Michał Szafarczyk

Karol Dobiczek, Maciej Mozolewski, Szymon Bobek et al.

Deep learning models for 12-lead electrocardiogram (ECG) analysis achieve high diagnostic performance but lack the intuitive interpretability required for clinical integration. Standard feature attribution methods are limited by the inherent difficulty in mapping abstract waveform fluctuations to physical anatomical pathologies. To resolve this, we propose a cross-modal method that projects feature attributions from high-performance 12-lead ECG models onto the CineECG 3D anatomical space. Our study reveals that while models trained directly on CineECG signals suffer from reduced accuracy and incoherent attributions, the proposed mapping mechanism effectively recovers clinically relevant feature rankings. Validated against a ground-truth dataset of 20 cases annotated by domain experts, the mapped explanations yield a Dice score of 0.56, significantly outperforming the 0.47 baseline of standard 12-lead attributions. These findings indicate that cross-modal averaging mapping effectively filters attribution instability and improves the localization of pathological features, combining the diagnostic expressiveness of standard ECG with the intuitive clarity of anatomical visualization.

Michał Szafarczyk, Piotr Ludynia, Przemysław Kukla

Machine learning solutions are very popular in the field of chemoinformatics, where they have numerous applications, such as novel drug discovery or molecular property prediction. Molecular fingerprints are algorithms commonly used for vectorizing chemical molecules as a part of preprocessing in this kind of solution. However, despite their popularity, there are no libraries that implement them efficiently for large datasets, utilizing modern, multicore architectures. On top of that, most of them do not provide the user with an intuitive interface, or one that would be compatible with other machine learning tools. In this project, we created a Python library that computes molecular fingerprints efficiently and delivers an interface that is comprehensive and enables the user to easily incorporate the library into their existing machine learning workflow. The library enables the user to perform computation on large datasets using parallelism. Because of that, it is possible to perform such tasks as hyperparameter tuning in a reasonable time. We describe tools used in implementation of the library and asses its time performance on example benchmark datasets. Additionally, we show that using molecular fingerprints we can achieve results comparable to state-of-the-art ML solutions even with very simple models.