Simon See

Xiufeng Huang, Ka Chun Cheung, Simon See et al.

Remarkable advancements in the recolorization of Neural Radiance Fields (NeRF) have simplified the process of modifying NeRF's color attributes. Yet, with the potential of NeRF to serve as shareable digital assets, there's a concern that malicious users might alter the color of NeRF models and falsely claim the recolorized version as their own. To safeguard against such breaches of ownership, enabling original NeRF creators to establish rights over recolorized NeRF is crucial. While approaches like CopyRNeRF have been introduced to embed binary messages into NeRF models as digital signatures for copyright protection, the process of recolorization can remove these binary messages. In our paper, we present GeometrySticker, a method for seamlessly integrating binary messages into the geometry components of radiance fields, akin to applying a sticker. GeometrySticker can embed binary messages into NeRF models while preserving the effectiveness of these messages against recolorization. Our comprehensive studies demonstrate that GeometrySticker is adaptable to prevalent NeRF architectures and maintains a commendable level of robustness against various distortions. Project page: https://kevinhuangxf.github.io/GeometrySticker/.

Yuxin Zhang, Yiyao Li, Ping Shu Ho et al.

Cell Painting combines multiplexed fluorescent staining, high-content imaging, and quantitative analysis to generate high-dimensional phenotypic readouts to support diverse downstream tasks such as mechanism-of-action (MoA) inference, toxicity prediction, and construction of drug-disease atlases. However, existing workflows are slow, costly and difficult to interpret. Approaches for drug screening modeling predominantly focus on molecular representation learning, while neglecting actual experimental context (e.g., cell line, dosing schedule, etc.), limiting generalization and MoA resolution. We introduce CP-Agent, an agentic multimodal large language model (MLLM) capable of generating mechanism-relevant, human-interpretable rationales for cell morphological changes under drug perturbations. At its core, CP-Agent leverages a context-aware alignment module, CP-CLIP, that jointly embeds high-content images and experimental metadata to enable robust treatment and MoA discrimination (achieving a maximum F1-score of 0.896). By integrating CP-CLIP outputs with agentic tool usage and reasoning, CP-Agent compiles rationales into a structured report to guide experimental design and hypothesis refinement. These capabilities highlight CP-Agent's potential to accelerate drug discovery by enabling more interpretable, scalable, and context-aware phenotypic screening -- streamlining iterative cycles of hypothesis generation in drug discovery.

Xiufeng Huang, Ruiqi Li, Yiu-ming Cheung et al.

3D Gaussian Splatting (3DGS) has become a crucial method for acquiring 3D assets. To protect the copyright of these assets, digital watermarking techniques can be applied to embed ownership information discreetly within 3DGS models. However, existing watermarking methods for meshes, point clouds, and implicit radiance fields cannot be directly applied to 3DGS models, as 3DGS models use explicit 3D Gaussians with distinct structures and do not rely on neural networks. Naively embedding the watermark on a pre-trained 3DGS can cause obvious distortion in rendered images. In our work, we propose an uncertainty-based method that constrains the perturbation of model parameters to achieve invisible watermarking for 3DGS. At the message decoding stage, the copyright messages can be reliably extracted from both 3D Gaussians and 2D rendered images even under various forms of 3D and 2D distortions. We conduct extensive experiments on the Blender, LLFF and MipNeRF-360 datasets to validate the effectiveness of our proposed method, demonstrating state-of-the-art performance on both message decoding accuracy and view synthesis quality.

Gavin Wong, Ping Shu Ho, Ivan Au Yeung et al.

Biological pathways map gene-gene interactions that govern all human processes. Despite their importance, most ML models treat genes as unstructured tokens, discarding known pathway structure. The latest pathway-informed models capture pathway-pathway interactions, but still treat each pathway as a "bag of genes" via MLPs, discarding its topology and gene-gene interactions. We propose a Graph Attention Network (GAT) framework that models pathways at the gene level. We show that GATs generalize much better than MLPs, achieving an 81% reduction in MSE when predicting pathway dynamics under unseen treatment conditions. We further validate the correctness of our biological prior by encoding drug mechanisms via edge interventions, boosting model robustness. Finally, we show that our GAT model is able to correctly rediscover all five gene-gene interactions in the canonical TP53-MDM2-MDM4 feedback loop from raw time-series mRNA data, demonstrating potential to generate novel biological hypotheses directly from experimental data.