Yuhan Chen

Yuhan Chen, Nuwa Xi, Yanrui Du et al.

Molecule discovery serves as a cornerstone in numerous scientific domains, fueling the development of new materials and innovative drug designs. Recent developments of in-silico molecule discovery have highlighted the promising results of cross-modal techniques, which bridge molecular structures with their descriptive annotations. However, these cross-modal methods frequently encounter the issue of data scarcity, hampering their performance and application. In this paper, we address the low-resource challenge by utilizing artificially-real data generated by Large Language Models (LLMs). We first introduce a retrieval-based prompting strategy to construct high-quality pseudo data, then explore the optimal method to effectively leverage this pseudo data. Experiments show that using pseudo data for domain adaptation outperforms all existing methods, while also requiring a smaller model scale, reduced data size and lower training cost, highlighting its efficiency. Furthermore, our method shows a sustained improvement as the volume of pseudo data increases, revealing the great potential of pseudo data in advancing low-resource cross-modal molecule discovery. Our code and data are available at https://github.com/SCIR-HI/ArtificiallyR2R.

Zhenning Yang, Yuhan Chen, Patrick Tser Jern Kon et al.

To unleash the full potential of AI for Science, we must untether the agents from a purely digital environment. The agent's ability to control and explore in real-world labs is essential because the physical lab remains foundational to scientific discovery. While some tasks can be performed on a computer (e.g., data analysis, running simulated experiments), Eureka moments could occur at any time while operating lab instruments (e.g., when a scientist notices unexpected clues, intuition may prompt a real-time course change). Although autonomous labs are on the rise, which expose programmable APIs to control scientific instruments via software, bridging the gap between increasingly powerful AI agents and automated lab equipment requires innovation that draws insights from computer systems. We propose a new paradigm called ``Experiment-as-Code (EaC) Labs,'' where a core concept is to encode experiments as declarative configurations that can be compiled down to device-level APIs. AI agents come up with hypotheses and experiments, written as an ensemble of declarative configurations. The systems layer performs program analysis, safety checks, resource assignment, and job orchestration. Finally, programmatic experimentation occurs via actuating the device APIs. This is a general stack that is science-, lab-, and instrument-independent, representing a novel synthesis across the physical, systems, and intelligence layers to unleash the next breakthrough in AI for Science.

Yuhan Chen, Pengwen Dai, Chuan Wang et al.

Text-video retrieval tasks have seen significant improvements due to the recent development of large-scale vision-language pre-trained models. Traditional methods primarily focus on video representations or cross-modal alignment, while recent works shift toward enriching text expressiveness to better match the rich semantics in videos. However, these methods use only interactions between text and frames/video, and ignore rich interactions among the internal frames within a video, so the final expanded text cannot capture frame contextual information, leading to disparities between text and video. In response, we introduce Energy-Aware Fine-Grained Relationship Learning Network (EagleNet) to generate accurate and context-aware enriched text embeddings. Specifically, the proposed Fine-Grained Relationship Learning mechanism (FRL) first constructs a text-frame graph by the generated text candidates and frames, then learns relationships among texts and frames, which are finally used to aggregate text candidates into an enriched text embedding that incorporates frame contextual information. To further improve fine-grained relationship learning in FRL, we design Energy-Aware Matching (EAM) to model the energy of text-frame interactions and thus accurately capture the distribution of real text-video pairs. Moreover, for more effective cross-modal alignment and stable training, we replace the conventional softmax-based contrastive loss with the sigmoid loss. Extensive experiments have demonstrated the superiority of EagleNet across MSRVTT, DiDeMo, MSVD, and VATEX. Codes are available at https://github.com/draym28/EagleNet.

Yanrui Du, Sendong Zhao, Yuhan Chen et al. · baidu

Pre-trained models have achieved success in Chinese Short Text Matching (STM) tasks, but they often rely on superficial clues, leading to a lack of robust predictions. To address this issue, it is crucial to analyze and mitigate the influence of superficial clues on STM models. Our study aims to investigate their over-reliance on the edit distance feature, commonly used to measure the semantic similarity of Chinese text pairs, which can be considered a superficial clue. To mitigate STM models' over-reliance on superficial clues, we propose a novel resampling training strategy called Gradually Learn Samples Containing Superficial Clue (GLS-CSC). Through comprehensive evaluations of In-Domain (I.D.), Robustness (Rob.), and Out-Of-Domain (O.O.D.) test sets, we demonstrate that GLS-CSC outperforms existing methods in terms of enhancing the robustness and generalization of Chinese STM models. Moreover, we conduct a detailed analysis of existing methods and reveal their commonality.

Peijie Dong, Lujun Li, Yuedong Zhong et al.

In this paper, we present the first structural binarization method for LLM compression to less than 1-bit precision. Although LLMs have achieved remarkable performance, their memory-bound nature during the inference stage hinders the adoption of resource-constrained devices. Reducing weights to 1-bit precision through binarization substantially enhances computational efficiency. We observe that some weights in binarized LLMs can be randomly flipped without significant performance degradation, suggesting the potential for further compression. To exploit this, our STBLLM employs an N:M sparsity technique to achieve structural binarization of the weights. Specifically, we introduce a novel Standardized Importance (SI) metric, which considers weight magnitude and input feature norm to more accurately assess weight significance. Then, we propose a layer-wise approach, allowing different layers of the LLM to be sparsified with varying N:M ratios, thereby balancing compression and accuracy. Furthermore, we implement a fine-grained grouping strategy for less important weights, applying distinct quantization schemes to sparse, intermediate, and dense regions. Finally, we design a specialized CUDA kernel to support structural binarization. We conduct extensive experiments on LLaMA-1/2/3, OPT family, and Mistral to evaluate the effectiveness of STBLLM. The results demonstrate that our approach performs better than other compressed binarization LLM methods while significantly reducing memory requirements.

Xiang Zhang, Jiaqi Wei, Yuejin Yang et al.

Chain-of-Thought (CoT) prompting has significantly advanced task-solving capabilities in natural language processing with large language models. Unlike standard prompting, CoT encourages the model to generate intermediate reasoning steps, non-answer tokens, that help guide the model toward more accurate final outputs. These intermediate steps enable more complex reasoning processes such as error correction, memory management, future planning, and self-reflection. However, applying CoT to non-natural language domains, such as protein and RNA language models, is not yet possible, primarily due to the limited expressiveness of their token spaces (e.g., amino acid tokens). In this work, we propose and define the concept of language expressiveness: the ability of a given language, using its tokens and grammar, to encode information. We show that the limited expressiveness of protein language severely restricts the applicability of CoT-style reasoning. To overcome this, we introduce reflection pretraining, for the first time in a biological sequence model, which enables the model to engage in intermediate reasoning through the generation of auxiliary "thinking tokens" beyond simple answer tokens. Theoretically, we demonstrate that our augmented token set significantly enhances biological language expressiveness, thereby improving the overall reasoning capacity of the model. Experimentally, our pretraining approach teaches protein models to self-correct and leads to substantial performance gains compared to standard pretraining.

Yuchen Xia, Jiho Kim, Yuhan Chen et al.

