Ming Hu

Yiheng Zhong, Zihong Luo, Chengzhi Liu et al.

Segment Anything Model (SAM) demonstrates powerful zero-shot capabilities; however, its accuracy and robustness significantly decrease when applied to medical image segmentation. Existing methods address this issue through modality fusion, integrating textual and image information to provide more detailed priors. In this study, we argue that the granularity of text and the domain gap affect the accuracy of the priors. Furthermore, the discrepancy between high-level abstract semantics and pixel-level boundary details in images can introduce noise into the fusion process. To address this, we propose Prior-Guided SAM (PG-SAM), which employs a fine-grained modality prior aligner to leverage specialized medical knowledge for better modality alignment. The core of our method lies in efficiently addressing the domain gap with fine-grained text from a medical LLM. Meanwhile, it also enhances the priors' quality after modality alignment, ensuring more accurate segmentation. In addition, our decoder enhances the model's expressive capabilities through multi-level feature fusion and iterative mask optimizer operations, supporting unprompted learning. We also propose a unified pipeline that effectively supplies high-quality semantic information to SAM. Extensive experiments on the Synapse dataset demonstrate that the proposed PG-SAM achieves state-of-the-art performance. Our code is released at https://github.com/logan-0623/PG-SAM.

Ming Hu, Kun Yuan, Yaling Shen et al.

Surgical practice involves complex visual interpretation, procedural skills, and advanced medical knowledge, making surgical vision-language pretraining (VLP) particularly challenging due to this complexity and the limited availability of annotated data. To address the gap, we propose OphCLIP, a hierarchical retrieval-augmented vision-language pretraining framework specifically designed for ophthalmic surgical workflow understanding. OphCLIP leverages the OphVL dataset we constructed, a large-scale and comprehensive collection of over 375K hierarchically structured video-text pairs with tens of thousands of different combinations of attributes (surgeries, phases/operations/actions, instruments, medications, as well as more advanced aspects like the causes of eye diseases, surgical objectives, and postoperative recovery recommendations, etc). These hierarchical video-text correspondences enable OphCLIP to learn both fine-grained and long-term visual representations by aligning short video clips with detailed narrative descriptions and full videos with structured titles, capturing intricate surgical details and high-level procedural insights, respectively. Our OphCLIP also designs a retrieval-augmented pretraining framework to leverage the underexplored large-scale silent surgical procedure videos, automatically retrieving semantically relevant content to enhance the representation learning of narrative videos. Evaluation across 11 datasets for phase recognition and multi-instrument identification shows OphCLIP's robust generalization and superior performance.

Tianbin Li, Yanzhou Su, Wei Li et al.

Despite significant advancements in general AI, its effectiveness in the medical domain is limited by the lack of specialized medical knowledge. To address this, we formulate GMAI-VL-5.5M, a multimodal medical dataset created by converting hundreds of specialized medical datasets with various annotations into high-quality image-text pairs. This dataset offers comprehensive task coverage, diverse modalities, and rich image-text data. Building upon this dataset, we develop GMAI-VL, a general medical vision-language model, with a three-stage training strategy that enhances the integration of visual and textual information. This approach significantly improves the model's ability to process multimodal data, supporting accurate diagnoses and clinical decision-making. Experiments show that GMAI-VL achieves state-of-the-art performance across various multimodal medical tasks, including visual question answering and medical image diagnosis.

Feilong Tang, Zhongxing Xu, Ming Hu et al.

In medical image analysis, multi-organ semi-supervised segmentation faces challenges such as insufficient labels and low contrast in soft tissues. To address these issues, existing studies typically employ semi-supervised segmentation techniques using pseudo-labeling and consistency regularization. However, these methods mainly rely on individual data samples for training, ignoring the rich neighborhood information present in the feature space. In this work, we argue that supervisory information can be directly extracted from the geometry of the feature space. Inspired by the density-based clustering hypothesis, we propose using feature density to locate sparse regions within feature clusters. Our goal is to increase intra-class compactness by addressing sparsity issues. To achieve this, we propose a Density-Aware Contrastive Learning (DACL) strategy, pushing anchored features in sparse regions towards cluster centers approximated by high-density positive samples, resulting in more compact clusters. Specifically, our method constructs density-aware neighbor graphs using labeled and unlabeled data samples to estimate feature density and locate sparse regions. We also combine label-guided co-training with density-guided geometric regularization to form complementary supervision for unlabeled data. Experiments on the Multi-Organ Segmentation Challenge dataset demonstrate that our proposed method outperforms state-of-the-art methods, highlighting its efficacy in medical image segmentation tasks.