Mohit Meena

Sahar Almahfouz Nasser, Nikhil Cherian Kurian, Saqib Shamsi et al.

We present WSSAMNet, a weakly supervised method for medical image registration. Ours is a two step method, with the first step being the computation of segmentation masks of the fixed and moving volumes. These masks are then used to attend to the input volume, which are then provided as inputs to a registration network in the second step. The registration network computes the deformation field to perform the alignment between the fixed and the moving volumes. We study the effectiveness of our technique on the BraTSReg challenge data against ANTs and VoxelMorph, where we demonstrate that our method performs competitively.

Sahar Almahfouz Nasser, Shashwat Pathak, Keshav Singhal et al.

Graph neural networks (GNNs) present a promising alternative to CNNs and transformers in certain image processing applications due to their parameter-efficiency in modeling spatial relationships. Currently, a major area of research involves the converting non-graph input data for GNN-based models, notably in scenarios where the data originates from images. One approach involves converting images into nodes by identifying significant keypoints within them. Super-Retina, a semi-supervised technique, has been utilized for detecting keypoints in retinal images. However, its limitations lie in the dependency on a small initial set of ground truth keypoints, which is progressively expanded to detect more keypoints. Having encountered difficulties in detecting consistent initial keypoints in brain images using SIFT and LoFTR, we proposed a new approach: radiomic feature-based keypoint detection. Demonstrating the anatomical significance of the detected keypoints was achieved by showcasing their efficacy in improving registration processes guided by these keypoints. Subsequently, these keypoints were employed as the ground truth for the keypoint detection method (LK-SuperRetina). Furthermore, the study showcases the application of GNNs in image matching, highlighting their superior performance in terms of both the number of good matches and confidence scores. This research sets the stage for expanding GNN applications into various other applications, including but not limited to image classification, segmentation, and registration.

Mohit Meena, Yash Punjabi, Abhishek A et al.

Graph Neural Networks (GNNs) have emerged as powerful tools for learning over graph-structured data, yet recent studies have shown that their performance gains are beginning to plateau. In many cases, well-established models such as GCN and GAT, when appropriately tuned, can match or even exceed the performance of more complex, state-of-the-art architectures. This trend highlights a key limitation in the current landscape: the difficulty of selecting the most suitable model for a given graph task or dataset. To address this, we propose Self-Adaptive Graph Mixture of Models (SAGMM), a modular and practical framework that learns to automatically select and combine the most appropriate GNN models from a diverse pool of architectures. Unlike prior mixture-of-experts approaches that rely on variations of a single base model, SAGMM leverages architectural diversity and a topology-aware attention gating mechanism to adaptively assign experts to each node based on the structure of the input graph. To improve efficiency, SAGMM includes a pruning mechanism that reduces the number of active experts during training and inference without compromising performance. We also explore a training-efficient variant in which expert models are pretrained and frozen, and only the gating and task-specific layers are trained. We evaluate SAGMM on 16 benchmark datasets covering node classification, graph classification, regression, and link prediction tasks, and demonstrate that it consistently outperforms or matches leading GNN baselines and prior mixture-based methods, offering a robust and adaptive solution for real-world graph learning.

Bhakti Baheti, Satrajit Chakrabarty, Hamed Akbari et al.

Registration of longitudinal brain MRI scans containing pathologies is challenging due to dramatic changes in tissue appearance. Although there has been progress in developing general-purpose medical image registration techniques, they have not yet attained the requisite precision and reliability for this task, highlighting its inherent complexity. Here we describe the Brain Tumor Sequence Registration (BraTS-Reg) challenge, as the first public benchmark environment for deformable registration algorithms focusing on estimating correspondences between pre-operative and follow-up scans of the same patient diagnosed with a diffuse brain glioma. The BraTS-Reg data comprise de-identified multi-institutional multi-parametric MRI (mpMRI) scans, curated for size and resolution according to a canonical anatomical template, and divided into training, validation, and testing sets. Clinical experts annotated ground truth (GT) landmark points of anatomical locations distinct across the temporal domain. Quantitative evaluation and ranking were based on the Median Euclidean Error (MEE), Robustness, and the determinant of the Jacobian of the displacement field. The top-ranked methodologies yielded similar performance across all evaluation metrics and shared several methodological commonalities, including pre-alignment, deep neural networks, inverse consistency analysis, and test-time instance optimization per-case basis as a post-processing step. The top-ranked method attained the MEE at or below that of the inter-rater variability for approximately 60% of the evaluated landmarks, underscoring the scope for further accuracy and robustness improvements, especially relative to human experts. The aim of BraTS-Reg is to continue to serve as an active resource for research, with the data and online evaluation tools accessible at https://bratsreg.github.io/.