Due to the cost-prohibitive nature of training Large Language Models (LLMs), fine-tuning has emerged as an attractive alternative for specializing LLMs for specific tasks using limited compute resources in a cost-effective manner. In this paper, we characterize sparse Mixture of Experts (MoE) based LLM fine-tuning to understand their accuracy and runtime performance on a single GPU. Our evaluation provides unique insights into the training efficacy of sparse and dense versions of MoE models, as well as their runtime characteristics, including maximum batch size, execution time breakdown, end-to-end throughput, GPU hardware utilization, and load distribution. Our study identifies the optimization of the MoE layer as crucial for further improving the performance of LLM fine-tuning. Using our profiling results, we also develop and validate an analytical model to estimate the cost of LLM fine-tuning on the cloud. This model, based on parameters of the model and GPU architecture, estimates LLM throughput and the cost of training, aiding practitioners in industry and academia to budget the cost of fine-tuning a specific model.

Ang Lv, Jinpeng Li, Yuhan Chen et al.

In open-domain dialogue generation tasks, contexts and responses in most datasets are one-to-one mapped, violating an important many-to-many characteristic: a context leads to various responses, and a response answers multiple contexts. Without such patterns, models poorly generalize and prefer responding safely. Many attempts have been made in either multi-turn settings from a one-to-many perspective or in a many-to-many perspective but limited to single-turn settings. The major challenge to many-to-many augment multi-turn dialogues is that discretely replacing each turn with semantic similarity breaks fragile context coherence. In this paper, we propose DialoGue Path Sampling (DialoGPS) method in continuous semantic space, the first many-to-many augmentation method for multi-turn dialogues. Specifically, we map a dialogue to our extended Brownian Bridge, a special Gaussian process. We sample latent variables to form coherent dialogue paths in the continuous space. A dialogue path corresponds to a new multi-turn dialogue and is used as augmented training data. We show the effect of DialoGPS with both automatic and human evaluation.

Ang Lv, Kaiyi Zhang, Shufang Xie et al.

Recent research observed a noteworthy phenomenon in large language models (LLMs), referred to as the ``reversal curse.'' The reversal curse is that when dealing with two entities, denoted as $a$ and $b$, connected by their relation $R$ and its inverse $R^{-1}$, LLMs excel in handling sequences in the form of ``$aRb$,'' but encounter challenges when processing ``$bR^{-1}a$,'' whether in generation or comprehension. For instance, GPT-4 can accurately respond to the query ``Tom Cruise's mother is?'' with ``Mary Lee Pfeiffer,'' but it struggles to provide a satisfactory answer when asked ``Mary Lee Pfeiffer's son is?'' In this paper, we undertake the first-ever study of how the reversal curse happens in LLMs. Our investigations reveal that the reversal curse can stem from the specific training objectives, which become particularly evident in the widespread use of next-token prediction within most causal language models. We hope this initial investigation can draw more attention to the reversal curse, as well as other underlying limitations in current LLMs.

Jianyou Wang, Youze Zheng, Longtian Bao et al.

Scientists have long sought to accurately predict outcomes of real-world events before they happen. Can AI systems do so more reliably? We study this question through clinical trial outcome prediction, a high-stakes open challenge even for domain experts. We introduce CT Open, an open-access, live platform that will run four challenge every year. Anyone can submit predictions for each challenge. CT Open evaluates those submissions on trials whose outcomes were not yet public at the time of submission but were made public afterwards. Determining if a trial's outcome is public on the internet before a certain date is surprisingly difficult. Outcomes posted on official registries may lag behind by years, while the first mention may appear in obscure articles. To address this, we propose a novel, fully automated decontamination pipeline that uses iterative LLM-powered web search to identify the earliest mention of trial outcomes. We validate the pipeline's quality and accuracy by human expert's annotations. Since CT Open's pipeline ensures that every evaluated trial had no publicly reported outcome when the prediction was made, it allows participants to use any methodology and any data source. In this paper, we release a training set and two time-stamped test benchmarks, Winter 2025 and Summer 2025. We believe CT Open can serve as a central hub for advancing AI research on forecasting real-world outcomes before they occur, while also informing biomedical research and improving clinical trial design. CT Open Platform is hosted at $\href{https://ct-open.net/}{https://ct-open.net/}$

Yi Gu, Chao Han, Yuhan Chen et al.

The last decades have witnessed a rapid increase of Earth observation satellites (EOSs), leading to the increasing complexity of EOSs scheduling. On account of the widespread applications of large region observation, this paper aims to address the EOSs observation scheduling problem for large region targets. A rapid coverage calculation method employing a projection reference plane and a polygon clipping technique is first developed. We then formulate a nonlinear integer programming model for the scheduling problem, where the objective function is calculated based on the developed coverage calculation method. A greedy initialization-based resampling particle swarm optimization (GI-RPSO) algorithm is proposed to solve the model. The adopted greedy initialization strategy and particle resampling method contribute to generating efficient and effective solutions during the evolution process. In the end, extensive experiments are conducted to illustrate the effectiveness and reliability of the proposed method. Compared to the traditional particle swarm optimization and the widely used greedy algorithm, the proposed GI-RPSO can improve the scheduling result by 5.42% and 15.86%, respectively.

Asbjørn Munk, Stefano Cerri, Vardan Nersesjan et al.

Clinical deployment of automated brain MRI analysis faces a fundamental challenge: clinical data is heterogeneous and noisy, and high-quality labels are prohibitively costly to obtain. Self-supervised learning (SSL) can address this by leveraging the vast amounts of unlabeled data produced in clinical workflows to train robust \textit{foundation models} that adapt out-of-domain with minimal supervision. However, the development of foundation models for brain MRI has been limited by small pretraining datasets and in-domain benchmarking focused on high-quality, research-grade data. To address this gap, we organized the FOMO25 challenge as a satellite event at MICCAI 2025. FOMO25 provided participants with a large pretraining dataset, FOMO60K, and evaluated models on data sourced directly from clinical workflows in few-shot and out-of-domain settings. Tasks covered infarct classification, meningioma segmentation, and brain age regression, and considered both models trained on FOMO60K (method track) and any data (open track). Nineteen foundation models from sixteen teams were evaluated using a standardized containerized pipeline. Results show that (a) self-supervised pretraining improves generalization on clinical data under domain shift, with the strongest models trained \textit{out-of-domain} surpassing supervised baselines trained \textit{in-domain}. (b) No single pretraining objective benefits all tasks: MAE favors segmentation, hybrid reconstruction-contrastive objectives favor classification, and (c) strong performance was achieved by small pretrained models, and improvements from scaling model size and training duration did not yield reliable benefits.

Haochun Wang, Sendong Zhao, Zewen Qiang et al.

Large Language Models (LLMs) have demonstrated remarkable success in diverse natural language processing (NLP) tasks in general domains. However, LLMs sometimes generate responses with the hallucination about medical facts due to limited domain knowledge. Such shortcomings pose potential risks in the utilization of LLMs within medical contexts. To address this challenge, we propose knowledge-tuning, which leverages structured medical knowledge bases for the LLMs to grasp domain knowledge efficiently and facilitate reliable response generation. We also release cMedKnowQA, a Chinese medical knowledge question-answering dataset constructed from medical knowledge bases to assess the medical knowledge proficiency of LLMs. Experimental results show that the LLMs which are knowledge-tuned with cMedKnowQA, can exhibit higher levels of accuracy in response generation compared with vanilla instruction-tuning and offer a new reliable way for the domain adaptation of LLMs.

