Nan Hu

Anupama Goparaju, Alexandre Bone, Nan Hu et al.

Statistical shape modeling (SSM) is widely used in biology and medicine as a new generation of morphometric approaches for the quantitative analysis of anatomical shapes. Technological advancements of in vivo imaging have led to the development of open-source computational tools that automate the modeling of anatomical shapes and their population-level variability. However, little work has been done on the evaluation and validation of such tools in clinical applications that rely on morphometric quantifications (e.g., implant design and lesion screening). Here, we systematically assess the outcome of widely used, state-of-the-art SSM tools, namely ShapeWorks, Deformetrica, and SPHARM-PDM. We use both quantitative and qualitative metrics to evaluate shape models from different tools. We propose validation frameworks for anatomical landmark/measurement inference and lesion screening. We also present a lesion screening method to objectively characterize subtle abnormal shape changes with respect to learned population-level statistics of controls. Results demonstrate that SSM tools display different levels of consistencies, where ShapeWorks and Deformetrica models are more consistent compared to models from SPHARM-PDM due to the groupwise approach of estimating surface correspondences. Furthermore, ShapeWorks and Deformetrica shape models are found to capture clinically relevant population-level variability compared to SPHARM-PDM models.

Weidong Zhan, Yue Wang, Nan Hu et al. · pku

Currently, long-chain reasoning remains a key challenge for large language models (LLMs) because natural texts lack sufficient explicit reasoning data. However, existing benchmarks suffer from limitations such as narrow coverage, short reasoning paths, or high construction costs. We introduce SCoRE (Scenario-based Commonsense Reasoning Evaluation), a benchmark that synthesizes multi-hop questions from scenario schemas of entities, relations, and logical rules to assess long-chain commonsense reasoning. SCoRE contains 100k bilingual (Chinese-English) multiple-choice questions whose reasoning chains span 2-11 hops and are grouped into various difficulty levels. Each question is accompanied by fine-grained knowledge labels, explicit reasoning chains, and difficulty levels for diagnostic evaluation. Evaluation results on cutting-edge LLMs such as o3-mini and Deepseek R1 shows that even the best model attains only 69.78% accuracy on SCoRE (even only 47.91% on the hard set), with errors often stemming from rare knowledge, logical inconsistency, and over-interpretation of simple questions. SCoRE offers a scalable, extensible framework for evaluating and diagnosing the long-chain commonsense reasoning abilities of LLMs and guiding future advances in model design and training.