Jun Wen

Zenan Huang, Jun Wen, Siheng Chen et al.

Domain adaptation methods reduce domain shift typically by learning domain-invariant features. Most existing methods are built on distribution matching, e.g., adversarial domain adaptation, which tends to corrupt feature discriminability. In this paper, we propose Discriminative Radial Domain Adaptation (DRDA) which bridges source and target domains via a shared radial structure. It's motivated by the observation that as the model is trained to be progressively discriminative, features of different categories expand outwards in different directions, forming a radial structure. We show that transferring such an inherently discriminative structure would enable to enhance feature transferability and discriminability simultaneously. Specifically, we represent each domain with a global anchor and each category a local anchor to form a radial structure and reduce domain shift via structure matching. It consists of two parts, namely isometric transformation to align the structure globally and local refinement to match each category. To enhance the discriminability of the structure, we further encourage samples to cluster close to the corresponding local anchors based on optimal-transport assignment. Extensively experimenting on multiple benchmarks, our method is shown to consistently outperforms state-of-the-art approaches on varied tasks, including the typical unsupervised domain adaptation, multi-source domain adaptation, domain-agnostic learning, and domain generalization.

Zhen Zhang, Wanjing Zhou, Juncheng Li et al.

Compared with individual agents, large language model based multi-agent systems have shown great capabilities consistently across diverse tasks, including code generation, mathematical reasoning, and planning, etc. Despite their impressive performance, the effectiveness and robustness of these systems heavily rely on their communication topology, which is often fixed or generated in a single step. This restricts fine-grained structural exploration and flexible composition, resulting in excessive token utilization on simple tasks while limiting capability on complicated tasks. To mitigate this challenge, we introduce RADAR, a redundancy-aware and query-adaptive generative framework that actively reduce communication overhead. Motivated by recent progress in conditional discrete graph diffusion models, we formulate communication topology design as a step-by-step generation process, guided by the effective size of the graph. Comprehensive experiments on six benchmarks demonstrate that RADAR consistently outperforms recent baselines, achieving higher accuracy, lower token consumption, and greater robustness across diverse scenarios. Our code and data are available at https://github.com/cszhangzhen/RADAR.

Zhaoying Wang, Yingdan Shi, Xiang Liu et al.

Drug-side effect research is vital for understanding adverse reactions arising in complex multi-drug therapies. However, the scarcity of higher-order datasets that capture the combinatorial effects of multiple drugs severely limits progress in this field. Existing resources such as TWOSIDES primarily focus on pairwise interactions. To fill this critical gap, we introduce HODDI, the first Higher-Order Drug-Drug Interaction Dataset, constructed from U.S. Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) records spanning the past decade, to advance computational pharmacovigilance. HODDI contains 109,744 records involving 2,506 unique drugs and 4,569 unique side effects, specifically curated to capture multi-drug interactions and their collective impact on adverse effects. Comprehensive statistical analyses demonstrate HODDI's extensive coverage and robust analytical metrics, making it a valuable resource for studying higher-order drug relationships. Evaluating HODDI with multiple models, we found that simple Multi-Layer Perceptron (MLP) can outperform graph models, while hypergraph models demonstrate superior performance in capturing complex multi-drug interactions, further validating HODDI's effectiveness. Our findings highlight the inherent value of higher-order information in drug-side effect prediction and position HODDI as a benchmark dataset for advancing research in pharmacovigilance, drug safety, and personalized medicine. The dataset and codes are available at https://github.com/TIML-Group/HODDI.

Junyu Gao, Wei Lin, Bin Zhao et al.

This technical report attempts to provide efficient and solid kits addressed on the field of crowd counting, which is denoted as Crowd Counting Code Framework (C$^3$F). The contributions of C$^3$F are in three folds: 1) Some solid baseline networks are presented, which have achieved the state-of-the-arts. 2) Some flexible parameter setting strategies are provided to further promote the performance. 3) A powerful log system is developed to record the experiment process, which can enhance the reproducibility of each experiment. Our code is made publicly available at \url{https://github.com/gjy3035/C-3-Framework}. Furthermore, we also post a Chinese blog\footnote{\url{https://zhuanlan.zhihu.com/p/65650998}} to describe the details and insights of crowd counting.

