Q.Y. Li

Chenjun Li, Dian Yang, Shun Yao et al.

In this study, we developed an Evidence-based Ensemble Neural Network, namely EVENet, for anatomical brain parcellation using diffusion MRI. The key innovation of EVENet is the design of an evidential deep learning framework to quantify predictive uncertainty at each voxel during a single inference. To do so, we design an evidence-based ensemble learning framework for uncertainty-aware parcellation to leverage the multiple dMRI parameters derived from diffusion MRI. Using EVENet, we obtained accurate parcellation and uncertainty estimates across different datasets from healthy and clinical populations and with different imaging acquisitions. The overall network includes five parallel subnetworks, where each is dedicated to learning the FreeSurfer parcellation for a certain diffusion MRI parameter. An evidence-based ensemble methodology is then proposed to fuse the individual outputs. We perform experimental evaluations on large-scale datasets from multiple imaging sources, including high-quality diffusion MRI data from healthy adults and clinically diffusion MRI data from participants with various brain diseases (schizophrenia, bipolar disorder, attention-deficit/hyperactivity disorder, Parkinson's disease, cerebral small vessel disease, and neurosurgical patients with brain tumors). Compared to several state-of-the-art methods, our experimental results demonstrate highly improved parcellation accuracy across the multiple testing datasets despite the differences in dMRI acquisition protocols and health conditions. Furthermore, thanks to the uncertainty estimation, our EVENet approach demonstrates a good ability to detect abnormal brain regions in patients with lesions, enhancing the interpretability and reliability of the segmentation results.

Quanjiang Li, Zhiming Liu, Wei Luo et al.

Multimodal large language models (MLLMs) frequently suffer from object hallucinations, yet the visual perceptual mechanism underlying this failure remains poorly understood. In this work, we reveal that hallucinations are strongly associated with a human-like attention distraction phenomenon, where humans under divided focus experience degraded visual clarity and produce inaccurate descriptions, while in models the same mechanism manifests as spatial inconsistency in multi-head attention and temporal fading of attention to image tokens during decoding. We further provide theoretical insights that attention dispersion increases model complexity and degrades classification generalization. Motivated by these findings, we propose an Attention-Focused Approach for Improved Image Perception (AFIP), which corrects attention distraction via cross-head attention enrichment and reinforces visual grounding through dynamic historical attention enhancement. Extensive experiments on multiple benchmarks and models validate the effectiveness of AFIP without additional training.

Qiyuan Li, Haijiang Liu, Caicai Guo et al.

The large-scale development of large language models (LLMs) in medical contexts, such as diagnostic assistance and treatment recommendations, necessitates that these models possess accurate medical knowledge and deliver traceable decision-making processes. Clinical knowledge, encompassing the insights gained from research on the causes, prognosis, diagnosis, and treatment of diseases, has been extensively examined within real-world medical practices. Recently, there has been a notable increase in research efforts aimed at integrating this type of knowledge into LLMs, encompassing not only traditional text and multimodal data integration but also technologies such as knowledge graphs (KGs) and retrieval-augmented generation (RAG). In this paper, we review the various initiatives to embed clinical knowledge into training-based, KG-supported, and RAG-assisted LLMs. We begin by gathering reliable knowledge sources from the medical domain, including databases and datasets. Next, we evaluate implementations for integrating clinical knowledge through specialized datasets and collaborations with external knowledge sources such as KGs and relevant documentation. Furthermore, we discuss the applications of the developed medical LLMs in the industrial sector to assess the disparity between models developed in academic settings and those in industry. We conclude the survey by presenting evaluation systems applicable to relevant tasks and identifying potential challenges facing this field. In this review, we do not aim for completeness, since any ostensibly complete review would soon be outdated. Our goal is to illustrate diversity by selecting representative and accessible items from current research and industry practices, reflecting real-world situations rather than claiming completeness. Thus, we emphasize showcasing diverse approaches.