Sifan Wang, Bowen Li, Yuhan Chen et al.

While physics-informed neural networks (PINNs) have become a popular deep learning framework for tackling forward and inverse problems governed by partial differential equations (PDEs), their performance is known to degrade when larger and deeper neural network architectures are employed. Our study identifies that the root of this counter-intuitive behavior lies in the use of multi-layer perceptron (MLP) architectures with non-suitable initialization schemes, which result in poor trainablity for the network derivatives, and ultimately lead to an unstable minimization of the PDE residual loss. To address this, we introduce Physics-informed Residual Adaptive Networks (PirateNets), a novel architecture that is designed to facilitate stable and efficient training of deep PINN models. PirateNets leverage a novel adaptive residual connection, which allows the networks to be initialized as shallow networks that progressively deepen during training. We also show that the proposed initialization scheme allows us to encode appropriate inductive biases corresponding to a given PDE system into the network architecture. We provide comprehensive empirical evidence showing that PirateNets are easier to optimize and can gain accuracy from considerably increased depth, ultimately achieving state-of-the-art results across various benchmarks. All code and data accompanying this manuscript will be made publicly available at \url{https://github.com/PredictiveIntelligenceLab/jaxpi}.

Guangrui Bai, Yifan Mei, Yahui Deng et al.

Explicit reconstruction constraints derived from the decoupled representation are further imposed to suppress abnormal channel amplification and chromatic noise. Experiments on LOLv2-Real, MIT-Adobe FiveK, and LSRW show that the proposed method achieves competitive or superior quantitative and visual performance, reaching 29.71 dB PSNR and 0.89 SSIM on LOLv2-Real. DarkFace experiments further indicate improved downstream face detection under low-light conditions. Code and pretrained models are available at: https://github.com/mubaisam/ICD.

Yanrui Du, Sendong Zhao, Ming Ma et al.

Extensive work has been devoted to improving the safety mechanism of Large Language Models (LLMs). However, LLMs still tend to generate harmful responses when faced with malicious instructions, a phenomenon referred to as "Jailbreak Attack". In our research, we introduce a novel automatic jailbreak method RADIAL, which bypasses the security mechanism by amplifying the potential of LLMs to generate affirmation responses. The jailbreak idea of our method is "Inherent Response Tendency Analysis" which identifies real-world instructions that can inherently induce LLMs to generate affirmation responses and the corresponding jailbreak strategy is "Real-World Instructions-Driven Jailbreak" which involves strategically splicing real-world instructions identified through the above analysis around the malicious instruction. Our method achieves excellent attack performance on English malicious instructions with five open-source advanced LLMs while maintaining robust attack performance in executing cross-language attacks against Chinese malicious instructions. We conduct experiments to verify the effectiveness of our jailbreak idea and the rationality of our jailbreak strategy design. Notably, our method designed a semantically coherent attack prompt, highlighting the potential risks of LLMs. Our study provides detailed insights into jailbreak attacks, establishing a foundation for the development of safer LLMs.

Yuhan Chen, Yicui Shi, Guofa Li et al.

In low-light environments like nighttime driving, image degradation severely challenges in-vehicle camera safety. Since existing enhancement algorithms are often too computationally intensive for vehicular applications, we propose UltraFast-LieNET, a lightweight multi-scale shifted convolutional network for real-time low-light image enhancement. We introduce a Dynamic Shifted Convolution (DSConv) kernel with only 12 learnable parameters for efficient feature extraction. By integrating DSConv with varying shift distances, a Multi-scale Shifted Residual Block (MSRB) is constructed to significantly expand the receptive field. To mitigate lightweight network instability, a residual structure and a novel multi-level gradient-aware loss function are incorporated. UltraFast-LieNET allows flexible parameter configuration, with a minimum size of only 36 parameters. Results on the LOLI-Street dataset show a PSNR of 26.51 dB, outperforming state-of-the-art methods by 4.6 dB while utilizing only 180 parameters. Experiments across four benchmark datasets validate its superior balance of real-time performance and enhancement quality under limited resources. Code is available at https://githubhttps://github.com/YuhanChen2024/UltraFast-LiNET

Yanrui Du, Sendong Zhao, Danyang Zhao et al.

Large Language Models (LLMs) are increasingly deployed in various applications. As their usage grows, concerns regarding their safety are rising, especially in maintaining harmless responses when faced with malicious instructions. Many defense strategies have been developed to enhance the safety of LLMs. However, our research finds that existing defense strategies lead LLMs to predominantly adopt a rejection-oriented stance, thereby diminishing the usability of their responses to benign instructions. To solve this problem, we introduce the MoGU framework, designed to enhance LLMs' safety while preserving their usability. Our MoGU framework transforms the base LLM into two variants: the usable LLM and the safe LLM, and further employs dynamic routing to balance their contribution. When encountering malicious instructions, the router will assign a higher weight to the safe LLM to ensure that responses are harmless. Conversely, for benign instructions, the router prioritizes the usable LLM, facilitating usable and helpful responses. On various open-sourced LLMs, we compare multiple defense strategies to verify the superiority of our MoGU framework. Besides, our analysis provides key insights into the effectiveness of MoGU and verifies that our designed routing mechanism can effectively balance the contribution of each variant by assigning weights. Our work released the safer Llama2, Vicuna, Falcon, Dolphin, and Baichuan2.

Yanrui Du, Sendong Zhao, Haochun Wang et al.

Explaining black-box model behavior with natural language has achieved impressive results in various NLP tasks. Recent research has explored the utilization of subsequences from the input text as a rationale, providing users with evidence to support the model decision. Although existing frameworks excel in generating high-quality rationales while achieving high task performance, they neglect to account for the unreliable link between the generated rationale and model decision. In simpler terms, a model may make correct decisions while attributing wrong rationales, or make poor decisions while attributing correct rationales. To mitigate this issue, we propose a unified two-stage framework known as Self-Attribution and Decision-Making (SADM). Through extensive experiments on five reasoning datasets from the ERASER benchmark, we demonstrate that our framework not only establishes a more reliable link between the generated rationale and model decision but also achieves competitive results in task performance and the quality of rationale. Furthermore, we explore the potential of our framework in semi-supervised scenarios.

Tianci Huo, Lingfeng Qi, Yuhan Chen et al.

Inevitable specular highlights in practical environments severely impair the visual performance, thus degrading the task effectiveness and efficiency. Although there exist considerable methods that focus on local information from convolutional neural network models or global information from transformer models, the single-type model falls into a modeling dilemma between local fine-grained details and global long-range dependencies, thus deteriorating for specular highlights with different scales. Therefore, to accommodate specular highlights of all scales, we propose a multi-model architecture for specular highlight removal (MM-SHR) that effectively captures fine-grained features in highlight regions and models long-range dependencies between highlight and highlight-free areas. Specifically, we employ convolution operations to extract local details in the shallow layers of MM-SHR, and utilize the attention mechanism to capture global features in the deep layers, ensuring both operation efficiency and removal accuracy. To model long-range dependencies without compromising computational complexity, we utilize a coarse-to-fine manner and propose Omni-Directional Attention Integration Block(OAIBlock) and Adaptive Region-Aware Hybrid-Domain Dual Attention Convolutional Network(HDDAConv) , which leverage omni-directiona pixel-shifting and window-dividing operations at the raw features to achieve specular highlight removal. Extensive experimental results on three benchmark tasks and six types of surface materials demonstrate that MM-SHR outperforms state-of-the-art methods in both accuracy and efficiency for specular highlight removal. The implementation will be made publicly available at https://github.com/Htcicv/MM-SHR.

