Chengze Ye

Siyuan Mei, Yan Xia, Yipeng Sun et al.

Generating CT volumes from MRI and CBCT can improve treatment planning in adaptive radiotherapy while avoiding additional radiation exposure. However, direct regression of CT intensities is challenged by the inherently high dynamic range and long-tailed distributions, thereby averaging out sparse yet clinically important structures. To alleviate this issue, we reformulate the regression target into multiple windowed representations, leveraging the inductive prior that CT intensities are structure-deterministic and window-separable. These windowed views exhibit smoother distributions and admit structured fusion back to the full-range CT. Building on this reformulation, we introduce WING, a WINdow-prior-based Generative network comprising: 1) a new Gated Inception Generator to produce multi-window predictions, enabling multi-shape kernel interactions to capture cross-modality correspondence; 2) a Fuse-and-Refine Transformer to aggregate the windowed outputs and learn residuals for detail refinement; and 3) a joint adversarial training objective to enhance window-conditioned realism. Extensive experiments demonstrate that our compact WING achieves state-of-the-art performance on the MRI-to-CT and CBCT-to-CT benchmarks, while supporting multi-anatomy synthesis with a single model.

Chengze Ye, Linda-Sophie Schneider, Yipeng Sun et al.

This study presents a novel approach for reconstructing cone beam computed tomography (CBCT) for specific orbits using known operator learning. Unlike traditional methods, this technique employs a filtered backprojection type (FBP-type) algorithm, which integrates a unique, adaptive filtering process. This process involves a series of operations, including weightings, differentiations, the 2D Radon transform, and backprojection. The filter is designed for a specific orbit geometry and is obtained using a data-driven approach based on deep learning. The approach efficiently learns and optimizes the orbit-related component of the filter. The method has demonstrated its ability through experimentation by successfully learning parameters from circular orbit projection data. Subsequently, the optimized parameters are used to reconstruct images, resulting in outcomes that closely resemble the analytical solution. This demonstrates the potential of the method to learn appropriate parameters from any specific orbit projection data and achieve reconstruction. The algorithm has demonstrated improvement, particularly in enhancing reconstruction speed and reducing memory usage for handling specific orbit reconstruction.

Chengze Ye, Linda-Sophie Schneider, Yipeng Sun et al.

This paper introduces a novel method for reconstructing cone beam computed tomography (CBCT) images for arbitrary orbits using a differentiable shift-variant filtered backprojection (FBP) neural network. Traditional CBCT reconstruction methods for arbitrary orbits, like iterative reconstruction algorithms, are computationally expensive and memory-intensive. The proposed method addresses these challenges by employing a shift-variant FBP algorithm optimized for arbitrary trajectories through a deep learning approach that adapts to a specific orbit geometry. This approach overcomes the limitations of existing techniques by integrating known operators into the learning model, minimizing the number of parameters, and improving the interpretability of the model. The proposed method is a significant advancement in interventional medical imaging, particularly for robotic C-arm CT systems, enabling faster and more accurate CBCT reconstructions with customized orbits. Especially this method can also be used for the analytical reconstruction of non-continuous orbits like circular plus arc. The experimental results demonstrate that the proposed method significantly accelerates the reconstruction process compared to conventional iterative algorithms. It achieves comparable or superior image quality, as evidenced by metrics such as the mean squared error (MSE), the peak signal-to-noise ratio (PSNR), and the structural similarity index measure (SSIM). The validation experiments show that the method can handle data from different trajectories, demonstrating its flexibility and robustness across different scan geometries. Our method demonstrates a significant improvement, particularly for the sinusoidal trajectory, achieving a 38.6% reduction in MSE, a 7.7% increase in PSNR, and a 5.0% improvement in SSIM. Furthermore, the computation time for reconstruction was reduced by more than 97%.

Yipeng Sun, Linda-Sophie Schneider, Chengze Ye et al.

Cone-Beam Computed Tomography (CBCT) is essential in medical imaging, and the Feldkamp-Davis-Kress (FDK) algorithm is a popular choice for reconstruction due to its efficiency. However, FDK is susceptible to noise and artifacts. While recent deep learning methods offer improved image quality, they often increase computational complexity and lack the interpretability of traditional methods. In this paper, we introduce an enhanced FDK-based neural network that maintains the classical algorithm's interpretability by selectively integrating trainable elements into the cosine weighting and filtering stages. Recognizing the challenge of a large parameter space inherent in 3D CBCT data, we leverage wavelet transformations to create sparse representations of the cosine weights and filters. This strategic sparsification reduces the parameter count by $93.75\%$ without compromising performance, accelerates convergence, and importantly, maintains the inference computational cost equivalent to the classical FDK algorithm. Our method not only ensures volumetric consistency and boosts robustness to noise, but is also designed for straightforward integration into existing CT reconstruction pipelines. This presents a pragmatic enhancement that can benefit clinical applications, particularly in environments with computational limitations.

Chengze Ye, Linda-Sophie Schneider, Yipeng Sun et al.

The differentiable shift-variant filtered backprojection (FBP) model enables the reconstruction of cone-beam computed tomography (CBCT) data for any non-circular trajectories. This method employs deep learning technique to estimate the redundancy weights required for reconstruction, given knowledge of the specific trajectory at optimization time. However, computing the redundancy weight for each projection remains computationally intensive. This paper presents a novel approach to compress and optimize the differentiable shift-variant FBP model based on Principal Component Analysis (PCA). We apply PCA to the redundancy weights learned from sinusoidal trajectory projection data, revealing significant parameter redundancy in the original model. By integrating PCA directly into the differentiable shift-variant FBP reconstruction pipeline, we develop a method that decomposes the redundancy weight layer parameters into a trainable eigenvector matrix, compressed weights, and a mean vector. This innovative technique achieves a remarkable 97.25% reduction in trainable parameters without compromising reconstruction accuracy. As a result, our algorithm significantly decreases the complexity of the differentiable shift-variant FBP model and greatly improves training speed. These improvements make the model substantially more practical for real-world applications.