Patrick Langer

Fan Wu, Tsai-Ning Wang, Nicolas Zumarraga et al. · eth-zurich, harvard

Auscultation is a vital diagnostic tool, yet its utility is often limited by subjective interpretation. While general-purpose Audio-Language Models (ALMs) excel in general domains, they struggle with the nuances of physiological signals. We propose a framework that aligns multi-site auscultation recordings directly with a frozen Large Language Model (LLM) embedding space via gated cross-attention. By leveraging the LLM's latent world knowledge, our approach moves beyond isolated classification toward holistic, patient-level assessment. On the CaReSound benchmark, our model achieves a state-of-the-art 0.865 F1-macro and 0.952 BERTScore. We demonstrate that lightweight, domain-specific encoders rival large-scale ALMs and that multi-site aggregation provides spatial redundancy that mitigates temporal truncation. This alignment of medical acoustics with text foundations offers a scalable path for bridging signal processing and clinical assessment.

Kevin Riehl, Andres L. Marin, Nikofors Zacharof et al.

Scientific peer review increasingly struggles to assess reproducibility at the scale and complexity of modern research output. Evaluating reproducibility requires reconstructing experimental dependencies, methodological choices, data flows, and result-generating procedures, which often exceeds what human reviewers can provide. Agentic Reproducibility Assessment (ARA) formalizes reproducibility assessment as a structured reasoning task over scientific documents. Given a paper, ARA extracts a directed workflow graph linking sources, methods, experiments, and outputs, then evaluates its reconstructability using structural and content-based scores for reproducibility assessments. Experiments on 213 ReScience C articles - the largest cross-domain benchmark of human-validated computational reproducibility studies considered to date - demonstrate ARA's generalizability and consistent workflow reconstruction and assessment across LLMs, model temperatures, and scientific domains. ARA achieves ~61% accuracy on three benchmarks, and the highest accuracy reported on ReproBench (60.71% vs. 36.84%) and GoldStandardDB (61.68% vs. 43.56%), highlighting its potential to complement human review at scale and enabling next-generation peer review. Code and Data available: https://github.com/AndresLaverdeMarin/agentic_reproducibility_assessment.

Patrick Langer, Thomas Kaar, Max Rosenblattl et al.

LLMs have emerged as powerful tools for interpreting multimodal data. In medicine, they hold particular promise for synthesizing large volumes of clinical information into actionable insights and digital health applications. Yet, a major limitation remains their inability to handle time series. To overcome this gap, we present OpenTSLM, a family of Time Series Language Models (TSLMs) created by integrating time series as a native modality to pretrained LLMs, enabling reasoning over multiple time series of any length. We investigate two architectures for OpenTSLM. The first, OpenTSLM-SoftPrompt, models time series implicitly by concatenating learnable time series tokens with text tokens via soft prompting. Although parameter-efficient, we hypothesize that explicit time series modeling scales better and outperforms implicit approaches. We thus introduce OpenTSLM-Flamingo, which integrates time series with text via cross-attention. We benchmark both variants against baselines that treat time series as text tokens or plots, across a suite of text-time-series Chain-of-Thought (CoT) reasoning tasks. We introduce three datasets: HAR-CoT, Sleep-CoT, and ECG-QA-CoT. Across all, OpenTSLM models outperform baselines, reaching 69.9 F1 in sleep staging and 65.4 in HAR, compared to 9.05 and 52.2 for finetuned text-only models. Notably, even 1B-parameter OpenTSLM models surpass GPT-4o (15.47 and 2.95). OpenTSLM-Flamingo matches OpenTSLM-SoftPrompt in performance and outperforms on longer sequences, while maintaining stable memory requirements. By contrast, SoftPrompt grows exponentially in memory with sequence length, requiring around 110 GB compared to 40 GB VRAM when training on ECG-QA with LLaMA-3B. Expert reviews by clinicians find strong reasoning capabilities exhibited by OpenTSLMs on ECG-QA. To facilitate further research, we provide all code, datasets, and models open-source.

Frederik Rajiv Manichand, Robin Deuber, Robert Jakob et al. · eth-zurich, harvard

Estimating Body Mass Index (BMI) from camera images with machine learning models enables rapid weight assessment when traditional methods are unavailable or impractical, such as in telehealth or emergency scenarios. Existing computer vision approaches have been limited to datasets of up to 14,500 images. In this study, we present a deep learning-based BMI estimation method trained on our WayBED dataset, a large proprietary collection of 84,963 smartphone images from 25,353 individuals. We introduce an automatic filtering method that uses posture clustering and person detection to curate the dataset by removing low-quality images, such as those with atypical postures or incomplete views. This process retained 71,322 high-quality images suitable for training. We achieve a Mean Absolute Percentage Error (MAPE) of 7.9% on our hold-out test set (WayBED data) using full-body images, the lowest value in the published literature to the best of our knowledge. Further, we achieve a MAPE of 13% on the completely unseen~(during training) VisualBodyToBMI dataset, comparable with state-of-the-art approaches trained on it, demonstrating robust generalization. Lastly, we fine-tune our model on VisualBodyToBMI and achieve a MAPE of 8.56%, the lowest reported value on this dataset so far. We deploy the full pipeline, including image filtering and BMI estimation, on Android devices using the CLAID framework. We release our complete code for model training, filtering, and the CLAID package for mobile deployment as open-source contributions.