Yihong Luo, Yuhan Chen, Siya Qiu et al.

Graph Neural Networks (GNNs) have shown superior performance in node classification. However, GNNs perform poorly in the Few-Shot Node Classification (FSNC) task that requires robust generalization to make accurate predictions for unseen classes with limited labels. To tackle the challenge, we propose the integration of Sharpness-Aware Minimization (SAM)--a technique designed to enhance model generalization by finding a flat minimum of the loss landscape--into GNN training. The standard SAM approach, however, consists of two forward-backward steps in each training iteration, doubling the computational cost compared to the base optimizer (e.g., Adam). To mitigate this drawback, we introduce a novel algorithm, Fast Graph Sharpness-Aware Minimization (FGSAM), that integrates the rapid training of Multi-Layer Perceptrons (MLPs) with the superior performance of GNNs. Specifically, we utilize GNNs for parameter perturbation while employing MLPs to minimize the perturbed loss so that we can find a flat minimum with good generalization more efficiently. Moreover, our method reutilizes the gradient from the perturbation phase to incorporate graph topology into the minimization process at almost zero additional cost. To further enhance training efficiency, we develop FGSAM+ that executes exact perturbations periodically. Extensive experiments demonstrate that our proposed algorithm outperforms the standard SAM with lower computational costs in FSNC tasks. In particular, our FGSAM+ as a SAM variant offers a faster optimization than the base optimizer in most cases. In addition to FSNC, our proposed methods also demonstrate competitive performance in the standard node classification task for heterophilic graphs, highlighting the broad applicability. The code is available at https://github.com/draym28/FGSAM_NeurIPS24.

Yuhan Chen, Yihong Luo, Yifan Song et al.

Despite extensive research efforts focused on OOD detection on images, OOD detection on nodes in graph learning remains underexplored. The dependence among graph nodes hinders the trivial adaptation of existing approaches on images that assume inputs to be i.i.d. sampled, since many unique features and challenges specific to graphs are not considered, such as the heterophily issue. Recently, GNNSafe, which considers node dependence, adapted energy-based detection to the graph domain with state-of-the-art performance, however, it has two serious issues: 1) it derives node energy from classification logits without specifically tailored training for modeling data distribution, making it less effective at recognizing OOD data; 2) it highly relies on energy propagation, which is based on homophily assumption and will cause significant performance degradation on heterophilic graphs, where the node tends to have dissimilar distribution with its neighbors. To address the above issues, we suggest training EBMs by MLE to enhance data distribution modeling and remove energy propagation to overcome the heterophily issues. However, training EBMs via MLE requires performing MCMC sampling on both node feature and node neighbors, which is challenging due to the node interdependence and discrete graph topology. To tackle the sampling challenge, we introduce DeGEM, which decomposes the learning process into two parts: a graph encoder that leverages topology information for node representations and an energy head that operates in latent space. Extensive experiments validate that DeGEM, without OOD exposure during training, surpasses previous state-of-the-art methods, achieving an average AUROC improvement of 6.71% on homophilic graphs and 20.29% on heterophilic graphs, and even outperform methods trained with OOD exposure. Our code is available at: https://github.com/draym28/DeGEM.

Bowen Ding, Yuhan Chen, Jiayang Lv et al.

While effective post-training integrates Supervised Fine-Tuning (SFT) and Reinforcement Learning (RL), the optimal mechanism for utilizing expert trajectories remains unresolved. We propose the Plasticity-Ceiling Framework to theoretically ground this landscape, decomposing performance into foundational SFT performance and the subsequent RL plasticity. Through extensive benchmarking, we establish the Sequential SFT-then-RL pipeline as the superior standard, overcoming the stability deficits of synchronized approaches. Furthermore, we derive precise scaling guidelines: (1) Transitioning to RL at the SFT Stable or Mild Overfitting Sub-phase maximizes the final ceiling by securing foundational SFT performance without compromising RL plasticity; (2) Refuting ``Less is More'' in the context of SFT-then-RL scaling, we demonstrate that Data Scale determines the primary post-training potential, while Trajectory Difficulty acts as a performance multiplier; and (3) Identifying that the Minimum SFT Validation Loss serves as a robust indicator for selecting the expert trajectories that maximize the final performance ceiling. Our findings provide actionable guidelines for maximizing the value extracted from expert trajectories.

Weikai Xu, Kun Huang, Yunren Feng et al.

Recent advances in vision-language models have enabled mobile GUI agents to perceive visual interfaces and execute user instructions, but reliable prediction of action consequences remains critical for long-horizon and high-risk interactions. Existing mobile world models provide either text-based or image-based future states, yet it remains unclear which representation is useful, whether generated rollouts can replace real environments, and how test-time guidance helps agents of different strengths. To answer the above questions, we filter and annotate mobile world-model data, then train world models across four modalities: delta text, full text, diffusion-based images, and renderable code. These models achieve SoTA performance on both MobileWorldBench and Code2WorldBench. Furthermore, by evaluating their downstream utility on AITZ, AndroidControl, and AndroidWorld, we obtain three findings. First, renderable code reconstruction achieves high in-distribution fidelity and provides effective multimodal supervision for data construction, while text-based feedback is more robust for online out-of-distribution (OOD) execution. Second, world-model-generated trajectories can provide transferable interaction experience in the training process and improve agents' end-to-end task performance, although these data do not preserve the original distribution. Last, for overconfident mobile agents with low action entropy, posterior self-reflection provides limited gains, suggesting that world models are more effective as prior perception or training supervision than as universal post-hoc verifiers.

Bo Pan, Yixiao Fu, Ke Wang et al.

Data visualization generation using Large Language Models (LLMs) has shown promising results but often produces suboptimal visualizations that require human intervention for improvement. In this work, we introduce VIS-Shepherd, a specialized Multimodal Large Language Model (MLLM)-based critic to evaluate and provide feedback for LLM-generated data visualizations. At the core of our approach is a framework to construct a high-quality visualization critique dataset, where we collect human-created visualization instances, synthesize corresponding LLM-generated instances, and construct high-quality critiques. We conduct both model-based automatic evaluation and human preference studies to evaluate the effectiveness of our approach. Our experiments show that even small (7B parameters) open-source MLLM models achieve substantial performance gains by leveraging our high-quality visualization critique dataset, reaching levels comparable to much larger open-source or even proprietary models. Our work demonstrates significant potential for MLLM-based automated visualization critique and indicates promising directions for enhancing LLM-based data visualization generation. Our project page: https://github.com/bopan3/VIS-Shepherd.

Yutao Zhu, Kun Zhou, Kelong Mao et al.