Sihang Zeng, Yujuan Fu, Sitong Zhou et al. · uw

Large language models (LLMs) offer a generalizable approach for modeling patient trajectories, but suffer from the long and noisy nature of electronic health records (EHR) data in temporal reasoning. To address these challenges, we introduce Traj-CoA, a multi-agent system involving chain-of-agents for patient trajectory modeling. Traj-CoA employs a chain of worker agents to process EHR data in manageable chunks sequentially, distilling critical events into a shared long-term memory module, EHRMem, to reduce noise and preserve a comprehensive timeline. A final manager agent synthesizes the worker agents' summary and the extracted timeline in EHRMem to make predictions. In a zero-shot one-year lung cancer risk prediction task based on five-year EHR data, Traj-CoA outperforms baselines of four categories. Analysis reveals that Traj-CoA exhibits clinically aligned temporal reasoning, establishing it as a promisingly robust and generalizable approach for modeling complex patient trajectories.

Sihang Zeng, Lucas Jing Liu, Jun Wen et al.

Trustworthy survival prediction is essential for clinical decision making. Longitudinal electronic health records (EHRs) provide a uniquely powerful opportunity for the prediction. However, it is challenging to accurately model the continuous clinical progression of patients underlying the irregularly sampled clinical features and to transparently link the progression to survival outcomes. To address these challenges, we develop TrajSurv, a model that learns continuous latent trajectories from longitudinal EHR data for trustworthy survival prediction. TrajSurv employs a neural controlled differential equation (NCDE) to extract continuous-time latent states from the irregularly sampled data, forming continuous latent trajectories. To ensure the latent trajectories reflect the clinical progression, TrajSurv aligns the latent state space with patient state space through a time-aware contrastive learning approach. To transparently link clinical progression to the survival outcome, TrajSurv uses latent trajectories in a two-step divide-and-conquer interpretation process. First, it explains how the changes in clinical features translate into the latent trajectory's evolution using a learned vector field. Second, it clusters these latent trajectories to identify key clinical progression patterns associated with different survival outcomes. Evaluations on two real-world medical datasets, MIMIC-III and eICU, show TrajSurv's competitive accuracy and superior transparency over existing deep learning methods.

Jun Wen, Jue Hou, Clara-Lea Bonzel et al.

Electronic health record (EHR) data are increasingly used to support real-world evidence (RWE) studies. Yet its ability to generate reliable RWE is limited by the lack of readily available precise information on the timing of clinical events such as the onset time of heart failure. We propose a LAbel-efficienT incidenT phEnotyping (LATTE) algorithm to accurately annotate the timing of clinical events from longitudinal EHR data. By leveraging the pre-trained semantic embedding vectors from large-scale EHR data as prior knowledge, LATTE selects predictive EHR features in a concept re-weighting module by mining their relationship to the target event and compresses their information into longitudinal visit embeddings through a visit attention learning network. LATTE employs a recurrent neural network to capture the sequential dependency between the target event and visit embeddings before/after it. To improve label efficiency, LATTE constructs highly informative longitudinal silver-standard labels from large-scale unlabeled patients to perform unsupervised pre-training and semi-supervised joint training. Finally, LATTE enhances cross-site portability via contrastive representation learning. LATTE is evaluated on three analyses: the onset of type-2 diabetes, heart failure, and the onset and relapses of multiple sclerosis. We use various evaluation metrics present in the literature including the $ABC_{gain}$, the proportion of reduction in the area between the observed event indicator and the predicted cumulative incidences in reference to the prediction per incident prevalence. LATTE consistently achieves substantial improvement over benchmark methods such as SAMGEP and RETAIN in all settings.

Peng Wang, Jun Wen, Chenyang Si et al.

Skeleton-based action recognition is widely used in varied areas, e.g., surveillance and human-machine interaction. Existing models are mainly learned in a supervised manner, thus heavily depending on large-scale labeled data which could be infeasible when labels are prohibitively expensive. In this paper, we propose a novel Contrast-Reconstruction Representation Learning network (CRRL) that simultaneously captures postures and motion dynamics for unsupervised skeleton-based action recognition. It mainly consists of three parts: Sequence Reconstructor, Contrastive Motion Learner, and Information Fuser. The Sequence Reconstructor learns representation from skeleton coordinate sequence via reconstruction, thus the learned representation tends to focus on trivial postural coordinates and be hesitant in motion learning. To enhance the learning of motions, the Contrastive Motion Learner performs contrastive learning between the representations learned from coordinate sequence and additional velocity sequence, respectively. Finally, in the Information Fuser, we explore varied strategies to combine the Sequence Reconstructor and Contrastive Motion Learner, and propose to capture postures and motions simultaneously via a knowledge-distillation based fusion strategy that transfers the motion learning from the Contrastive Motion Learner to the Sequence Reconstructor. Experimental results on several benchmarks, i.e., NTU RGB+D 60, NTU RGB+D 120, CMU mocap, and NW-UCLA, demonstrate the promise of the proposed CRRL method by far outperforming state-of-the-art approaches.

Ning Ma, Jiajun Bu, Lixian Lu et al.

