Jun Bai

Po-Yu Liang, Xueting Huang, Tibo Duran et al.

Generating peptides with desired properties is crucial for drug discovery and biotechnology. Traditional sequence-based and structure-based methods often require extensive datasets, which limits their effectiveness. In this study, we proposed a novel method that utilized autoencoder shaped models to explore the protein embedding space, and generate novel peptide analogs by leveraging protein language models. The proposed method requires only a single sequence of interest, avoiding the need for large datasets. Our results show significant improvements over baseline models in similarity indicators of peptide structures, descriptors and bioactivities. The proposed method validated through Molecular Dynamics simulations on TIGIT inhibitors, demonstrates that our method produces peptide analogs with similar yet distinct properties, highlighting its potential to enhance peptide screening processes.

Jun Bai, Di Wu, Tristan Shelley et al.

Material defects (MD) represent a primary challenge affecting product performance and giving rise to safety issues in related products. The rapid and accurate identification and localization of MD constitute crucial research endeavors in addressing contemporary challenges associated with MD. In recent years, propelled by the swift advancement of machine learning (ML) technologies, particularly exemplified by deep learning, ML has swiftly emerged as the core technology and a prominent research direction for material defect detection (MDD). Through a comprehensive review of the latest literature, we systematically survey the ML techniques applied in MDD into five categories: unsupervised learning, supervised learning, semi-supervised learning, reinforcement learning, and generative learning. We provide a detailed analysis of the main principles and techniques used, together with the advantages and potential challenges associated with these techniques. Furthermore, the survey focuses on the techniques for defect detection in composite materials, which are important types of materials enjoying increasingly wide application in various industries such as aerospace, automotive, construction, and renewable energy. Finally, the survey explores potential future directions in MDD utilizing ML technologies. This survey consolidates ML-based MDD literature and provides a foundation for future research and practice.

Yongcheng Liu, Bin Fan, Lingfeng Wang et al.

Semantic labeling for very high resolution (VHR) images in urban areas, is of significant importance in a wide range of remote sensing applications. However, many confusing manmade objects and intricate fine-structured objects make it very difficult to obtain both coherent and accurate labeling results. For this challenging task, we propose a novel deep model with convolutional neural networks (CNNs), i.e., an end-to-end self-cascaded network (ScasNet). Specifically, for confusing manmade objects, ScasNet improves the labeling coherence with sequential global-to-local contexts aggregation. Technically, multi-scale contexts are captured on the output of a CNN encoder, and then they are successively aggregated in a self-cascaded manner. Meanwhile, for fine-structured objects, ScasNet boosts the labeling accuracy with a coarse-to-fine refinement strategy. It progressively refines the target objects using the low-level features learned by CNN's shallow layers. In addition, to correct the latent fitting residual caused by multi-feature fusion inside ScasNet, a dedicated residual correction scheme is proposed. It greatly improves the effectiveness of ScasNet. Extensive experimental results on three public datasets, including two challenging benchmarks, show that ScasNet achieves the state-of-the-art performance.