Large language models (LLMs) have become the foundation of many applications, leveraging their extensive capabilities in processing and understanding natural language. While many open-source LLMs have been released with technical reports, the lack of training details hinders further research and development. This paper presents the development of YuLan, a series of open-source LLMs with $12$ billion parameters. The base model of YuLan is pre-trained on approximately $1.7$T tokens derived from a diverse corpus, including massive English, Chinese, and multilingual texts. We design a three-stage pre-training method to enhance YuLan's overall capabilities. Subsequent phases of training incorporate instruction-tuning and human alignment, employing a substantial volume of high-quality synthesized data. To facilitate the learning of complex and long-tail knowledge, we devise a curriculum-learning framework throughout across these stages, which helps LLMs learn knowledge in an easy-to-hard manner. YuLan's training is finished on Jan, 2024 and has achieved performance on par with state-of-the-art LLMs across various English and Chinese benchmarks. This paper outlines a comprehensive technical roadmap for developing LLMs from scratch. Our model and codes are available at https://github.com/RUC-GSAI/YuLan-Chat.

Hongzhan Lin, Ang Lv, Yuhan Chen et al.

Many studies have revealed that large language models (LLMs) exhibit uneven awareness of different contextual positions. Their limited context awareness can lead to overlooking critical information and subsequent task failures. While several approaches have been proposed to enhance LLMs' context awareness, achieving both effectiveness and efficiency remains challenging. In this paper, for LLMs utilizing RoPE as position embeddings, we introduce a novel method called "Mixture of In-Context Experts" (MoICE) to address this challenge. MoICE comprises two key components: a router integrated into each attention head within LLMs and a lightweight router-only training optimization strategy: (1) MoICE views each RoPE angle as an `in-context' expert, demonstrated to be capable of directing the attention of a head to specific contextual positions. Consequently, each attention head flexibly processes tokens using multiple RoPE angles dynamically selected by the router to attend to the needed positions. This approach mitigates the risk of overlooking essential contextual information. (2) The router-only training strategy entails freezing LLM parameters and exclusively updating routers for only a few steps. When applied to open-source LLMs including Llama and Mistral, MoICE surpasses prior methods across multiple tasks on long context understanding and generation, all while maintaining commendable inference efficiency.

Yuhan Chen, Yihong Luo, Jing Tang et al.

Heterophily has been considered as an issue that hurts the performance of Graph Neural Networks (GNNs). To address this issue, some existing work uses a graph-level weighted fusion of the information of multi-hop neighbors to include more nodes with homophily. However, the heterophily might differ among nodes, which requires to consider the local topology. Motivated by it, we propose to use the local similarity (LocalSim) to learn node-level weighted fusion, which can also serve as a plug-and-play module. For better fusion, we propose a novel and efficient Initial Residual Difference Connection (IRDC) to extract more informative multi-hop information. Moreover, we provide theoretical analysis on the effectiveness of LocalSim representing node homophily on synthetic graphs. Extensive evaluations over real benchmark datasets show that our proposed method, namely Local Similarity Graph Neural Network (LSGNN), can offer comparable or superior state-of-the-art performance on both homophilic and heterophilic graphs. Meanwhile, the plug-and-play model can significantly boost the performance of existing GNNs. Our code is provided at https://github.com/draym28/LSGNN.

Yuhan Chen, Yicui Shi, Guofa Li et al.

Skeleton-based action recognition is widely utilized in sensor systems including human-computer interaction and intelligent surveillance. Nevertheless, current sensor devices typically generate sparse skeleton data as discrete coordinates, which inevitably discards fine-grained spatiotemporal details during highly dynamic movements. Moreover, the rigid constraints of predefined physical sensor topologies hinder the modeling of latent long-range dependencies. To overcome these limitations, we propose KGS-GCN, a graph convolutional network that integrates kinematics-driven Gaussian splatting with probabilistic topology. Our framework explicitly addresses the challenges of sensor data sparsity and topological rigidity by transforming discrete joints into continuous generative representations. Firstly, a kinematics-driven Gaussian splatting module is designed to dynamically construct anisotropic covariance matrices using instantaneous joint velocity vectors. This module enhances visual representation by rendering sparse skeleton sequences into multi-view continuous heatmaps rich in spatiotemporal semantics. Secondly, to transcend the limitations of fixed physical connections, a probabilistic topology construction method is proposed. This approach generates an adaptive prior adjacency matrix by quantifying statistical correlations via the Bhattacharyya distance between joint Gaussian distributions. Ultimately, the GCN backbone is adaptively modulated by the rendered visual features via a visual context gating mechanism. Empirical results demonstrate that KGS-GCN significantly enhances the modeling of complex spatiotemporal dynamics. By addressing the inherent limitations of sparse inputs, our framework offers a robust solution for processing low-fidelity sensor data. This approach establishes a practical pathway for improving perceptual reliability in real-world sensing applications.

Yuhan Chen, Tao Liu, Jie Huang

The leader-following consensus problem for general linear multi-agent systems over jointly connected switching networks has been a challenging problem and the solvability of the problem has been limited to the class of linear multi-agent systems whose system matrix is marginally stable. This condition is restrictive since it even excludes the most commonly used double-integrator system. This paper presents a breakthrough by demonstrating that leader-following exponential consensus is achievable for general linear multi-agent systems over jointly connected switching networks, even when the system matrix is exponentially unstable. The degree of instability can be explicitly characterized by two key quantities that arise from the jointly connected condition on a switching graph. By exploiting duality, we further show that the output-based distributed observer design problem for a general leader system is solvable over jointly connected switching networks, even when the system matrix is exponentially unstable. This is also in sharp contrast to the existing distributed observers, which rely on the assumption that the leader system is marginally stable.

Yicui Shi, Yuhan Chen, Xiangfei Huang et al.

Low-light image enhancement aims to restore the visibility of images captured by visual sensors in dim environments by addressing their inherent signal degradations, such as luminance attenuation and structural corruption. Although numerous algorithms attempt to improve image quality, existing methods often cause a severe loss of intrinsic signal priors. To overcome these challenges, we propose a Dual-Stream Transformer Network (DST-Net) based on illumination-agnostic signal prior guidance and multi-scale spatial convolutions. First, to address the loss of critical signal features under low-light conditions, we design a feature extraction module. This module integrates Difference of Gaussians (DoG), LAB color space transformations, and VGG-16 for texture extraction, utilizing decoupled illumination-agnostic features as signal priors to continuously guide the enhancement process. Second, we construct a dual-stream interaction architecture. By employing a cross-modal attention mechanism, the network leverages the extracted priors to dynamically rectify the deteriorated signal representation of the enhanced image, ultimately achieving iterative enhancement through differentiable curve estimation. Furthermore, to overcome the inability of existing methods to preserve fine structures and textures, we propose a Multi-Scale Spatial Fusion Block (MSFB) featuring pseudo-3D and 3D gradient operator convolutions. This module integrates explicit gradient operators to recover high-frequency edges while capturing inter-channel spatial correlations via multi-scale spatial convolutions. Extensive evaluations and ablation studies demonstrate that DST-Net achieves superior performance in subjective visual quality and objective metrics. Specifically, our method achieves a PSNR of 25.64 dB on the LOL dataset. Subsequent validation on the LSRW dataset further confirms its robust cross-scene generalization.

