Yinan Chen

Ran Gu, Guotai Wang, Jiangshan Lu et al.

Generalization to previously unseen images with potential domain shifts and different styles is essential for clinically applicable medical image segmentation, and the ability to disentangle domain-specific and domain-invariant features is key for achieving Domain Generalization (DG). However, existing DG methods can hardly achieve effective disentanglement to get high generalizability. To deal with this problem, we propose an efficient Contrastive Domain Disentanglement and Style Augmentation (CDDSA) framework for generalizable medical image segmentation. First, a disentangle network is proposed to decompose an image into a domain-invariant anatomical representation and a domain-specific style code, where the former is sent to a segmentation model that is not affected by the domain shift, and the disentangle network is regularized by a decoder that combines the anatomical and style codes to reconstruct the input image. Second, to achieve better disentanglement, a contrastive loss is proposed to encourage the style codes from the same domain and different domains to be compact and divergent, respectively. Thirdly, to further improve generalizability, we propose a style augmentation method based on the disentanglement representation to synthesize images in various unseen styles with shared anatomical structures. Our method was validated on a public multi-site fundus image dataset for optic cup and disc segmentation and an in-house multi-site Nasopharyngeal Carcinoma Magnetic Resonance Image (NPC-MRI) dataset for nasopharynx Gross Tumor Volume (GTVnx) segmentation. Experimental results showed that the proposed CDDSA achieved remarkable generalizability across different domains, and it outperformed several state-of-the-art methods in domain-generalizable segmentation.

Jianghao Wu, Guotai Wang, Ran Gu et al.

Domain Adaptation (DA) is important for deep learning-based medical image segmentation models to deal with testing images from a new target domain. As the source-domain data are usually unavailable when a trained model is deployed at a new center, Source-Free Domain Adaptation (SFDA) is appealing for data and annotation-efficient adaptation to the target domain. However, existing SFDA methods have a limited performance due to lack of sufficient supervision with source-domain images unavailable and target-domain images unlabeled. We propose a novel Uncertainty-aware Pseudo Label guided (UPL) SFDA method for medical image segmentation. Specifically, we propose Target Domain Growing (TDG) to enhance the diversity of predictions in the target domain by duplicating the pre-trained model's prediction head multiple times with perturbations. The different predictions in these duplicated heads are used to obtain pseudo labels for unlabeled target-domain images and their uncertainty to identify reliable pseudo labels. We also propose a Twice Forward pass Supervision (TFS) strategy that uses reliable pseudo labels obtained in one forward pass to supervise predictions in the next forward pass. The adaptation is further regularized by a mean prediction-based entropy minimization term that encourages confident and consistent results in different prediction heads. UPL-SFDA was validated with a multi-site heart MRI segmentation dataset, a cross-modality fetal brain segmentation dataset, and a 3D fetal tissue segmentation dataset. It improved the average Dice by 5.54, 5.01 and 6.89 percentage points for the three tasks compared with the baseline, respectively, and outperformed several state-of-the-art SFDA methods.

Yinan Chen, Chuming Lin, Zhennan Chen et al.

While instruction-based video editing has seen significant progress, joint audio-visual editing remains constrained by the absence of dedicated datasets and benchmarks. To bridge this gap, we present JAVEdit-100k, the first large-scale, high-quality dataset tailored for instruction-guided joint audio-visual editing. Focusing on human-centric videos, JAVEdit-100k comprises approximately 100K editing triplets spanning five distinct categories, including subject editing and speech editing. This dataset is rigorously constructed via four meticulously designed generation pipelines, seamlessly paired with an agent-in-the-loop quality control mechanism. Furthermore, to address the lack of standardized evaluation within the field, we introduce JAVEditBench, a comprehensive benchmark featuring curated source videos and human-aligned instructions across all editing categories. Finally, we propose JAVEdit, a pioneering baseline model for instruction-guided joint audio-visual editing. Experiments show that \model\ outperforms all baselines on five of six evaluation metrics.

