types is critical for understanding their contribution to brain functions. Yet, automated and reliable classification of neurons remains a challenge, primarily because of their biological complexity. Typical approaches include laborious and expensive immunohistochemical analysis while feature extraction algorithms based on cellular characteristics have recently been proposed. The former rely on molecular markers, which are often expressed in many cell types, while the latter suffer from similar issues: finding features that are distinctive for each class has proven to be equally challenging. Moreover, both approaches are time consuming and demand a lot of human intervention. In this work we establish the first, automated cell-type classification method that relies on neuronal activity rather than molecular or cellular features. We test our method on a real-world dataset comprising of raw calcium activity signals for four neuronal types. We compare the performance of three different deep learning models and demonstrate that our method can achieve automated classification of neuronal cell types with unprecedented accuracy.