Domain Adaptation has been widely used to deal with the distribution shift in vision, language, multimedia etc. Most domain adaptation methods learn domain-invariant features with data from both domains available. However, such a strategy might be infeasible in practice when source data are unavailable due to data-privacy concerns. To address this issue, we propose a novel adaptation method via hypothesis transfer without accessing source data at adaptation stage. In order to fully use the limited target data, a semi-supervised mutual enhancement method is proposed, in which entropy minimization and augmented label propagation are used iteratively to perform inter-domain and intra-domain alignments. Compared with state-of-the-art methods, the experimental results on three public datasets demonstrate that our method gets up to 19.9% improvements on semi-supervised adaptation tasks.

Jun Wen, Changjian Shui, Kun Kuang et al.

Domain adaptation (DA) aims to transfer discriminative features learned from source domain to target domain. Most of DA methods focus on enhancing feature transferability through domain-invariance learning. However, source-learned discriminability itself might be tailored to be biased and unsafely transferable by spurious correlations, \emph{i.e.}, part of source-specific features are correlated with category labels. We find that standard domain-invariance learning suffers from such correlations and incorrectly transfers the source-specifics. To address this issue, we intervene in the learning of feature discriminability using unlabeled target data to guide it to get rid of the domain-specific part and be safely transferable. Concretely, we generate counterfactual features that distinguish the domain-specifics from domain-sharable part through a novel feature intervention strategy. To prevent the residence of domain-specifics, the feature discriminability is trained to be invariant to the mutations in the domain-specifics of counterfactual features. Experimenting on typical \emph{one-to-one} unsupervised domain adaptation and challenging domain-agnostic adaptation tasks, the consistent performance improvements of our method over state-of-the-art approaches validate that the learned discriminative features are more safely transferable and generalize well to novel domains.

Changjian Shui, Qi Chen, Jun Wen et al.

We reveal the incoherence between the widely-adopted empirical domain adversarial training and its generally-assumed theoretical counterpart based on $\mathcal{H}$-divergence. Concretely, we find that $\mathcal{H}$-divergence is not equivalent to Jensen-Shannon divergence, the optimization objective in domain adversarial training. To this end, we establish a new theoretical framework by directly proving the upper and lower target risk bounds based on joint distributional Jensen-Shannon divergence. We further derive bi-directional upper bounds for marginal and conditional shifts. Our framework exhibits inherent flexibilities for different transfer learning problems, which is usable for various scenarios where $\mathcal{H}$-divergence-based theory fails to adapt. From an algorithmic perspective, our theory enables a generic guideline unifying principles of semantic conditional matching, feature marginal matching, and label marginal shift correction. We employ algorithms for each principle and empirically validate the benefits of our framework on real datasets.

Yaoxian Song, Jun Wen, Yuejiao Fei et al.

Robotic arm grasping is a fundamental operation in robotic control task goals. Most current methods for robotic grasping focus on RGB-D policy in the table surface scenario or 3D point cloud analysis and inference in the 3D space. Comparing to these methods, we propose a novel real-time multimodal hierarchical encoder-decoder neural network that fuses RGB and depth data to realize robotic humanoid grasping in 3D space with only partial observation. The quantification of raw depth data's uncertainty and depth estimation fusing RGB is considered. We develop a general labeling method to label ground-truth on common RGB-D datasets. We evaluate the effectiveness and performance of our method on a physical robot setup and our method achieves over 90\% success rate in both table surface and 3D space scenarios.

Dongsheng Ruan, Jun Wen, Nenggan Zheng et al.

Squeeze-and-Excitation (SE) block presents a channel attention mechanism for modeling global context via explicitly capturing dependencies across channels. However, we are still far from understanding how the SE block works. In this work, we first revisit the SE block, and then present a detailed empirical study of the relationship between global context and attention distribution, based on which we propose a simple yet effective module, called Linear Context Transform (LCT) block. We divide all channels into different groups and normalize the globally aggregated context features within each channel group, reducing the disturbance from irrelevant channels. Through linear transform of the normalized context features, we model global context for each channel independently. The LCT block is extremely lightweight and easy to be plugged into different backbone models while with negligible parameters and computational burden increase. Extensive experiments show that the LCT block outperforms the SE block in image classification task on the ImageNet and object detection/segmentation on the COCO dataset with different backbone models. Moreover, LCT yields consistent performance gains over existing state-of-the-art detection architectures, e.g., 1.5$\sim$1.7% AP$^{bbox}$ and 1.0$\sim$1.2% AP$^{mask}$ improvements on the COCO benchmark, irrespective of different baseline models of varied capacities. We hope our simple yet effective approach will shed some light on future research of attention-based models.

Long Yang, Yu Zhang, Gang Zheng et al.