Shuo Han, Jiacheng Liu, Jiayun Wu et al. · pku

Graph Representation Learning (GRL) is an influential methodology, enabling a more profound understanding of graph-structured data and aiding graph clustering, a critical task across various domains. The recent incursion of attention mechanisms, originally an artifact of Natural Language Processing (NLP), into the realm of graph learning has spearheaded a notable shift in research trends. Consequently, Graph Attention Networks (GATs) and Graph Attention Auto-Encoders have emerged as preferred tools for graph clustering tasks. Yet, these methods primarily employ a local attention mechanism, thereby curbing their capacity to apprehend the intricate global dependencies between nodes within graphs. Addressing these impediments, this study introduces an innovative method known as the Graph Transformer Auto-Encoder for Graph Clustering (GTAGC). By melding the Graph Auto-Encoder with the Graph Transformer, GTAGC is adept at capturing global dependencies between nodes. This integration amplifies the graph representation and surmounts the constraints posed by the local attention mechanism. The architecture of GTAGC encompasses graph embedding, integration of the Graph Transformer within the autoencoder structure, and a clustering component. It strategically alternates between graph embedding and clustering, thereby tailoring the Graph Transformer for clustering tasks, whilst preserving the graph's global structural information. Through extensive experimentation on diverse benchmark datasets, GTAGC has exhibited superior performance against existing state-of-the-art graph clustering methodologies.

Qi Su, Na Wang, Jiawen Xie et al.

The automatic lung lobe segmentation algorithm is of great significance for the diagnosis and treatment of lung diseases, however, which has great challenges due to the incompleteness of pulmonary fissures in lung CT images and the large variability of pathological features. Therefore, we propose a new automatic lung lobe segmentation framework, in which we urge the model to pay attention to the area around the pulmonary fissure during the training process, which is realized by a task-specific loss function. In addition, we introduce an end-to-end pulmonary fissure generation method in the auxiliary pulmonary fissure segmentation task, without any additional network branch. Finally, we propose a registration-based loss function to alleviate the convergence difficulty of the Dice loss supervised pulmonary fissure segmentation task. We achieve 97.83% and 94.75% dice scores on our private dataset STLB and public LUNA16 dataset respectively.

Zhucun Xue, Jiangning Zhang, Teng Hu et al.

The quality of the video dataset (image quality, resolution, and fine-grained caption) greatly influences the performance of the video generation model. The growing demand for video applications sets higher requirements for high-quality video generation models. For example, the generation of movie-level Ultra-High Definition (UHD) videos and the creation of 4K short video content. However, the existing public datasets cannot support related research and applications. In this paper, we first propose a high-quality open-sourced UHD-4K (22.4\% of which are 8K) text-to-video dataset named UltraVideo, which contains a wide range of topics (more than 100 kinds), and each video has 9 structured captions with one summarized caption (average of 824 words). Specifically, we carefully design a highly automated curation process with four stages to obtain the final high-quality dataset: \textit{i)} collection of diverse and high-quality video clips. \textit{ii)} statistical data filtering. \textit{iii)} model-based data purification. \textit{iv)} generation of comprehensive, structured captions. In addition, we expand Wan to UltraWan-1K/-4K, which can natively generate high-quality 1K/4K videos with more consistent text controllability, demonstrating the effectiveness of our data curation.We believe that this work can make a significant contribution to future research on UHD video generation. UltraVideo dataset and UltraWan models are available at https://xzc-zju.github.io/projects/UltraVideo.

Yali Bi, Enyu Che, Yinan Chen et al.

Medical image segmentation aims to identify anatomical structures at the voxel-level. Segmentation accuracy relies on distinguishing voxel differences. Compared to advancements achieved in studies of the inter-class variance, the intra-class variance receives less attention. Moreover, traditional linear classifiers, limited by a single learnable weight per class, struggle to capture this finer distinction. To address the above challenges, we propose a Multi-Prototype-based Embedding Refinement method for semi-supervised medical image segmentation. Specifically, we design a multi-prototype-based classification strategy, rethinking the segmentation from the perspective of structural relationships between voxel embeddings. The intra-class variations are explored by clustering voxels along the distribution of multiple prototypes in each class. Next, we introduce a consistency constraint to alleviate the limitation of linear classifiers. This constraint integrates different classification granularities from a linear classifier and the proposed prototype-based classifier. In the thorough evaluation on two popular benchmarks, our method achieves superior performance compared with state-of-the-art methods. Code is available at https://github.com/Briley-byl123/MPER.