Yuhan Chen, Ang Lv, Ting-En Lin et al.

In this paper, we demonstrate that an inherent waveform pattern in the attention allocation of large language models (LLMs) significantly affects their performance in tasks demanding a high degree of context awareness, such as utilizing LLMs for tool-use. Specifically, the crucial information in the context will be potentially overlooked by model when it is positioned in the trough zone of the attention waveform, leading to decreased performance. To address this issue, we propose a novel inference method named Attention Buckets. It allows LLMs to process their input through multiple parallel processes. Each process utilizes a distinct base angle for the rotary position embedding, thereby creating a unique attention waveform. By compensating an attention trough of a particular process with an attention peak of another process, our approach enhances LLM's awareness to various contextual positions, thus mitigating the risk of overlooking crucial information. In the largest tool-use benchmark, our method elevates a 7B model to achieve state-of-the-art performance, comparable to that of GPT-4. On other benchmarks and some RAG tasks, which also demand a thorough understanding of contextual content, Attention Buckets also exhibited notable enhancements in performance.

Zhihua Tian, Yuhan Chen, Yao Tang et al.

Generative Engine Optimization (GEO) aims to improve content visibility in AI-generated responses. However, existing methods measure contribution-how much a document influences a response-rather than citation, the mechanism that actually drives traffic back to creators. Also, these methods apply generic rewriting rules uniformly, failing to diagnose why individual document are not cited. This paper introduces a diagnostic approach to GEO that asks why a document fails to be cited and intervenes accordingly. We develop a unified framework comprising: (1) the first taxonomy of citation failure modes spanning different stages of a citation pipeline; (2) AgentGEO, an agentic system that diagnoses failures using this taxonomy, selects targeted repairs from a corresponding tool library, and iterates until citation is achieved; and (3) a document-centric benchmark evaluating whether optimizations generalize across held-out queries. AgentGEO achieves over 40% relative improvement in citation rates while modifying only 5% of content, compared to 25% for baselines. Our analysis reveals that generic optimization can harm long-tail content and some documents face challenges that optimization alone cannot fully address-findings with implications for equitable visibility in AI-mediated information access.

Kaiyi Zhang, Ang Lv, Yuhan Chen et al.

In this paper, by treating in-context learning (ICL) as a meta-optimization process, we explain why LLMs are sensitive to the order of ICL examples. This understanding leads us to the development of Batch-ICL, an effective, efficient, and order-agnostic inference algorithm for ICL. Differing from the standard N-shot learning approach, Batch-ICL employs $N$ separate 1-shot forward computations and aggregates the resulting meta-gradients. These aggregated meta-gradients are then applied to the forward computation of a zero-shot query to generate the final prediction. This batch processing approach renders the LLM agnostic to the order of ICL examples. Through extensive experiments and analysis, we demonstrate that Batch-ICL consistently outperforms most permutations of ICL examples. In some cases, it even exceeds the performance of the best order for standard ICL, all while reducing the computational resources required. Furthermore, we develop a novel variant of Batch-ICL featuring multiple "epochs" of meta-optimization. This variant implicitly explores permutations of ICL examples, further enhancing ICL performance.

Ang Lv, Yuhan Chen, Kaiyi Zhang et al.

In this paper, we delve into several mechanisms employed by Transformer-based language models (LLMs) for factual recall tasks. We outline a pipeline consisting of three major steps: (1) Given a prompt ``The capital of France is,'' task-specific attention heads extract the topic token, such as ``France,'' from the context and pass it to subsequent MLPs. (2) As attention heads' outputs are aggregated with equal weight and added to the residual stream, the subsequent MLP acts as an ``activation,'' which either erases or amplifies the information originating from individual heads. As a result, the topic token ``France'' stands out in the residual stream. (3) A deep MLP takes ``France'' and generates a component that redirects the residual stream towards the direction of the correct answer, i.e., ``Paris.'' This procedure is akin to applying an implicit function such as ``get\_capital($X$),'' and the argument $X$ is the topic token information passed by attention heads. To achieve the above quantitative and qualitative analysis for MLPs, we proposed a novel analytic method aimed at decomposing the outputs of the MLP into components understandable by humans. Additionally, we observed a universal anti-overconfidence mechanism in the final layer of models, which suppresses correct predictions. We mitigate this suppression by leveraging our interpretation to improve factual recall confidence. The above interpretations are evaluated across diverse tasks spanning various domains of factual knowledge, using various language models from the GPT-2 families, 1.3B OPT, up to 7B Llama-2, and in both zero- and few-shot setups.

Yuhan Chen, Wenxuan Yu, Guofa Li et al.

2D Gaussian Splatting (2DGS) is an emerging explicit scene representation method with significant potential for image compression due to high fidelity and high compression ratios. However, existing low-light enhancement algorithms operate predominantly within the pixel domain. Processing 2DGS-compressed images necessitates a cumbersome decompression-enhancement-recompression pipeline, which compromises efficiency and introduces secondary degradation. To address these limitations, we propose LL-GaussianImage, the first zero-shot unsupervised framework designed for low-light enhancement directly within the 2DGS compressed representation domain. Three primary advantages are offered by this framework. First, a semantic-guided Mixture-of-Experts enhancement framework is designed. Dynamic adaptive transformations are applied to the sparse attribute space of 2DGS using rendered images as guidance to enable compression-as-enhancement without full decompression to a pixel grid. Second, a multi-objective collaborative loss function system is established to strictly constrain smoothness and fidelity during enhancement, suppressing artifacts while improving visual quality. Third, a two-stage optimization process is utilized to achieve reconstruction-as-enhancement. The accuracy of the base representation is ensured through single-scale reconstruction and network robustness is enhanced. High-quality enhancement of low-light images is achieved while high compression ratios are maintained. The feasibility and superiority of the paradigm for direct processing within the compressed representation domain are validated through experimental results.

Yuhan Chen, Ying Fang, Guofa Li et al.

Significant progress has been made in low-light image enhancement with respect to visual quality. However, most existing methods primarily operate in the pixel domain or rely on implicit feature representations. As a result, the intrinsic geometric structural priors of images are often neglected. 2D Gaussian Splatting (2DGS) has emerged as a prominent explicit scene representation technique characterized by superior structural fitting capabilities and high rendering efficiency. Despite these advantages, the utilization of 2DGS in low-level vision tasks remains unexplored. To bridge this gap, LL-GaussianMap is proposed as the first unsupervised framework incorporating 2DGS into low-light image enhancement. Distinct from conventional methodologies, the enhancement task is formulated as a gain map generation process guided by 2DGS primitives. The proposed method comprises two primary stages. First, high-fidelity structural reconstruction is executed utilizing 2DGS. Then, data-driven enhancement dictionary coefficients are rendered via the rasterization mechanism of Gaussian splatting through an innovative unified enhancement module. This design effectively incorporates the structural perception capabilities of 2DGS into gain map generation, thereby preserving edges and suppressing artifacts during enhancement. Additionally, the reliance on paired data is circumvented through unsupervised learning. Experimental results demonstrate that LL-GaussianMap achieves superior enhancement performance with an extremely low storage footprint, highlighting the effectiveness of explicit Gaussian representations for image enhancement.