Improving sample efficiency has been a longstanding goal in reinforcement learning. This paper proposes $\mathtt{VRMPO}$ algorithm: a sample efficient policy gradient method with stochastic mirror descent. In $\mathtt{VRMPO}$, a novel variance-reduced policy gradient estimator is presented to improve sample efficiency. We prove that the proposed $\mathtt{VRMPO}$ needs only $\mathcal{O}(ε^{-3})$ sample trajectories to achieve an $ε$-approximate first-order stationary point, which matches the best sample complexity for policy optimization. The extensive experimental results demonstrate that $\mathtt{VRMPO}$ outperforms the state-of-the-art policy gradient methods in various settings.

Long Yang, Yu Zhang, Jun Wen et al.

Off-policy learning is powerful for reinforcement learning. However, the high variance of off-policy evaluation is a critical challenge, which causes off-policy learning falls into an uncontrolled instability. In this paper, for reducing the variance, we introduce control variate technique to $\mathtt{Expected}$ $\mathtt{Sarsa}$($λ$) and propose a tabular $\mathtt{ES}$($λ$)-$\mathtt{CV}$ algorithm. We prove that if a proper estimator of value function reaches, the proposed $\mathtt{ES}$($λ$)-$\mathtt{CV}$ enjoys a lower variance than $\mathtt{Expected}$ $\mathtt{Sarsa}$($λ$). Furthermore, to extend $\mathtt{ES}$($λ$)-$\mathtt{CV}$ to be a convergent algorithm with linear function approximation, we propose the $\mathtt{GES}$($λ$) algorithm under the convex-concave saddle-point formulation. We prove that the convergence rate of $\mathtt{GES}$($λ$) achieves $\mathcal{O}(1/T)$, which matches or outperforms lots of state-of-art gradient-based algorithms, but we use a more relaxed condition. Numerical experiments show that the proposed algorithm performs better with lower variance than several state-of-art gradient-based TD learning algorithms: $\mathtt{GQ}$($λ$), $\mathtt{GTB}$($λ$) and $\mathtt{ABQ}$($ζ$).

Jun Wen, Nenggan Zheng, Junsong Yuan et al.

Domain adaptation is an important technique to alleviate performance degradation caused by domain shift, e.g., when training and test data come from different domains. Most existing deep adaptation methods focus on reducing domain shift by matching marginal feature distributions through deep transformations on the input features, due to the unavailability of target domain labels. We show that domain shift may still exist via label distribution shift at the classifier, thus deteriorating model performances. To alleviate this issue, we propose an approximate joint distribution matching scheme by exploiting prediction uncertainty. Specifically, we use a Bayesian neural network to quantify prediction uncertainty of a classifier. By imposing distribution matching on both features and labels (via uncertainty), label distribution mismatching in source and target data is effectively alleviated, encouraging the classifier to produce consistent predictions across domains. We also propose a few techniques to improve our method by adaptively reweighting domain adaptation loss to achieve nontrivial distribution matching and stable training. Comparisons with state of the art unsupervised domain adaptation methods on three popular benchmark datasets demonstrate the superiority of our approach, especially on the effectiveness of alleviating negative transfer.

Jun Wen, Risheng Liu, Nenggan Zheng et al.

Unsupervised domain adaptation methods aim to alleviate performance degradation caused by domain-shift by learning domain-invariant representations. Existing deep domain adaptation methods focus on holistic feature alignment by matching source and target holistic feature distributions, without considering local features and their multi-mode statistics. We show that the learned local feature patterns are more generic and transferable and a further local feature distribution matching enables fine-grained feature alignment. In this paper, we present a method for learning domain-invariant local feature patterns and jointly aligning holistic and local feature statistics. Comparisons to the state-of-the-art unsupervised domain adaptation methods on two popular benchmark datasets demonstrate the superiority of our approach and its effectiveness on alleviating negative transfer.

Liangqu Long, Wei Wang, Jun Wen et al.

Few-shot learning that trains image classifiers over few labeled examples per category is a challenging task. In this paper, we propose to exploit an additional big dataset with different categories to improve the accuracy of few-shot learning over our target dataset. Our approach is based on the observation that images can be decomposed into objects, which may appear in images from both the additional dataset and our target dataset. We use the object-level relation learned from the additional dataset to infer the similarity of images in our target dataset with unseen categories. Nearest neighbor search is applied to do image classification, which is a non-parametric model and thus does not need fine-tuning. We evaluate our algorithm on two popular datasets, namely Omniglot and MiniImagenet. We obtain 8.5\% and 2.7\% absolute improvements for 5-way 1-shot and 5-way 5-shot experiments on MiniImagenet, respectively. Source code will be published upon acceptance.