Yinan Chen, Jiangning Zhang, Yali Bi et al.

Image inversion is a fundamental task in generative models, aiming to map images back to their latent representations to enable downstream applications such as editing, restoration, and style transfer. This paper provides a comprehensive review of the latest advancements in image inversion techniques, focusing on two main paradigms: Generative Adversarial Network (GAN) inversion and diffusion model inversion. We categorize these techniques based on their optimization methods. For GAN inversion, we systematically classify existing methods into encoder-based approaches, latent optimization approaches, and hybrid approaches, analyzing their theoretical foundations, technical innovations, and practical trade-offs. For diffusion model inversion, we explore training-free strategies, fine-tuning methods, and the design of additional trainable modules, highlighting their unique advantages and limitations. Additionally, we discuss several popular downstream applications and emerging applications beyond image tasks, identifying current challenges and future research directions. By synthesizing the latest developments, this paper aims to provide researchers and practitioners with a valuable reference resource, promoting further advancements in the field of image inversion. We keep track of the latest works at https://github.com/RyanChenYN/ImageInversion

Xiangde Luo, Jieneng Chen, Tao Song et al.

Deep learning-based semi-supervised learning (SSL) algorithms have led to promising results in medical images segmentation and can alleviate doctors' expensive annotations by leveraging unlabeled data. However, most of the existing SSL algorithms in literature tend to regularize the model training by perturbing networks and/or data. Observing that multi/dual-task learning attends to various levels of information which have inherent prediction perturbation, we ask the question in this work: can we explicitly build task-level regularization rather than implicitly constructing networks- and/or data-level perturbation-and-transformation for SSL? To answer this question, we propose a novel dual-task-consistency semi-supervised framework for the first time. Concretely, we use a dual-task deep network that jointly predicts a pixel-wise segmentation map and a geometry-aware level set representation of the target. The level set representation is converted to an approximated segmentation map through a differentiable task transform layer. Simultaneously, we introduce a dual-task consistency regularization between the level set-derived segmentation maps and directly predicted segmentation maps for both labeled and unlabeled data. Extensive experiments on two public datasets show that our method can largely improve the performance by incorporating the unlabeled data. Meanwhile, our framework outperforms the state-of-the-art semi-supervised medical image segmentation methods. Code is available at: https://github.com/Luoxd1996/DTC

Yinan Chen, Yang Zhou, Xiaoxia Huang et al.

Existing collaborative WiFi sensing systems rely on perfect node synchronization and complete data availability. However, real-world edge deployments suffer from heterogeneous computing and network dropouts, leading to asynchronous and incomplete features. We propose CREWS, a robust collaborative sensing framework that inherently resists these network volatility. First, CREWS employs a topology-agnostic aggregator invariant to the arrival order and subset size of incoming features. Second, rather than discarding delayed observations, it utilizes a staleness-aware adaptive replay mechanism. By treating stale features from lagging nodes as system-induced hard samples, CREWS transforms synchronization delays into beneficial training regularization. We theoretically prove the joint convergence of this architecture and demonstrate how replay bounds the bias-variance trade-off. Extensive evaluations and an 8-node heterogeneous hardware testbed demonstrate its superior resilience. Under severe conditions i.e., 50\% transient dropout rate or out-of-distribution jitter, CREWS restricts accuracy degradation to merely 2.2 percentage points, substantially outperforming state-of-the-art baselines.

Zhihao Shuai, Yinan Chen, Shunqiang Mao et al.

