Yilin He

Jinquan Guan, Junhong Guo, Qi Chen et al.

Oral Squamous Cell Carcinoma (OSCC) is a prevalent and aggressive malignancy where deep learning-based computer-aided diagnosis and prognosis can enhance clinical assessments.However, existing publicly available OSCC datasets often suffer from limited patient cohorts and a restricted focus on either diagnostic or prognostic tasks, limiting the development of comprehensive and generalizable models. To bridge this gap, we introduce Multi-OSCC, a new histopathology image dataset comprising 1,325 OSCC patients, integrating both diagnostic and prognostic information to expand existing public resources. Each patient is represented by six high resolution histopathology images captured at x200, x400, and x1000 magnifications-two per magnification-covering both the core and edge tumor regions.The Multi-OSCC dataset is richly annotated for six critical clinical tasks: recurrence prediction (REC), lymph node metastasis (LNM), tumor differentiation (TD), tumor invasion (TI), cancer embolus (CE), and perineural invasion (PI). To benchmark this dataset, we systematically evaluate the impact of different visual encoders, multi-image fusion techniques, stain normalization, and multi-task learning frameworks. Our analysis yields several key insights: (1) The top-performing models achieve excellent results, with an Area Under the Curve (AUC) of 94.72% for REC and 81.23% for TD, while all tasks surpass 70% AUC; (2) Stain normalization benefits diagnostic tasks but negatively affects recurrence prediction; (3) Multi-task learning incurs a 3.34% average AUC degradation compared to single-task models in our multi-task benchmark, underscoring the challenge of balancing multiple tasks in our dataset. To accelerate future research, we publicly release the Multi-OSCC dataset and baseline models at https://github.com/guanjinquan/OSCC-PathologyImageDataset.

Yilin He, Chaojie Wang, Hao Zhang et al.

Graph neural networks (GNNs), which propagate the node features through the edges and learn how to transform the aggregated features under label supervision, have achieved great success in supervised feature extraction for both node-level and graph-level classification tasks. However, GNNs typically treat the graph structure as given and ignore how the edges are formed. This paper introduces a graph generative process to model how the observed edges are generated by aggregating the node interactions over a set of overlapping node communities, each of which contributes to the edges via a logical OR mechanism. Based on this generative model, we partition each edge into the summation of multiple community-specific weighted edges and use them to define community-specific GNNs. A variational inference framework is proposed to jointly learn a GNN-based inference network that partitions the edges into different communities, these community-specific GNNs, and a GNN-based predictor that combines community-specific GNNs for the end classification task. Extensive evaluations on real-world graph datasets have verified the effectiveness of the proposed method in learning discriminative representations for both node-level and graph-level classification tasks.