Paritosh Parmar, Eric Peh, Ruirui Chen et al.

Causal video question answering (QA) has garnered increasing interest, yet existing datasets often lack depth in causal reasoning. To address this gap, we capitalize on the unique properties of cartoons and construct CausalChaos!, a novel, challenging causal Why-QA dataset built upon the iconic "Tom and Jerry" cartoon series. Cartoons use the principles of animation that allow animators to create expressive, unambiguous causal relationships between events to form a coherent storyline. Utilizing these properties, along with thought-provoking questions and multi-level answers (answer and detailed causal explanation), our questions involve causal chains that interconnect multiple dynamic interactions between characters and visual scenes. These factors demand models to solve more challenging, yet well-defined causal relationships. We also introduce hard incorrect answer mining, including a causally confusing version that is even more challenging. While models perform well, there is much room for improvement, especially, on open-ended answers. We identify more advanced/explicit causal relationship modeling & joint modeling of vision and language as the immediate areas for future efforts to focus upon. Along with the other complementary datasets, our new challenging dataset will pave the way for these developments in the field.

Jiaqi Wei, Yuejin Yang, Xiang Zhang et al. · tsinghua

Artificial intelligence (AI) is reshaping scientific discovery, evolving from specialized computational tools into autonomous research partners. We position Agentic Science as a pivotal stage within the broader AI for Science paradigm, where AI systems progress from partial assistance to full scientific agency. Enabled by large language models (LLMs), multimodal systems, and integrated research platforms, agentic AI shows capabilities in hypothesis generation, experimental design, execution, analysis, and iterative refinement -- behaviors once regarded as uniquely human. This survey provides a domain-oriented review of autonomous scientific discovery across life sciences, chemistry, materials science, and physics. We unify three previously fragmented perspectives -- process-oriented, autonomy-oriented, and mechanism-oriented -- through a comprehensive framework that connects foundational capabilities, core processes, and domain-specific realizations. Building on this framework, we (i) trace the evolution of AI for Science, (ii) identify five core capabilities underpinning scientific agency, (iii) model discovery as a dynamic four-stage workflow, (iv) review applications across the above domains, and (v) synthesize key challenges and future opportunities. This work establishes a domain-oriented synthesis of autonomous scientific discovery and positions Agentic Science as a structured paradigm for advancing AI-driven research.

Yuhan Chen, Ang Lv, Jian Luan et al.

Many positional encodings (PEs) are designed to exhibit long-term decay, based on an entrenched and long-standing inductive opinion: tokens farther away from the current position carry less relevant information. We argue that long-term decay is outdated in the era of LLMs, as LLMs are now applied to tasks demanding precise retrieval of in-context information from arbitrary positions. Firstly, we present empirical analyses on various PEs, demonstrating that models inherently learn attention with only a local-decay pattern while forming a U-shape pattern globally, contradicting the principle of long-term decay. Furthermore, we conduct a detailed analysis of rotary position encoding (RoPE, a prevalent relative positional encoding in LLMs), and found that the U-shape attention is caused by some learned components, which are also the key factor limiting RoPE's expressiveness and extrapolation.Inspired by these insights, we propose High-frequency rotary Position Encoding (HoPE). HoPE replaces the specific components in RoPE with position-independent ones, retaining only high-frequency signals, which also breaks the principle of long-term decay in theory. HoPE achieves two major advantages: (1) Without constraints imposed by long-term decay, contradictory factors that limit spontaneous attention optimization and model extrapolation performance are removed. (2) Components representing positions and semantics are are optimized. These enhances model's context awareness and extrapolation, as validated by extensive experiments.

Youze Zheng, Jianyou Wang, Yuhan Chen et al.

Predicting the outcomes of prospective clinical trials remains a major challenge for large language models. Prior work has shown that both traditional correlational predictors, such as random forests and logistic regression, and strong commercial LLMs achieve limited performance on this task. In this paper, we propose DeepImagine, a framework for teaching LLMs biomedical reasoning through successive counterfactual imagining. The central idea is to approximate hidden causal mechanisms of clinical trials by training models to infer how observed trial results would change under controlled perturbations of experimental conditions, such as dosage, outcome measures, study arms, geography, and other trial attributes. To support this objective, we construct both natural and approximate counterfactual pairs from real clinical trials with reported outcomes. For settings where strict counterfactual supervision is available, such as paired outcome measures or dose-ranging study arms within the same trial, we train models with supervised fine-tuning. For broader settings where only approximate counterfactual pairs can be retrieved, we optimize models with reinforcement learning using verifiable rewards based on downstream benchmark correctness. We further augment training with synthetic reasoning traces that provide causally plausible explanations for local counterfactual transitions. Using this pipeline, we train language models under 10B parameters, including Qwen3.5-9B, and evaluate them on clinical trial outcome prediction. We aim to show that DeepImagine consistently improves over untuned language models and traditional correlational baselines. Finally, we aim to show that the learned reasoning trajectories provide interpretable signals about how models represent trial-level mechanisms, suggesting a practical path toward more mechanistic and scientifically useful biomedical language models.

Bowen Ding, Yuhan Chen, Futing Wang et al.

Large Reasoning Models (LRMs) excel at solving complex problems but face an overthinking dilemma. When handling simple tasks, they often produce verbose responses overloaded with thinking tokens (e.g., wait, however). These tokens trigger unnecessary high-level reasoning behaviors like reflection and backtracking, reducing efficiency. In this work, our pilot study reveals that these thinking-token-induced behaviors are not essential for effective problem-solving and may even hinder correct reasoning within constrained token budgets. We identify this phenomenon as the thinking trap. To mitigate this issue, we propose Dual Policy Preference Optimization (DuP-PO), a novel algorithm featuring: (1) A rollout sampling strategy that guarantees balanced exposure to responses with and without thinking tokens; (2) A fine-grained advantage control technique to dynamically regulate the prediction of target tokens; (3) A policy shaping method ensuring stable gradient contributions from thinking tokens. Experimental results on five popular math reasoning benchmarks show that DuP-PO performs well on the popular LRM, which significantly improves their token efficiency during reasoning, while achieving superior performance of the base model.

Nuwa Xi, Yuhan Chen, Sendong Zhao et al.

Chain-of-Thought (CoT) serves as a critical emerging ability in LLMs, especially when it comes to logical reasoning. Attempts have been made to induce such ability in small models as well by distilling from the data with CoT generated by Large Language Models (LLMs). However, existing methods often simply generate and incorporate more data from LLMs and fail to note the importance of efficiently utilizing existing CoT data. We here propose a new training paradigm AS-ES (Abstractive Segments - Extractive Segments) learning, which exploits the inherent information in CoT for iterative generation. Experiments show that our methods surpass the direct seq2seq training on CoT-extensive tasks like MWP and PET summarization, without data augmentation or altering the model itself. Furthermore, we explore the reason behind the inefficiency of small models in learning CoT and provide an explanation of why AS-ES learning works, giving insights into the underlying mechanism of CoT.

Qi Li, Junpan Wu, Xiang Liu et al.