Weakly supervised medical image segmentation (MIS) using generative models is crucial for clinical diagnosis. However, the accuracy of the segmentation results is often limited by insufficient supervision and the complex nature of medical imaging. Existing models also only provide a single outcome, which does not allow for the measurement of uncertainty. In this paper, we introduce DiffSeg, a segmentation model for skin lesions based on diffusion difference which exploits diffusion model principles to ex-tract noise-based features from images with diverse semantic information. By discerning difference between these noise features, the model identifies diseased areas. Moreover, its multi-output capability mimics doctors' annotation behavior, facilitating the visualization of segmentation result consistency and ambiguity. Additionally, it quantifies output uncertainty using Generalized Energy Distance (GED), aiding interpretability and decision-making for physicians. Finally, the model integrates outputs through the Dense Conditional Random Field (DenseCRF) algorithm to refine the segmentation boundaries by considering inter-pixel correlations, which improves the accuracy and optimizes the segmentation results. We demonstrate the effectiveness of DiffSeg on the ISIC 2018 Challenge dataset, outperforming state-of-the-art U-Net-based methods.

Yinan Chen, Jiangning Zhang, Teng Hu et al.

Instruction-guided video editing has emerged as a rapidly advancing research direction, offering new opportunities for intuitive content transformation while also posing significant challenges for systematic evaluation. Existing video editing benchmarks fail to support the evaluation of instruction-guided video editing adequately and further suffer from limited source diversity, narrow task coverage and incomplete evaluation metrics. To address the above limitations, we introduce IVEBench, a modern benchmark suite specifically designed for instruction-guided video editing assessment. IVEBench comprises a diverse database of 600 high-quality source videos, spanning seven semantic dimensions, and covering video lengths ranging from 32 to 1,024 frames. It further includes 8 categories of editing tasks with 35 subcategories, whose prompts are generated and refined through large language models and expert review. Crucially, IVEBench establishes a three-dimensional evaluation protocol encompassing video quality, instruction compliance and video fidelity, integrating both traditional metrics and multimodal large language model-based assessments. Extensive experiments demonstrate the effectiveness of IVEBench in benchmarking state-of-the-art instruction-guided video editing methods, showing its ability to provide comprehensive and human-aligned evaluation outcomes.

Yinan Chen

The field of natural language processing (NLP) has made significant progress with the rapid development of deep learning technologies. One of the research directions in text sentiment analysis is sentiment analysis of medical texts, which holds great potential for application in clinical diagnosis. However, the medical field currently lacks sufficient text datasets, and the effectiveness of sentiment analysis is greatly impacted by different model design approaches, which presents challenges. Therefore, this paper focuses on the medical domain, using bidirectional encoder representations from transformers (BERT) as the basic pre-trained model and experimenting with modules such as convolutional neural network (CNN), fully connected network (FCN), and graph convolutional networks (GCN) at the output layer. Experiments and analyses were conducted on the METS-CoV dataset to explore the training performance after integrating different deep learning networks. The results indicate that CNN models outperform other networks when trained on smaller medical text datasets in combination with pre-trained models like BERT. This study highlights the significance of model selection in achieving effective sentiment analysis in the medical domain and provides a reference for future research to develop more efficient model architectures.

Xiangde Luo, Tao Song, Guotai Wang et al.

Lung nodule detection from 3D Computed Tomography scans plays a vital role in efficient lung cancer screening. Despite the SOTA performance obtained by recent anchor-based detectors using CNNs for this task, they require predetermined anchor parameters such as the size, number, and aspect ratio of anchors, and have limited robustness when dealing with lung nodules with a massive variety of sizes. To overcome these problems, we propose a 3D sphere representation-based center-points matching detection network that is anchor-free and automatically predicts the position, radius, and offset of nodules without the manual design of nodule/anchor parameters. The SCPM-Net consists of two novel components: sphere representation and center points matching. First, to match the nodule annotation in clinical practice, we replace the commonly used bounding box with our proposed bounding sphere to represent nodules with the centroid, radius, and local offset in 3D space. A compatible sphere-based intersection over-union loss function is introduced to train the lung nodule detection network stably and efficiently. Second, we empower the network anchor-free by designing a positive center-points selection and matching process, which naturally discards pre-determined anchor boxes. An online hard example mining and re-focal loss subsequently enable the CPM process to be more robust, resulting in more accurate point assignment and mitigation of class imbalance. In addition, to better capture spatial information and 3D context for the detection, we propose to fuse multi-level spatial coordinate maps with the feature extractor and combine them with 3D squeeze-and-excitation attention modules. Experimental results on the LUNA16 dataset showed that our proposed framework achieves superior performance compared with existing anchor-based and anchor-free methods for lung nodule detection.

