David M. Leslie

Robin Mitra, Sarah F. McGough, Tapabrata Chakraborti et al. · oxford

Missing data are an unavoidable complication in many machine learning tasks. When data are `missing at random' there exist a range of tools and techniques to deal with the issue. However, as machine learning studies become more ambitious, and seek to learn from ever-larger volumes of heterogeneous data, an increasingly encountered problem arises in which missing values exhibit an association or structure, either explicitly or implicitly. Such `structured missingness' raises a range of challenges that have not yet been systematically addressed, and presents a fundamental hindrance to machine learning at scale. Here, we outline the current literature and propose a set of grand challenges in learning from data with structured missingness.

David Leslie

Innovations in data science and AI/ML have a central role to play in supporting global efforts to combat COVID-19. The versatility of AI/ML technologies enables scientists and technologists to address an impressively broad range of biomedical, epidemiological, and socioeconomic challenges. This wide-reaching scientific capacity, however, also raises a diverse array of ethical challenges. The need for researchers to act quickly and globally in tackling SARS-CoV-2 demands unprecedented practices of open research and responsible data sharing at a time when innovation ecosystems are hobbled by proprietary protectionism, inequality, and a lack of public trust. Moreover, societally impactful interventions like digital contact tracing are raising fears of surveillance creep and are challenging widely held commitments to privacy, autonomy, and civil liberties. Prepandemic concerns that data-driven innovations may function to reinforce entrenched dynamics of societal inequity have likewise intensified given the disparate impact of the virus on vulnerable social groups and the life-and-death consequences of biased and discriminatory public health outcomes. To address these concerns, I offer five steps that need to be taken to encourage responsible research and innovation. These provide a practice-based path to responsible AI/ML design and discovery centered on open, accountable, equitable, and democratically governed processes and products. When taken from the start, these steps will not only enhance the capacity of innovators to tackle COVID-19 responsibly, they will, more broadly, help to better equip the data science and AI/ML community to cope with future pandemics and to support a more humane, rational, and just society.