The reasoning large language model (RLLM) has been proven competitive in solving complex reasoning tasks such as mathematics, coding, compared to general LLM. However, the serving performance and behavior of RLLM remains unexplored, which may undermine the deployment and utilization of RLLM in real-world scenario. To close this gap, in this paper, we conduct a comprehensive study of RLLM service. We first perform a pilot study on comparing the serving performance between RLLM and traditional LLM and reveal that there are several distinct differences regarding serving behavior: (1) significant memory usage and fluctuations; (2) straggler requests; (3) adaptive running time; (4) domain preference. Then we further investigate whether existing inference optimization techniques are valid for RLLM. Our main takeaways are that model quantization methods and speculative decoding can improve service system efficiency with small compromise to RLLM accuracy, while prefix caching, KV cache quantization may even degrade accuracy or serving performance for small RLLM. Lastly, we conduct evaluation under real world workload modeled by Gamma distribution to verify our findings. Empirical results of real world workload evaluation across different dataset are aligned with our main findings regarding RLLM serving. We hope our work can provide the research community and industry with insights to advance RLLM inference serving.

Shuqi Li, Shufang Xie, Hongda Sun et al.

Traditional drug discovery processes are both time-consuming and require extensive professional expertise. With the accumulation of drug-target interaction (DTI) data from experimental studies, leveraging modern machine-learning techniques to discern patterns between drugs and target proteins has become increasingly feasible. In this paper, we introduce the Multi-channel Interaction Network (MIN), a novel framework designed to predict DTIs through two primary components: a representation learning module and a multi-channel interaction module. The representation learning module features a C-Score Predictor-assisted screening mechanism, which selects critical residues to enhance prediction accuracy and reduce noise. The multi-channel interaction module incorporates a structure-agnostic channel, a structure-aware channel, and an extended-mixture channel, facilitating the identification of interaction patterns at various levels for optimal complementarity. Additionally, contrastive learning is utilized to harmonize the representations of diverse data types. Our experimental evaluations on public datasets demonstrate that MIN surpasses other strong DTI prediction methods. Furthermore, the case study reveals a high overlap between the residues selected by the C-Score Predictor and those in actual binding pockets, underscoring MIN's explainability capability. These findings affirm that MIN is not only a potent tool for DTI prediction but also offers fresh insights into the prediction of protein binding sites.

Yuhan Chen, Lumei Su, Lihua Chen et al.

In this paper, the LCV2 modular method is proposed for the Grounded Visual Question Answering task in the vision-language multimodal domain. This approach relies on a frozen large language model (LLM) as intermediate mediator between the off-the-shelf VQA model and the off-the-shelf visual grounding (VG) model, where the LLM transforms and conveys textual information between the two modules based on a designed prompt. LCV2 establish an integrated plug-and-play framework without the need for any pre-training process. This framework can be deployed for VQA Grounding tasks under low computational resources. The modularized model within the framework allows application with various state-of-the-art pre-trained models, exhibiting significant potential to be advance with the times. Experimental implementations were conducted under constrained computational and memory resources, evaluating the proposed method's performance on benchmark datasets including GQA, CLEVR, and VizWiz-VQA-Grounding. Comparative analyses with baseline methods demonstrate the robust competitiveness of LCV2.

Yuhan Chen, Shang Qu, Zhiqiang Gao et al.

Post-translational modifications (PTMs) serve as a dynamic chemical language regulating protein function, yet current proteomic methods remain blind to a vast portion of the modified proteome. Standard database search algorithms suffer from a combinatorial explosion of search spaces, limiting the identification of uncharacterized or complex modifications. Here we introduce OmniNovo, a unified deep learning framework for reference-free sequencing of unmodified and modified peptides directly from tandem mass spectra. Unlike existing tools restricted to specific modification types, OmniNovo learns universal fragmentation rules to decipher diverse PTMs within a single coherent model. By integrating a mass-constrained decoding algorithm with rigorous false discovery rate estimation, OmniNovo achieves state-of-the-art accuracy, identifying 51\% more peptides than standard approaches at a 1\% false discovery rate. Crucially, the model generalizes to biological sites unseen during training, illuminating the dark matter of the proteome and enabling unbiased comprehensive analysis of cellular regulation.

Yuhan Chen, Yuxuan Liu, Long Zhang et al.

Multi-turn interaction remains challenging for online reinforcement learning. A common solution is trajectory-level optimization, which treats each trajectory as a single training sample. However, this approach can be inefficient and yield misleading learning signals: it applies uniform sampling across tasks regardless of difficulty, penalizes correct intermediate actions in failed trajectories, and incurs high sample-collection costs. To address these issues, we propose STEP (Success-rate-aware Trajectory-Efficient Policy optimization), a framework that dynamically allocates sampling based on per-task success rates and performs step-level optimization. STEP maintains a smoothed success-rate record to guide adaptive trajectory resampling, allocating more effort to harder tasks. It then computes success-rate-weighted advantages and decomposes trajectories into step-level samples. Finally, it applies a step-level GRPO augmentation to refine updates for low-success tasks. Experiments on OSWorld and AndroidWorld show that STEP substantially improves sample efficiency and training stability over trajectory-level GRPO, converging faster and generalizing better under the same sampling budget.

Yunfan Lu, Nico Messikommer, Xiaogang Xu et al.

Event frame hybrid sensors integrate an Active Pixel Sensor (APS) and an Event Vision Sensor (EVS) within a single chip, combining the high dynamic range and low latency of the EVS with the rich spatial intensity information from the APS. While this tight integration offers compact, temporally precise imaging, the complex circuit architecture introduces non-trivial noise patterns that remain poorly understood and unmodeled. In this work, we present the first unified, statistics-based imaging noise model that jointly describes the noise behavior of APS and EVS pixels. Our formulation explicitly incorporates photon shot noise, dark current noise, fixed-pattern noise, and quantization noise, and links EVS noise to illumination level and dark current. Based on this formulation, we further develop a calibration pipeline to estimate noise parameters from real data and offer a detailed analysis of both APS and EVS noise behaviors. Finally, we propose HESIM, a statistically grounded simulator that generates RAW frames and events under realistic, jointly calibrated noise statistics. Experiments on two hybrid sensors validate our model across multiple imaging tasks (e.g., video frame interpolation and deblurring), demonstrating strong transfer from simulation to real data.

Yijun Xu, Jingrui Zhang, Hongyi Liu et al.

Reconstruction of rigid motion over large spatiotemporal scales remains a challenging task due to limitations in modeling paradigms, severe motion blur, and insufficient physical consistency. In this work, we propose PEGS, a framework that integrates Physical priors with Event stream enhancement within a 3D Gaussian Splatting pipeline to perform deblurred target-focused modeling and motion recovery. We introduce a cohesive triple-level supervision scheme that enforces physical plausibility via an acceleration constraint, leverages event streams for high-temporal resolution guidance, and employs a Kalman regularizer to fuse multi-source observations. Furthermore, we design a motion-aware simulated annealing strategy that adaptively schedules the training process based on real-time kinematic states. We also contribute the first RGB-Event paired dataset targeting natural, fast rigid motion across diverse scenarios. Experiments show PEGS's superior performance in reconstructing motion over large spatiotemporal scales compared to mainstream dynamic methods.