Xiangde Luo, Wenjun Liao, Jieneng Chen et al.

Gross Target Volume (GTV) segmentation plays an irreplaceable role in radiotherapy planning for Nasopharyngeal Carcinoma (NPC). Despite that Convolutional Neural Networks (CNN) have achieved good performance for this task, they rely on a large set of labeled images for training, which is expensive and time-consuming to acquire. In this paper, we propose a novel framework with Uncertainty Rectified Pyramid Consistency (URPC) regularization for semi-supervised NPC GTV segmentation. Concretely, we extend a backbone segmentation network to produce pyramid predictions at different scales. The pyramid predictions network (PPNet) is supervised by the ground truth of labeled images and a multi-scale consistency loss for unlabeled images, motivated by the fact that prediction at different scales for the same input should be similar and consistent. However, due to the different resolution of these predictions, encouraging them to be consistent at each pixel directly has low robustness and may lose some fine details. To address this problem, we further design a novel uncertainty rectifying module to enable the framework to gradually learn from meaningful and reliable consensual regions at different scales. Experimental results on a dataset with 258 NPC MR images showed that with only 10% or 20% images labeled, our method largely improved the segmentation performance by leveraging the unlabeled images, and it also outperformed five state-of-the-art semi-supervised segmentation methods. Moreover, when only 50% images labeled, URPC achieved an average Dice score of 82.74% that was close to fully supervised learning.

Qi Duan, Guotai Wang, Rui Wang et al.

Clinical research on smart health has an increasing demand for intelligent and clinic-oriented medical image computing algorithms and platforms that support various applications. To this end, we have developed SenseCare research platform, which is designed to facilitate translational research on intelligent diagnosis and treatment planning in various clinical scenarios. To enable clinical research with Artificial Intelligence (AI), SenseCare provides a range of AI toolkits for different tasks, including image segmentation, registration, lesion and landmark detection from various image modalities ranging from radiology to pathology. In addition, SenseCare is clinic-oriented and supports a wide range of clinical applications such as diagnosis and surgical planning for lung cancer, pelvic tumor, coronary artery disease, etc. SenseCare provides several appealing functions and features such as advanced 3D visualization, concurrent and efficient web-based access, fast data synchronization and high data security, multi-center deployment, support for collaborative research, etc. In this report, we present an overview of SenseCare as an efficient platform providing comprehensive toolkits and high extensibility for intelligent image analysis and clinical research in different application scenarios. We also summarize the research outcome through the collaboration with multiple hospitals.

Yechong Huang, Tao Song, Jiahang Xu et al.

Multi-modality image registration is one of the most underlined processes in medical image analysis. Recently, convolutional neural networks (CNNs) have shown significant potential in deformable registration. However, the lack of voxel-wise ground truth challenges the training of CNNs for an accurate registration. In this work, we propose a cross-modality similarity metric, based on the KL-divergence of image variables, and implement an efficient estimation method using a CNN. This estimation network, referred to as KLDivNet, can be trained unsupervisedly. We then embed the KLDivNet into a registration network to achieve the unsupervised deformable registration for multi-modality images. We employed three datasets, i.e., AAL Brain, LiTS Liver and Hospital Liver, with both the intra- and inter-modality image registration tasks for validation. Results showed that our similarity metric was effective, and the proposed registration network delivered superior performance compared to the state-of-the-art methods.