Shaojie Li

Shaojie Li, Zhaoshuo Diao

The recent development of deep learning large models in medicine shows remarkable performance in medical image analysis and diagnosis, but their large number of parameters causes memory and inference latency challenges. Knowledge distillation offers a solution, but the slide-level gradients cannot be backpropagated for student model updates due to high-resolution pathological images and slide-level labels. This study presents an Efficient Fine-tuning on Compressed Models (EFCM) framework with two stages: unsupervised feature distillation and fine-tuning. In the distillation stage, Feature Projection Distillation (FPD) is proposed with a TransScan module for adaptive receptive field adjustment to enhance the knowledge absorption capability of the student model. In the slide-level fine-tuning stage, three strategies (Reuse CLAM, Retrain CLAM, and End2end Train CLAM (ETC)) are compared. Experiments are conducted on 11 downstream datasets related to three large medical models: RETFound for retina, MRM for chest X-ray, and BROW for histopathology. The experimental results demonstrate that the EFCM framework significantly improves accuracy and efficiency in handling slide-level pathological image problems, effectively addressing the challenges of deploying large medical models. Specifically, it achieves a 4.33% increase in ACC and a 5.2% increase in AUC compared to the large model BROW on the TCGA-NSCLC and TCGA-BRCA datasets. The analysis of model inference efficiency highlights the high efficiency of the distillation fine-tuning method.

Shaojie Li, Haichen Qu, Xinqi Dong et al.

Exploring the application of deep learning technologies in the field of medical diagnostics, Magnetic Resonance Imaging (MRI) provides a unique perspective for observing and diagnosing complex neurodegenerative diseases such as Alzheimer Disease (AD). With advancements in deep learning, particularly in Convolutional Neural Networks (CNNs) and the Xception network architecture, we are now able to analyze and classify vast amounts of MRI data with unprecedented accuracy. The progress of this technology not only enhances our understanding of brain structural changes but also opens up new avenues for monitoring disease progression through non-invasive means and potentially allows for precise diagnosis in the early stages of the disease. This study aims to classify MRI images using deep learning models to identify different stages of Alzheimer Disease through a series of innovative data processing and model construction steps. Our experimental results show that the deep learning framework based on the Xception model achieved a 99.6% accuracy rate in the multi-class MRI image classification task, demonstrating its potential application value in assistive diagnosis. Future research will focus on expanding the dataset, improving model interpretability, and clinical validation to further promote the application of deep learning technology in the medical field, with the hope of bringing earlier diagnosis and more personalized treatment plans to Alzheimer Disease patients.