Xian Wu

Xinquan Yang, Jinheng Xie, Yawen Huang et al.

Long-tailed pulmonary anomalies in chest radiography present formidable diagnostic challenges. Despite the recent strides in diffusion-based methods for enhancing the representation of tailed lesions, the paucity of rare lesion exemplars curtails the generative capabilities of these approaches, thereby leaving the diagnostic precision less than optimal. In this paper, we propose a novel data synthesis pipeline designed to augment tail lesions utilizing a copious supply of conventional normal X-rays. Specifically, a sufficient quantity of normal samples is amassed to train a diffusion model capable of generating normal X-ray images. This pre-trained diffusion model is subsequently utilized to inpaint the head lesions present in the diseased X-rays, thereby preserving the tail classes as augmented training data. Additionally, we propose the integration of a Large Language Model Knowledge Guidance (LKG) module alongside a Progressive Incremental Learning (PIL) strategy to stabilize the inpainting fine-tuning process. Comprehensive evaluations conducted on the public lung datasets MIMIC and CheXpert demonstrate that the proposed method sets a new benchmark in performance.

Minye Shao, Xingyu Miao, Haoran Duan et al.

3D medical image generation is essential for data augmentation and patient privacy, calling for reliable and efficient models suited for clinical practice. However, current methods suffer from limited anatomical fidelity, restricted axial length, and substantial computational cost, placing them beyond reach for regions with limited resources and infrastructure. We introduce TRACE, a framework that generates 3D medical images with spatiotemporal alignment using a 2D multimodal-conditioned diffusion approach. TRACE models sequential 2D slices as video frame pairs, combining segmentation priors and radiology reports for anatomical alignment, incorporating optical flow to sustain temporal coherence. During inference, an overlapping-frame strategy links frame pairs into a flexible length sequence, reconstructed into a spatiotemporally and anatomically aligned 3D volume. Experimental results demonstrate that TRACE effectively balances computational efficiency with preserving anatomical fidelity and spatiotemporal consistency. Code is available at: https://github.com/VinyehShaw/TRACE.

Lei Li, Xiao Zhou, Yingying Zhang et al.

Medical question answering (QA) requires extensive access to domain-specific knowledge. A promising direction is to enhance large language models (LLMs) with external knowledge retrieved from medical corpora or parametric knowledge stored in model parameters. Existing approaches typically fall into two categories: Retrieval-Augmented Generation (RAG), which grounds model reasoning on externally retrieved evidence, and Generation-Augmented Generation (GAG), which depends solely on the models internal knowledge to generate contextual documents. However, RAG often suffers from noisy or incomplete retrieval, while GAG is vulnerable to hallucinated or inaccurate information due to unconstrained generation. Both issues can mislead reasoning and undermine answer reliability. To address these challenges, we propose MedRGAG, a unified retrieval-generation augmented framework that seamlessly integrates external and parametric knowledge for medical QA. MedRGAG comprises two key modules: Knowledge-Guided Context Completion (KGCC), which directs the generator to produce background documents that complement the missing knowledge revealed by retrieval; and Knowledge-Aware Document Selection (KADS), which adaptively selects an optimal combination of retrieved and generated documents to form concise yet comprehensive evidence for answer generation. Extensive experiments on five medical QA benchmarks demonstrate that MedRGAG achieves a 12.5% improvement over MedRAG and a 4.5% gain over MedGENIE, highlighting the effectiveness of unifying retrieval and generation for knowledge-intensive reasoning. Our code and data are publicly available at https://anonymous.4open.science/r/MedRGAG

Zichuan Fu, Xian Wu, Guojing Li et al.

Large Language Models (LLMs) require continuous updates to maintain accurate and current knowledge as the world evolves. While existing knowledge editing approaches offer various solutions for knowledge updating, they often struggle with sequential editing scenarios and harm the general capabilities of the model, thereby significantly hampering their practical applicability. This paper proposes a two-stage framework combining robust supervised fine-tuning (R-SFT) with model merging for knowledge editing. Our method first fine-tunes the LLM to internalize new knowledge fully, then merges the fine-tuned model with the original foundation model to preserve newly acquired knowledge and general capabilities. Experimental results demonstrate that our approach significantly outperforms existing methods in sequential editing while better preserving the original performance of the model, all without requiring any architectural changes. Code is available at: https://github.com/Applied-Machine-Learning-Lab/MM4KE.

Hao Wu, Yuan Gao, Xingjian Shi et al.

To address the dual challenges of inherent stochasticity and non-differentiable metrics in physical spatiotemporal forecasting, we propose Spatiotemporal Forecasting as Planning (SFP), a new paradigm grounded in Model-Based Reinforcement Learning. SFP constructs a novel Generative World Model to simulate diverse, high-fidelity future states, enabling an "imagination-based" environmental simulation. Within this framework, a base forecasting model acts as an agent, guided by a beam search-based planning algorithm that leverages non-differentiable domain metrics as reward signals to explore high-return future sequences. These identified high-reward candidates then serve as pseudo-labels to continuously optimize the agent's policy through iterative self-training, significantly reducing prediction error and demonstrating exceptional performance on critical domain metrics like capturing extreme events.

Hao Wu, Yuan Gao, Ruijian Gou et al.

Reliable long-term forecasting of Earth system dynamics is fundamentally limited by instabilities in current artificial intelligence (AI) models during extended autoregressive simulations. These failures often originate from inherent spectral bias, leading to inadequate representation of critical high-frequency, small-scale processes and subsequent uncontrolled error amplification. Inspired by the nested grids in numerical models used to resolve small scales, we present TritonCast. At the core of its design is a dedicated latent dynamical core, which ensures the long-term stability of the macro-evolution at a coarse scale. An outer structure then fuses this stable trend with fine-grained local details. This design effectively mitigates the spectral bias caused by cross-scale interactions. In atmospheric science, it achieves state-of-the-art accuracy on the WeatherBench 2 benchmark while demonstrating exceptional long-term stability: executing year-long autoregressive global forecasts and completing multi-year climate simulations that span the entire available $2500$-day test period without drift. In oceanography, it extends skillful eddy forecast to $120$ days and exhibits unprecedented zero-shot cross-resolution generalization. Ablation studies reveal that this performance stems from the synergistic interplay of the architecture's core components. TritonCast thus offers a promising pathway towards a new generation of trustworthy, AI-driven simulations. This significant advance has the potential to accelerate discovery in climate and Earth system science, enabling more reliable long-term forecasting and deeper insights into complex geophysical dynamics.